UA Flashcards Unit 2 1) Diseases affecting the glomerulus are primarily caused by: 2) All of the following are symptoms of acute glomerulonephritis except: A. Periorbital edema B. Hematuria C. Proteinuria D. Hypoalbuminemia 3) The major cause of the nephrotic syndrome in children is: 4) Damage to the glomerulus can occur as a result of all of the following except: A. Increased filtration of electrolytes B. Deposition of immune complexes C. Deposition of amyloid materials D. Cellular infiltration 5) The buildup of crescentic formations on the glomerular capillaries is characteristic of: 6) The most common cause of end-stage renal disease is: 7) A renal disorder associated with heroin abuse is: 8) Blood tests can be used to confirm the diagnosis of acute glomerulonephritis because of the detection of: 9) Goodpasture syndrome and Wegener’s granulomatosis are associated with the presence of which of the following in the urine sediment? 10) The presence of which crystals can be associated with nephrotic syndrome? 11) A patient with symptoms of pulmonary hemoptysis and urinary hematuria should be tested for: 12) Which of the following disorders has the most favorable patient prognosis? A. Rapidly progressive glomerulonephritis B. Henoch-Schönlein purpura C. IgA nephropathy D. Goodpasture syndrome 13) Glomerular basement membrane thickening occurs in membranous glomerulonephritis as a result of deposition of: 14) The presence of heavy proteinuria is most characteristic of: 15) The pronounced edema associated with nephrotic syndrome is related to the: Immunological disorders 16) Oval fat bodies and fatty casts are characteristic urine sediment constituents in patients with: 17) A decrease in systemic blood flow affects the Nephrotic syndrome D Minimal change disease A Rapidly progressive glomerulonephritis Diabetic nephropathy Focal segmental glomerulosclerosis Antistreptococcal antibodies Red blood cell casts Cholesterol Antiglomerular basement membrane antibody B IgG immune complexes Nephrotic syndrome Hypoalbuminemia Ischemia 1 UA Flashcards Unit 2 renal tubules by producing: 18) Glucosuria and generalized aminoaciduria are characteristics of: 19) Which inherited renal disorder manifests itself in the development of gout in teenage years? 20) In which part of the kidney is uromodulin produced? 21) Which of the following renal disorders is most likely to be inherited? A. Nephrotic syndrome B. Acute interstitial nephritis C. Acute tubular necrosis D. Fanconi syndrome 22) Administration of a nephrotoxic antibiotic to a patient with a decreased glomerular filtration rate may cause: 23) The presence of increased renal tubular epithelial cell casts is most indicative of: 24) Infection of the bladder is termed 25) Cystitis can be differentiated from pyelonephritis by: 26) In diabetic nephropathy, solid material deposited around the capillary tufts includes: 27) The finding of bacterial casts can be associated with: 28) The most serious tubulointerstitial disorder is: 29) An increased urinary eosinophils are diagnostic for: 30) Microscopic urinalysis findings of a patient with acute interstitial nephritis include all of the following except: A. Bacteria B. White blood cells C. Red blood cells D. White blood cell casts 31) Acute renal failure may be classified as all of the following except: A. Rapidly progressive B. Prerenal C. Renal D. Postrenal 32) In which disorder would waxy and broad casts be most likely to be seen? 33) Causes of acute renal failure can include all of the following except: A. Malignancy B. Goodpasture syndrome C. Acute tubular necrosis D. Renal calculi 34) Most renal calculi are composed of: 35) Lithotripsy is a procedure that is performed to: Fanconi syndrome Uromodulin-associated kidney disease Proximal and distal tubules D Acute tubular necrosis Acute tubular necrosis Cystitis The presence of white blood cell casts Glycosylated protein Acute pyelonephritis Chronic pyelonephritis Acute interstitial nephritis A A Chronic renal failure B Calcium Aid in the remove of renal calculi 2 UA Flashcards Unit 2 36) The microscopic hematuria associated with renal lithiasis is caused by: 37) All of the following may be helpful in preventing the formation of renal calculi except: A. Increased hydration B. Increased exercise C. Dietary restrictions D. Adjustment of urine pH 38) Initial screening for PKU performed on newborns before their discharge from the hospital uses a blood sample rather than a urine sample because: 39) A routine urinalysis is performed on a specimen that has turned dark after standing in the laboratory. The urine is acidic and has negative chemical tests except for the appearance of a red color on the ketone area of the reagent strip. One should suspect: 40) A positive Guthrie test is interpreted by observing: 41) Patients who have unusually fair complexions can be indicative for phenylketonuria because: 42) A false-positive reaction for urinary ketones could be present in patients who have: 43) A positive urine Clinitest reaction can be seen in patients with: 44) Confirmation of maple syrup urine disease is made on the basis of: 45) A disease that causes large amounts of branched-chain amino acids to be excreted in the urine is: 46) Urine with the characteristic odor of “sweaty feet” and a positive ketone test indicates: 47) Which of the following foods contains serotonin, which can interfere with 5-HIAA testing? 48) The presence of maple syrup urine disease is first suspected by the presence of abnormal urine: 49) The finding of a “blue diaper” is indicative of a defect in the metabolism of: 50) Patients who produce kidney stones at an early age should be tested for the presence of: 51) Porphyrins are intermediary compounds in the formation of: 52) The specimen of choice when testing for protoporphyrin is: 53) The most common cause of acquired porphyria is: A. Fanconi syndrome B. Neurologic Tissue irritation B Increased serum phenylalanine can be detected earlier Melanuria Bacterial growth occurs around the positive control disc and the patient disc Tyrosine is not available for conversion to melanin Melanuria A. Alkaptonuria MS/MS Maple syrup urine disease Isovaleric acidemia Pineapples Odor Tryptophan Cystinuria Heme Blood Lead poisoning A 3 UA Flashcards Unit 2 C. Psychiatric D. Photosensitivity 54) The presence of porphobilinogen in the urine can be suspected when: 55) Urine from a child suspected of having lead poisoning has a red fluorescence under Wood’s lamp. This finding is: 56) The concept of vampires is associated with: 57) Characteristic urine odors are associated with all of the following disorders except: A. Alkaptonuria B. PKU C. Maple syrup urine disease D. Isovaleric acidemia 58) The presence of amino acids is of particular concern in which population? 59) All of the following can be classified as metabolic rather than renal disorders except: A. Tyrosyluria B. Maple syrup urine disease C. Cystinuria D. Indicanuria 60) The presence of “orange sand” in an infant’s diaper is indicative of: 61) A patient diagnosed with Lesch-Nyhan disease can have all of the following conditions, except: A. Cystinosis B. Increase in uric acid C. Self-destructive tendencies D. Severe motor defects 62) Mental retardation is a symptom of all of the following except: A. Hurler’s syndrome B. Galactosuria C. PKU D. Cystinuria 63) Melituria refers to an increase in urinary: 64) GALT deficiency is a disorder affecting the metabolism of: Choose the characteristic odor for the following disorders: 65) Phenylketonuria 66) Cystinosis 67) Isovaleric acidemia 68) Maple syrup urine disease True/False 69) Failure of a metabolic pathway to reach completion may be caused by an inborn error of metabolism 70) Persons diagnosed with PKU should avoid foods containing the chemical additive Acidic urine turns a port wine color after standing Consistent with lead poisoning because coproporphyrin fluoresces under ultraviolet light Porphyrias A Newborns C Lesch-Nyhan disease A D Sugar Galactose Mousy Sulfur Sweaty feet Sweet True True 4 UA Flashcards Unit 2 aspartame 71) The 2,4-dinitrophenylhydrazine reaction is the confirmatory test for maple syrup urine disease 72) Argentaffin cell tumors produce large amounts of serotonin 73) Both cystine and leucine crystals are present in the urine of patients with cystinuria 74) The free erythrocyte protoporphyrin test is the recommended screening test for lead poisoning 75) Uric acid crystals are frequently seen in the urine of pediatric patients. 76) The presence of a massive amount of urinary calcium oxalate crystals is indicative of LeschNyhan disease 77) A negative reagent strip test for glucose and a positive Clinitest on a pregnant woman are associated with gestational diabetes 78) If CSF tubes numbered 2 and 3 cannot be analyzed within 1 hour, the correct procedure is to: 79) A xanthochromic CSF specimen will appear: 80) Cell counts on CSF are performed on: 81) A broad spectrum of reactive and nonreactive lymphocytes in the CSF is associated with: 82) The third tube of CSF collected from a lumbar puncture shoul be used for: 83) The primary disadvantage in using a cytocentrifuge to prepare CSF differential slides is: 84) Nucleated red blood cells (RBCs) seen in the CSF indicate: 85) White blood cell (WBC) counts on clear CSF specimens are performed: 86) To determine the WBC count on a cloudy CSF specimen that contains both RBCs and WBCs, it is necessary to: 87) An increase in neutrophils with pyknotic nuclei can be seen in which situation? 88) When using the cytocentrifuge, a daily control slide of saline and albumin is prepared to check: A. The correct centrifuge speed B. For the presence of WBCs C. For bacterial contamination D. The pH of staining buffer 89) Three tubes of CSF are submitted to the laboratory. They are numbered 1, 2, and 3 and show blood in all tubes but decreasing in amount as one inspects tubes 1 through 3. This False True False True False False False Refrigerate tube 3 and leave tube 2 at room temperature Yellow and clear Cells as they are counted in the hemocytometer Viral meningitis Hematology tests Cellular distortion Bone marrow contamination from the puncture On undiluted specimens if there is no cell overlapping Dilute the specimen using glacial acetic acid Traumatic tap specimen C A traumatic or bloody tap is suspected and, in all likelihood, no pathogenic significance should be attached to the presence of the blood 5 UA Flashcards Unit 2 observation should be interpreted as: 90) The presence of hemosiderin containing macrophages in CSF indicates 91) A CSF specimen, in which there is uneven distribution of blood among the three tubes and clots are detected, is an indication of: 92) The presence of xanthochromia and an increased D-dimer test in the CSF is indicative of: 93) Examination of a CSF shows 1000 WBCs, of which 75% are lymphocytes and 25% are monocytes. This finding is consistent with: 94) Damage to the blood-brain barrier by Mycobacterium tuberculosis may cause the CSF to: 95) Dilution of CSF prior to performing a total cell count should be made using: 96) Increased CSF eosinophils are associated with: 97) Melanoma cells in the CSF must be differentiated from: 98) Conditions that produce elevated CSF protein include all of the following except: A. Fluid leakage B. Meningitis C. Multiple sclerosis D. Hemorrhage 99) Myelin basic protein is measured in the CSF to assess the condition of patients with: 100) Measurement of CSF lactate is useful for monitoring cases of: 101) The CSF/serum albumin index is performed to determine: 102) To determine if IgG is being produced within the central nervous system, the laboratory must calculate the: 103) The lowest levels of CSF lactate can be found in patients with: 104) Crystals with a bright yellow color seen in macrophages are called: 105) The presence of increased glutamine in the CSF can indicate: 106) Gram stains performed on CSF specimens are helpful in the: 107) Specimens from patients suspected of having fungal meningitis should be tested with: 108) India ink preparations are useful in the diagnosis of: 109) When a CSF specimen is received in the microbiology laboratory, the first thing the technologist should do is: 110) A questionable India ink preparation on the CSF from an immunocompromised patient Cerebral hemorrhage Traumatic tap A cerebral hemorrhage Viral meningitis Contain a pellicle or clot Normal saline Introduction of foreign material Macrophages containing hemosiderin A Multiple sclerosis Bacterial meningitis The integrity of the blood-brain barrier IgG index Bacterial meningitis Hematoidin Reye’s syndrome Detection of bacterial and fungal meningitis Gram stain and India ink Fungal meningitis Centrifuge the specimen A cryptococcal antigen test 6 UA Flashcards Unit 2 should be further tested using: 111) Which of the following structures contain one-way valves? 112) A report of many gram-positive cocci on a clear CSF sample with a normal cell count may be the result of: 113) A positive cryptococcal antigen test with a negative India ink preparation may indicate: 114) A false-positive CSF serologic test for neurosyphilis in a treated patient can occur if: 115) A positive serum FTA-ABS and a negative VDRL on CSF indicate: 116) A patient previously diagnosed with acquired immunodeficiency arrives in the emergency room with symptoms of meningitis. A lumbar puncture is performed. Using the information provided, in addition to Gram stain, what additional testing should be performed? 117) A patient previously diagnosed with acquired immunodeficiency arrives in the emergency room with symptoms of meningitis. A lumbar puncture is performed. Based on the information provided, what diagnostically significant observation might be made on the Gram stain? 118) A patient previously diagnosed with acquired immunodeficiency arrives in the emergency room with symptoms of meningitis. A lumbar puncture is performed. Based on the information provided, what type of meningitis would most probably be suspected in this patient? 119) True or False? Xanthochromic CSF may appear pink, orange, or yellow. 120) True or False? Neutrophils may be present in normal CSF. 121) True or False? The formation of clots does not occur in CSF that does not contain blood. 122) True or False? The presence of macrophages containing hematoidin crystals indicates a recent hemorrhage. 123) True or False? Oligoclonal bands are located in the gamma region of the CSF protein electrophoresis. 124) True or False? When calculating an IgG index, the serum albumin concentration must be converted to milligrams per deciliter. 125) True or False? A CSF lactate level should not be performed on a xanthochromic specimen. 126) True or False? Bacterial antigen tests have replaced the Gram stain as the method of choice for detecting meningitis. Arachnoid granulations Use of contaminated albumin in the cytocentrifuge The presence of rheumatoid factor Fluid from a traumatic tap is tested by the FTA-ABS test Successfully treated syphilis Cryptococcal antigen test Starburst microbial pattern Fungal True True False False True False True False 7 UA Flashcards Unit 2 127) True or False? The recommended serologic test for the diagnosis of neurosyphilis is the rapid plasma reagin test. 128) Semen analysis on postvasectomy patients should be performed: 129) To determine if a questionable specimen is semen, the specimen should be tested for: 130) Absence of a normal sperm acrosome can: 131) Yellow color in a semen specimen may be caused by all of the following except: A. Urine B. Preservation at room temperature C. Medications D. Prolonged abstinence 132) Normal semen should liquefy: 133) An increased amount of prostatic fluid in a semen specimen will: 134) If the first portion of the ejaculation is not collected, which parameter of the semen analysis is most critically affected? 135) Semen viscosity is most closely related to: 136) Proper collection of a semen specimen should include all of the following except: A. In a sterile container B. After a 3-day period of sexual abstinence C. At the laboratory followed by 1 hour of refrigeration D. At home and delivery to the laboratory within 1 hour 137) Abnormal sperm morphology is determined by: 138) Before analysis, semen specimens should be: 139) Sperm motility after 1 hour should be at least: 140) Prior to reporting a postvasectomy specimen as negative for the presence of sperm, the specimen must be: False 141) Sperm can be immobilized before performing a sperm concentration using all of the following except: A. Heat B. Normal saline C. Sodium bicarbonate D. Tap water 142) Evaluation of sperm motility includes: 143) Computer-assisted semen analysis determines all of the following except: A. Sperm morphology B. Sperm count C. Trajectory of sperm motion D. Velocity of sperm motility B Until two consecutive monthly specimens show no sperm Acid phosphatase Affect ovum penetration B Within 1 hour Lower the pH Sperm concentration Specimen liquefaction C Head and tail morphology and size Allowed to completely liquefy 50% Dentrifuged Differentiation between forward and lateral movement A 8 UA Flashcards Unit 2 144) When performing sperm morphology analysis, the minimum number of sperm that should be evaluated is: 145) When using routine morphology criteria, the normal value is greater than: 146) When using Kruger’s strict morphology criteria, the normal value is greater than: 147) Semen specimens should be processed for analysis: 148) The normal sperm concentration is: 149) A yellow semen specimen with a normal sperm concentration and decreased motility may contain: 150) When performing sperm morphology analysis on a semen specimen with a sperm concentration of 20 million, 10 spermatids are seen. This result is: 151) A sperm motility report graded 2.0 is interpreted as: 152) While performing a sperm morphology examination, a technologist counts 10 neutrophils per 100 mature sperm. To determine if this observation is significant, the technologist must also know the: 153) The finding of 3 million neutrophils per milliliter in a semen specimen is: 154) The purpose of diluting semen specimens with sodium bicarbonate and formalin before counting is to: 155) The motility component of a sperm analysis includes all of the following except evaluation of the A. Progressive and Brownian movement B. Percentage of motile sperm C. Quality of movement D. Motility of normal and abnormal sperm 156) Using a 1:20 dilution of semen, a student counts 70 sperm in the five RBC squares on one side of the Neubauer hemocytometer and 82 sperm on the other side. The student should 157) The sugar of interest in most cases of infertility is 200 158) Development of male antisperm antibodies can be caused by all of the following except A. Vasovasostomy B. Infection C. Prolonged abstinence D. Trauma C 30% normal forms 14% normal forms After complete liquefaction 20 to 160 million/mL Urine Indicative of abnormal sperm maturation Slow forward motility with noticeable lateral movement Sperm concentration Indicative of infection Immobilize and preserve the sperm D Repeat the count Fructose 9 UA Flashcards Unit 2 159) The immunobead test detects 160) Where there is a lack of prostatic fluid, all of the following chemicals are decreased in the semen except A. Alpha-glucosidase B. Zinc C. Citrate D. Acid phosphatase 161) When examining a specimen for the presence of sperm, the type of microscopy recommended for use is 162) Sperm function tests include all of the following except the A. Hamster egg penetration assay B. Cervical mucus penetration test C. Meiosis and mitosis assay D. In vitro acrosome reaction 163) All of the following can be used to evaluate continued infertility with a normal sperm count except A. Semen fructose level B. Eosin-nigrosin stain C. Plasma and semen agglutination D. Immunobead test 164) A semen specimen in which clumping of sperm is observed should be further tested using the 165) Which of the following parameters directly relates to and provides a check on the sperm motility evaluation? 166) When an abnormally low sperm count is encountered in a fertility examination, the follow-up test of choice is 167) Which of the following is a normal finding in an eosin-nigrosin stain? 168) Normal semen analyses accompanied by continued infertility would most probably be caused by 169) Spermatogenesis takes place in the 170) True/False: A semen pH of 6.0 is associated with a decrease in prostatic fluid 171) True/False: Semen specimens can contain HIV and hepatitis viruses 172) True/False: Greater than 1 million spermatids per milliliter indicates reproductive tract infection 173) True/False: The size of the acrosome and the presence of vacuoles are included when sperm morphology is evaluated using Kruger’s strict criteria Male antisperm antibodies A Phase C A Immunobead test Viability stain Female agglutination studies 75% of the cells appear bluish white Female antisperm antibodies Seminiferous tubules False True False True 10 UA Flashcards Unit 2 174) True/False: Slides for evaluation of sperm morphology can be stained using Papanicolaou stain True 175) True/False: The semen analysis is classified as a moderately complex test by the Clinical Laboratory Improvement AmendmentsCLIA 176) True/False: The World Health Organization has standardized the performance and reporting of semen analysis 177) True/False: Antisperm antibodies are produced by both males and females 178) True/False: The immunobead test will differentiate between antisperm antibodies directed against the sperm head and tail 179) All of the following statements on synovial fluid are true except that it: A. Surrounds all joints in the body B. Is found only in the knee C. Acts as a lubricant D. Supplies nourishment to cartilage 180) Which of the following descriptions of synovial fluid does not correlate? 181) Crystals that are found in synovial fluid during attacks of gout are most likely: 182) In gout, both serum and synovial fluid will have increased levels of: 183) Synovial fluid is produced by: 184) The concentration of which of the following chemicals found in synovial fluid differs most noticeably from the plasma concentration? 185) A turbid synovial fluid with yellow-green color indicates: 186) All of the following primary cells are seen in normal synovial fluid except: A. Macrophages B. Neutrophils C. Monocytes D. Synovial tissue cells 187) All of the following can cause crystals to be present in the synovial fluid except: A. Metabolic disorders B. Increased ingestion of dairy products C. Degeneration of cartilage D. Injection of medications 188) A cloudy, yellow-green synovial fluid with 100,000 white blood cells (WBCs), a predominance of neutrophils, and a decreased glucose should be classified as: False True True True B Sepsis: uniform blood Monosodium urate Uric acid Ultrafiltration of plasma Protein Infection B B Septic 11 UA Flashcards Unit 2 189) An arthrocentesis is performed on a patient with lupus erythematosus that produces a cloudy yellow fluid with 2000 WBCs, of which 55% is neutrophils. This fluid should be classified as: 190) A clear, pale yellow synovial fluid with good viscosity and a WBC count of 1000 should be classified as: 191) To determine if an unknown fluid is synovial fluid, the fluid can be tested: 192) A milky-appearing synovial fluid can be associated with the presence of: 193) Which of the following crystals would most likely be present in conjunction with calcium pyrophosphate crystals in synovial fluid? 194) The recommended diluting fluid for synovial fluid cell counts is: 195) Neutrophils that contain precipitated rheumatoid factor in their cytoplasm are called: 196) All of the following are tests frequently performed on synovial fluid except: A. Gram stain B. WBC count C. Uric acid D. Differential 197) Vacuolated macrophages containing ingested neutrophils seen in synovial fluid are called: 198) Before performing a cell count on highly viscous synovial fluid, it may be necessary to incubate the fluid with: 199) In the Ropes’ or mucin clot test, normal synovial fluid: 200) Synovial fluid for crystal examination should be: 201) Crystals that appear to be rhombic-shaped and are blue when aligned with the slow vibration of red compensated polarized light are: 202) Delayed analysis of synovial fluid affects the results of all of the following tests except the: A. Mucin clot test B. Glucose C. Crystal examination D. WBC count 203) The presence of neutrophils containing dark granules in the synovial fluid is associated with: 204) Crystals frequently seen in patients’ joints with chronic inflammation are: 205) In addition to routine culture media, synovial fluid cultures should include: Inflammatory Noninflammatory By adding acetic acid and observing clot formation Monosodium urate crystals Hydroxyapatite Saline Ragocytes C Reiter’s cells Hyaluronidase Forms a solid clot when added to glacial acetic acid Examined unstained under direct and red compensated polarized light Calcium pyrophosphate A Rheumatoid arthritis Cholesterol Chocolate agar 12 UA Flashcards Unit 2 206) All of the following diseases are frequently associated with joint disorders except: A. Lyme disease B. Tuberculosis C. Lupus erythematosus D. Rheumatoid arthritis 207) Based on the information provided, what is the significance of the blood-streaked fluid? 208) Based on the information provided, what type of diluting fluid should be used for the WBC count? 209) Vacuolated macrophages containing ingested neutrophils are called: B 210) Fat droplets seen in synovial fluid are associated with: 211) Synovial fluid crystals seen in patients undergoing renal dialysis most commonly are: 212) True/False: Synovial fluid viscosity is caused by the presence of filtered serum proteins. 213) True/False: The polymerization of hyaluronic acid is decreased when arthritis is present. 214) True/False: Monosodium urate crystals may be present in synovial fluid from patients receiving chemotherapy for leukemia. 215) True/False: Automated cell counters should not be used for synovial fluid cell counts. 216) True/False: The predominant cell in normal synovial fluid is the lymphocyte. 217) True/False: Monosodium urate crystals are found both extracellularly and intracellularly. 218) True/False: Red compensated polarized microscopy separates light into slow and fast rays. 219) True/False: Synovial fluid should be routinely cultured for the presence of Borrelia burgdorferi. 220) True/False: Normal synovial fluid glucose values are 60% to 70% of the blood glucose. 221) Peritoneal lavage is performed to: 222) Exudate fluids usually result from: 223) The pathologic accumulation of fluid in a body cavity is termed a/an: 224) Which of the following is most often associated with the formation of a transudate? 225) The cells lining the pleural cavities are primarily: 226) The function of serous fluid is to: Crush injuries and Chronic inflammation Traumatic collection Hypotonic saline Reiter’s cells Calcium oxalate False True True False False True True False False Detect intra-abdominal bleeding Inflammation of the serous membrane Effusion Congestive heart failure Mesothelial cells Provide lubrication for the serous membranes 13 UA Flashcards Unit 2 227) Production of serous fluid is controlled by all of the following except: A. Lymphatic secretions B. Hydrostatic pressure C. Oncotic pressure D. Capillary permeability 228) Peritoneal fluid is collected by a procedure called: 229) Serous fluid effusions may result from all of the following except: A. Congestive heart failure B. Lymphatic obstruction C. Increased capillary permeability D. Dehydration 230) A pleural fluid delivered to the laboratory on ice would be accompanied by a requisition to test for: 231) Pleural fluid can be better classified as to transudative or exudative origin by performing a: A 232) A decrease in the number of mesothelial cells seen on a pleural fluid differential indicates: 233) A decrease in the number of mesothelial cells seen on a pleural fluid differential indicates: 234) All of the following are unique characteristics of malignant cells except: A. Hyperchromatic nucleoli B. Cytoplasmic molding C. Cellular clumping D. Abnormal nuclear-to-cytoplasm ratios 235) Elevated pleural fluid amylase can be indicative of all of the following except: A. Pancreatitis B. Esophageal rupture C. Tuberculosis D. Malignancy 236) A blood-streaked pericardial exudate with an increased amount of neutrophils is indicative : 237) Structures seen in peritoneal fluid that may be associated with either benign or malignant conditions are: 238) A fluid obtained by thoracentesis has a cholesterol result of 100 mg/dL. This would be classified as a/an: 239) Differentiation between a hemothorax and a hemorrhagic effusion on a bloody pleural fluid is done by: 240) A pleural fluid pH of less than 6.0 is Tuberculosis Paracentesis D pH Fluid-to-serum cholesterol ratio Tuberculosis C C Bacterial endocarditis Psammoma bodies Pleural exudate Performing a hematocrit value, because a hemothorax will give a value close to that of blood Esophageal rupture 14 UA Flashcards Unit 2 indicative of: 241) Requests for amylase and alkaline phosphatase determinations on ascitic fluid are received in suspected cases of: 242) Which of the following tests is valuable in the diagnosis of esophageal rupture? 243) A milky pleural fluid that stains strongly positive with Sudan III indicates: 244) A milky, green-tinged pleural fluid: 245) A pericardial exudate from a patient diagnosed with AIDS might be tested with: 246) The test performed on peritoneal lavage fluid is the: 247) An ascitic fluid absolute neutrophil count of 1000/µL is most indicative of: 248) A screening test performed on a cloudy, green ascitic fluid would be a/an: 249) What is the significance of an ascitic fluid exudate with a positive CA 125 and a negative CEA? 250) What is the significance of a peritoneal fluid with an elevated creatinine level? 251) What is the significance of a pleural fluid with a hematocrit value of 30% (blood hematocrit: 34%)? 252) Increased serous fluid can be caused by all of the following except: A. Lymphatic obstruction B. Inflammation C. Increased plasma sodium D. Increased hydrostatic pressure 253) The finding of a mesothelioma cell in pericardial fluid is indicative of: 254) Normal values for chemistry tests on serous fluid are different from values obtained on serum. 255) Transudate serous fluid effusions are a complication of the nephrotic syndrome. 256) Additional testing is most frequently performed on transudates rather than exudates. 257) A significant finding in a serous effusion is an increase in mesothelial cells. 258) Reactive mesothelial cells indicate a malignant effusion. 259) Pleural fluid amylase is elevated in cases of pancreatitis. Gastrointestinal perforations Pleural fluid pH Thoracic duct leakage Stains weakly with Sudan III An acid-fast stain RBC count Bacterial peritonitis Ictotest Ovarian malignancy Ruptured bladder Hemothorax C Metastatic malignancy False True False False False True 15 UA Flashcards Unit 2 260) Amniotic fluid is formed by all of the following except: A. Fetal urine B. Fetal cell metabolism C. Fetal swallowing D. Transfer of water across the placenta 261) A dark green amniotic fluid is associated with: 262) A primary function of amniotic fluid is to: 263) The volume of amniotic fluid increases after the first trimester as a result of: 264) Amniotic fluid for fetal lung maturity testing should be preserved: 265) A dark yellow amniotic fluid is caused by: 266) Measurement of amniotic fluid creatinine levels can be used to: 267) To differentiate between maternal and fetal blood in blood-streaked amniotic fluid, the fluid is tested for 268) The presence of a fetal neural tube disorder may be detected by: 269) An increased level of alpha fetoprotein in amniotic fluid should be further tested for: 270) Hemolytic disease of the newborn is caused by: 271) Analysis of amniotic fluid bilirubin levels is performed using: 272) Alpha fetoprotein is produced by the fetal: 273) The purpose of plotting amniotic fluid bilirubin on a Liley graph is to 274) Hemolytic disease of the newborn endangers the fetus by: 275) The A450 of an amniotic fluid is plotted in zone 3 of a Liley graph. The physician should: 276) Interference with the amniotic fluid bilirubin analysis on centrifuged fluid is most likely caused by: 277) The foam, or shake, test is a screening test for amniotic fluid: 278) In the determination of fetal lung maturity, which of the following components is produced by the body at the 35th week of gestation? 279) Amniotic fluid tests for determining fetal lung maturity include 280) Decreased levels of phosphatidyl glycerol in amniotic fluid can be associated with: 281) The test for amniotic fluid lamellar bodies uses which of following? 282) The Amniostat agglutination test is performed on amniotic fluid from pregnant women to detect the presence of: C Meconium Provide protection for the fetus Production of fetal urine In the refrigerator Bilirubin Differentiate between amniotic fluid and maternal urine Fetal hemoglobin Increased maternal serum alpha fetoprotein Acetylcholinesterase Maternal antibodies Spectrophotometry Liver Determine further treatment Destroying fetal RBCs Request testing for fetal lung maturity Oxyhemoglobin Surfactants Phosphatidyl glycerol L/S ratio and lamellar bodies Hyaline membrane disorder SS An automated cell counter Phosphatidyl glycerol 16 UA Flashcards Unit 2 283) The most frequent concern of premature Lungs delivery is underdevelopment of the: 284) The principle of the shake test and foam Reduce the surface tension of an alcoholic solution stability index is that phospholipids: 285) Lamellar bodies contain: Phospholipids 286) When an L/S ratio by thin-layer chromatographyLecithin is twice as concentrated as sphingomyelin performed, a mature fetal lung will show 287) The method of choice for testing amniotic Amniostat fluid contaminated with hemoglobin for fetal lung maturity is: 288) The test of choice for testing amniotic fluid Amniostat-FLM from a diabetic patient for fetal lung maturity is the 289) A fern test is performed to differentiate Urine and amniotic fluid between: 290) Failure of the fetus to begin swallowing will Polyhydramnios result in: 291) The volume of amniotic fluid is regulated by True fetal swallowing. 292) Amniotic fluid for cytogenetic analysis False should be delivered to the laboratory in ice. 293) Meconium is composed of bowel True constituents 294) Acetylcholinesterase testing can be False performed on amniotic fluid containing blood, if the specimen is centrifuged. 295) Production of both lecithin and False sphingomyelin increases after 35 weeks gestation. 296) Most laboratories detect the presence of False phosphatidylglycerol using thin-layer chromatography. 297) When performing the foam stability index, True amniotic fluid is mixed with ethanol. 298) Pneumocytes in the fetal lungs produce True lamellar bodies. 299) Lamellar bodies are approximately the same False size as red blood cells. 300) The normal brown color of the feces is Stercobilin produced by: 301) Stools from persons with steatorrhea Fat contain excess amounts of: 302) Which of the following pairings of stool Yellow-green: barium sulfate appearance and cause does not match? 303) A black, tarry looking stool is indicative of: Upper gastrointestinal (GI) bleeding 304) A pale, frothy looking stool is indicative of: Excess fat 17 UA Flashcards Unit 2 305) All of the following are secreted into the small intestine by the pancreas except: A. Bile salts B. Chymotrypsin C. Lipase D. Elastase 1 306) The recommended specimen for quantitative fecal testing is a: 307) The presence of amebic dysentery may be suspected when a stool: 308) The unpleasant odor associated with fecal analysis is caused primarily by: 309) Diarrhea can result from all of the following except: A. Disruption of the normal intestinal bacterial flora B. Addition of pathogenic organisms to the normal intestinal flora C. Increased reabsorption of intestinal water and electrolytes D. Increased concentration of fecal electrolytes 310) Large orange-red droplets seen on direct microscopic examination of stools that have been mixed with Sudan III stain can represent: 311) Microscopic examination of stools mixed with Sudan III stain, glacial acetic acid, and then heated will show small orange-red droplets that represent: 312) When performing microscopic examination of a stool for muscle fibers, the structures that are counted: 313) Crystals seen in a stool after it has been mixed with acetic acid, Sudan III stain, and heated may be composed of: 314) Wet preparations for the detection of fecal neutrophils are stained with 315) Microscopic examination of stools for fecal cells provides preliminary information as to the cause of diarrhea because: 316) Increased neutrophils in a stool sample may indicate that the patient has which of the following? 317) A positive lactoferrin latex agglutination test can indicate which of the following? 318) The term occult blood in fecal analysis can indicate which of the following? 319) A negative trypsin test on a fecal sample can indicate which of the following? A 72-hour specimen Is coated with blood-streaked mucus Bacterial metabolism C Neutral fats Fatty acids, soaps, and neutral fats Have vertical and horizontal striations Cholesterol Methylene blue Neutrophils are present in conditions that affect the intestinal wall Salmonella infection Enteroinvasive Escherichia coli Blood that is not visibly apparent in the stool specimen Pancreatic insufficiency 18 UA Flashcards Unit 2 320) To prevent false-positive fecal occult blood results, patients should be instructed to avoid eating all of the following for 3 days before testing except: A. Horseradish B. Chicken C. Melons D. Red meat 321) Before and during collection of a sample for quantitative fecal fats, a patient should: 322) The coefficient of fat retention should be at least: 323) The most sensitive fecal enzyme test for the diagnosis of pancreatic insufficiency measures: 324) A bloody stool from a neonate should be emulsified in water, centrifuged, and the supernatant tested with: 325) Tests for the detection of occult blood rely on which chemical reaction? 326) In the Van de Kamer method for quantitative fecal fat determinations, fecal lipids are: 327) A patient whose stool exhibits increased fats, undigested muscle fibers, and the inability to digest gelatin may have: 328) A stool pH of 5.0 correlates with a: 329) A bloody stool produced by a newborn should: 330) False-negative results for upper GI bleeding can be caused by: 331) When performing the Apt test, a pink color that remains in the supernatant during testing indicates: 332) What is the significance of the pale, frothy stool? 333) The absence of what substance most likely accounts for increased orange droplets? 334) What is the condition indicated by increased orange droplets? 335) How long should the slide for muscle fibers sit before being examined? 336) An Apt test performed on a black, tarry stool is negative for fetal hemoglobin. 337) In the evaluation of a stool specimen, the results were abnormal in the trypsin test and normal in a chymotrypsin test. 338) Quantitative fecal fat testing performed on a patient maintained on a diet of 100 g of fat per day is 5 g per day. The coefficient of fat retention is reported as normal. 339) An unusual number of positive occult blood tests are reported by a new employee in a satellite clinic. B Consume 100 g of fat per day 95% Elastase 1 NaOH Pseudoperoxidase activity of hemoglobin Converted to fatty acids before titrating with sodium hydroxide Cystic fibrosis Positive Clinitest Have an Apt test performed on it Degradation of hemoglobin to porphyrin The presence of fetal hemoglobin Biliary obstruction Bile salts Steatorrhea 5 minutes Concerned; patients may not be receiving dietary instructions Not concerned; 95% retention is normal Not concerned; 95% retention is normal Concerned; patients may not be receiving dietary instructions 19 UA Flashcards Unit 2 340) The electrolyte content of normal feces is similar to that of plasma. 341) Microbial infections produce osmotic diarrhea. 342) A stool that appears black and tarry may be associated with bismuth ingestion 343) The neutral fat and split fat stains are confirmatory tests for steatorrhea. 344) Staphylococcal food poisoning produces secretory diarrhea and increased fecal neutrophils. 345) The guaiac test detects both hemoglobin and porphyrin. 346) The Apt test should not be performed on a black, tarry stool. 347) True or False? The D-xylose and lactose tolerance tests are abnormal in persons with malabsorption or maldigestion disorders. 348) True or False? Steatorrhea is seen in association with decreased elastase 1 in the feces. 349) Which of the following is the most likely reason a physician would collect vaginal fluid for analysis? 350) Which of the following vaginitis conditions is of a noninfectious origin? 351) A vaginal secretion collection can be performed to help for all of the following except: A. Determine causative agent B. Avoid reinfection C. Prevent pregnancy D. Provide a basis for treatment 352) Vaginal secretion collection kits are specific for which of the following? 353) Which of the following specimen handling combinations is incorrect? 354) A vaginal fluid collection kit is dropped off in the laboratory for analysis and the technologist notices condensation inside the biohazard bag. Which of the following tests cannot be performed? 355) You receive a call from a physician’s practice asking about “extra swabs” for a vaginal secretions collection for Neisseria possible infection. Which of the following swabs cannot be used and why? 356) Which of the following secretion combinations are considered to be normal? 357) A vaginal fluid was collected from a 25-yearold female that showed the following results: appearance is pink with flocculent discharge, True False True False False False True True True Vaginitis Chemical irritation C For the organism sought Herpes simplex virus (HSV): room temperature Trichomonas motility testing Sterile wood shaft swabs with cotton because they are toxic to Neisseria White, flocculent discharge Patient is normal and is menstruating 20 UA Flashcards Unit 2 pH is 3.9, whiff test is negative, many Grampositive rods, clue cells are absent. What is your interpretation of these results? 358) When testing for vaginal pH, the health-care provider collecting the sample should: 359) A vaginal pH value of 6.0 could indicate which of the following conditions? 360) Which of the following conditions is not likely if a vaginal pH value is greater than 4.5? 361) Based on the following description, identify the cell: a large irregular shaped cell that ranges from 25 to 70 microns in diameter with a prominent central nucleus that is 8–10 microns in size, a cytoplasm that contains no granules, with “shaggy” borders. 362) Which diagnostic test uses a 10% solution of potassium hydroxide to detect the volatilization of amines to produce a distinctive odor? 363) Which of the following bacterial characteristics best describes the “normal flora” found in a vaginal specimen? 364) Normal flora is predominantly of which genus? 365) Of the following organisms, which one requires DNA probe amplified by the polymerase chain reaction (PCR)? 366) All of the following cellular elements are seen in patients with desquamative inflammatory vaginitis, except: A. Clue cells B. Basal cells C. Red blood cells D. White blood cells 367) All of the following cellular elements can be seen in patients with candidiasis, except: A. Clue cells B. White blood cells C. Epithelial cells D. Budding yeast 368) A female patient presents to her OB/GYN with the following complaints: genital itching, dysuria, and an abnormal looking white “chunky” substance on her undergarments. The immediate next step the physician should take is: 369) The fetal fibronectin test is used to determine which of the following conditions? 370) The test for placental alpha-1 microglobulin protein is used to determine: Place the specimen on the pH paper before placing swab into the saline solution Bacterial infection Vulvovaginal candidiasis Clue cell Whiff test Gram-positive large rods Lactobacillus sp Trichomonas vaginalis A A Perform a saline wet prep Preterm delivery Fetal membrane rupture 21