Recurrence of fibrillary glomerulonephritis in a renal transplant recipient
Mitwalli, A [ 1 ]; Shah, I [ 1 ]; Hammad, D [ 1 ]; Kafoury, H [ 1 ]
INTERNATIONAL UROLOGY AND NEPHROLOGY
Volume: 45, Issue: 5, Pages: 1527-1532, DOI: 10.1007/s11255-012-0238-5, Published:
OCT 2013
Publisher SPRINGER, VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT,
NETHERLANDS
ISSN: 0301-1623
eISSN: 1573-2584
Abstract
Fibrillary glomerulonephritis (FGN) is a rare glomerular deposition disease and a rare
cause of nephrotic syndrome. The patients usually present with renal insufficiency,
nephrotic range proteinuria and microscopic hematuria. The electron microscopy study is
the only means of diagnosis. The clinical course of the disease is generally unpredictive
and the patients inevitably progress to ESRD. Here, we describe a case of FGN, which
presented with nephrotic syndrome and impaired renal function. Renal biopsy showed
that 26 out of 30 glomeruli were completely sclerosed. Remaining showed mesangial
expansion and double contour consistent with a membranoproliferative pattern, with 70 %
interstitial fibrosis and tubular atrophy. Immunofluorescence revealed C3 (2+) diffuse
mesangial deposits. Electron microscopic showed subendothelial dense deposits with
organized tubular structures. During follow-up, the patient underwent renal
transplantation from a living unrelated kidney donor. Later on, as the renal allograft
function showed deterioration, renal biopsy was performed and showed recurrence of
FGN in the renal allograft.
Keywords
Author Keywords:Fibrillary glomerulonephritis; Nephrotic syndrome; ESRD; Immune
deposits
KeyWords Plus:IMMUNOTACTOID MICROTUBULAR GLOMERULOPATHY;
CLINICAL-FEATURES; DISTINCT; DISEASE
Author Information
Reprint Address: Mitwalli, A E-mail Addresses:amituualli@ksu.edu.sa
King Saud Univ, King Khalid Univ Hosp, Riyadh, Saudi Arabia.
Organization-Enhanced Name(s)
King Khalid University Hospital
King Saud University
Addresses:
[ 1 ] King Saud Univ, King Khalid Univ Hosp, Riyadh, Saudi Arabia
Organization-Enhanced Name(s)
King Khalid University Hospital
King Saud University