Biomaterials II
Program
Week
1
2
3
4
5
Monday (3h)
September 17 (IST)
Revisiting basic concepts:
- Materials classes in biomedicine
- Structure and defects
- Mechanical properties
(tensile test, fatigue, creep)
- Phase Transformations
(phase and TTT diagrams)
September 24 (IST)
Imaging biomaterials and biological
structures:
- Optical microscopy
(fluorescent and confocal microscopy)
- Electron microscopy
(scanning, transmission, diffraction, Xray spectroscopy)
- Atomic force microscopy (contact,
intermittent and non-contact)
October 1 (IST)
Demonstration class:
- Hands on operation of
Electron microscopes
Wednesday (2h)
September 19 (IST)
Demonstration class:
- X-ray Lab
- Metallography
October 8 (IST)
Shape memory alloys
- Diffusional vs diffusionless
transformations
- Shape memory effect: 1-way vs 2-ways
- Materials examples
- Biomedical applications
- Fatigue case study
October 15 (IST)
Biomedical polymers
- Biological/natural and synthetic
polymers
- Mechanical properties and rheology
- Processing
Specific biomedical applications
(hydrogels, smart polymers)
October 10 (IST)
Shape memory alloys
-Demonstration: SMA kit
September 26 (IST)
No class
October 3 (IST)
Demonstration class:
- X-ray assignment
October 17 (FMUL)
Respiratory System:
- Biopathology and lesion mechanisms
- Respiratory failure and consequences
- Repairing the respiratory system – biomaterials
for tracheobronchial substitution
- Properties and requisites
- State-of-the-art
6
October 22 (IST)
Nanotechnology in biomedicine from a
materials science perspective
- Bottom -up vs top-down approaches
- Properties
- Biomedical applications
October 24 (FMUL)
Skin
- Biology and healing
- Lesion most common causes and
physiopathologic reaction
- Cutaneous grafts: types and instrumentation for
harvesting
- Skin substitutes
- State-of-the-art
7
8
October 29 (IST)
Implants and artificial organs
- Soft tissue reconstruction
- Orthopedic applications
- Ophthalmological applications
- Extracorporeal artificial organs
- Tissue engineering
November 5 (IST)
Attrition and wear
- Friction coefficient
- Wear mechanisms
- Characterization methods
- Case studies: Tooth, joint and implant
wear
October 31
No class
IST/FMUL Biomedicine Congress
November 7 (FMUL)
Heart
- Biopathology and common lesions mechanisms
- Surgical repair
- Extracorporeal circulation and biomedical
requisites
- Valve repair/replacement: requisites, prosthetic
types, working principles and limitations
- State-of-the-art
9
November 12 (IST)
Visit
- Company (to define)
November 14 (FMUL)
Plastic surgery (facial and mammal)
- Clinic-pathological common aspects
- Reconstruction: implant and prosthesis types
- State-of-the-art
10
November 19 (IST)
Host reactions to biomaterials
- Inflammation, wound healing, and the
foreign-body response
- Systemic toxicity and hypersensitivity
- Tumorigenesis
November 21 (FMUL)
Dental pathology
- Biomaterials for molds and models
- Dental amalgams and metal alloys, prostheses
and dental porcelains
- State-of-the-art
11
November 26 (IST)
Degradation of materials in the
biological environment
November 28 (FMUL)
Digestive system
12
13
- Chemical and biochemical degradation
of polymers
- Degradative effects of the biological
environment on metals and ceramics
- Pathological calcification of
biomaterials
- Biopathology and common lesions mechanisms
December 3 (IST)
Mechanical behavior of biological
materials
- Molecular and cell biomechanics
- Characterization methods at
molecular, cell and tissue levels
- Rheological models
- Case study: Cytoadherence of diseased
cells
December 10 (IST)
Demonstration class
- Hands on operation of
atomic force microscopes and
nanotribometer
December 5 (FMUL)
Vertebral column and nervous system
- Current therapeutic interventions - novel
developments and materials
- Requisites, indications and limitations
- State-of-the-art
- Novel therapeutic developments
- Novel biomaterials
- State-of-the-art
December 12 (FMUL)
Vascular system
- Biopathology and common lesions mechanisms
- Circulation physiopathology and fluid dynamics
- Therapeutic intervention on the vascular
systems – repair and replacement
- Requisites, materials types, working
mechanisms and limitations
- State-of-the-art
14
December 17 (IST)
Demonstration class:
Biomaterials Labs visits
December 19
No class
Evaluation Method


IST: 2 tests or exam (70%) + assignments (10%)
FMUL: compulsory attendance to classes + exam (20%)
Bibliography

BIOMATERIALS SCIENCE An Introduction to Materials in Medicine, 2nd Edition
Edited by Buddy D. Ratner, Allan S. Hoffman, Frederick J. Schoen, Jack E. Lemons,
Elsevier, 2004.