Supplementary material: Keywords for each research question
Key words
For research question “What are the definitions of conditions related to salivary
gland dysfunction and xerostomia, such as xerostomia, dry mouth, hyposalivation,
sialorrhea, etc.?”: Xerostomia/Hyposalivation/Reduced saliva flow/Reduced saliva
secretion/Salivary gland dysfunction/Hypersalivation/Sialorrhea/Increased
salivation/Increased saliva flow/Salivary gland degeneration/Salivary gland
hypertrophy AND Burning mouth, Stomatodynia, Dysphagia, Odynophagia,
Altered taste, Dysgeusia, Mucositis, Indigestion, Sialosis, Sialadenosis,
Hypertension, Liver cirrhosis, Mucosal wetness, Ptyalism, Drooling, Mucosal
wetness, Aplasia of salivary glands, Ectodermal dysplasia.
For research question “Which are the accepted/validated methods for assessing
salivary gland dysfunction?”: Salivary glands/Saliva/Xerostomia/Dry
mouth/Hyposalivation AND Diagnostic techniques and procedures, Sialometry,
Saliva collection, Periotron, Salivary gland biopsy, Salivary gland histopathology,
Salivary scintigraphy, Sialography, Sialochemistry, Stenson’s duct, Wharton’s
duct, Stimulated saliva, Unstimulated saliva, Salivary flow rate, Salivary
dysfunction, Salivary gland palpation.
Salivary gland dysfunction/Dry mouth/Xerostomia/Hyposalivation AND Oral
health, Impact on oral health; Salivary gland dysfunction/ Dry mouth/
Xerostomia/Hyposalivation AND Nordic Orofacial Test-Screening, Quality of life,
Oral health impact profile, Oral impact on daily performances, Geriatric oral
health assessment index, DMFT, Community periodontal index, Plaque index,
Gingivitis index, Candida colonies, Caries, Decayed teeth, Oral mucositis, Oral
infection, Glossitis.
Dry mouth/ Xerostomia/Decreased salivary flow/Burning
mouth/Hyposalivation/Drooling AND Visual analogue scale, Questionnaire, Oral
symptoms, Diagnostic tools, Dysphagia, Burning mouth, Stomatodynia,
Dysgeusia, Altered taste, Oral irritation, Oral burning.
For research question “What epidemiological data exist regarding MISGD and
medication-induced xerostomia and its societal costs?”: Medication/Drugs AND
Salivary glands/Saliva/Dry mouth/Xerostomia/Hyposalivation AND
Epidemiology, Prevalence, Incidence, Reduced salivary flow, Alteration of saliva
components/Alteration of saliva biomarkers/Alteration of saliva
electrolytes/Peptides/Proteins.
Medication/Drugs AND Salivary glands/Saliva/Dry mouth/Xerostomia
/Hyposalivation AND costs, Direct costs, Cost effectiveness, Indirect costs,
Economic impact, Economics, Illness cost, Disease cost, Disease burden,
Healthcare usage, Outpatient cost, Cost utility, Dry mouth palliative treatment,
Hyposalivation treatment.
For research question “Which management measures of MISGD and its oral
sequelae have been described and what is their efficacy?”: Medication/Drugs AND
Salivary glands/Saliva/Dry mouth/Xerostomia/Hyposalivation AND Prevention,
Amifostine, Fluoride, Monopharmacy, Acupuncture.
Medication/Drugs AND Salivary glands/Saliva/Dry
mouth/Xerostomia/Hyposalivation AND Prevention, Prevention of adverse effects,
Amifostine, Efficiency, Oral Health, Efficacy of preventive measures, Relief,
Benefit of treatment, Fluoride.
Medication/Drugs AND Salivary glands/Saliva/Dry
mouth/Xerostomia/Hyposalivation/Reduced salivary flow AND Saliva substitutes,
Artificial saliva, Oral lubricants, Lactoperoxidase, Lysozyme, Lactoferrin, Topical
treatment, Fluoride, Xylitol, Antifungal, Antibiotic, Anti-inflammatory/
Sialogogue, Pilocarpine, Cevimeline, Chewing gum.
Medication/Drugs AND Salivary glands/Saliva/Dry
mouth/Xerostomia/Hyposalivation, reduced salivary flow AND Efficacy/Saliva
substitutes, Artificial saliva, Oral lubricants, Lactoperoxidase, Lysozyme,
Lactoferrin, Fluoride, Xylitol, Antifungal, Antibiotic, Anti-inflammatory,
Sialogogue, Pilocarpine, Cevimeline.
Medication/Drugs AND Salivary glands/Saliva/Dry
mouth/Xerostomia/Hyposalivation AND Prevention, Amifostine, Topical
fluorides, Xylitol gum, Biotene gel, Mouth rinse, Preventive measures.
Medication/Drugs AND Salivary glands/Saliva/Dry mouth/Xerostomia/
Hyposalivation AND Efficacy of/ Preventive measures, Caries prevention,
Fluorides, Oral hygiene, Pilocarpine, Cevimeline, Xylitol gum, Antifungal agents,
Antibacterial agents.
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Medication/Drugs AND Salivary glands/Saliva/Dry mouth/Xerostomia/
Hyposalivation AND Saliva substitutes, Artificial saliva, Oral lubricants,
Lactoperoxidase, Lysozyme, Lactoferrin, Antifungal, Antibiotic, Antiinflammatory, Analgesic, Antiseptic rinse, Fluoride, Xylitol gum, Sialogogue,
Biotène, Pilocarpine, Cevimeline, Chewing gum.
Medication/Drugs AND Salivary glands/Saliva/Dry
mouth/Xerostomia/Hyposalivation AND Efficacy of/ Effectiveness of/ Saliva
substitutes, Artificial saliva, Oral lubricants, Lactoperoxidase, Lysozyme,
Lactoferrin, Antifungal, Antibiotic, Anti-inflammatory, Analgesic, Antiseptic
rinse, Fluoride, Xylitol gum, Sialogogue, Biotene, Fluoride, Pilocarpine,
Cevimeline.
For research question “Which diagnostic and/or preventive and/or
therapeutic/attenuating methods of MISGD are under research/development?”:
Medication/Drugs AND Salivary glands/Saliva/Xerostomia/Dry
mouth/Hyposalivation AND Diagnostic techniques and procedures, Diagnostic
methods, Saliva proteomics, Biomarkers, Screening, New methods,
Electrostimulation.
Medication/Drugs AND Salivary glands/Saliva/Xerostomia/Dry
mouth/Hyposalivation AND Prevention, New research, Chewing gum.
Medication/Drugs AND Salivary glands/Saliva/Xerostomia/Dry
mouth/Hyposalivation AND Treatment techniques and procedures, Therapeutic
method, Palliative treatment, Relief of symptoms, Mouthrinse formulation,
Acupuncture, Electrostimulation, Saliva substitute, Chewing gum.
Medication/Drugs AND Salivary glands/Saliva/Xerostomia/Dry
mouth/Hyposalivation/Drooling/Hypersalivation AND Therapy, Treatment,
Management, Management strategies, Trial, Palliative treatment, Symptom relief,
Flow rate stimulation; Relief of AND Drooling, Xerostomia, Hyposalivation,
Hypersalivation, Dysphagia, Burning mouth, Stomatodynia Dysgeusia, Altered
taste, Oral irritation, Oral burning, Dry mouth, Decreased saliva flow,
Stomatodynia, Oral mucositis, Altered taste, Dysgeusia, Dysphagia, Odynophagia,
Sialorrhea.
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