Animal Resources Centre Volume 1, Issue 1 May 2015 The Rodent Reporter ARC First Quarter Update Did you know? The ARC was built on the current site in 1981 and has undergone many renovations and extensions over the years. The ARC currently has 25 mouse and 11 rat strains in production. We have 89 Customer- owned mouse lines and 3 customer-owned rat lines The ARC currently has 67 employees. ANIMAL RESOURCES CENTRE PO Box 1180 Canning Vale Perth, W.A. 6970 Phone: +61 (8) 9332-5033 E-Mail: info@arc.wa.gov.au www.arc.wa.gov.au The ARC received breeding pairs of the in-demand NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (more affectionately known as, NSG) mice late in 2014, and they are currently undergoing breeding to increase the colony size for increased availability (currently available in small numbers). The NSG mice are useful for research in islet transplantation, hematopoietic stem cells and cancer stem cells. The ARC is currently conducting feasibility studies to determine the possibility of housing the outbred rat strain, Long Evans. If we go ahead, we expect availability to begin in early 2016. Stay in touch with us for further updates. Customer surveys are due out in late May, so keep an eye out for your opportunity to let us know what we excel at, what can be improved or where else we might be able to assist you. We welcome all feedback received. The ARC has now discontinued the DBA/1J mouse strain. The ARC staff would love to meet you and your colleagues. Please let us know if you have a conference or meeting that you think might benefit from our attendance and allow the ARC to explain our services or assist with your research. Discussion has begun into the possibility of gaining AAALAC accreditation of the ARC facility, watch this space for updates. The Benefits of sourcing SPF animals from a centralized breeding facility Have you considered outsourcing your colony maintenance, allowing you to reallocate your time and save valuable research space? The benefit of a centralized breeding facility (such as the ARC) for the purpose of medical/research needs has been long known. The main benefit is a reduction in excess animal production; it is also cost effective and allows for better utilization of laboratory space. Whilst AEC’s strictly scrutinize animals selected for use in projects, there are cases where only single sex, certain ages or sporadic usage is required. This can mean there are a lot of animals from a breeding colony not utilized by that same project. By using a centralized breeding facility, many varied project requirements are collated together meaning that animal breeding can be better managed to reduce overproduction (animals that might not be utilised for one project, would be for another). At the ARC, we always consider the 3R’s and have the ability to utilize excess animals. Another benefit of centralization is the availability of other thirdparty services on site. We are able to offer complete services including importation/exportation, quarantine, rederivation or cryopreservation, custom maintenance, cross breeding, sample collection and technical support. The Rodent Reporter page 2 Animal Resources Centre Newsletter Importing rodents to Australia? Ask Roger the rodent! Q: Some of my C57Bl6/J mice are barbering each other, what does this mean? A: Barbering is an abnormal repetitive behavior that results in hair loss commonly around the face. Most often seen in a group housing situation termed dominant barbering, it has also been noted in sexual over-grooming, maternal grooming and stress-evoked barbering. Where identified (and possible), the groomer should be removed from the box (as observed by a lack of over-grooming), if possible, reducing the number of animals in the cage can also help. Supplying environmental enrichment such as wood blocks, tubes or houses can help distract mice from this behavior however; caution is advised as some forms of enrichment can create territorial behaviour in some strains. 1. Life of a Lab Mouse Scenario #1 – “Luck of the draw….” When you contact the ARC regarding an interest into importing animals, you will be connected with our dedicated Imports Co-coordinator, Andrew, who will then assist you with the process. Once we have a contact name or supplier of the required rodent strain(s), Andrew will contact the supplier to ascertain availability of animals, request health reports and confirm if importation to the ARC will be possible. facility whilst they undergo their period of Quarantine. Andrew co-ordinates the imported animals for entry into Australia by ensuring correct documents are gathered, permits are submitted and Australian Quarantine are notified of the pending import. Once clearance has been received from the Department of Agriculture (Quarantine), the animals are available for despatch to the customer or moved to the ARC custom strain barrier for ongoing maintenance. On arrival, the imported animals will arrive at the ARC international quarantine For further information: imports@arc.wa.gov.au Did you know we can collect samples for you? Does your research require simple measured data or samples to be collected? This service allows you to utilise your precious time elsewhere whilst we take care of the ‘grunt’ work. The ARC has experienced Animal Technicians and dedicated Laboratory staff that are trained to collect specific samples or data on your behalf. Samples that can be requested include but are not limited to, Whole Blood, Serum/Plasma, Urine, Muscle, and data collection Get to know our rodents! NSG Mice are highly immunocompromised that require special considerations for housing and use. If you are considering using these mice, please contact the ARC for an information sheet and speak to our experienced staff for assistance in utilizing this strain. Get to know our staff! Name: Rory Length of time at ARC: 34 years (since the beginning!) Initial position when hired: Animal Technician Current Position: Training Officer Senior What do you enjoy most working at the ARC? I have really enjoyed watching the ARC grow and evolve over time. Seeing the buildings develop and the staff learning and growing from young adults into parents themselves. such as Weight, Blood Pressure, and Blood Glucose can also be provided. If you would like to utilize this service, or have another request, please contact us to discuss your requirements and receive a quote. For further information: orders@arc.wa.gov.au newsletter is making it useful to your readers. A great way to add useful content to this newsletter is to develop and write your own articles, or include a calendar of upcoming events or a special offer that promotes a new product. You canmany also memories research from I have articles or facility find “filler” the small we started, articles by accessing the in what seemed like the World Wide Web. You can middle of the bush (before write about a variety of the freeway came through), topics but try to keep to articles breeding your short.chickens, through to the ARC as it Much the content you standsoftoday. put in your newsletter can also be used for your Web site. Microsoft Word offers a simple way to convert your newsletter to a Web publication. 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