FROM GENE TO PHENOTYPE - ADVANCES IN MOLECULAR BIOLOGY AND BIOMEDICINE March 4-6, 2015, Warsaw Venue: International Institute of Molecular and Cellular Biology March 4, 2015 DECIPHERING GENOMES AND TRANSLATIONAL MEDICINE 9.30-10.00 Bozena Kaminska (Postgraduate School of Molecular Medicine) - Human Genome Project - a breakthrough in molecular medicine 10.00-10.40 Rafał Płoski (Warsaw Medical University) - Whole exome sequencing in medical genetics 10.40-11.10 Coffee break 11.10-11.50 Zbigniew Gaciong (Warsaw Medical University) - "Omics" and clinical practice: Hope or hype? 11.50 -12.20 Krystian Jazdzewski (Warsaw Medical University/CENT Warsaw University) - NGS in diagnostics 12.20 -12.50 Lunch break 12.50-13.30 13.30-14.10 14.10-14.30 14.30 15.10 15.10-15.50 15.50-16.30 16.30-17.00 Wojciech Młynarski (Medical University of Łódź) - On the wings of IKAROS: molecular targeted therapy in acute lymphoblastic leukemia Tomasz Stoklosa (Warsaw Medical University) - Studies on the pathogenesis of chronic myeloid leukemia- from molecular genetics to targeted therapy and back Coffee break Ewa Bartnik (Warsaw, University) - Mitochondrial mutations, polymorphisms and diseases Przemyslaw Juszczynski (Institute of Hematology, Warsaw) - FOXO1 in diffuse large B-cell lymphomas: mechanisms of regulation and rational targeting strategies. Marcin Nowotny (International Institute of Molecular and Cellular Biology, Warsaw) Introduction to structural biology - how to explain the effect of a disease-causing mutation Gerardas Dambrauskas (EMEA, Cambridge, UK) - New Insights into Tumor Biology using nCounterR technology from NanoString March 5, 2015 RNA AND DNA WORLD 9.00-9.40 Artur Jarmolowski (Adam Mickiewicz University, Poznan) - Transcription-splicing crosstalk 9.40-10.20 Jacek Jaworski (International Institute of Molecular and Cellular Biology, Warsaw) Identification of molecular targets for TSC pathology by RNAi 10.20-11.00 Andrzej Dziembowski (Institute of Biochemistry and Biophysics/Warsaw University) - Exosome and RNA degradation 11.00-11.30 Coffee break 11.30-12.10 Zofia Szweykowska-Kulinska (Adam Mickiewicz University, Poznan) Posttranscriptional regulation of miRNA expression in plants 12.10 -12.50 Magdalena Dziembowska (CENT Warsaw University) - Dendritic mRNAs: transport, translation and function in synaptic plasticity 12.50-13.30 Lunch break 13.30-14.00 Bartosz Wojtas (Nencki Institute) - How to explore TCGA? -miRNA profiling in brain tumors 14.00-14.40 Agnieszka Dobrzyn (Nencki Institute, Warsaw) - Diabetes: molecular mechanisms and clinical relevance 14.40-15.20 Agnieszka Chacinska (International Institute of Molecular and Cellular Biology, Warsaw) 15.20-16.00 Janusz Błasiak (Medical University of Łódź) - DNA repair: a double-edged sword in genomic stability of cancer cells Exiqon presentation - Targeting non-coding RNA 16.00-16.20 March 6, 2015 GENE EXPRESSION, EPIGENETICS AND SYSTEM BIOLOGY 9.00-9.40 Marta Maleszewska (Nencki Institute, Warsaw) - Epigenetic control of macrophage polarization 9.40-10.20 Bartek Wilczynski (Warsaw University) - Computing the hierarchy of topologically associated chromatin domains 10.20-11.00 Jan Komorowski (University of Uppsala, Sweden) - Gene regulatory networks how to explore Encode data? 11.00-11.30 Coffee break 11.30-11.50 Sascha Ott (University of Warwick, UK) - Identification of digital genomic footprints from DNase-seq data 11.50 -12.30 Grzegorz Wilczynski (Nencki Institute, Warsaw) High-order chromatin structure and neuronal gene expression 12.30-13.00 Lunch break Workshop on biostatistics 13.00-15.00 Max Bielecki - Workshop on biostatistics Exiqon presen