Vanessa Mezines Hon English 3 October 15, 2013 Animal Rights Think of those poor animals being trapped in cases waiting for their turn to be poked and prodded by these so called human beings. The make-up you are putting on right now; think of all the animals that had to suffer for you. Animals should not be used for animal testing because it is harmful to them. They can be killed. Also they are being tortured. Animals can be harmed by this testing of cosmetics. Every year, thousands of new cosmetic, personal care and household products are introduced into the marketplace. Virtually all of them have been animal-tested at various stages of their development. Long before they appear on the shelves of your local supermarket, these products have gone through a long and complex testing process that leaves millions of animals mutilated, burned, poisoned and gassed in outmoded and unnecessary tests. The Draize tests for eye and skin irritancy are equally horrifying. In the Draize test for eye irritancy, solutions of products are applied directly into the eyes of conscious rabbits. During the test period, which usually lasts at least seven days, the rabbits may suffer extreme pain while being restrained, and blindness often occurs. At the end of the test period, all the animals are killed in order to determine the internal effects of the toxic substances. The Draize test for skin irritancy consists of immobilizing an animal while test substances are applied to shaved and abraded skin. Toxic products that have been tested on animals such as permanent wave solutions, oven cleaners, soaps and detergents are regularly introduced into the marketplace. That's because no amount of animal testing can change the fact that many of these products are harmful if ingested or used in a way not intended by the manufacturer. Animal testing merely determines the level of toxicity. Despite the fact that they have been animal-tested, these products are no less deadly if a person eats or drinks them accidentally. Using animals in cosmetics research was banned in the UK in 1998 and will be illegal across the EU by 2009. Last night, a spokesperson for L'Oreal, the world's biggest cosmetics manufacturer, said: "We have invested considerable time and effort for over two decades in developing and validating alternative safety testing methods. As a result, we voluntarily stopped animal testing on our entire range of cosmetics products in 1989." In the notorious LD-50 test, a group of animals is forced to ingest, inhale or otherwise consume varying amounts of a substance and suffer excruciating pain in the process. The test is complete when 50% of the test animals die. The surviving 50% are killed, autopsied and analyzed to determine which organs and systems were affected and why they didn't die during the test. More than 100 million animals every year suffer and die in cruel chemical, drug, food, and cosmetics tests as well as in biology lessons, medical training exercises, and curiosity-driven medical experiments at universities. Exact numbers aren't available because mice, rats, birds, and cold-blooded animals who make up more than 95 percent of animals used in experiments are not covered by even the minimal protections of the Animal Welfare Act and therefore go uncounted. To test cosmetics, household cleaners, and other consumer products, hundreds of thousands of animals are poisoned, blinded, and killed every year by cruel corporations. Mice and rats are forced to inhale toxic fumes, dogs are force-fed pesticides, and rabbits have corrosive chemicals rubbed onto their skin and eyes. Many of these tests are not even required by law, and they often produce inaccurate or misleading results. Even if a product harms animals, it can still be marketed to consumers. Cruel and deadly toxicity tests are also conducted as part of massive regulatory testing programs that are often funded by U.S. taxpayers' money. The Environmental Protection Agency, the Food and Drug Administration, the National Toxicology Program, and the Department of Agriculture are just a few of the government agencies that subject animals to painful and crude tests. TYPE OF TEST Skin sensitization ANIMALS USED 32 guinea pigs or 16 mice Skin irritation/ corrosion 1-3 rabbits Eye irritation/ corrosion 1-3 rabbits Acute oral toxicity WHAT THE ANIMALS ENDURE PURPOSE OF TEST The test substance is applied to the surface of the skin or injected under the skin of a guinea Tests for pig, or applied to allergic the ear of a mouse. reaction on Her skin may show skin. signs of redness, ulcers, scaling, inflammation, and itchiness. The test substance Tests for is applied to the skin irritation shaved skin of a (reversible rabbit. His skin may skin damage) show signs of and skin redness, rash, corrosion lesions, scaling, (severe and inflammation, irreversible and/or other signs skin of damage. damage). Tests for The test substance eye irritation is applied to a (reversible rabbit’s eye(s). His eye damage) eye(s) may show and eye signs of redness, corrosion bleeding, ulcers, (severe and blindness, and/or irreversible other signs of eye damage damage). The test substance Determines is forced down a the amount 7 rats Acute dermal toxicity 20 rats, rabbits or guinea pigs Acute inhalation toxicity 20 rats Repeat dose (28 day) and subchronic (90 day) toxicity 40 rats (28 day) or 80 rats (90 day) rat’s throat using a of a feeding tube. She substance may experience that causes diarrhea, half of the convulsions, exposed bleeding from the animals to mouth, seizures, die within 14 paralysis, and/or days of death. exposure when the substance is swallowed. Determines the amount of a The test substance substance is applied to the that causes shaved skin of the half of the rat, guinea pig, or exposed rabbit and covered animals to with a patch to die within 14 keep her from days of licking or otherwise exposure removing the when the substance. substance is applied to the skin for 24 hours. A rat is placed into a tube and forced to inhale the test substance. She may experience bleeding of the nose, convulsions, paralysis, seizures, and/or death. Determines the amount of a substance that causes half of the exposed animals to die within 14 days of exposure when the substance is inhaled. A rat is force-fed a substance, is forced to breathe in a substance, or has a substance applied to their skin daily for 28 or 90 days. At the end of Tests for changes in the cells or organs caused by repeat exposure. the exposure period he is killed and his organs are examined. Carcinogenicity or combined carcinogenicity/ chronic toxicity 400 mice or rats Toxicokinetics 4-12 rats A mouse is exposed to a substance either by being fed the substance through their food or water, being force-fed the substance, having it rubbed on their skin, or being forced to inhale the substance. After two years of daily exposure, she is killed so her tissues can be examined for signs of cancer (or other signs of toxicity). A rat is exposed to a substance either by being fed the substance through their food or water, being force-fed the substance, having it rubbed on their skin, or being forced to inhale the substance. He may be exposed once or multiple times depending on the substance. Blood is drawn at daily intervals to determine the peak concentration of substance in the blood. He is then killed at a specific time-point; different animals are killed at different times to obtain a record of Tests for cancer and other longterm effects of exposure. Measures the absorption, distribution, and metabolism of a substance throughout the tissues and organs following exposure. how the substance moves through their body over time. Reproductive/ developmental screen Reproductive toxicity in two generations 675 rats 2,600 rats Male and female adult rats are exposed to the test substance, usually by force-feeding, for two to four weeks and then Tests for mated. The effects on pregnant mother is fertility, ability then exposed daily to reproduce, throughout and birth pregnancy and for defects. four days after her pups are born. Four days after birth, she and her pups are killed and their tissues examined. Male and female adult rats are exposed, usually by force-feeding, for at least two weeks and then mated. The pregnant mothers are then exposed daily throughout pregnancy and Tests for breast-feeding and effects on are then killed. fertility, ability After weaning, the to reproduce, pups are force-fed and birth throughout their defects. lifetimes, sometimes experiencing symptoms of chronic poisoning such as weight loss or convulsions. Pups that survive until puberty are then mated, and force-feeding continues through the second generation's pregnancy and breast feeding. At the time of weaning of the second generation, mothers and pups are all killed and their tissues examined. Developmental toxicity Genotoxicity/ mutagenicity* A pregnant female is exposed, usually by force-feeding, starting at the initiation of pregnancy (through implantation) and contiuing throughout the pregnancy. She is Tests for 480 rabbits (100 adult females and 480 then killed on the birth defects. day before she is pups) or 1,300 rats (100 adult females expected to give and 1,200 pups) birth (on average, 22 days for rats or 31 days for rabbits). Her pups are extracted and evaluated for signs of developmental abnormalities. There are several different tests for genetic alterations that use mice or rats. In a common test, a mouse or rat Tests for the is force-fed the beginning substance on a stages of 12-500 mice daily basis for at cancer. or rats least 14 days. Samples of his bone marrow and/or blood are taken to look for genetic changes. In laboratories all across America, millions of animals are used for the testing of cosmetic products, even though the FDA does not require it and the rest of the world has pretty much banned the practice. According to statistics from the American Society for the Prevention of Cruelty to Animals (ASPCA), more than half of the 1.4 million animals counted by the USDA feel pain from the experiments performed by cosmetic companies. What’s worse is that none of those tests are necessary, according to one expert. People say that they would rather have animals to be tested on than humans. Which makes sense because they would rather an animal die than a human because taking a human rights away.