Session C3 Paper #6055 Disclaimer — This paper partially fulfills a writing requirement for first year (freshman) engineering students at the University of Pittsburgh Swanson School of Engineering. This paper is a student, not a professional, paper. This paper is based on publicly available information and may not be provide complete analyses of all relevant data. If this paper is used for any purpose other than these authors’ partial fulfillment of a writing requirement for first year (freshman) engineering students at the University of Pittsburgh Swanson School of Engineering, the user does so at his or her own risk. FORMATTING REQUIREMENTS: REVISED PROPOSAL AND ANNOTATED BIBLIOGRAPHY Abhilash Dhanvada, abd49@pitt.edu, Lora 6:00, Ganesh Kumar, gak36@pitt.edu, Bursic 2:00 Revised Proposal — Wars still rage throughout the world, resulting in numerous soldiers putting their lives on the line for their countries. In the United States alone, over 1500 soldiers have become amputees serving their country in just the past 15 years [1]. This number needs to brought down to zero. The countless conflicts that still seethe is a matter for politicians, however, the engineering community can still do their part. Those who protect our country deserve the highest level of care and commitment to their rehabilitation. The high level of traumatic casualties that have occurred has emphasized the need for technological advancements in the fields of artificial limbs and prosthetics. In this paper, we will highlight the projects that have been focused on updating artificial limbs by way of touch-sensitive artificial skin and then delve deeper into the project that has shown the most promise. In addition, we will address the ethics revolving around artificial skin and explain the significance of this technology with respect to our chosen engineering field. In order to integrate prosthetics with touch-sensitive capabilities, engineers are working on a technology called the skin inspired organic digital mechanoreceptor. Mechanoreceptors are sense organs are cells that respond to mechanical stimuli such as touch and sound. The mechanoreceptor then sends these messages to the brain, which processes and organizes all or the information. Regular skin works by relying on the cutaneous mechanoreceptors that output digital signals for tactile sensing in which the intensity of stimulation is converted into a series of voltage pulses [2]. The organic digital mechanoreceptor is made of three parts: a micro structured resistive pressure sensor, flexible printed organic electronic circuits, and nerve cells containing light activated ion channels [3]. To mimic the effects of the skin’s cutaneous mechanoreceptors, the pressure sensors change conductance in response to applied pressures [3]. The sensors are connected to the electronic circuits which convert the pressure signals into a series of electrical pulses and increases the pulse frequency in response to increasing pressure [3]. The electrical pulses modulate the frequency of a lightemitting diode which sends light from the LED through an optical fiber to stimulate neurons in the brain [3]. This work represents a step toward the design and use of large-area organic electronic skins with neural-integrated touch feedback for replacement limbs. University of Pittsburgh Swanson School of Engineering 1 2016/01/29 The reason that we believe that this technology should be developed is because we want to help amputees. In the United States, there are more than two million people who are amputees [4]. Amputees generally use prosthetics that restore a degree of function, but inadequate tactile feedback is the leading shortcoming of these prosthetic limbs. For artificial hands, a few sensors that relay grasp pressure back to the user can provide the functionality needed to enable delicate tasks. The technological update made to these prosthetics by fitting them with the mechanoreceptors will be beneficial. We believe that the new prosthetics equipped with the mechanoreceptors are more comfortable to use, improve mobility and independence for disabled people, enhance motor control skills, and relieve phantom limb pain associated with limb loss. REFERENCES [1] H. Fischer. (2015, August). “A Guide to U.S. Military Casualty Statistics.” Congressional Research Service. (online article). https://www.fas.org/sgp/crs/natsec/RS22452.pdf [2] W. Bae, Z. Bao, A. Berndt, et al. “A Skin-Inspired Organic Digital Mechanoreceptor.” Science. (online article). http://science.sciencemag.org/content/350/6258/313.full [3] C. Arnaud. “Artificial Skin Sends Touching Signals to Nerve Cells.” Scientific American. (Online Article). http://www.scientificamerican.com/article/artificial-skinsends-touching-signals-to-nerve-cells/ [4] R. Brookmeyer, P. Ephraim, K. MacKenzie, et al. (2008, March). “Estimating the Prevalence of limb loss in the United States.” Archives of Physical Medicine and Rehabilitation. (online article). http://www.archives-pmr.org/article/S00039993(07)01748-0/abstract BIBLIOGRAPHY P. Anikeeva, R. Koppes. (2015, October). “Restoring the Sense of Touch.” Science. (Online Article). http://science.sciencemag.org/content/350/6258/274.full This article, from the world’s foremost, peer-reviewed academic journals published by the AAAS, references the report published by the Stanford research group heading our Abhilash Dhanvada Ganesh Kumar topic’s research. The article peer-reviews the report and discusses the implementation, limitation, and success criteria of this new technology. Information from this article will be used to expose the thoughts and ideas that other engineers have about this technology as well as the challenges that this technology faces. amputees living in the U.S. This article focuses on the number of amputees living in the U.S. during 2008 meaning the number is considerably higher. Information from this article will provide us with exact numbers to provide further support for why we need our technology. H. Fischer. (2015, August). “A Guide to U.S. Military Casualty Statistics.” Congressional Research Service. (Online Article). https://www.fas.org/sgp/crs/natsec/RS22452.pdf This article, from a government research service specializing in U.S. military casualty statistics, provides information about the number of amputees that come back from the war. This article focuses on the wars that are fought in the Middle East. Information from this article will provide us with specific numbers that can be used to further prove why we need our technology. C. Arnaud. “Artificial Skin Sends Touching Signals to Nerve Cells.” Scientific American. (Online Article). http://www.scientificamerican.com/article/artificial-skinsends-touching-signals-to-nerve-cells/ This article, from a peer-reviewed journal specializing in topics of science, provides information on the individual parts that make up the Organic Digital Mechanoreceptor. This article focuses on the process of how the sensor can detect sensations of touch and relay them to the brain. Information from this article will provide us with the ability to further explain how this device works. D. Johnson. (2015, October 15). “The Artificial Skin That Could Deliver the Sense of Touch Directly to the Brain”. IEEE Spectrum. (Online Article). http://spectrum.ieee.org/nanoclast/biomedical/bionics/prosth etic-artificial-skin-delivers-the-sense-of-touch-directly-tothe-brain This article - published, peer-reviewed, and edited by the Institute of Electrical and Electronics Engineers - describes the new development of tactility-enabled artificial skin. The article gives the reader a well-rounded synopsis of the topic in a way that is easy to understand for those without technical knowledge. Information from this article will be used to inform readers about the inspiration behind our topic as well aid in explaining the topic in layman’s terms for our readers’ benefit. W. Bae, Z. Bao, A. Berndt, et al. “A Skin-Inspired Organic Digital Mechanoreceptor.” Science. (Online Article). http://science.sciencemag.org/content/350/6258/313.full This article, from an online report written by professionals in the topic of organic mechanoreceptors, provides information how these receptors are constructed and used. This article focuses on how to mimic human skin and stimulate pulses in accordance with pressure levels in order to artificially regain the sense of touch. Information from this article will provide us with the techniques that researchers used in order to create this device. “Biomedical Engineering Society Code of Ethics.” Biomedical Engineering Society. (2004, February). (Online Document). http://bmes.org/files/2004%20Approved%20%20Code%20o f%20Ethics(2).pdf This document, published by the Biomedical Engineering Society, defines the guidelines by which those in the biomedical profession must conduct themselves. This document presents specifics about the ethical and moral issues faced by biomedical engineers and the subsequent steps one must take to address such issues. Information from this document will be used to discuss and hypothesize about any ethically questionable issues that may arise from the development of tactility-enabled artificial skin. “Reverse Engineer the Brain”. National Academy of Engineering. (2016). (Online Article). http://www.engineeringchallenges.org/challenges/9109.aspx This article, released by the NAE which advises the federal government from an engineering perspective, sets out one of fourteen Grand Challenges that the engineering community faces in this century. The article explains the need for reverse engineering the brain in order to bring forth advancements in communication, manufacturing, and most importantly, healthcare. Information from this article will be used to exemplify the relevance of our chosen topic to the engineering community as a whole. R. Brookmeyer, P. Ephraim, K. MacKenzie, et al. (2008, March). “Estimating the Prevalence of limb loss in the United States.” Archives of Physical Medicine and Rehabilitation. (Online Article). http://www.archives-pmr.org/article/S00039993(07)01748-0/abstract This article, from a research paper that focused on estimating the number of U.S. citizens living with certain conditions, provides information about the number of 2