MARTIN GARTZ HANSON, PH.D. (216) 262-4050 gartz.hanson@gmail.com RESEARCH SCIENTIST Trusted, motivated and respected research scientist with a significant history of meaningful research in neuroscience and developmental biology. My experience combines electrophysiological, pharmacological, cell culture, molecular and translatable approaches to understand diseases of development. My mission is to combine basic and translational sciences in an industry setting. AREAS OF EXPERTISE AND RESPONSIBILITIES Managed multi-functional groups of scientists and collaborators using basis science and translational approaches in parallel projects. Designed, performed and analyzed experiments for various published rodent neuroscience projects. Designed and executed in vivo biomarker studies for therapeutic relevance. Developed neurodegenerative disease models using rodent explant and cell cultures. Independently innovated assays for imaging and pharmacology. Proposed novel targets and strategies for metabolic and neurodegenerative diseases. Managed external resources in a meticulous manner to best achieve scientific and laboratory goals. PROFESSIONAL EXPERIENCE UNIVERSITY OF COLORADO, Aurora, CO CONSULTANT, Department of Cell and Developmental Biology 2015 + UNIVERSITY OF COLORADO, Aurora, CO RESEARCH ASSOCIATE, Pediatrics Department 2014 to 2015 HOWARD HUGHES MEDICAL INSTITUTE, Aurora, CO RESEARCH SCIENTIST, Pediatrics Department 2011 to 2014 UNIVERSITY OF COLORADO, Aurora, CO POSTDOCTORAL FELLOW, Pediatrics Department 2005 to 2011 CASE WESTERN RESERVE UNIVERSITY, Cleveland, OH POSTDOCTORAL FELLOW, Neurobiology Department 2004 to 2005 STANFORD UNIVERSITY, Palo Alto, CA RESEARCH TECHNICIAN, Neuroscience Department 1994 to 1998 E DUCATION Ph.D. in Neuroscience 2004 Case Western Reserve University, Cleveland, OH Bachelor of Arts in Biology 1993 Central Methodist University, Fayette, MO M. GARTZ HANSON, PH.D. (216) 262-4050 GARTZ.HANSON@GMAIL.COM page 2 PUBLICATIONS Research Articles Ebens, A., Brose, K., Leonardo, E. D., Hanson, M. G., Jr., Bladt, F., Birchmeier, C., Barres, B. A., and Tessier-Lavigne, M. (1996). Hepatocyte growth factor/scatter factor is an axonal chemoattractant and a neurotrophic factor for spinal motor neurons. Neuron 17, 1157-72. Hanson, M. G., Jr., Shen, S., Wiemelt, A. P., McMorris, F. A., and Barres, B. A. (1998). Cyclic AMP elevation is sufficient to promote the survival of spinal motor neurons in vitro. J. Neurosci 18, 736171. Meyer-Franke, A., Wilkinson, G. A., Kruttgen, A., Hu, M., Munro, E., Hanson, M. G., Jr., Reichardt, L. F., and Barres, B. A. (1998). Depolarization and cAMP elevation rapidly recruit TrkB to the plasma membrane of CNS neurons. Neuron 21, 681-93. Hanson M.G. and Landmesser L.T. (2003) Characterization of the circuits that generate spontaneous episodes of activity in the early embryonic mouse spinal cord. J Neurosci. 2003 23, 587-600. Hanson, M. G., and Landmesser, L. T. (2004). Normal patterns of spontaneous activity are required for correct motor axon guidance and the expression of specific guidance molecules. Neuron 43, 687701. Christopher P. Myers, C.P, Lewcock, J.W., Hanson, M. G., Gosgnach, S, Aimone, J.B., Gage, F.H., Lee, KF, Landmesser, L. T, and Pfaff, S.L. (2005) Cholinergic input is required during embryonic development to mediate proper assembly of spinal locomotor circuits. Neuron. 46:37-49. Li X, Gutierrez D.V., Hanson M.G., Han J, Mark M.D., Chiel H, Hegemann P, Landmesser L.T., Herlitze S (2005) Fast noninvasive activation and inhibition of neural and network activity by vertebrate rhodopsin and green algae channelrhodopsin. Proc Natl Acad Sci. 102:17816-21. Hanson M.G, Landmesser L.T. (2006) Increasing the frequency of spontaneous rhythmic activity disrupts pool-specific axon fasciculation and pathfinding of embryonic spinal motoneurons. J Neurosci. 26:12769-80. Hanson M.G., Fregoso V.L., Vrana J.D., Tucker C.L., Niswander L.A. (2014) Peripheral nervous system defects in a mouse model for peroxisomal biogenesis disorders. Dev Biol. 2014 Nov 1;395(1):84-95. Hanson M.G. and Niswander L.A. (2014) An explant muscle model to examine the refinement of the synaptic landscape. J Neurosci Methods. 2014 Dec 30;238:95-104. Hanson M.G., Wilde J.J., Moreno, R.l. Minic, A.D., Niswander L.A. (2015) Potassium dependent rescue of a myopathy with core-like structures in mouse. eLife Jan 7; 4. Hanson M.G and Niswander L.A. (2015) Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos. Dev Biol. 2015 DOI:10.1016/j.ydbio.2015.05.018 Hanson M.G., Aiken J., Sietsema D., Sept D., Niswander L.A. , Moore J.K. (2015) Novel α-tubulin mutation disrupts neural development and microtubule stability. (Accepted Dev. Bio. Nov. 2015) Moreno R.L. and Hanson M.G. (2015) Ryanodine receptor type 3 is involved in removal of postsynaptic neuromuscular junctions during development and disease. (Submitted to PlosOne Dec. 2015) Reviews Hanson, M.G., Milner, L.D. and Landmesser, L.T. (2008) Spontaneous rhythmic activity in early chick spinal cord influences distinct motor axon pathfinding decisions. Brain Res Rev. 2008 Jan;57(1):7785. M. GARTZ HANSON, PH.D. (216) 262-4050 GARTZ.HANSON@GMAIL.COM page 3 ACADEMIC FUNDING Muscular Dystrophy Association Developmental Grant #69338 Ruth L. Kirschstein National Research Service F32 NS059267 “EXPLORING A NEW MOUSE MODEL OF LOCOMOTOR DEVELOPMENT” 2008 to 2011 NIH R21 NS085749 Co-Investigator “THE AMELIORATION OF PEROXISOMAL DISORDERS DUE TO DEFECTS IN PEX10” $230,175 total -final year funding -75% effort 2013 to 2015 References of Support Lee A. Niswander Dept. of Pediatrics University of Colorado-Denver Research One South (RC1-South); Room 12106 Aurora, CO 80045 (303) 724-3790 Lee.Niswander@ucdenver.edu Lynn T. Landmesser Arline J. & Curtis F. Garvin Professor Dept. of Neurosciences Case Western Reserve University School of Medicine Room E653 10900 Euclid Ave Cleveland OH, 44106-4975 (216) 368-3996 ltl@case.edu Ben A. Barres Chair Dept of Neurobiology Stanford University School of Medicine 299 W. Campus Drive Sherman Fairchild Bldg. 2nd floor Palo Alto, CA (650) 723-3231 barres@stanford.edu 2007 to 2010