Young-In Kim-Hoehamer, Ph.D.
4-22-2015
CURRICULUM VITAE
NAME: Young-In Kim-Hoehamer, Ph.D.
(Other/Maiden name: Young-In Kim)
BIRTH PLACE: South Korea
CITIZENSHIP: South Korea, U.S.A. permanent resident
EDUCATION:
Undergraduate
Kangwon National University, March 1993- February 1997, B.S.
Graduate
Kangwon National University, March 1997- February 1999, M.S.
Seoul National University, March 2002-August 2004, Ph.D.
Post-Graduate
Seoul National University, August 2005-November 2005, Postdoctoral fellow
The University of Tennessee Health Science Center, December 2005-October 2011, Postdoctoral
fellow
Clinical Research
The University of Tennessee Health Science Center, August 2014- May 2015
12 credits certificate program
HONORS/AWARDS:
Educational
Institutional, 1993-1997: Kangwon National University student scholarship
Institutional, 1997-1999: Kangwon National University graduate student scholarship
Professional
Institutional, 2011: Accredo Pediatric Scientist Award
Institutional, 2009: Outstanding poster presentation award (UTHSC/Le Bonheur Children’s
Hospital Pediatric Research Day)
Institutional, 2008: Accredo Pediatric Scientist Award
Institutional, 2007: Accredo Pediatric Scientist Award
National, 2006: Korean Research Foundation Post-doctoral Fellowship
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Young-In Kim-Hoehamer, Ph.D.
4-22-2015
SOCIETY MEMBERSHIPS:
2007-PRESENT: Member of American Association of Immunologists
2013-PRESENT: Member of American Association for Microbiology
ACADEMIC, PROFESSIONAL, AND RESEARCH APPOINTMENTS:
Instructor, December 2012 - Present: Division of Infectious Diseases, University of
Tennessee Health Science Center
Research Associate, November 2011-November 2012: Department of Pediatrics, University of
Tennessee Health Science Center
TEACHING EXPERIENCE:
2005, Public hygiene, 20 students at Sook Myung Women’s University, 2 credit hours, Lecturer
2004, Vaccines and immunology, 50 students at Seoul Women’s University, 2 credit hours,
Lecturer
1997-1999, Biology, 40 students per class (two classes), in the Department of Biology, Kangwon
National University, 1 credit hour, Teaching Assistant.
OTHER PROFESSIONAL AFFILIATIONS AND ACTIVITIES:
COMMITTEES AND OFFICES HELD:
The UTHSC PostDoc Advisory Committee member
2013 - Present
The UTHSC Postdoctoral Association (PhDA): Faculty Representative
2013 - Present
Judge for the Travel award - The UTHSC Postdoctoral Association (PhDA): 2013
Judge for the poster session on ‘The UTHSC PostDoc research day’
December 12th 2013
Judge for the Travel award - The UTHSC Postdoctoral Association (PhDA): 2014
Judge for the oral session on ‘The UTHSC PostDoc research day’
December 10th 2014
Scholarship oversight committee
Nora Daher, M.D. - Dr. Daher was a Fellow in the Allergy/Immunology April 2012 – August 2013,
University of Tennessee and Le Bonheur Children’s Hospital fellowship program. My role was as
research supervisor and member of the scholarship oversight committee. Dr. Daher was trained
under my supervision in Dr. Ae-Kyung Yi’s laboratory. During this time, she won a Le Bonheur
small grant with the title ‘TLR3 deficiency and association with recurrent varicella.’ Since
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Young-In Kim-Hoehamer, Ph.D.
4-22-2015
December 1st 2012, I have joined her scholarship oversight committee. Currently, she is an allergy
immunologist at Allergy and Asthma Care.
Undergraduate student training
Aditya Biswas - August 2012; November 2013
Undergraduate student at Rhodes College. My role was as research mentor for a project involving
development of cell-mediated immune response in respiratory syncytial virus (RSV) infections
and mathematical models to capture the viral kinetics of RSV infections in vitro.
Benjamin Patters - August 2012; July 2013
Undergraduate student at the University of Tennessee, Knoxville; biochemistry major
My role was as research mentor for a project involving development of cell-mediated immune
response in RSV infections. Currently, he is a Ph.D. student at the University of Tennessee
Health Science Center.
Scott Freeburg- June-July; 2013
Undergraduate student at the Kenyon College, biology major
My role was as research mentor for a project involving development of cell-mediated immune
response in RSV infections.
Charlie Freeburg- June-July; 2013
Undergraduate student at the Davison College, Biology major
My role was as research for a project involving development of cell-mediated immune response
in RSV infections.
EDITORIAL POSTS AND ACTIVITIES:
Reviewer status
PLoS ONE
Future Medicine
2014-PRESENT
2015-PRESENT
GRANTS AND CONTRACTS:
Funded
Le Bonheur Children’s Hospital
Project title: Study on molecular mechanisms of IRAK-M expression by TLR ligands
Role: PI
Grant period: 2 years (2007 - 2008)
Award: $30,000
Le Bonheur Children’s Hospital
Project title: PKD1 in the pathogenesis of hypersensitivity pneumonitis
Role: PI
Grant period: 1 year (2011)
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Award: $10,000
Young-In Kim-Hoehamer, Ph.D.
4-22-2015
AstraZeneca
Project title: Development of mathematical models to capture the viral kinetics of respiratory
syncytial virus infections in vitro and in vivo
Role: PI
Grant Period: 1 year (November 26th, 2013-November 25th, 2014)
Award: $170,400
PEER-REVIEWED JOURNAL ARTICLES:
1. Hur DY, Kim DJ, Kim S, Kim YI, Cho D, Lee DS, Hwang Y, Bae K, Chang KY, Lee WJ. Role of
follicular dendritic cells in the apoptosis of germinal center B cells. Immunol Lett. 2000 May
1;72(2):107-11 (cited in 25 publications, IF: 2.34).
2. Hur DY, Kim S, Kim YI, Min HY, Kim DJ, Lee DS, Cho D, Hwang YI, Hwang DH, Park SH, Ahn HK,
Chang KY, Kim YB, Lee WJ. CM1, a possible novel activation molecule on human lymphocytes.
Immunol Lett. 2000 Oct 3;74(2):95-102 (cited in 4 publications, IF:2.34).
3. Park H, Byun D, Kim TS, Kim YI, Kang JS, Hahm ES, Kim SH, Lee WJ, Song HK, Yoon DY, Kang CJ,
Lee C, Houh D, Kim H, Cho B, Kim Y, Yang YH, Min KH, Cho DH. Enhanced IL-18 expression in
common skin tumors. Immunol Lett. 2001 Dec 3;79(3):215-9 (cited in 31 publications, IF: 2.34).
4. Kim D, Hur DY, Kim YS, Lee K, Lee Y, Cho D, Kang JS, Kim YI, Hahm E, Yang Y, Yoon S, Kim S, Lee
WB, Park HY, Kim YB, Hwang YI, Chang KY, Lee WJ. CM1 ligation initiates apoptosis in a caspase
8-dependent manner in Ramos cells and in a mitochondria controlled manner in Raji cells.
Hum Immunol. 2002 Jul;63(7):576-87 (cited in 4 publications, IF:2.30).
5. Cho D, Seung Kang J, Hoon Park J, Kim YI, Hahm E, Lee J, Yang Y, Jeon J, Song H, Park H, Kim T,
Pang S, Kim CW, Il Hwang Y, Jae Lee W. The enhanced IL-18 production by UVB irradiation
requires ROI and AP-1 signaling in human keratinocyte cell line (HaCaT). Biochem Biophys Res
Commun. 2002 Oct 25;298(2):289-95. (cited in 14 publications, IF: 2.41)
6. Kim YI, Park S, Jeoung DI, Lee H. Point mutations affecting the oligomeric structure of Nm23
H1 abrogates its inhibitory activity on colonization and invasion of prostate cancer cells.
Biochem Biophys Res Commun. 2003 Jul 25; 307(2):281-9 (cited in 19 publications, IF:2.41).
7. Kang JS, Cho D, Kim YI, Hahm E, Yang Y, Kim D, Hur D, Park H, Bang S, Hwang YI, Lee WJ. L
ascorbic acid (vitamin C) induces the apoptosis of B16 murine melanoma cells via a caspase-8
independent pathway. Cancer Immunol Immunother. 2003 Nov;52(11):693-8 (cited in 21
publications, IF: 3.64).
8. Cho D, Hahm E, Kang JS, Kim YI, Yang Y, Park JH, Kim D, Kim S, Kim YS, Hur D, Park H, Pang S, Il
Hwang Y, Lee WJ. Vitamin C downregulates interleukin-18 production by increasing reactive
oxygen intermediate and mitogen-activated protein kinase signalling in B16F10 murine
melanoma cells. Melanoma Res. 2003 Dec;13(6):549-554. (cited in 11 publications, IF: 2.52).
9. Cho D*, Kim YI*, Kang J, Hahm E, Yang Y, Kim D, Kim S, Kim Y, Hur D, Park HJ, Hwang YI, Kim T,
Lee WJ. (*shared first author) Resistance to cytotoxic chemotherapy is induced by NK cells in
non-Hodgkin's lymphoma cells. J. Clinical Immunol. 2004 Sep; 24(5): 552-9 (cited in 2
publications, IF:3.38).
10. Yang Y, Hahm E, Kim Y, Kang J, Lee W, Han I, Myung P, Kang H, Park H, Cho D. Regulation of IL18 expression by CRH in mouse microglial cells. Immunol Lett. 2005 May 15;98(2):291-6 (cited
in 11 publications, IF: 2.34).
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Young-In Kim-Hoehamer, Ph.D.
4-22-2015
11. Kang JS, Cho DH, Kim YI, Hahm ES, Kim YS, Jin SN, Kim HN, Kim DJ, Hur DY, Park HJ, Hwang YI,
Lee WJ. Sodium ascorbate (vitamin C) induces apoptosis in melanoma cells via the down
regulation of transferring receptor dependent iron uptake. J Cell Physiol. 2005 Jul;204(1):192-7
(cited in 25 publications, IF: 4.22).
12. Kim YS, Park GB, Choi YM, Kwon OS, Song HK, Kang JS, Kim YI, Lee WJ, Hur DY. Ligation of
centrocyte/centroblast marker 1 on Epstein-Barr virus-transformed B lymphocytes induces cell
death in a reactive oxygen species-dependent manner. Hum Immunol. 2006 Oct;67(10):795
807 (cited in 4 publications, IF: 2.30).
13. Hahm E, Jin DH, Kang JS, Kim YI, Hong SW, Lee SK, Kim HN, Jung DJ, Kim JE, Shin DH, Hwang YI,
Kim YS, Hur DY, Yang Y, Cho D, Lee MS, Lee WJ. The molecular mechanisms of vitamin C on cell
cycle regulation in B16F10 murine melanoma. J Cell Biochem. 2007 Nov 1;102(4):1002-10
(cited in 15 publications, IF: 3.06).
14. Kim YI, Park JE, Martine A. Yi AK. CpG DNA prevents liver injury and shock-mediated death by
modulating expression of IL-1R-associated kinase family proteins. J Biol Chem. 2008 May
30;283(22):15258-70 (cited in 9 publications, IF: 4.65).
15. Talati AJ, Kim HJ, Kim YI, Yi AK, English BK. Role of bacterial DNA in macrophage activation by
group B streptococci. Microbes Infect. 2008 August - September;10(10- 11):1106-13 (cited in
13 publications, IF: 2.92).
16. Park JE, Kim YI, Yi AK. Protein kinase D1: A new component in Toll-Like receptor 9 signaling. J
Immunol 2008 Aug 1;181(3):2044-55 (cited in 11 publications, IF:5.52 ).
17. Park JE, Kim YI, Yi AK. Protein kinase D1 is essential for MyD88-dependent TLR signaling
pathway. J Immunol. 2009 May 15;182(10):6316-27 (cited in 12 publications, IF: 5.52 ).
18. Kim YI, Park JE, Brand D, Fitzpatrick EA, Yi AK. Protein kinase D1 is essential for the
proinflammatory response induced by hypersensitivity pneumonitis-causing thermophilic
actinomycetes Saccharopolyspora rectivirgula. J Immunol. 2010 Mar 15;184(6):3145-56 (cited
in 6 publications, IF: 5.52 ).
19. Kim YI, Park JE, Kwon KH, Hong CY, Yi AK. IRAK2- and PKD1-dependent regulation of
interleukin-1 receptor-associated kinase-monocyte expression by CpG DNA. PLoS ONE 2012
Aug 7(8):e43970 (IF: 3.73).
20. Cormier SA, Shrestha B, Saravia J, Shen L, DeVincenzo J, Kim YI, and You D. Limited type I IFNs
and plasmacytoid dendritic cells during neonatal respiratory syncytial virus infection permit
immunopathogenesis upon reinfection. J Virology. 2014 Aug 15;88(16):9350-60. doi:
10.1128/JVI.00818-14 (IF: 4.855).
21. Kim YI*, DeVincenzo J*, Jones BG, Rudraraju R, Harrison L, Meyers R, Cehelsky J, Alvarez R,
Hurwitz JL (*shared first author). Respiratory syncytial virus human experimental infection
model: provenance, production, morphology, and sequence of low-passaged Memphis-37
challenge virus. PloS One, 2014 Nov 21;9(11):e113100. IF: 3.73)
22. Kim YI*, Murphy R*, Majumdar S, Sullivan A, Harrison L, Aitkin J, DeVincenzo JP (*shared first
author). Relating plaque morphology to respiratory syncytial virus strain, viral load, and
disease severity in children. Pediatric Research 2015 (accepted , IF: 2.84).
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Young-In Kim-Hoehamer, Ph.D.
4-22-2015
OTHER PUBLICATIONS
1. NCBI GenBank (BankIt1750538 Seq1 KM360090) Aug 13 2014
DeVincenzo JP, Jones BG, Kim YI, and Hurwitz JL, Respiratory syncytial virus human
experimental infection model: provenance, production, and sequence of low-passaged
Memphis-37 challenge virus
Abstracts presented and published
1. Young-In Kim, Hyunsook Yoon, Antonio Martinez, Jeoung-Eun Park, Beom-Sue Kim, and Ae
Kyung Yi. CpG DNA prevents liver injury and shock-mediated death by modulating the
expression of IL-1R-associated kinase family protein. Presented at the Keystone symposia,
Keystone CO, April 2007.
2. Jeoung-Eun Park, Young-In Kim, and Ae-Kyung Yi. Protein kinase D1: A new component in Tolllike receptor 9 signaling in macrophages. Presented at the Keystone symposia, Keystone CO,
February 2008.
3. Jeoung-Eun Park, Young-In Kim, and Ae-Kyung Yi. Protein kinase D1: A new component in Tolllike receptor 9 signaling in macrophages. Presented at the UTHSC/Le Bonheur Children’s
Hospital Pediatric Research Day, Memphis, TN, October 2008.
4. Young-In Kim, Hyunsook Yoon, Antonio Martinez, Jeoung-Eun Park, Beom-Sue Kim, and AeKyung Yi. CpG DNA prevents liver injury and shock-mediated death by modulating the
expression of IL-1R-associated kinase family protein. Presented at the UTHSC/Le Bonheur
Children’s Hospital Pediatric Research Day, Memphis, TN, October 2008.
5. Jeoung-Eun Park, Young-In Kim, and Ae-Kyung Yi. Protein kinase D1 is essential for the MyD88dependent TLR signaling pathway. Presented at the UTHSC/Le Bonheur Children’s Hospital
Pediatric Research Day, Memphis, TN, September 2009.
6. Young-In Kim, Jeoung-Eun Park, and Ae-Kyung Yi. Protein Kinase D1 is essential for
proinflammatory response induced by hypersensitivity pneumonitis-causing thermophilic
actinomycetes Sacchropolyspora rectivirgula. Presented at the UTHSC/Le Bonheur Children’s
Hospital Pediatric Research Day, Memphis, TN, September 2009.
7. Young-In Kim, Jeoung-Eun Park, Ki-Han Kwon, Cheol Yi Hong, and Ae-Kyung Yi. IRAK-2-and
PKD1-dependent regulation of interleukine-1 receptor-associated kinase-monocyte expression
by CpG DNA. Presented at the UTHSC/Le Bonheur Children’s Hospital Pediatric Research Day,
Memphis, TN, November 2010.
8. Young-In Kim, Arnold E. Postlethwaite, and Ae-Kyung Yi. A newly identified vitamin D3 analog
20-hydroxyvitamin D3 suppresses Toll-like receptor4-mediated inflammatory cytokine via a
vitamin D receptor-dependent manner. Presented at the UTHSC/Le Bonheur Children’s Hospital
Pediatric Research Day, Memphis, TN, November 2011.
9. Young-In Kim, Lisa G. Harrison and John P. DeVincenzo. Quantification of respiratory syncytial
virus-specific cell-mediated immune responses. Presented at the UTHSC/Le Bonheur Children’s
Hospital Pediatric Research Day, Memphis, TN, November 2012.
10. Young-In Kim, Aditya Biswas, Benjamin Patters, Lisa G. Harrison and John P. DeVincenzo.
Respiratory syncytial virus-specific cell-mediated immune responses in human peripheral blood.
Presented at the UTHSC/Le Bonheur Children’s Hospital Pediatric Research Day, Memphis, TN,
November 2013.
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Young-In Kim-Hoehamer, Ph.D.
4-22-2015
11. Kirtikumar Upadhyay, Jeoung-Eun Park, Young-In Kim, Elizabeth Meals, Ajay T. Talati, B. Keith
English and Ae-Kyung Yi. Group B streptococci induce proinflammatory responses via a protein
kinase D1-dependent pathway. Presented at the UTHSC/Le Bonheur Children’s Hospital
Pediatric Research Day, Memphis, TN, November 2013.
12. Young-In Kim, Lisa G. Harrison and John P. DeVincenzo. Respiratory syncytial virus-specific cellmediated immune responses in human peripheral blood. Presented at the AAI, Pittsburgh,
Pennsylvania, May 2-6, 2014.
13. Ae-Kyung Yi, Jeoung-Eun Park, and Young-In Kim. Protein kinase D1 links IRAK1 and TRAF6 in
the MyD88-dependent Toll-like receptor signaling pathway. Presented at the AAI, Pittsburgh,
Pennsylvania, May 2-6, 2014.
14. Ae-Kyung Yi, Tae Won Yoon, David D. Brand, Young-In Kim, Jeoung-Eun Park, and John M.
Stuart. A pharmacological protein kinase D inhibitor ameliorates experimental arthritis.
Presented at the AAI, Pittsburgh, Pennsylvania, May 2-6, 2014.
15. Julia L. Hurwitz, Rhiannon Penkert, Sherri L. Surman, Bart G. Jones, Robert E. Sealy, Rajeev
Rudraraju, Charles Russell, Allen Portner, Bindiya Bagga, Young-In Kim, and John P. DeVincenzo.
Correlates of protection and vaccine development with Memphis-37. Presented at the 9th
International Respiratory Syncytial Virus Symposium, Capetown, South Africa, November 09-13
2014).
16. Young-In Kim, John P. DeVincenzo, Bart G. Jones, R Rudraraju, Lisa Harrison, R Meyers, L
Cehelsky J, R Alvarez, Julia L. Hurwitz. Respiratory syncytial virus human experimental infection
model: provenance, production, morphology, and sequence of low-passaged Memphis-37
challenge virus. Presented at the UTHSC/Le Bonheur Children’s Hospital Pediatric Research Day,
Memphis, TN, November 2014, Memphis, TN, November 19, 2014.
17. Young-In Kim, Ryan Murphy, Sirshendu Majumdar, Lisa G. Harrison, Jody Aitken, John P.
DeVincenzo. Relating plaque morphology to respiratory syncytial virus subgroup, viral load, and
disease severity in children. Presented at the UTHSC/Le Bonheur Children’s Hospital Pediatric
Research Day, Memphis, TN, November 2014, Memphis, TN, November 19, 2014.
18. Ae-Kyung Yi, Jeoung-Eun Park, and Young-In Kim. Protein kinase D1 links IRAK1 and TRAF6 in
the MyD88-dependent Toll-like receptor signaling pathway. Presented at the UTHSC/Le
Bonheur Children’s Hospital Pediatric Research Day, Memphis, TN, November 2014, Memphis,
TN, November 19, 2014.
19. Ae-Kyung Yi, Tae Won Yoon, David D. Brand, Young-In Kim, Jeoung-Eun Park, and John M.
Stuart. A pharmacological protein kinase D inhibitor ameliorates experimental arthritis.
Presented at the UTHSC/Le Bonheur Children’s Hospital Pediatric Research Day, Memphis, TN,
November 19, 2014, Memphis, TN, November 2014.
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