Date: 15th December’ 2015 From: Dr. Hari N. Pati Advinus Therapeutics Ltd, 21 & 22, Phase II, Bangalore-560058, E-mail- hari.pati@advinus.com Tel.: +91-9900212096 To: Professor Sazali Hamzah Associate Editor, Synthetic Communications Subject: Submission of revised manuscript for publication in Synthetic Communications. Dear Professor Hamzah, Thank you very much for reviewing our manuscript entitled “Efficient synthesis of β-lactam-containing α-hydroxylphosphonates using Tartaric acid and Fumaric acid as mild catalysts” for publication in Synthetic Communications. As per the reviewer’s comments and suggestions, the necessary corrections have been made in the revised manuscript; and clean spectra have been incorporated in the supplementary data file as well. I am herewith submitting the revised manuscript along with rebuttal file and supplementary document for your kind perusal. On behalf of all authors, I request you to consider this manuscript for review and further publication in your esteemed journal. It would be our privilege to have publication in Synthetic Communications. I look forward to hear from you. Thanking you. Sincerely, Dr. Hari N. Pati Advinus Therapeutics Ltd. Bangalore, India.