Table S2: List of genes differentially expressed in both high and low dose arsenic exposure (+/1.5 fold).
Gene Name
aat-7
ads-1
aip-1
air-2
alh-10
amt-4
aqp-1
aqp-11
asm-2
bec-1
cat-4
cdd-1
cdk-1
cpg-1
cey-2
cln-3.3
cnc-4
col-8
col-19
col-62
col-76
col-103
col-143
col-178
col-184
cpr-4
cpr-5
ctl-2
cyb-2.2
daf-21
dao-3
dhs-2
Brief Description
predicted amino acid transporter catalytic subunit
ortholog of human alkyl-dihydroxyacetonephosphate synthase precursor (AGPS)
that is required for normal larval development
AN-1-like zinc finger-containing protein homologous to arsenite-inducible RNAassociated protein (AIRAP)
aurora/Ipl1-related serine/threonine protein kinase
aldehyde dehydrogenase
member of the ammonium transporter protein family
aquaglyceroporin
putative aquaporin
similar to human acid sphingomyelinase (ASM)
orthologous to the yeast and mammalian autophagy proteins
Apg6/Vps30p/beclin1
ortholog of the human GTP cyclohydrolase I gene
cytidine deaminase
cyclin-dependent kinase
encodes a protein with three chitin-binding peritrophin-A domains and two
mucin-like regions
cold-shock/Y-box domain-containing gene
predicted transmembrane protein that comprises one of three C. elegans
homologs of human CLN3
caenacin peptide
collagen
collagen
collagen
collagen
collagen
collagen
collagen
collagen
cathepsin B-like cysteine protease gene
cysteine protease.
catalase
cyclin
member of the Hsp90 family of molecular chaperones
encodes a protein containing tetrahydrofolate dehydrogenase/cyclohydrolase
catalytic and NAD(P)-binding domains
short-chain dehydrogenase predicted to be mitochondrial.
dhs-4
dhs-8
dhs-9
dhs-12
dhs-20
dhs-22
dlk-1
ech-7
ech-9
elo-1
elo-5
elo-6
fis-2
ftn-1
ftn-2
gcs-1
gfi-1
gln-5
gln-6
gna-2
grl-14
gst-1
gst-2
gst-4
gst-5
gst-6
gst-7
gst-8
gst-10
gst-12
gst-13
gst-14
gst-16
gst-19
gst-20
gst-22
gst-25
gst-27
gst-30
gst-31
gst-38
gst-39
gst-40
short-chain dehydrogenase predicted to be mitochondrial.
short-chain dehydrogenase predicted to be mitochondrial.
member of the short-chain dehydrogenases/reductases family (SDR).
alcohol dehydrogenase
short-chain dehydrogenase predicted to be mitochondrial.
short-chain dehydrogenase predicted to be mitochondrial.
mitogen-activated protein kinase kinase kinase (MAPKKK)
enoyl-CoA hydratase
enoyl-CoA hydratase
a component of C-18 polyunsaturated fatty acid (PUFA) elongase
polyunsaturated fatty acid (PUFA) elongase
polyunsaturated fatty acid (PUFA) elongase
unknown
ferritin heavy chain homolog
ferritin heavy chain homolog
gamma-glutamine cysteine synthetase heavy chain (GCS(h))
encodes a protein that contains 21 ET modules
carbamoyl-phosphate synthase (CPSase) (2 domains), Biotin-requiring enzymes
glutamine synthase
glucosamine 6-phosphate N-acetyltransferase
hedgehog-like protein
glutathione S-transferase
glutathione S-transferase
glutathione S-transferase
glutathione S-transferase
glutathione S-transferase
glutathione S-transferase
glutathione S-transferase
glutathione S-transferase
glutathione S-transferase
glutathione S-transferase
glutathione S-transferase
glutathione S-transferase
glutathione S-transferase
glutathione S-transferase
glutathione S-transferase
glutathione S-transferase
glutathione S-transferase
glutathione S-transferase
glutathione S-transferase
glutathione S-transferase
glutathione S-transferase
glutathione S-transferase
hmt-1
hgo-1
hil-3
hsp-16.1
hsp-16.2
hsp-16.41
hsp-16.49
hsp-17
hsp-70
ida-1
ife-3
ins-35
inx-15
itr-1
kgb-2
lec-8
lec-9
lec-10
lec-11
lys-4
lys-8
max-1
mbf-1
mel-32
mrp-1
mrp-7
msp-31
msp-33
msp-49
mtl-1
mtl-2
nas-31
nhr-28
nhr-34
nhr-55
nhr-70
nhr-74
nhr-104
nhr-115
nhx-2
nlp-31
nlt-1
encodes a predicted transmembrane half-molecule ATP-binding cassette (ABC)
transporter
homogentisate 1,2-dioxygenase
histone h1
hsp16/hsp20/alphaB-crystallin (HSP16) family
hsp16/hsp20/alphaB-crystallin (HSP16) family
hsp16/hsp20/alphaB-crystallin (HSP16) family
hsp16/hsp20/alphaB-crystallin (HSP16) family
hsp16/hsp20/alphaB-crystallin (HSP16) family
hsp70 family of molecular chaperones.
protein tyrosine phosphatase-like receptor
homolog of the mRNA cap-binding protein eIF4E
insulin-related peptide
unknown
putative inositol (1,4,5) trisphosphate receptor
protein kinase
lectin
lectin
galactose-binding lectin
galectin family
lysozyme
lysozyme
novel, conserved PH/MyTH4/FERM domain-containing gene
Helix-turn-helix motif containing gene
serine hydroxymethyltransferase
ATP-binding cassette (ABC) transporter
ATP-binding cassette (ABC) transporter
major sperm protein family
major sperm protein family
major sperm protein family
metallothionein
metallothionein
zinc metalloprotease
nuclear receptor superfamily
nuclear receptor superfamily
nuclear receptor superfamily
nuclear receptor superfamily
nuclear receptor superfamily
nuclear receptor superfamily
nuclear receptor superfamily
sodium/proton exchanger
neuropeptide-like protein
SCP-2 sterol transfer family
pas-1
pbs-3
pbs-6
pcp-2
pcp-4
pgp-1
pos-1
prk-1
rme-2
rpn-10
rpn-11
rpt-2
rpt-6
sax-1
skr-19
spe-11
spn-4
srr-4
ssp-9
sss-2
nck-1
prdx-2
tba-7
tbb-6
tsp-10
ubc-20
vit-1
vit-3
vit-4
vit-5
vit-6
gspd-1
B0272.4
clec-41
B0513.4
C01H6.4
C05C10.5
C07A9.8
C08E8.4
fbxa-98
ugt-22
type 6 alpha subunit of the 26S proteasome's 20S protease core particle (CP)
B-type subunit of the 26S proteasome's 20S protease core particle
homolog of mammalian PSMB1
lysosomal carboxypeptidase
peptidase
member of the P-glycoprotein subclass of the ATP-binding cassette (ABC)
transporter superfamily
CCCH-type zinc-finger protein
Protein kinase
low-density lipoprotein (LDL) receptor superfamily
member of the von Willebrand factor, type A superfamily
non-ATPase subunit of the 19S regulatory complex of the proteasome
ATPase
triple A ATPase that is a subunit of the 26S proteasome 19S regulatory particle
(RP) base subcomplex
homolog of Ndr kinase
homolog of Skp1
novel, conserved PH/MyTH4/FERM domain-containing gene
encodes a protein containing an RNP-type RNA-binding domain
unknown
unknown
unknown
SH2/SH3 domain-containing protein
2-Cys peroxiredoxins
tubulin alpha subunit
tubulin beta chain
transpanin
ubiquitin conjugating enzyme
vitellogenin
vitellogenin
vitellogenin
vitellogenin
vitellogenin
orthologous to human GLUCOSE-6-PHOSPHATE DEHYDROGENASE
enoyl-CoA hydratase/isomerase
C-type lectin
unknown
Flavin-binding monooxygenase-like
novel
Putative membrane protein encoding gene
unknown
F-box motif containing gene
UDP-glucoronosyl and UDP-glucosyl transferases
C10C5.2
wht-2
C12C8.2
C13B4.1
C14B1.2
C15A11.4
C15A11.7
C15H11.8
clec-87
C28D4.5
C29F3.7
C32H11.1
C32H11.3
C32H11.4
dod-24
C35A5.3
cyp-25A1
cyp-25A2
C39E9.12
C40H1.7
cdc-48.2
unknown
subfamily G of the ATP-binding cassette transporters
cystathionine gamma-lyase orthologous to human CTH
unknown
unknown
amine oxidase
unknown
DNA-directed RNA polymerase I like
C-type lectin
unknown
unknown
unknown
unknown
unknown
unknown
sodium/phosphate transport protein
cytochrome P450
cytochrome P450
unknown
unknown
encodes a AAA (ATPase associated with various cellular activities)