Prof. Amorde
Organic Chemistry I
APPENDIX
MSDS ASSIGNMENT 1
Petroleum Ether
Ethanol
Acetone
What is the
toxicity?
Inhalation rat LC50: 3400 ppm/4H.
Investigated as a reproductive effector.
Methyl Alcohol (Methanol) Oral rat LD50:
5628 mg/kg; inhalation rat LC50: 64000
ppm/4H; skin rabbit LD50: 15800 mg/kg;
Irritation data-standard Draize test: skin,
rabbit: 20mg/24 hr. Moderate; eye, rabbit:
100 mg/24 hr. Moderate. Investigated as a
mutagen, reproductive effector.
LD50/LC50: CAS# 67-64-1:
Dermal, guinea pig: LD50 = >9400 uL/kg;
Draize test, rabbit, eye: 10 uL Mild;
Draize test, rabbit, eye: 20 mg Severe;
Draize test, rabbit, eye: 20 mg/24H
Moderate;
Draize test, rabbit, skin: 500 mg/24H Mild;
Inhalation, mouse: LC50 = 44 gm/m3/4H;
Inhalation, rat: LC50 = 50100 mg/m3/8H;
Oral, mouse: LD50 = 3 gm/kg;
Oral, rabbit: LD50 = 5340 mg/kg;
Oral, rat: LD50 = 5800 mg/kg;
How do you
safely handle
it?
Protect against physical damage.
Skin Protection:
Wear impervious protective clothing,
including boots, gloves, lab coat, apron or
coveralls, as appropriate, to prevent skin
contact. Wear protective gloves and clean
body-covering clothing.
Eye Protection:
Use chemical safety goggles and/or a full
face shield where splashing is possible.
Maintain eye wash fountain and quickdrench facilities in work area.
Protect against physical damage.
Skin Protection:
Rubber or neoprene gloves and additional
protection including impervious boots,
apron, or coveralls, as needed in areas of
unusual exposure.
Eye Protection:
Use chemical safety goggles. Maintain eye
wash fountain and quick-drench facilities in
work area.
Protect against physical damage. Skin Skin
Protection:
Wear appropriate protective gloves to
prevent skin exposure.
Eye Protection:
Wear chemical goggles.
Petroleum Ether
What is the
density?
0.66 g/mL
Are there any No information found
reproductive
hazards?
Ethanol
Acetone
1.1 g/mL
Investigated as a mutagen, reproductive
effector.
0.8 g/mL
TDLo(Oral, rat) = 273
gm/kg;Reproductive - Paternal Effects spermatogenesis (incl. genetic material,
sperm morphology, motility, and count).
What is the
difference
between
acute
exposure and
chronic
exposure?
Acute toxicity looks at lethal effects following oral, dermal or inhalation exposure. It is broken into five categories of severity where
Category 1 requires the least amount of exposure to be lethal and Category 5 requires the most exposure to the be lethal.
What does
flashpoint
mean?
The flash point of a flammable liquid is the lowest temperature at which it can form an ignitable mixture in air. At this temperature the
vapor may cease to burn when the source of ignition is removed.
What routes
of exposure
should we be
most
concerned
about?
Inhalation may cause symptoms of
intoxication and peripheral nerve
disorders and central nervous system
depression. Symptoms of overexposure
include loss of appetite, muscle weakness,
impairment of motor action, dizziness and
drowsiness. May also cause throat
irritation.
What is the
structure?
Chronic toxicity involves an analysis of long term exposure including life cycle stages. This method of analysis has less standardized
testing as well as data.
-17.6C, 0.F
12C (54F)
Ingestion. Toxic. Symptoms parallel
inhalation. Can intoxicate and cause
blindness. Usual fatal dose: 100-125
milliliters.
-20C (-4F)
Inhalation of vapors irritates the
respiratory tract. May cause coughing,
dizziness, dullness, and headache. Higher
concentrations can produce central
nervous system depression, narcosis, and
unconsciousness.
Petroleum Ether
What is the
set-up of the
separation
funnel?
What is the
3D image of
the structure?
Ethanol
Acetone