Supplementary Table 1: Selected candidate genes for targeted resequencing based on our
previous linkage and association results in the MSTF AA and EA samples
Gene Name
Gene
Symbol
Chromosome
Reference
Ankyrin repeat and kinase domain containing 1
ANKK1
11
[1]
Beta-arestin 1
ARRB1
11
[2]
Beta-arrestin 2
ARRB2
17
[2]
Brain-derived neurotrophic factor
BDNF
11
[3]
Cadherin 13
CDH13
16
Catechol-O-methyltransferase
COMT
22
[4]
Choline acetyltransferase
CHAT
10q11
[5]
DOPA decarboxylase
DDC
7
[6]
Dopamine beta-monooxygenase
DBH
9q34
[7]
Dopamine receptor 1
DRD1
5
[8]
Dopamine receptor 2
DRD2
11
[1]
Dopamine receptor 3
DRD3
3
[9]
Dynamin 1
DNM1
9
[10]
GABA-B receptor subunit 2
GABBR2
9
[11]
Glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
GRIN3A
9
[12]
Neurexin 1
NRXN1
2
[13]
Neurexin 2
NRXN2
11q13
Neurexin 3
NRXN3
14q31
Neurotrophic tyrosine kinase receptor type 2
NTRK2
9
Nicotinic receptor, alpha 1 subunit
CHRNA1
2
Nicotinic receptor, alpha 10 subunit
CHRNA10
11p15
Nicotinic receptor, alpha 2 subunit
CHRNA2
8
Nicotinic receptor, alpha 3 subunit
CHRNA3
15
[15]
Nicotinic receptor, alpha 4 subunit
CHRNA4
20
[16]
Nicotinic receptor, alpha 5 subunit
CHRNA5
15
[15]
Nicotinic receptor, alpha 6 subunit
CHRNA6
8
Nicotinic receptor, alpha 7 subunit
CHRNA7
15
Nicotinic receptor, alpha 9 subunit
CHRNA9
4p14
Nicotinic receptor, beta 1 subunit
CHRNB1
17p12
[14]
Nicotinic receptor, beta 2 subunit
CHRNB2
1q21
[16]
Nicotinic receptor, beta 3 subunit
CHRNB3
8p11
[17]
Nicotinic receptor, beta 4 subunit
CHRNB4
15q24
[15]
Taste receptor, type 2, member 38
TAS2R38
7
[18]
References:
1
Huang, W, Payne, TJ, Ma, JZ, Beuten, J, Dupont, RT, Inohara, N and Li, MD (2009)
Significant association of ANKK1 and detection of a functional polymorphism with nicotine
dependence in an African-American sample. Neuropsychopharmacology, 34: 319-330.
2
Sun, D, Ma, JZ, Payne, TJ and Li, MD (2007) beta-Arrestins 1 and 2 are associated with
nicotine dependence in European American smokers. Mol Psychiatry.
3
Beuten, J, Ma, JZ, Payne, TJ, Dupont, RT, Quezada, P, Huang, W, Crews, KM and Li,
MD (2005) Significant association of BDNF haplotypes in European-American male smokers
but not in European-American female or African-American smokers. Am J Med Genet B
Neuropsychiatr Genet, 139: 73-80.
4
Beuten, J, Payne, TJ, Ma, JZ and Li, MD (2006) Significant association of catechol-Omethyltransferase (COMT) haplotypes with nicotine dependence in male and female smokers of
two ethnic populations. Neuropsychopharmacology, 31: 675-684.
5
Wei, J, Ma, JZ, Payne, TJ, Cui, W, Ray, R, Mitra, N, Lerman, C and Li, MD (2010)
Replication and extension of association of choline acetyltransferase with nicotine dependence in
European and African American smokers. Human genetics, 127: 691-698.
6
Ma, JZ, Beuten, J, Payne, TJ, Dupont, RT, Elston, RC and Li, MD (2005) Haplotype
analysis indicates an association between the DOPA decarboxylase (DDC) gene and nicotine
dependence. Human molecular genetics, 14: 1691-1698.
7
Thorgeirsson, TE, Gudbjartsson, DF, Surakka, I, Vink, JM, Amin, N, Geller, F, Sulem, P,
Rafnar, T, Esko, T, Walter, S et al. (2010) Sequence variants at CHRNB3-CHRNA6 and
CYP2A6 affect smoking behavior. Nature genetics, 42: 448-453.
8
Huang, W, Ma, JZ, Payne, TJ, Beuten, J, Dupont, RT and Li, MD (2008) Significant
association of DRD1 with nicotine dependence. Human genetics, 123: 133-140.
9
Huang, W, Payne, TJ, Ma, JZ and Li, MD (2008) A functional polymorphism, rs6280, in
DRD3 is significantly associated with nicotine dependence in European-American smokers. Am
J Med Genet B Neuropsychiatr Genet, 147B: 1109-1115.
10
Xu, Q, Huang, W, Payne, TJ, Ma, JZ and Li, MD (2009) Detection of genetic association
and a functional polymorphism of dynamin 1 gene with nicotine dependence in European and
African Americans. Neuropsychopharmacology, 34: 1351-1359.
11
Beuten, J, Ma, JZ, Payne, TJ, Dupont, RT, Crews, KM, Somes, G, Williams, NJ, Elston,
RC and Li, MD (2005) Single- and Multilocus Allelic Variants within the GABAB Receptor
Subunit 2 (GABAB2) Gene Are Significantly Associated with Nicotine Dependence. Am. J.
Hum. Genet., 76: 859-864.
12
Ma, JZ, Payne, TJ and Li, MD (2010) Significant association of glutamate receptor,
ionotropic N-methyl-D-aspartate 3A (GRIN3A), with nicotine dependence in European- and
African-American smokers. Human genetics, 127: 503-512.
13
Nussbaum, J, Xu, Q, Payne, TJ, Ma, JZ, Huang, W, Gelernter, J and Li, MD (2008)
Significant association of the neurexin-1 gene (NRXN1) with nicotine dependence in Europeanand African-American smokers. Human molecular genetics, 17: 1569-1577.
14
Beuten, J, Ma, JZ, Payne, TJ, Dupont, RT, Lou, XY, Crews, KM, Elston, RC and Li, MD
(2007) Association of Specific Haplotypes of Neurotrophic Tyrosine Kinase Receptor 2 Gene
(NTRK2) with Vulnerability to Nicotine Dependence in African-Americans and EuropeanAmericans. Biological psychiatry, 61: 48-55.
15
Li, MD, Xu, Q, Lou, XY, Payne, TJ, Niu, T and Ma, JZ (2010) Association and
interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine
dependence in African and European Americans. Am J Med Genet B Neuropsychiatr Genet,
153B: 745-756.
16
Li, MD, Beuten, J, Ma, JZ, Payne, TJ, Lou, XY, Garcia, V, Duenes, AS, Crews, KM and
Elston, RC (2005) Ethnic- and gender-specific association of the nicotinic acetylcholine receptor
alpha4 subunit gene (CHRNA4) with nicotine dependence. Human molecular genetics, 14:
1211-1219.
17
Cui, WY, Wang, S, Yang, J, Yi, SG, Yoon, D, Kim, YJ, Payne, TJ, Ma, JZ, Park, T and
Li, MD (2013) Significant association of CHRNB3 variants with nicotine dependence in
multiple ethnic populations. Molecular psychiatry.
18
Mangold, JE, Payne, TJ, Ma, JZ, Chen, G and Li, MD (2008) Bitter taste receptor gene
polymorphisms are an important factor in the development of nicotine dependence in African
Americans. J Med Genet, 45: 578-582.