2013
Tatin F, Taddei A, Weston A, Fuchs E, Devenport D, Tissir F, Makinen T. Planar Cell
Polarity Protein Celsr1 Regulates Endothelial Adherens Junctions and Directed Cell
Rearrangements during Valve Morphogenesis. Dev Cell. 2013;26(1):31-44 (Abstract)
Bazigou E, Makinen T. Flow control in our vessels: vascular valves make sure there is no
way back. Cell Mol Life Sci. 2013;70(6):1055-66. (Abstract)
Martinez-Corral I, Makinen T. Regulation of lymphatic vascular morphogenesis: Implications
for pathological (tumor) lymphangiogenesis. Exp Cell Res 2013; doi:pii: S00144827(13)00034-7 (Abstract)
Nikitenko LL, Shimosawa T, Henderson S, Mäkinen T, Shimosawa H, Qureshi U, Pedley B,
Rees MCP, Fujita T and Boshoff C. Adrenomedullin Haploinsufficiency Predisposes to
Secondary Lymphedema. J Invest Dermatol. 2013 Jan 30. doi: 10.1038/jid.2013.47 (Abstract)
2012
Lutter S, Xie S, Tatin F, Makinen T. Smooth muscle-endothelial cell communication activates
Reelin signaling and regulates lymphatic vessel formation. J Cell Biol. 2012;197(6):837-49
(Abstract)
Ostergaard P, Simpson MA, Mendola A, Vasudevan P, Connell FC, van Impel A, Moore AT,
Loeys BL, Ghalamkarpour A, Onoufriadis A, Martinez-Corral I, Devery S, Leroy JG, van
Laer L, Singer A, Bialer MG, McEntagart M, Quarrell O, Brice G, Trembath RC, SchulteMerker S, Makinen T, Vikkula M, Mortimer PS, Mansour S, Jeffery S. Mutations in KIF11
cause autosomal-dominant microcephaly variably associated with congenital lymphedema
and chorioretinopathy. Am J Hum Genet. 2012;90(2):356-62 (Abstract)
Chen CY, Bertozzi C, Zou Z, Yuan L, Lee JS, Lu M, Stachelek SJ, Srinivasan S, Guo L,
Vicente A, Mericko P, Levy RJ, Makinen T, Oliver G, Kahn ML. Blood flow reprograms
lymphatic vessels to blood vessels. J Clin Invest. 2012;122(6):2006-17. (Abstract).
Sabine A, Agalarov Y, Maby-El Hajjami H, Jaquet M, Hagerling R,Pollmann C, Bebber D,
Pfenniger A, Miura N, Dormond O, Calmes JM, Adams RH, Makinen T, Kiefer F, Kwak BR,
Petrova TV. PROX1, FOXC2, and mechanotransduction cooperate to control connexin37 and
calcineurin during lymphatic-valve formation. Dev Cell. 2012;22(2):430-45 (Abstract)
Wallgard E, Nitzsche A, Larsson J, Guo X, Dieterich LC, Dimberg A, Olofsson T, Pontén
FC, Mäkinen T, Kalén M, Hellström M. Paladin (X99384) is expressed in the vasculature and
shifts from endothelial to vascular smooth muscle cells during mouse development. Dev Dyn.
2012;241(4):770-86 (Abstract)
2011
Bazigou E, Lyons OTA, Smith A, Venn GE, Cope C, Brown NA and Makinen T. Genes
regulating lymphangiogenesis control venous valve formation and maintenance in mice. J
Clin Invest. 2011;121(8):2984-92. doi: 10.1172/JCI58050 (Abstract)
Calvo CF, Fontaine RH, Soueid J, Tammela T, Makinen T, Alfaro-Cervello C, Bonnaud F,
Miguez A, Benhaim L, Xu Y, Barallobre MJ, Moutkine I, Lyytikkä J, Tatlisumak T, Pytowski
B, Zalc B, Richardson W, Kessaris N, Garcia-Verdugo JM, Alitalo K, Eichmann A, Thomas
JL. Vascular endothelial growth factor receptor 3 directly regulates murine neurogenesis.
Genes Dev. 2011;25:831-844 (Abstract)
Mellor RH, Tate N, Stanton AW, Hubert C, Mäkinen T, Smith A, Burnand KG, Jeffery S,
Levick JR, Mortimer PS. Mutations in FOXC2 in Humans (Lymphoedema Distichiasis
Syndrome) Cause Lymphatic Dysfunction on Dependency. J Vasc Res.2011;48(5):397-407
(Abstract)
Ostergaard P, Simpson MA, Connell FC, Steward C, Brice G, Woollard WJ, Kilo T,
Smithson S, Lunt P, Murday VA, Hodgson S, Keenan R, Pilz D, Martinez-Corral I, Makinen
T, Mortimer P, Jeffery S, Trembath RC, Mansour S. Mutations in GATA2 cause primary
lymphedema associated with a predisposition to acute myeloid leukemia (Emberger
syndrome). Nat Gen 2011;43:929-923. (Abstract)
Tammela T, Zarkada G, Nurmi H, Jakobsson L, Heinolainen K, Tvorogov D, Zheng W,
Franco CA, Murtomäki A, Aranda E, Miura N, Ylä-Herttuala S, Fruttiger M, Mäkinen T,
Eichmann A, Pollard JW, Gerhardt H, Alitalo K. VEGFR-3 controls tip to stalk conversion at
vessel fusion sites by reinforcing Notch signalling. Nat Cell Biol. 2011;13:1202-13.
(Abstract)
2010
Foster KE, Gordon J, Cardenas K, Veiga-Fernandes H, Makinen T, Grigorieva E, Wilkinson
DG, Blackburn CC, Richie E, Manley NR, Adams RH, Kioussis D, Coles MC. EphB-ephrinB2 interactions are required for thymus migration during organogenesis. Proc Natl Acad Sci
U S A.2010;107(30):13414-9 (Abstract)
Mellor RH, Hubert CE, Stanton AW, Tate N, Akhras V, Smith A, Burnand KG, Jeffery S,
Mäkinen T, Levick JR, Mortimer PS. Lymphatic dysfunction, not aplasia, underlies Milroy
disease. Microcirculation. 2010;17(4):281-96 (Abstract)
Wang Y, Nakayama M, Pitulescu ME, Schmidt TS, Bochenek ML, Sakakibara A, Adams S,
Davy A, Deutsch U, Lüthi U, Barberis A, Benjamin LE, Mäkinen T, Nobes CD, Adams RH.
Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis. Nature.
2010;465(7297):483-6 (Abstract)
2009
Bazigou E, Xie S, Chen C, Weston A, Miura N, Sorokin L, Adams R, Muro AF, Sheppard D,
Makinen T. Integrin-a9 is required for fibronectin matrix assembly during lymphatic valve
morphogenesis. Dev. Cell. 2009;17:175-186 (Abstract)
2008
Haiko P, Makinen T, Keskitalo S, Taipale J, Karkkainen MJ, Baldwin ME, Stacker SA,
Achen MG, Alitalo K. Deletion of vascular endothelial growth factor C (VEGF-C) and
VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos. Mol. Cell Biol.
2008;15:4843-4850 (Abstract)
2007
Hosking B, Makinen T. Lymphatic vasculature: a molecular perspective. Bioessays.
2007;29:1192-1202 (Abstract)
Makinen T, Alitalo K. Lymphangiogenesis in development and disease. Novartis Found
Symp. 2007;283:87-98 (Abstract)
Makinen T, Norrmen,V, Petrova TV. Molecular mechanisms of lymphatic vascular
development. Cell Mol. Life Sci. 2007;64:1915-1929 (Abstract)
2006
Kadison SR, Mäkinen T, Klein R, Henkemeyer M, Kaprielian Z. EphB receptors and ephrinB3 regulate axon guidance at the ventral midline of the embryonic mouse spinal cord. J.
Neurosci. 2006;30:8909-8914 (Abstract)
Karpanen T, Mäkinen T. Regulation of lymphangiogenesis – from cell fate determination to
vessel remodeling. Exp. Cell Res. 2006;312:575-583 (2006). (Abstract)
Karpanen T, Wirzenius M, Mäkinen T, Veikkola T, Haisma HJ, Achen MG, Stacker SA,
Pytowski B, Ylä-Herttuala S, Alitalo K. Lymphangiogenic growth factor responsiveness is
modulated by postnatal lymphatic vessel maturation. Am. J. Pathol. 2006;169:708-718
(Abstract)
2005
Eichmann A, Mäkinen T, Alitalo K. Neural guidance molecules regulate vascular remodeling
and vessel navigation. Genes Dev. 2005;19:1013-1021 (Abstract)
Mäkinen T, Adams RH, Bailey J, Lu Q, Ziemiecki A, Alitalo K, Klein R, Wilkinson GA.
PDZ interaction site in ephrinB2 is required for the remodelling of lymphatic vasculature.
Genes Dev. 2005;19:397-410 (Abstract)
2004
He Y, Rajantie I, Ilmonen M, Makinen T, Karkkainen MJ, Haiko P, Salven P, Alitalo K.
Preexisting lymphatic endothelium but not endothelial progenitor cells are essential for tumor
lymphangiogenesis and lymphatic metastasis. Cancer Res. 2004;64:3737-3740 (Abstract)
Mäkinen, T. and Alitalo, K. Detection, isolation and culture of lymphatic endothelial cells. In:
Methods in Endothelial Cell Biology. (2004) Ed. Hellmut Augustin, Springer Verlag,
GmbH&Co, KG
Ober EA, Olofsson B, Mäkinen T, Jin SW, Shoji W, Koh GY, Alitalo K, Stainier DY. Vegfc
is required for vascular development and endoderm morphogenesis in zebrafish. EMBO Rep.
2004;5:78-84 (Abstract)
Wang HW, Trotter MW, Lagos D, Bourboulia D, Henderson S, Mäkinen T, Elliman S,
Flanagan AM, Alitalo K, Boshoff C. Kaposi sarcoma herpesvirus-induced cellular
reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma.
Nat. Genet. 2004;36:687-693 (Abstract)
2003
Dixelius J, Makinen T, Wirzenius M, Karkkainen MJ, Wernstedt C, Alitalo K, ClaessonWelsh L. Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3)
heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine
phosphorylation sites. J. Biol. Chem. 2003;278:40973-40979 (Abstract)
Mäkinen T. Imusuonten kasvutekijät liittyvät etäpesäkkeiden muodostumiseen. Duodecim.
2003;118:126-128
Veikkola T, Lohela M, Ikenberg K, Mäkinen T, Korff T, Saaristo A, Petrova T, Jeltsch M,
Augustin HG, Alitalo K. Intrinsic versus microenvironmental regulation of lymphatic
endothelial cell phenotype and function. FASEB J. 2003;17:2006-2013 (Abstract)
2002
Karkkainen MJ, Mäkinen T, Alitalo K. Lymphatic endothelium: a new frontier of metastasis
research? Nat. Cell Biol. 2002;4:E2-E5 (Abstract)
Kubo H, Cao R, Brakenhielm E, Mäkinen T, Cao Y, Alitalo K. Blockade of vascular
endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced
lymphangiogenesis in mouse cornea. Proc. Natl. Acad. Sci. USA. 2002;99:8868-8873
(Abstract)
Mäkinen, T. and Alitalo., K. Molecular mechanisms of lymphangiogenesis. In: Cold Spring
Harbor Symp. Quant. Biol. 67, 189-196 (2002).
Petrova TV*, Mäkinen T*, Mäkelä TP, Saarela J, Virtanen I, Ferrell RE, Finegold DN,
Kerjaschki D, Ylä-Herttuala S, Alitalo K.Lymphatic endothelial reprogramming of vascular
endothelial cells by the Prox-1 homeobox transcription factor. EMBO J. 2002;21:4593-4599
(Abstract)
2001
Mäkinen T, Jussila L, Veikkola T, Karpanen T, Kettunen MI, Pulkkanen KJ, Kauppinen R,
Jackson DG, Kubo H, Nishikawa S, Ylä-Herttuala S, Alitalo K. Inhibition of
lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF
receptor-3. Nat. Med. 2001;2:199-205 (Abstract)
Mäkinen T, Veikkola T, Mustjoki S, Karpanen T, Catimel B, Nice EC, Wise L, Mercer A,
Kowalski H, Kerjaschki D, Stacker SA, Achen MG, Alitalo K. Isolated lymphatic endothelial
cells transduce growth, survival and migration signals via the VEGF-C/D receptor VEGFR-3.
EMBO J. 2001;20:4762-4773 (Abstract)
Veikkola T, Jussila L, Makinen T, Karpanen T, Jeltsch M, Petrova TV, Kubo H, Thurston G,
McDonald DM, Achen MG, Stacker SA, Alitalo K. Signalling via vascular endothelial
growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice. EMBO J.
2001;20:1223-1231 (Abstract)
2000
Achen MG, Roufail S, Domagala T, Catimel B, Nice EC, Geleick DM, Murphy R, Scott AM,
Caesar C, Makinen T, Alitalo K, Stacker SA. Monoclonal antibodies to vascular endothelial
growth factor-D block interactions with both VEGF receptor-2 and VEGF receptor-3. Eur. J.
Biochem. 2000;267:2505-15 (Abstract)
1999
Makinen T*, Olofsson B, Karpanen T, Hellman U, Soker S, Klagsbrun M, Eriksson U,
Alitalo K.Differential binding of vascular endothelial growth factor B splice and proteolytic
isoforms by Neuropilin-1. J. Biol. Chem. 1999;274:21217-21222 (Abstract)
Narko K, Enholm B, Mäkinen T, Ristimäki A. Effect of inflammatory cytokines on the
expression of the vascular endothelial growth factor-C. Int. J. Exp. Pathol. 1999;80:109-112
(Abstract)
Partanen TA, Makinen T, Arola J, Suda T, Weich HA, Alitalo K. Endothelial growth factor
receptors in the human fetal heart. Circulation. 1999;100:583-586 (Abstract)
Petrova TV, Makinen T, Alitalo K. Signalling via vascular endothelial growth factor
receptors. Exp. Cell Res. 1999;253:117-130 (Abstract)
Wise LM, Veikkola T, Mercer AA, Savory LJ, Fleming SB, Caesar C, Vitali A, Makinen T,
Alitalo K, Stacker SA. Vascular endothelial growth factor (VEGF)-like protein from orf virus
NZ2 binds to VEGFR2 and neuropilin-1. Proc. Natl. Acad. Sci. USA. 1999;96:3071-3076
(Abstract)
1998
Achen MG, Jeltsch M, Kukk E, Mäkinen T, Vitali A, Wilks AF, Alitalo K, Stacker SA.
Vascular endothelial growth factor-D (VEGF-D) is a ligand for the tyrosine kinases VEGF
receptor-2 (Flk1) and VEGF receptor-3 (Flt4). Proc. Natl. Acad. Sci. USA. 1998;95:548-553
(Abstract)
Taipale, J., Makinen, T., Arighi, E., Kukk, E., Karkkainen, M. and Alitalo, K. Vascular
endothelial growth factor receptor-3. In: Curr. Top. Microbiol. p.85-96 (1998) Ed. Lena
Claesson-Welsh, Springer Verlag, GmbH&Co, KG.