What is chemotherapy?

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Information for patients
their families and carers
Chemotherapy
Derriford Hospital
Derriford Road
Plymouth
PL6 8DH
Tel: 0845 155 8155
Index
What is Chemotherapy?
4
How is Chemotherapy Given?
5
Side Effects of Chemotherapy
9
Other Matters
19
Important: When to call the Hospital or GP
21
Which number do I call?
23
Who can I talk to for advice?
23
Further advice and useful websites
25
Further information regarding chemotherapy can be
found by watching a short film produced by the
department.
Please enter:
Bit.ly/chemovideo
Into the search bar of your computer or device.
2
Chemotherapy information for patients, their families
and carers
This is an information booklet to help you and your family
understand chemotherapy, its effects on your body and
how you can help yourself. It will supplement the
information given to you by your doctors, nurse specialist,
ward nurses, and other staff you may meet.
You will also be given an information sheet from
Macmillan giving details of your specific chemotherapy
regime and chemotherapy drugs.
Contact numbers:
Chemotherapy Unit:
(Monday to Friday 9am to 5.00pm)
01752 763974
Birch Day Case Unit:
(Monday to Friday 8.30am to 6.30pm)
01752 432674
Brent Ward:
(overnight and weekends)
01752 792306
Bracken Ward:
(overnight and weekends)
01752 432494
Oncology Outpatients:
(Monday to Friday 9am to 5.00pm)
01752 763969
Emergencies:
Information on what to do in the event of an
emergency can be found on page 21 of this booklet.
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What is chemotherapy?
The word ‘chemotherapy’ means treatment with drugs.
The word is used mostly to mean the treatment of cancer.
Sometimes the drugs used to treat cancer are called
cytotoxic drugs. The word cytotoxic means poisonous or
toxic to the cells of the body.
Your chemotherapy treatment will depend on the type of
cancer you have. Different drugs work best on different
cancers. Sometimes only one drug is required. Often
more than one drug is used to make the treatment more
effective. A single treatment may be given, or it may be
repeated with a rest between each treatment.
Sometimes chemotherapy is used with surgery and / or
radiotherapy to treat certain types of cancer.
Chemotherapy given soon after surgery is often referred
to as adjuvant treatment. Similarly, if chemotherapy is
given before surgery it is called neo-adjuvant treatment.
How does chemotherapy work?
The drug will be given as tablets or capsules, or injected
into a vein, so that it can enter your bloodstream. Tablets
or capsules dissolve in your gut and the drug passes
through the gut wall into your bloodstream. The drug is
carried around your body in the bloodstream to reach the
cancer cells. The drug gets into the cancer cells and may
damage their genetic material (DNA). This may prevent
the cancer cells from growing and dividing in an
uncontrolled way.
However, cytotoxic drugs damage healthy cells as well,
but the healthy cells are much more able to recover than
the cancer cells. When healthy cells are affected, you
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may get temporary side effects, such as feeling sick,
losing your hair, or getting a sore mouth.
Usually your chemotherapy is followed by a rest period
e.g. chemotherapy on one day and then 20 days rest
period (this is then referred to as a cycle of
chemotherapy). The rest period is most often longer than
the chemo period. This rest or break is important as it
gives your body’s healthy cells time to recover from the
unwanted effects of the treatment.
This plan or regime of chemotherapy varies from cancer
to cancer. Cycles of chemotherapy can be as short as a
week or as long as six weeks. Your doctor and
chemotherapy nurse will explain the details to you.
How is chemotherapy given?
The way chemotherapy is given will depend on the drug
and the course of treatment. Chemotherapy can be given
in the following ways:
As an intravenous injection or drip
This is the most common way of giving chemotherapy.
These intravenous injections (IVs) may be given over a
few minutes, or as drips - intravenous infusions over an
hour or several hours. The type of IV will depend on your
particular cancer and which drugs are most effective.
As tablets or capsules
You may be given tablets and / or capsules as part, or all
of your treatment. The doctor, nurse and / or pharmacist
will explain the medicines to you and suggest when to
take them. If you have any questions about your
medicines please ask one of the staff.
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As a continuous infusion
Sometimes it is useful to infuse a chemotherapy drug
continuously. You will have a special tube put into one of
your veins and then a small portable pump which you
wear and pumps chemotherapy into the tube. See
Central or PICC lines (in next section).
Injected beneath the skin
A few drugs may be given to you as an injection just
beneath your skin (a subcutaneous injection) or into a
muscle (an intramuscular injection).
Injections and drips
Will it hurt?
One of our biggest concerns is not to hurt you. We
appreciate that you are already upset by having cancer
and that you may be feeling very vulnerable.
We have specialist Chemotherapy Nursing Services
running the Chemotherapy Unit and Birch Ward Day Unit,
and experienced highly trained cancer nurses on Brent
and Bracken Wards. Your Cancer Nurses have great
experience and expertise in putting in patient’s needles
(called cannulating).
We always use the smallest
possible size ‘needle’ (cannula) often a child size. Most
of these cannulae are put in the veins on the back of your
hand or the lower part of your forearm.
Some patients, due to the nature of their treatment, will
require Hickman Lines, or PICC lines, so that they can
have continuous or multiple chemotherapies.
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Hickman and PICC lines
A Hickman line is a long thin tube put into the large vein
above the heart. This tube then leads out to the surface
of your body underneath the skin of your chest. The tube
is left in place for several weeks or months while you
need treatment. It needs twice-weekly flushing to prevent
it becoming blocked.
PICC stands for Peripherally Inserted Central Catheter.
A PICC line is a long thin soft tube inserted into a large
vein in the upper arm. This tube then leads into the
bigger veins in your chest just above your heart. The
PICC is kept in place by an adhesive pad and a clear
plastic dressing.
Like other central lines the PICC can be left in place for
several weeks or months. It will need weekly flushing
and dressings, which can be done by the District Nurse or
the Practice Nurse at your local GP surgery. Alternatively,
a relative or carer can be taught to change the dressing.
If your Hickman or PICC line is not being used frequently,
it will still require regular flushing. Your oncology nurses
will advise you about this.
Cannulation - how can I help myself?
You may have noticed that when you are hot (in summer
or after a hot bath), the veins in your hands are very big
and prominent. Also, when you are cold, your hands and
nails look pale and your veins have ‘disappeared’. This is
your body’s normal way of maintaining its inner
temperature.
You can use this natural reaction to your advantage.
When your veins are prominent they will be easier to
cannulate. Therefore, on your way to the Unit and while
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waiting for your chemotherapy appointment, try to keep
yourself warm. You may not feel cold but an extra layer
of clothing can help your hand veins dilate and be visible.
Also in the cooler months please wear gloves, even
indoors in the clinic. It will also help to drink plenty of
fluids so that you are well hydrated. If despite these
measures your veins are still small we may warm your
hands using a bowl of hot water or a hot pack.
Drips and breast patients
Breast cancer patients who have had surgery are often
told by their surgical team that we cannot use the veins
on their surgery side. Please discuss this with your
chemotherapy nurse.
Will I have to stay in hospital?
If your chemotherapy is given to you in tablet form or as
an injection or short infusion, you will be treated as an
outpatient. This may be in the Chemotherapy Unit of
Plymouth Oncology Centre, or in the Day Case Unit on
Birch Ward.
If your chemotherapy infusion is over a longer period or
has significant side effects, you will need to be admitted
to our wards for one or more nights. Our two wards are
Brent Ward - general oncology, or Bracken Ward haematology.
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Will I have side effects?
Some people do not have any side effects after their
chemotherapy. If you do have side effects they are
usually only temporary, and will go when the treatment
has stopped.
When you visit the hospital again the doctor and nurse
will ask you if you have had any side effects. It is often
busy in hospital and clinics and you may not want to
bother the doctor with your problems, but it is important
that you tell the doctor and nurse about your side
effects. You may find it useful to write down when you
have any side effects, there are blank pages in the back
of this booklet.
What side effects may I have?
Reduced blood cell numbers
Chemotherapy often affects the bone marrow. This is
where your body produces your blood cells; red cells,
white cells and platelets. The white cells in your body are
important as they help you fight infection, they are also
short lived, and so they will be quickly reduced by
chemotherapy.
About a week after your chemotherapy the number of
white cells circulating in your blood stream will be
reduced and this will persist for several days. This means
that your body is much less resistant to infections, so a
minor infection can quickly become very serious and if left
untreated can be life-threatening.
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It is important that you call the hospital or your GP
immediately if you have a sore throat, your
temperature is raised above 38oC, if you notice any
unusual bleeding, bruises or you have small groups
of red-purple spots / rash.
Usually the number of white cells will return to normal
within 3 weeks of the chemotherapy treatment.
The other cells in the blood may gradually decline in
number with repeated treatments and if you become
anaemic (low haemoglobin or red cells) then you may be
offered a blood transfusion.
Nausea and vomiting
Our aim is to control nausea and to prevent vomiting as
far as possible following your chemotherapy. With many
drugs you will be given anti-sickness injections. You will
also be given anti-sickness tablets to take home. You will
be advised on how and when to take these by the
Chemotherapy Nurse.
There are also steps you can take yourself to minimise
symptoms:
 eat less, but more often, feelings of hunger can be
mistaken for feelings of sickness
 avoid eating fatty or fried foods
 avoid food with a strong smell, or the smell of food
cooking
 drink plenty of liquid, slowly, taking small sips
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 don’t lie down flat just before or after eating
 try to relax, perhaps to music or in the fresh air
 you may find ‘Sea bands’, the wrist bands useful, they
are available from chemists
 ginger tablets or capsules, or ginger biscuits can also
be helpful.
If you are still feeling or being sick despite trying this
advice and taking anti-sickness tablets, contact your GP
or the hospital (see numbers at the front of this book).
Diarrhoea
Some chemotherapy drugs may cause diarrhoea, which
usually settles within a couple of days. If you have
diarrhoea, try to drink plenty of water or other drinks to
replace the lost fluid. If you have been prescribed antidiarrhoea tablets, take these as per the prescription.
Also, eat less fibre, fruit, vegetables and cereals. You
may find that boiled whole grain rice is good for
controlling diarrhoea.
If symptoms persist for more than 24 hours, contact your
GP or the Hospital (numbers at the front of this book).
Constipation
Some chemotherapy and anti-sickness drugs may cause
constipation. To prevent this, try eating more fibre, fresh
fruit and vegetables and drink at least 2 jugs of water or
similar liquids per day. If this is not adequate and you
become constipated, your local pharmacist will advise
you on a suitable treatment. If you require further advice,
contact your GP or the Hospital (numbers at the front of
this book).
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Loss of appetite
You may find that you “go off” some foods just after your
chemotherapy. This may also happen if you feel sick.
You may notice an odd taste in your mouth, or that food
tastes strange. This is because the chemotherapy has
temporarily damaged your taste buds. If you have a
strange taste in your mouth you may find sucking a
strongly flavoured sweet or mint can disguise this. Fresh
or tinned pineapple can also help with this symptom.
If your appetite is poor and you are losing weight please
ask your doctor or nurse to arrange for you to see the
hospital dietitian.
Painful, burning, red skin following intravenous
chemotherapy
Chemotherapy drugs must be injected into a vein
carefully, so they don’t leak out of the vein and damage
the skin. Some chemotherapy drugs are very damaging
if they leak into the tissues.
If after you go home you develop a burning or painful
feeling near where the drug was injected, telephone
the hospital for advice immediately.
(Numbers at the front of this book).
Some chemotherapy will cause a brown/red pigmentation
on the skin above the vein where the drug is injected.
This is harmless and will gradually fade with time.
Sore mouth
You may find that your chemotherapy gives you a sore
mouth. It helps if you try and keep your mouth moist and
clean. Clean your mouth and gently brush your teeth with
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a soft toothbrush each morning, evening and after each
meal.
If you have dentures, take them out and clean them each
morning, evening and after each meal.
If you notice small white ulcers around your lips, or in
your mouth or throat, you may have ‘thrush’. This is a
common infection of the mouth when people are on
treatment or ‘run down’, please contact your G.P. who
can examine your mouth and prescribe some medicine or
mouth wash.
You may be given mouth wash solution to prevent
potential mouth ulcers. Please take this medicine as
directed and use it regularly. It is recommended that you
dilute these solutions as they can be too harsh used neat.
Diluting the mouthwash half and half with water will give
you more solution to rinse your mouth.
Hair loss
Many patients associate the word chemotherapy with hair
loss. It is often their biggest fear. However, many of the
chemotherapy drugs that we use will not cause serious
hair loss for most patients. More often they experience a
little hair thinning. You may also lose some of your
eyelashes, eyebrows and body hair.
Here is some useful advice to help prevent you from
damaging your hair:
 Avoid using hairdryers and other heated styling tools
 Avoid hair spray, dye and perms
 Cut down on the number of times you wash your hair
each week
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 Use a gentle (pH neutral) shampoo and a conditioner
 Brush and comb your hair gently, using a soft hair brush
or wide toothed comb
If you do experience hair loss it will happen about 2
weeks after your chemotherapy injections. The hair loss
is temporary and will grow back completely after
treatment is finished. You will usually see re-growth
within 3 - 4 weeks.
If you lose your hair you may prefer to wear a hat,
headscarf, turban or wig. If you would like a wig or
turban, the chemotherapy staff, clinic nurses or Mustard
Tree Support Centre staff can help arrange this.
Our wigs are currently supplied by Browns. They have a
shop in Plymouth city center and also visit the Macmillan
Cancer Support Centre every Thursday.
Which drugs cause hair loss?
Some drugs: Doxorubicin, Epirubicin, Etoposide,
Ifosfamide, Taxol and Taxotere are associated with
severe hair loss. Other drugs can cause hair loss but it is
dependent on the dose, the time taken to infuse the drug
and the number of drugs used. Your Chemotherapy
nurse will advise you further about this and more
information can be found in the Macmillan leaflet about
your particular chemotherapy regime.
Scalp Cooling
This is where a cold cap is placed on the head during
treatment. The coldness of the cap cools the cells in the
hair root and restricts the blood flow to these cells. This
causes the cells’ metabolism to slow down for a short
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while. They are then less affected by the circulating
chemotherapy. This is not suitable for all types of
chemotherapy treatment.
The cap is put on 30 minutes before treatment, the hair is
dampened and conditioner applied to ensure good
contact between the scalp and the cold cap. It remains on
the head throughout the treatment and for 1-2 hours
afterwards. Scalp cooling significantly increases the
length of time your treatment takes, but can be effective.
In the Oncology Chemotherapy Unit we use the latest
equipment for scalp cooling called the Paxman Scalp
Cooler. They have an informative website with details of
the procedure, photographs of the cooler and details of
cooling times at www.paxman-coolers.co.uk.
Fatigue (feeling exhausted all or most of the time)
Everyone has good days and bad days, but due to
disease and cancer treatments nearly everyone will
experience some fatigue. Fatigue can mean more than
being tired and weak. Other symptoms include leg pains,
difficulty walking and climbing stairs, shortness of breath,
difficulty concentrating and making decisions. This can
sometimes continue for weeks or months after treatment
is completed, making you feel irritable and low.
There are many ways of combating fatigue and many
strategies that can help you to manage your everyday
activities, e.g:
 Keeping a diary to monitor when you are most tired and
when you have most energy
 Spreading tasks out over the week
 Whenever possible sitting down to do chores
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 Asking others to cook and shop for you, or use precooked meals
 Regular light exercise
 Drinking plenty of fluids
 Using distraction techniques such as reading, visiting
friends, listening to music
 Knowing when you have done enough.
For more information you can read ‘Fatigue’ by
Macmillan, free to all cancer patients and carers. Your
Chemotherapy nurse can refer you to an Occupational
Therapist, who can advise you on strategies to manage
fatigue. You may also wish to speak to your specialist
nurse if you have one.
Sexual relationships
Chemotherapy and the disease itself can affect sexual
relationships. Some people may be unaffected by
treatment whilst others have changes in levels of desire,
changes in tolerance for physical activity and levels of
fatigue. Anxiety and stress can also have an affect on
sexual relationships. Often people find that sexual activity
is not important during treatment. However, once
treatment is over and normal life resumes, couples often
find that it is during this time they need support, advice
and information about resuming sexual activity.
Sexual feelings should return following treatment
although time is required to allow you and your partner to
come to terms with the changes and experiences you
have been through. These are very natural feelings and it
is important to talk them through with your partner.
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Feel free to discuss with your doctor and specialist nurse
any matters relating to your sexual relations. If they
cannot answer your questions they will be able to refer
you to a counsellor or other health professionals who can
help.
Your feelings
The very fact that you are having chemotherapy
treatment for cancer is very daunting. All at once your
whole life has been turned upside down. Future plans
often have to be put on hold and you may feel that your
life revolves around the hospital. We do understand this
and will try to support you in whatever way we can.
Fear, anxiety, irritability, depression and changes in mood
are all possible for patients being treated for cancer.
Some people deal with this by being quiet and not talking
about things, others find it helps to discuss their feelings
with as many people as possible. Some want to know
everything about their treatment and others very little,
preferring to ‘leave it to the doctor’.
Loss of concentration may be a consequence of all these
mixed feelings. You may find your mind wandering often.
This can affect your ability to listen and recall what your
nurses and doctors have said. If you miss something, do
not be embarrassed to ask again what was said. You
may find it useful to write down any questions you have
regarding your treatment.
At the back of this booklet is a section entitled ‘Who can I
talk to for advice?’ This gives information about our
support services, and there is a list of useful addresses
and websites.
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Fertility
Unfortunately some chemotherapy treatments, though not
all, cause infertility. This affect may be temporary or
permanent depending on the particular treatment you are
having. Your doctor will discuss this risk with you before
treatment starts. Pregnancy should be avoided during
chemotherapy and for two years afterwards in case the
drugs affect the developing baby. For this reason you
should use a reliable method of contraception.
For women
Some chemotherapy drugs may affect your ovaries and
stop them producing eggs, although not all drugs will
cause this to happen. If this does happen, it unfortunately
means that you can no longer become pregnant, your
periods will become irregular and eventually stop. It will
also bring on symptoms associated with the menopause.
If your ovaries are going to start working again after
treatment finishes (the infertility is short lived), your
periods will return to normal. At present ‘banking’ of eggs
is rarely practised, but you may wish to discuss this with
your consultant before starting chemotherapy.
For men
Some chemotherapy drugs will have no effect on your
fertility, but some drugs may reduce the number of sperm
you have or affect their ability to reach and fertilize the
female egg during intercourse. If the chemotherapy does
cause infertility, some men will remain infertile after
treatment stops while for some sperm returns to normal
levels.
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If you have not completed your family you may be able to
bank some of your sperm before chemotherapy starts. .
If this is possible you will be asked to produce several
sperm samples, which will be frozen and stored. This can
then be used later if necessary to make your partner
pregnant artificially.
Other matters
Tablets and Capsules
Keep your tablets or capsules in the bottle or blister pack
that they come in. Store them in a dark, cool dry place,
out of the reach of children. If it looks as though a
capsule has leaked inside the blister pack, do not open
that blister. Read the label carefully and please ask the
doctor, nurse or pharmacist if you are unsure about how
or when to take you medicine.
Is it ok to take other medicines and tablets?
Let your hospital doctor and / or your G.P. know if you are
taking any prescribed medicines or tablets, as well as any
you have bought from the chemist (pharmacy) or health
food shop. Please keep a list of all you medicines so that
you can tell the doctor or nurse when you come to the
hospital. If you do buy medicines at the chemists please
tell the pharmacist what medication you are taking.
Continuous chemotherapy at home
Some patients, because of their particular disease may
have continuous chemotherapy infusions via a pump into
a tube in their veins. If you have problems with the
equipment then you must telephone the relevant hospital
department. You will have been given contact numbers
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before going home. The numbers are also at the front of
this booklet.
If your pump, tube or chemotherapy syringe breaks,
disconnects or leaks please clamp off the pump.
Wrap the equipment in a plastic bag, telephone and
come to the relevant department as soon as is
practically possible. If any chemotherapy is spilt, put
on rubber gloves and mop up any chemical with
tissues, which you can then put in your syringe ‘burn
bin’.
Wash the affected area and your hands
thoroughly afterwards. Where possible do not allow
any other family members / carers to handle the
spillage.
Can I drink alcohol?
If you are taking the chemotherapy drug Procarbazine,
you must avoid alcoholic drinks, as well as low or nonalcoholic beers and lagers, during the course of capsules.
You may take small amounts of alcohol a few days after
having other chemotherapy drugs, but you should check
this with your doctor. Alcohol is dehydrating and you
should make up for this by drinking more water or soft
drinks as well.
Can I go on holiday?
If you have planned to go on holiday when a treatment is
due, please discuss this with your doctor, nurse or other
member of staff. Your hospital doctor may delay a
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treatment until you return. Generally we will fit around
your arrangements.
Many patients having chemotherapy will be more at
risk from sunburn. Chemotherapy makes your skin
more fragile or delicate. Some of the chemotherapy
chemicals can make you more sensitive to the ultraviolet
radiation of the sun. To avoid this, use a high factor
sunscreen or cover up your skin.
Emergencies or problems
Call the hospital if:
 You have a temperature of 380C or more
 Shivering episodes
 Flu like symptoms
 You have nose bleeds, bleeding gums, bad bruising,
black tarry stools (motions), or any signs of
unexpected bleeding
 Vomiting which is not relieved by your anti-sickness
medication
 Watery diarrhoea which has lasted more than 24
hours
 Mouth ulcers that stop you eating or drinking
 Chest pain or difficulty breathing
 Your skin is painful, red or blistered near where the
drug was injected
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 You are having Capecitabine chemotherapy and
your palms or soles become very sore and cracked
Call your G.P. if:
 You feel tired and breathless and look very pale (you
may be anaemic)
 You are still constipated despite eating more fruit,
vegetables and fibre
 You have other illness
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Which hospital should I telephone?
 If you are being treated in the Oncology Centre at
Derriford Hospital, telephone the Chemotherapy
Department on 01752 763974 (daytimes). At other
times, telephone Brent Ward on 01752 792306.
 If you have a condition called Lymphoma telephone
Birch Ward Day Case unit on 01752 792679.
 If you are being treated on Bracken Ward at Derriford
Hospital, telephone 01752 432494.
 If you are being treated on Brent Ward at Derriford
Hospital, telephone 01752 792306
 Oncology Outpatients: 01752 763969 (Monday to
Friday 9am to 5.30pm)
Who can I talk to for advice?
If you were treated in the Oncology Centre at Derriford
Hospital, you or your family can contact the cancer nurse
specialist who helps with your type of illness. She/he will
have given you a contact phone number at the beginning
of you treatment.
If you were treated on Bracken Ward at Derriford
Hospital, you or your family can telephone the ward on
01752 432494.
There are nurse specialists for many of the cancers such
as:
breast
colon and rectum
genito urinary tract cancers
gynaecological cancers
head and neck cancers
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leukaemia and lymphoma
lung
melanoma
neurological cancers
palliative care
sarcoma
upper gastro-intestinal tract (oesophagus, stomach,
pancreas etc.)
The Mustard Tree Macmillan Centre
You may also visit the Mustard Tree Macmillan Centre on
Level 3 at Derriford Hospital. It is open 9.30am - 4.30pm,
Monday - Friday, telephone (01752) 763672, you may
‘drop in’ at any time. The centre is open to anyone
affected by cancer - patients, relatives and carers.
People can use the centre at any period in their illness.
All the centre’s services are free of charge with the
exception of activities classes when a small charge is
made.
Additionally, if you have a clinic appointment or are
waiting for chemotherapy treatment you can wait in the
Mustard Tree Macmillan Centre. You will be made
welcome and offered refreshment (just let the clinic or
chemotherapy receptionist know where you are).
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Pastoral and Spiritual Care
A Chaplin is available 24hrs a day, contactable via
switchboard and here for absolutely everyone. They are
here to offer a listening ear, help people make sense of
their situation and only is desired can provide faith
support from all major religions.
Useful Websites
The following are just a few of the cancer related
websites available on the internet. Many of them have
further links to cancer information.
www.cancerhelp.org.uk
CancerHelp UK is the patient information website of
Cancer Research UK.
www.christie.man.ac.uk
the website of the Christie Cancer Hospital with useful
information on cancer and chemotherapy.
www.clic.uk.com
www.macmillan.org.uk
a very comprehensive information service.
www.mariecurie.org.uk
www.nhsdirect.nhs.uk
much information and useful links.
www.paxman-coolers.co.uk
website for the company that makes our scalp coolers.
www.plymouthhospitals.org.uk
Our website, look for the Plymouth Oncology Centre in
the departmental website section.
www.royalmarsden.org.uk
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The website of the Royal Marsden Hospitals, with useful
information on cancer and chemotherapy.
Notes
Please write down any notes you wish to make e.g.
questions to ask the doctor or nurse, lists of medicines
and when to take them, or how you have been feeling,
etc.
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Notes
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Notes
This booklet is available in large print and
other formats and languages.
Contact: Patient Services
Tel. 01752 763031
Revised Sept 2014,S Wellington For review: August 2016.
Ref: C-133/Oncology/SW/Chemotherapy v4
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