An Overview of Genetic Influences in Alcoholism: 2007 (Slide 1)

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Gail M. Basch, M.D

Rush University Medical Center

Revised October 2013

Alcohol Medical Scholars Program

Note: Outline contains detail that would allow someone to give the lecture.

Some slides contain animation that should be reviewed prior to lecturing to understand placement.

Special Populations- College Drinking (Slide 1)

I.

A.

Introduction.

College associated with heavy drinking. 1 2 3 (Slide 2)

1.

2.

3.

4.

5.

6.

B.

1.

2.

3.

Time of transition / exploration.

Time of life with heaviest drinking.

Incoming student believes heavy drinking = norm. 4,5

Pattern → much morbidity and mortality. 6

–9

(Slide 3)

C.

1.

2.

3.

4.

5.

2,000 student deaths / yr. from alc related causes. 9

~700,000 assaults / yr.

~80,000 sexual assaults / yr.

~2.8 million drove while intoxicated.

13

U.S. spends $62 billion / yr. underage drinking.

Students have heavy drinking episodes.

14 –16

(Slide 5)

~45% report heavy drinking / past 2 wks.

~20% ♂drink 10 drinks / occasion.

~10% ♀drink 8 drinks / occasion.

50% ~1+ blackout / college.

17,18

40 % ~1+ alcohol problem prior yr.

20% students drink 72% of all alcohol.

1

D. College heavy drinking → future drinking problems. (Slide 4)

1.

2.

Clues for prevention efforts.

Clues for Rx.

E.

3. Most clinicians learn little re: these issues.

This lecture reviews: (Slide 5)

1.

2.

3.

4.

Definitions.

Campus drinking & problems.

Risk factors for heavy drinking.

Prevention efforts.

II.

A.

Definitions.

Standard drink (10-12 g pure ethanol). 19 (Slide 6)

B.

1.

2.

Volumes. a. 12 oz. beer. b. 8 oz. malt liquor. c. 5 oz. wine. d. 1.5 oz. 80 proof liquor (spirits).

Volumes in Solo cup. (Slide 7)

a. 12 oz. beer

b. 5 oz. wine

c. 1 oz. spirits.

Heavy episodic drinking.

19 (Slide 8)

1.

2.

5+ std drinks for ♂.

4+ std drinks for ♀.

2

C.

3. ≥5 occasions during past month.

Blood alcohol concentration (BAC). 20 (Slide 9)

D.

1.

2.

3.

Std. drink ~ 12 g alcohol.

1 drink

BAC ~ ↑ 0.15g/dl ~15mg%.

BAC with a.

Drinks.

b. ♀.

c. ↓ Weight.

d. Drink without food.

4. BAC’s effects. 21 (Slide 10) a. ≤ 50mg% (1-3 drinks) → Well-being, ↓ inhib. b. ≤ 100 → Sleepiness, ↓ coordination. c. ≤ 200 → Anger, moodiness, confusion. d. ≤ 300 → Difficulty awakening. e. > 300 → ↓ Vital signs, coma, death.

Blackout.

17,18,22 (Slide 11)

1. Forget events that occurred when intox.

2. Remain consciousness.

E. Alcohol abuse & alcohol dependence = alcohol use disorders

(AUDs). (Slide 12)

1. Alcohol abuse: 1+ in same 12 mos (in absence of dep) of 23 a. b. c.

Role failure.

Risk of harm.

Legal problems.

3

2. d. Use despite problems.

Alcohol dependence: 3+ in same 12 months of: 23

F. a. b. c. d. e. f.

Tolerance.

Withdrawal.

Larger/ longer.

Unable to cut down.

↓Time elsewhere.

Use despite problems.

DSM 5 Alcohol use disorders.

24 (Slide 13)

1.

2.

3.

4.

 Abuse vs. dependence.

 Legal.

+ Craving.

Within same 12 mos: a. Craving b. Role failure.

c. Risk of harm.

d. Use despite problems. e. Tolerance. f. Withdrawal. g. Larger amts / longer time. h. Unable to cut down.

5. Severity scale: a. 23 → Mild.

4

III.

A. b. 45→ Mod.

c. ≥ 6 → Severe.

Campus drinking & problems. (Slide 14)

College students drink more than peers. 12,25

–28

(Slide 15)

B.

1. College drinking vs. non-college: a. Current drinkers / past yr: 63% vs 53%. b. Current heavy episodic drinking: 45% vs 38%. c. Current alcohol use disorders / past yr: 18% vs 15%. d. DWI / 2 wks: 40% vs 25 %. e. Highlights college risk factors (some mentioned below).

Risk factors: Some stude nt subgrps have ↑ risk alc probs. (Slide 16)

1. ~40% environment & ~60% genetics. (see pie chart).

2. a. Environment: Holidays, 21 st b-day, game day, Greek,

athletes. b. Genetics: AUD, impulsivity, low level of response to

alcohol (LR).

Environmental risk factors (~40%). (Slide 17) a. High-risk day/event →  drink. i. High-risk events.

9 28 –29

(Slide 21) a'. New Year’s Eve: BAC~0.126 g/dl. b'. c'. d'.

Spring Break: BAC~0.107 g/dl.

Graduation: BAC~0.093 g/dl.

Valentine’s Day: BAC~0.076 g/dl. e'. Weekday: BAC~0.076g/dl (see bar graph). ii. Next: At 21 st birthday. 9,30 (Slide 18)

5

a'. b'. c'. d'. e'. f'. g'.

Another example environmental risk.

83% drink to celebrate.

~25 % >21 b-day drinks.

~40% report blackouts.

For 50% this is highest ever drinks.

BAC~0.186 g/dl.

9

2 wks. after b-day: 72 %

DWI. iii. Next: Game day drinking. (Slide 19) a'. Another example environmental risk. b'. c'.

E.g. tailgating.

~60% drink on game day. d'. e'. f'. g'.

~7drinks/game.

↑ Impulsivity.

↑ Expectations.

→  drink. h'. b. Next: Members of fraternity/sorority. 31

–34

(Slide 20) i. Greek members drink

with

 alc related conseq. a'. b'.

Another example environmental risk.

~60% heavy drinkers in high school. c'. ~80% heavy episodic drinkers currently. ii. ↑ Drinker peer groups. a'. Leaders drink

 b'. c'.

Set drinking norms.

→  drink. iii. Fraternity/Sorority Blackouts: (Slide 21) a'. Members vs. non-members.

6

3. b'. Blackouts / past 2 wks:

1. ♂: 45% vs 23%.

2. ♀: 42% vs 20%. c. Next: Student athletes.

35

–38

(Slide 22) i. Athletes drink

with

alcohol related conseq. a'. Another example of environmental risk. b'. c'.

~50% heavy episodic drinkers.

If athlete + Greek system → drinks 

. ii. ↑ Drinker peer groups. a'. Team leaders drink

 b'. c'.

Set drinking norms.

→  drink.

Genetic risk factors (~60%). 2 a. Students with alcohol dependent relatives. (Slide 23) i. Example of inherited genetic risk factor. ii. 4x ↑ risk AUDs.

39,40 iii. Even if adopted out.

iv. →  drink. b. Next: ↑ Impulsivity. 7,41 –47

(Slide 24) i. Can inherit predisposition to impulsivity. ii. ↓ Ability to postpone reward. iii. ↑ Risk taking. iv. ↑ Urgency. v. → 

Drink. c. Next: Low sensitivity (low level of response).

39,48

–53

(Slide 25) i. Well-studied genetic risk factor. ii. Not same as tolerance. iii. Need



drinks for effects ( “drink others under table”).

7

iv. So



drinks /occasion. v. Join peers who



drinks /occasion. vi. Think everyone drinks



. vii.

Stress from heavy drinking. viii. Use

 drinks to cope. ix. →  drink.

IV.

A.

1.

Prevention efforts. (Slide 26)

Heavy drinking peers influence drinking. (Slide 27) 39,54 –57 58

O ffer ↑↑ number of drinks.

B.

2.

3. a. Students fear rejection if refuse drink. b. ~40% afraid to refuse. c. Lack skills to say no. d. → 

Drink.

Also overestimate peer/campus heavy drinking. 43 59

–64

58 a. Only 13 % students estimate drinking correctly. b. ↑Drinking to match estimation. c. Think heavy drinking desirable. d. → 

Drink.

If teach students about peer pressure → ↓ drink.

Next: Inaccurate beliefs. (Slide 28)

1. False beliefs. a. Re: benefits of heavy drinking. i. ~65% believe heavy drink → more fun. ii. ~55% believe heavy drink → better sex.

8

2. iii. Other myths. a'. b'. c'.

Lite beer → ↓alcohol.

Caffeine, exercise, shower → helps hangover.

Used to hangover → good sign. b. Re: alcohol used incorrectly for: i. Muscle tension relief. ii. Better sleep.

Re: mis / under-informed on dangers of heavy drinking. a. Believe can guess BAC. b. Minimize alcohol overdose dangers.

4. c. Alcohol + other drugs dangers.

Educate students about alc & real effects → ↓ drink.

C.

1.

2.

3.

4.

5.

Next: Alcohol to cope. 58 64,65 (Slide 29)

Students falsely believe alcohol ↓ stress.

Low doses → ↓ mild anxiety.

2 or 3 drinks → ↑ anxiety. a. Later in evening. b. Next morning.

Drink to treat alcohol-induced anxiety. a. Can interfere with searching for better ways to handle stress. b. Drinking takes place of healthy coping skills.

Correct false belief & teach healthy coping skill → ↓ drink.

D. Key elements of campus drinking prevention incl.

39,50,51,53 (Slide 30)

1. Orientation. a. Mandatory/optional internet program prior/during. b. Campus policy.

9

2.

3.

4.

5. c. 1st student screen.

Student health. a. S creening. b. B rief I ntervention. c. R eferral to T reatment.

Campus life. a. ↑ reasons not to drink. i. Promote choose not to drink. ii. Friday tests. iii.  3-day weekends. b. ↓ alcohol availability. i.  Kegs. ii.  Happy hours. c. ↑ Alcohol safety.. i. Safe rides. ii. Hotlines for alc OD. iii. Teach safer drinking. a'. b'.

Discourage pregaming (Drink before go out).

Discourage drinking games. c'. d'. e'. f'.

Count drinks.

Alternate alc and non-alc drinks.

Choose 1 type of alc only.

Preset # drinks.

Dorm counselors. a. Older. b. Salaried.

Prevention campaigns. a. National Alcohol Screening Month is April.

10

E. b. Campus-community partnership. i.

Alcohol prices. a'. Sales ↓. b'. Esp. freshmen. ii. ↓ Alcohol retail outlets. iii. Enforce carding.

iv. Sobriety checkpoints.

Prevention videos. 44,48 49 ,51 (Slide 31)

F.

1.

2.

3.

Taught about: a. Peer influence b. Accurate alcohol beliefs. c. Actual campus drinking patterns. d. New coping skills. e. Info: can't guess BAC. f. Info: dangers of alcohol + drugs.

How taught:. a. Series of 5.. b. Economical. c. Practical. d. Individualized feedback.

↓ Heavy drinking.

Tailoring prevention to risk → ↓ heavy drinking/problems.

V.

A.

Conclusion. (Slide 32)

This lecture reviewed:

1. Definitions of alcohol use and problems.

11

2.

3.

4.

Campus drinking & problems.

Risk factors for heavy drinking.

Prevention efforts.

12

References

1. Fillmore KM, Hartka E, Johnstone BM, Leino EV, Motoyoshi M, Temple MT. A meta-analysis of life course variation in drinking*. British Journal of Addiction .

1991;86(10):1221–1268. doi:10.1111/j.1360-0443.1991.tb01702.x.

2. Schuckit MA. Alcohol-use disorders. Lancet . 2009;373(9662):492–501. doi:10.1016/S0140-6736(09)60009-X.

3. Baer JS, Kivlahan DR, Blume AW, McKnight P, Marlatt GA. Brief intervention for heavy-drinking college students: 4-year follow-up and natural history. Am J Public

Health . 2001;91(8):1310–1316.

4. Wechsler H, Nelson TF. What we have learned from the Harvard School Of Public

Health College Alcohol Study: focusing attention on college student alcohol consumption and the environmental conditions that promote it. J Stud Alcohol Drugs . 2008;69(4):481–

490.

5. Neighbors C, Jensen M, Tidwell J, Walter T, Fossos N, Lewis MA. Social-norms interventions for light and nondrinking students. Group Processes & Intergroup

Relations . 2011;14(5):651–669. doi:10.1177/1368430210398014.

6. Baer JS, Stacy A, Larimer M. Biases in the Perception of Drinking Norms among

College Students: Journal of Studies on Alcohol and Drugs . 1991;52(6):580.

7. Balodis IM, Potenza MN, Olmstead MC. Binge drinking in undergraduates:

Relationships with gender, drinking behaviors, impulsivity and the perceived effects of alcohol. Behav Pharmacol . 2009;20(5-6):518–526. doi:10.1097/FBP.0b013e328330c779.

8. Barnett NP, Lebeau-Craven R, O’Leary TA, et al. Predictors of motivation to change after medical treatment for drinking-related events in adolescents. Psychol Addict

Behav . 2002;16(2):106–112.

9. BARNETT NP, GOLDSTEIN AL, MURPHY JG, COLBY SM, MONTI PM. “I’ll

Never Drink Like That Again”: Characteristics of Alcohol-Related Incidents and

Predictors of Motivation to Change in College Students. J Stud Alcohol . 2006;67(5):754–

763.

10. Knight JR, Wechsler H, Kuo M, Seibring M, Weitzman ER, Schuckit MA.

Alcohol abuse and dependence among U.S. college students. J Stud Alcohol .

2002;63(3):263–270.

11. 1College_Bulletin-508_361C4E.pdf. Available at: http://www.collegedrinkingprevention.gov/1College_Bulletin-508_361C4E.pdf.

Accessed January 13, 2013.

12. Hingson RW, Zha W, Weitzman ER. Magnitude of and Trends in Alcohol-Related

Mortality and Morbidity Among U.S. College Students Ages 18-24, 1998-2005. J Stud

Alcohol Drugs Suppl . 2009;(Supplement no. 16):12–20.

13. Fromme K, Wetherill R, Neal D. Turning 21 and the Associated Changes in

Drinking and Driving after Drinking Among College Students. J Am Coll Health .

2010;59(1):21–27. doi:10.1080/07448481.2010.483706.

13

14. harvardstudy.pdf. Available at: http://www.campusfiresafety.org/uploaded/harvardstudy.pdf. Accessed January 19, 2013.

15. White AM, Kraus CL, Swartzwelder H. Many college freshmen drink at levels far beyond the binge threshold. Alcohol Clin Exp Res . 2006;30(6):1006–1010. doi:10.1111/j.1530-0277.2006.00122.x.

16. Wechsler H, Lee JE, Nelson TF, Kuo M. Underage college students’ drinking behavior, access to alcohol, and the influence of deterrence policies. Findings from the

Harvard School of Public Health College Alcohol Study. J Am Coll Health .

2002;50(5):223–236. doi:10.1080/07448480209595714.

17. Mundt MP, Zakletskaia LI, Brown DD, Fleming MF. Alcohol-induced memory blackouts as an indicator of injury risk among college drinkers. Inj Prev . 2012;18(1):44–

49. doi:10.1136/ip.2011.031724.

18. Mundt MP, Zakletskaia LI. Prevention for College Students Who Suffer Alcohol-

Induced Blackouts Could Deter High-Cost Emergency Department Visits. Health Aff

(Millwood) . 2012;31(4):863–870. doi:10.1377/hlthaff.2010.1140.

19. DeJong W, Larimer ME, Wood MD, Hartman R. NIAAA’s Rapid Response to

College Drinking Problems Initiative: Reinforcing the Use of Evidence-Based

Approaches in College Alcohol Prevention. J Stud Alcohol Drugs Suppl .

2009;(Supplement no. 16):5–11.

20. Schuckit MA. Drug and Alcohol Abuse: A Clinical Guide to Diagnosis and

Treatment . Softcover reprint of hardcover 6th ed. 2006. Springer; 2010.

21. Acute_Alcohol_Intoxication_20121.ppt. Available at: http://www.alcoholmedicalscholars.org/web/presentations/ppt/Acute_Alcohol_Intoxicati on_20121.ppt. Accessed February 13, 2013.

22. Oorsouw K van, Merckelbach H, Ravelli D, Nijman H, Mekking-Pompen I.

Alcoholic blackout for criminally relevant behavior. J Am Acad Psychiatry Law .

2004;32(4):364–370.

23. Association AP. Diagnostic and Statistical Manual of Mental Disorders DSM-IV-

TR Fourth Edition . 4th ed. American Psychiatric Association; 2000.

24. by. Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5).

Barnes & Noble . Available at: http://www.barnesandnoble.com/w/diagnostic-andstatistical-manual-of-mental-disorders-5th-edition-american-psychiatricassociation/1116698742. Accessed October 1, 2013.

25. Carter AC, Brandon KO, Goldman MS. The College and Noncollege Experience:

A Review of the Factors That Influence Drinking Behavior in Young Adulthood. J Stud

Alcohol Drugs . 2010;71(5):742–750.

26. Dawson DA, Grant BF, Stinson FS, Chou PS. Another look at heavy episodic drinking and alcohol use disorders among college and noncollege youth. J Stud Alcohol .

2004;65(4):477–488.

27. Slutske WS. Alcohol use disorders among US college students and their noncollege-attending peers. Arch Gen Psychiatry . 2005;62(3):321–327. doi:10.1001/archpsyc.62.3.321.

14

28. Slutske WS, Hunt-Carter EE, Nabors-Oberg RE, et al. Do college students drink more than their non-college-attending peers? Evidence from a population-based longitudinal female twin study. J Abnorm Psychol . 2004;113(4):530–540. doi:10.1037/0021-843X.113.4.530.

29. PubMed Central Full Text PDF. Available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139334/pdf/nihms291068.pdf. Accessed

January 12, 2013.

30. Neighbors C, Atkins DC, Lewis MA, et al. Event Specific Drinking Among

College Students. Psychol Addict Behav . 2011;25(4):702–707. doi:10.1037/a0024051.

31. Cashin JR, Presley CA, Meilman PW. Alcohol use in the Greek system: follow the leader? J Stud Alcohol . 1998;59(1):63–70.

32. Scott-Sheldon LAJ, Carey KB, Carey MP. Health Behavior and College Students:

Does Greek Affiliation Matter? J Behav Med . 2008;31(1):61–70. doi:10.1007/s10865-

007-9136-1.

33. Larimer ME, Turner AP, Mallett KA, Geisner IM. Predicting Drinking Behavior and Alcohol-Related Problems Among Fraternity and Sorority Members: Examining the

Role of Descriptive and Injunctive Norms. Psychol Addict Behav . 2004;18(3):203–212. doi:10.1037/0893-164X.18.3.203.

34. Substance Abuse Higher in Fraternities and Sororities. About.com Alcoholism .

Available at: http://alcoholism.about.com/od/college/a/blnida050918.htm. Accessed

January 15, 2013.

35. Nelson TF, Wechsler H. Alcohol and college athletes. Med Sci Sports Exerc .

2001;33(1):43–47.

36. Grossbard JR, Geisner IM, Mastroleo NR, Kilmer JR, Turrisi R, Larimer ME.

Athletic identity, descriptive norms, and drinking among athletes transitioning to college.

Addict Behav . 2009;34(4):352–359. doi:10.1016/j.addbeh.2008.11.011.

37. Neal DJ, Fromme K. Hook ‘Em Horns and Heavy Drinking: Alcohol Use and

Collegiate Sports. Addict Behav . 2007;32(11):2681–2693. doi:10.1016/j.addbeh.2007.06.020.

38. Yusko DA, Buckman JF, White HR, Pandina RJ. Risk for excessive alcohol use and drinking-related problems in college student athletes. Addict Behav .

2008;33(12):1546–1556. doi:10.1016/j.addbeh.2008.07.010.

39. Schuckit MA, Smith TL, Trim R, et al. The performance of elements of a “level of response to alcohol”-based model of drinking behaviors in 13-year-olds.

Addiction .

2008;103(11):1786–1792. doi:10.1111/j.1360-0443.2008.02325.x.

40. Schuckit MA, Smith TL. The relationships of a family history of alcohol dependence, a low level of response to alcohol and six domains of life functioning to the development of alcohol use disorders. J Stud Alcohol . 2000;61(6):827–835.

41. 082-Presley.pdf. Available at: http://www.collegedrinkingprevention.gov/media/Journal/082-Presley.pdf. Accessed

January 27, 2013.

15

42. 3-15.pdf. Available at: http://pubs.niaaa.nih.gov/publications/arh321/3-15.pdf.

Accessed January 27, 2013.

43. Brown SA, McGue M, Maggs J, et al. A Developmental Perspective on Alcohol and Youths 16 to 20 Years of Age. PEDIATRICS . 2008;121(Supplement):S290–S310. doi:10.1542/peds.2007-2243D.

44. Decisionmakingshort.ppt. Available at: http://www.alcoholmedicalscholars.org/web/presentations/ppt/Decisionmakingshort.ppt.

Accessed January 26, 2013.

45. Kassel JD, Jackson SI, Unrod M. Generalized Expectancies for Negative Mood

Regulation and Problem Drinking among College Students. Journal of Studies on Alcohol and Drugs . 2000;61(2):332.

46. Arnett JJ. The Developmental Context of Substance Use in Emerging Adulthood.

Journal of Drug Issues . 2005;35(2):235.

47. Papachristou H, Nederkoorn C, Corstjens J, Jansen A. The role of impulsivity and perceived availability on cue-elicited craving for alcohol in social drinkers.

Psychopharmacology (Berl) . 2012;224(1):145–153. doi:10.1007/s00213-012-2747-4.

48. Trim RS, Simmons AN, Tolentino NJ, et al. Acute ethanol effects on brain activation in low- and high-level responders to alcohol. Alcohol Clin Exp Res .

2010;34(7):1162–1170. doi:10.1111/j.1530-0277.2010.01193.x.

49. Silveri MM. Adolescent brain development and underage drinking in the United

States: identifying risks of alcohol use in college populations. Harv Rev Psychiatry .

2012;20(4):189–200. doi:10.3109/10673229.2012.714642.

50. Schuckit MA, Smith TL, Hesselbrock V, et al. Clinical implications of tolerance to alcohol in nondependent young drinkers. Am J Drug Alcohol Abuse . 2008;34(2):133–

149. doi:10.1080/00952990701877003.

51. Schuckit MA, Smith TL, Kalmijn J, et al. Comparison across two generations of prospective models of how the low level of response to alcohol affects alcohol outcomes.

J Stud Alcohol Drugs . 2012;73(2):195–204.

52. Schuckit MA, Tapert S, Matthews SC, et al. fMRI differences between subjects with low and high responses to alcohol during a stop signal task. Alcohol Clin Exp Res .

2012;36(1):130–140. doi:10.1111/j.1530-0277.2011.01590.x.

53. Schuckit MA, Kalmijn JA, Smith TL, Saunders G, Fromme K. Structuring a college alcohol prevention program on the low level of response to alcohol model: a pilot study. Alcohol Clin Exp Res . 2012;36(7):1244–1252. doi:10.1111/j.1530-

0277.2011.01723.x.

54. Wood MD, Read JP, Mitchell RE, Brand NH. Do Parents Still Matter? Parent and

Peer Influences on Alcohol Involvement Among Recent High School Graduates.

Psychology of Addictive Behaviors . 2004;18(1):19–30. doi:10.1037/0893-164X.18.1.19.

55. BORSARI B, CAREY KB. How the quality of peer relationships influences college alcohol use. Drug Alcohol Rev . 2006;25(4):361–370. doi:10.1080/09595230600741339.

16

56. Kinard BR, Webster C. The Effects of Advertising, Social Influences, and Self-

Efficacy on Adolescent Tobacco Use and Alcohol Consumption. Journal of Consumer

Affairs . 2010;44(1):24–43. doi:10.1111/j.1745-6606.2010.01156.x.

57. LONCZAK HS, HUANG B, CATALANO RF, et al. The Social Predictors of

Adolescent Alcohol Misuse: A Test of the Social Development Model. J Stud Alcohol .

2001;62(2):179–189.

58. Schuckit MA, Smith TL, Danko GP, et al. An evaluation of the full level of response to alcohol model of heavy drinking and problems in COGA offspring. J Stud

Alcohol Drugs . 2009;70(3):436–445.

59. Labbe AK, Maisto SA. Alcohol expectancy challenges for college students: a narrative review. Clin Psychol Rev . 2011;31(4):673–683. doi:10.1016/j.cpr.2011.02.007.

60. White AM, Kraus CL, McCracken LA, Swartzwelder HS. Do College Students

Drink More Than They Think? Use of a Free-Pour Paradigm to Determine How College

Students Define Standard Drinks. Alcoholism: Clinical and Experimental Research .

2003;27(11):1750–1756. doi:10.1097/01.ALC.0000095866.17973.AF.

61. Devos-Comby L, Lange JE. “My drink is larger than yours”? A literature review of self-defined drink sizes and standard drinks. Curr Drug Abuse Rev . 2008;1(2):162–176.

62. Reslan S, Saules KK, Serras A. “Partier” self-concept mediates the relationship between college student binge drinking and related adverse consequences. Addict Behav .

2011;36(8):855–860. doi:10.1016/j.addbeh.2011.03.018.

63. Wechsler H, Nelson TF. Relationship between level of consumption and harms in assessing drink cut-points for alcohol research: Commentary on “Many college freshmen drink at levels far beyond the binge threshold” by white et Al. Alcohol Clin Exp Res .

2006;30(6):922–927. doi:10.1111/j.1530-0277.2006.00124.x.

64. Pressure to drink could be all in the mind - Epsom and St Helier University

Hospitals NHS Trust. Available at: http://www.epsom-sthelier.nhs.uk/news/newsarchive/2010/march-2010/pressure-to-drink-could-be-all-in-the-mind/. Accessed January

20, 2013.

65. Schuckit MA, Smith TL. Onset and course of alcoholism over 25 years in middle class men. Drug Alcohol Depend . 2011;113(1):21–28. doi:10.1016/j.drugalcdep.2010.06.017.

66. Schuckit MA, Smith TL, Heron J, et al. Testing a level of response to alcoholbased model of heavy drinking and alcohol problems in 1,905 17-year-olds. Alcohol Clin

Exp Res . 2011;35(10):1897–1904. doi:10.1111/j.1530-0277.2011.01536.x.

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