Knowledge Management Synopsis Knowledge Management (KM), with a staff of 23, provides high-level data and knowledge organization skills to optimize the enterprise clinical, research, and educational initiatives. Collaborating with clinicians and researchers, highly trained information specialists embed best practices in organizing, structuring and reusing the institution’s knowledge. The information specialists that constitute the Knowledge Management team, in addition to their unique expertise in library and information science, also hold deep knowledge and expertise in the areas of adult learning, molecular biology, public health, pharmacology and communication. Current knowledge management services include expert genetics/molecular biology information assistance to support biomedical research and in-depth clinical evidence to inform the development of local and national patient care guidelines. Evidence-based Practice Support. The Knowledge Management team employs a matrix of strategies to foster evidence-based medicine (EBM) practice. The team provides access to a list of commercial evidence-based databases through the Digital Library. This list encompasses critical resources such as UpToDate®; Cochrane Database of Systematic Reviews, Review of Effects, and Register of Controlled Trials; ACP Journal Club; and links to globally accessible EBM resources such as the National Guideline Clearinghouse™. The Digital Library also features KM’s internally-developed EBM databases such as the Clinical Informatics Consult Service (CICS) Evidence Based Site, which houses evidence syntheses created in response to complex clinical queries, and the Pathway/Order Set Literature Locator, which contains expert search strategies and summaries of literature to support evidence-based development of standardized clinical practice. Access to key National Center for Biotechnology Information resources including PubMed, GenBank™, Entrez Gene ™, Map Viewer™ and OMIM™, as well as others such as PharmGKB, Protein Data Bank (PDB), UCSC Genome Browser, Database of Genomic Variants (DGV), OpenHelix, and TRANSFAC is available throughout the Medical Center. In addition, the Medical Center information systems are accessible via the Digital Library. Clinical Programs and Services Facilitator. The Knowledge Management team is committed to service, and its most important resource is the expertise of its staff. Information specialists help students, residents and faculty stay abreast of the latest findings in the literature by actively participating on clinical rounds and providing targeted support to researchers. In addition to working as clinical and research informationists, KM information specialists participate in multidisciplinary teams throughout the Medical Center, supporting a variety of programs such as pathways/order sets development, the Institutional Review Board (IRB), and a variety of patient information services. KM team members contribute vetted personalized patient information links addressing diseases/conditions and lab findings/vital signs to the Medical Center’s online patient portal, MyHealthAtVanderbilt, and the medical center’s electronic medical record system, StarPanel. KM assistance with comprehensive literature reviews is available to researchers developing IRB protocols, and to IRB protocol analysts. 1 The Knowledge Management team has also been an integral part of Vanderbilt’s AHRQ-funded Evidence Based Practice Center (EPC) since its inception in 2007 to develop topics for comparative effectiveness review and authoring systematic reviews to evaluate evidence on various health topics. The team has been participating throughout the systematic review process, including authoring content in the final report. To support Vanderbilt’s Clinical and Translational Science Award (CTSA), the KM team provides expert training and consultation for requests received through StarBRITE: Biomedical Research Integration, Translation and Education online system, a one-stop shop for VUMC researchers in need of regulatory, study design, biostatistics, technology, or other support, such as location of data on known single nucleotide polymorphisms (from dbSNP, OMIM, HGVbaseG2P, and other databases) detected via Vanderbilt’s DNA Databank. Research Institution. Knowledge Management’s research interests include integrating evidence into the patient care and research workflow using informatics applications; assessing various stakeholder groups' interaction with health information; education, skills development, and leadership development of information professionals; optimal selection and use of information resources; health literacy projects and interventions; organizational knowledge management; and digital library development. Recently funded research projects include: Using Patient Literacy Levels and Learning Style Preferences to Optimize the Delivery of Health Information (IMLS LG-06-10-0186-10). By integrating both literacy levels and learning style preferences to improve the usefulness of condition-specific health information provided to patients during healthcare encounters, this research project will establish an infrastructure for developing customized information prescriptions that can be broadly adapted for use in varied care settings and with varied health conditions. Toward Personalized Medicine. The Knowledge Management team aims to advance the knowledgebase and capacities of VUMC for its personalized medicine missions. KM information scientists provide training to VUMC personnel and research community on pharmacogenetics and personalized medicine concepts and resources. In addition to group training, KM information scientists also offer drop-in office hours for VUMC practitioners, researchers, and students to gain assistance for using in-depth genetics and molecular biology databases. The scientists also participate in VUMC’s Diagnostic Management Team (DMT) to provide pharmacogenetics consultation services and informational support including the development of a knowledge base tailored for the information need of the DMT. 2