Friday, November 7, 2014 , 2014–
NextGen OSMB‐Investigators Combined Meeting
Admiral Fell Inn, Baltimore, Maryland
8:00- 9:00 am Breakfast OSMB/NHLBI Closed Session: Board Room: Dr. Thomas and OSMB
8:00- 9:00 am Investigators Breakfast Conference Room Adjacent
Main Conference Room Combined Investigator-OSMB Meeting 9:00- 4:30 pm
9:-00- 9:30
Meeting Introduction and Orientation: Dr. Jaquish
• Investigator Presentations (10 minutes, one presenter per site)
• OSMB Questions (15 minutes per site)
Investigator Presentations/ OSMB Review: Dr. Shuldiner, OSMB Chair
9:30‐9:40
Identifying the Gene Networks of Insulin Resistance: the GENESIPS Study
Quertermous , Stanford
9:40-9:55
OSMB Questions/Review
9:55‐10:05
10:05-10:20
10:20- 10:30
10:30-10:45
10:45-10:55
10:55-11:10
11:10-11:20
11:20-11:35
11:35-11:45
Functional GWAS for LVH Using iPS‐derived Cardiomyocytes: The HyperGEN ciPS Study
Broeckel , Medical College of Wisconsin
OSMB Questions/Review
Regulatory Genomic Studies in a Cohort of iPS Cell Derived Cardiomyocytes Frazer,
UCSD
OSMB Questions/Review
Elucidating Cardiovascular Phenotypes Employing Genome Editing of iPS cells
Eric Topol, Scripps La Jolla
OSMB Questions/Review
Globin Gene Expression in Sickle Cell Genotype‐Specific iPS cells
Martin Steinberg , Boston University
OSMB Questions/Review
Functional Genomics of Platelet Aggregation Using iPS and Derived Megakaryocytes
Lewis Becker , Johns Hopkins (Lew Becker presenting)
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11:45-12:00 OSMB Questions/Review
12:00-1:00
Lunch (OSMB Board Room) Investigators Conference Room Adjacent
1:00-1:10
iPS‐derived Hepatocytes for Interrogation of Lipid Phenotypes
Dan Rader , U Penn
OSMB Questions/Review
1:10-1:25
1:25-1:35
1:35-1:50
1:50-2:00
Integrating Lipid Genotypes And Phenotypes In iPS derived Hepatocytes/adipocytes , Chad
Cowan, Massachusetts General Hospital, (Chad Cowan presenting)
OSMB Questions/Review
2:00-2:15
iPSC Derived EC as Surrogates Using Pulmonary Hypertension as a Prototype Disease
Marlene Rabinovitch, Stanford
OSMB Questions/Review
2:15-2:45
Cell Repository Plans : Discussion
2:45-3:00
Quality Control Discussion
3:00- 4:00 pm Investigator Break (Please do not depart in the event that the OSMB might like to directly query a
specific investigator)
3:00- 4:00 pm OSMB in Session (Board Room)
4:00-4:30
OSMB Feedback and Discussion (Drs. Thomas and Jaquish)
4:30 pm
Closure
Investigators’ Overall Guidelines: PLEASE READ
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Given the very intensive schedule, to assure reasonable probability of finishing on time, we should adhere to the
following:
•
OSMB presentations must be sent to the secure Share File drop box by Wednesday evening, November 5, 2013
so they can be preloaded- instructions will be provided,
•
Each group has only one presenter,; others investigators may comment on slides from their seats
•
No breaks are designated in the schedule,; midmorning and midafternoon, snacks and beverages will be
replenished, and each person may take breaks as per your own need, noting of course that large numbers of
people should not be absent at the same time.
•
Presentations will be times with a “mild” audio signal when there are 3 minutes remaining.
•
Dr. Shuldiner will Chair the OSMB portions of the meeting.
•
Each project report will have had at least one assigned reviewer, so that greater attention will be given to each
project . If problems or serious concerns are noted, you may be contacted before the meeting by the Executive
Secretary, Jr. John Thomas, and be asked to address those issues in our presentation.
•
By this time, your overall aims are known by the OSMB and one another, so using the time as an update and to
present any novel findings, problems, or new methods would be a valuable way to use your presentation time.
Next Generation Genetic Association Studies:
Observational Safety Monitoring Board Members
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EXECUTICE SECRETARY John
W. Thomas, Ph.D.
Division of Blood Diseases and Resources
National Heart, Lung, and Blood Institute
Rockledge II Centre, Room 9150
6701 Rockledge Drive, Mail Stop 7950
Bethesda, MD 20892
Phone 301-435-0065 FAX 301-451-5453
Email mailto:ThomasJ@nhlbi.nih.gov
CHAIR
Alan Shuldiner, MD , U of MD
John A. Whitehurst Professor of Medicine, Associate Dean for Personalized Medicine
Head, Division of Endocrinology
Genetics; pharmacogenomics and personalized medicine; diabetes, obesity, and insulin resistance
MEMBERS
Robert Blelloch, MD, PhD, UCSF
Peter R. Carroll, MD Endowed Chair
Stem cell differentiation; obstetrics and gynecology; urology; cancer
Mina Chung, MD Cleveland Clinic/Case Western Reserve
Department of Cardiovascular Medicine, Heart and Vascular Institute
Department of Molecular Cardiology, Lerner Research Institute
Arrythmias; atrial fibrillation; genetics
Ellen Wright Clayton, MD, JD, Vanderbilt University
Professor of Law, Pediatrics
Director, Center for Biomedical Ethics and Society
Genetics and ethics
Babak Esmaeli-Azad, PhD DNA Microarray, Inc. President and CEO
Carlsbad, CA
Genomics; proteomics; stem cells
Mary Fabry, PhD Albert Einstein College of Medicine
Professor of Medicine, Emerita
Hematology; biophysics; and transgenics
Loren Field, PhD Indiana University School of Medicine
Professor of Medicine and Pediatrics
Regeneration and cardioprotection; cardiomyocytes and cardiogenic stem cells;
Fernando Martinez, MD, MS, U of Michigan
Professor Medicine, Director, Pulmonary Diagnostic Services
Lung disease and transplantation
Pei Pei Ping, PhD, UCLA
UCLA Professor and Director NHLBI Proteomics Center at UCLA
Program on Myocardial Ischemic Injury
Departments of Physiology, Medicine/Cardiology, and Bioinformatics Myocardial
Ischemic Injury; Proteomics, Bioinformatics.
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