Additional file 2.
Total number of reads per sample.
120000000
100000000
80000000
60000000
40000000
20000000
0
Total number of reads per sample for all (11) samples with an average of 97,890,272
reads per sample.
Summary of the differentially expressed genes in the “Axonal Guidance Signaling”
Pathway from IPA®.
Symbol
ABLIM2
ACTR3
ADAM8
ADAM11
ADAM12
ADAMTS1
ADAMTS2
ADAMTS6
ADAMTS7
ARPC5
ARPC1A
BMP7
C9orf3
COPS5
CXCR4
EGF
EPHA3
EPHB3
FZD1
GNA14
GNG2
HHIP
HRAS
LINGO1
LRRC4C
MET
MMP2
MMP9
MMP11
MMP13
MRAS
MYL3
MYL9
MYL10
MYL12B
PAK1
PAK3
PDGFD
PFN2
PIK3R6
PLXNA2
PLXNC1
PRKCH
ROBO1
ROBO3
Entrez Gene Name
actin binding LIM protein family, member 2
ARP3 actin-related protein 3 homolog (yeast)
ADAM metallopeptidase domain 8
ADAM metallopeptidase domain 11
ADAM metallopeptidase domain 12
ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADAM metallopeptidase with thrombospondin type 1 motif, 2
ADAM metallopeptidase with thrombospondin type 1 motif, 6
ADAM metallopeptidase with thrombospondin type 1 motif, 7
actin related protein 2/3 complex, subunit 5, 16kDa
actin related protein 2/3 complex, subunit 1A, 41kDa
bone morphogenetic protein 7
chromosome 9 open reading frame 3
COP9 signalosome subunit 5
chemokine (C-X-C motif) receptor 4
epidermal growth factor
EPH receptor A3
EPH receptor B3
frizzled class receptor 1
guanine nucleotide binding protein (G protein), alpha 14
guanine nucleotide binding protein (G protein), gamma 2
hedgehog interacting protein
Harvey rat sarcoma viral oncogene homolog
leucine rich repeat and Ig domain containing 1
leucine rich repeat containing 4C
MET proto-oncogene, receptor tyrosine kinase
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV
collagenase)
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV
collagenase)
matrix metallopeptidase 11 (stromelysin 3)
matrix metallopeptidase 13 (collagenase 3)
muscle RAS oncogene homolog
myosin, light chain 3, alkali; ventricular, skeletal, slow
myosin, light chain 9, regulatory
myosin, light chain 10, regulatory
myosin, light chain 12B, regulatory
p21 protein (Cdc42/Rac)-activated kinase 1
p21 protein (Cdc42/Rac)-activated kinase 3
platelet derived growth factor D
profilin 2
phosphoinositide-3-kinase, regulatory subunit 6
plexin A2
plexin C1
protein kinase C, eta
roundabout, axon guidance receptor, homolog 1 (Drosophila)
roundabout, axon guidance receptor, homolog 3 (Drosophila)
Fold Change
1.534
1.591
2.651
-2.568
2.214
-1.514
1.516
2.557
1.720
1.592
2.597
1.994
2.153
-1.653
1.973
1.594
2.422
1.801
1.990
-5.738
1.850
-2.551
1.823
-3.306
-5.124
1.815
2.183
2.337
2.545
2.461
2.989
5.358
1.732
4.976
1.941
1.687
-1.504
1.949
2.077
1.688
-1.590
1.585
-2.143
2.144
4.484
SEMA3A
SEMA3G
SEMA7A
SLIT3
SOS1
TUBA8
TUBA1B
TUBA1C
TUBB6
WNT11
WNT2B
sema domain, immunoglobulin domain (Ig), short basic domain, secreted,
(semaphorin) 3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted,
(semaphorin) 3G
semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
slit homolog 3 (Drosophila)
son of sevenless homolog 1 (Drosophila)
tubulin, alpha 8
tubulin, alpha 1b
tubulin, alpha 1c
tubulin, beta 6 class V
wingless-type MMTV integration site family, member 11
wingless-type MMTV integration site family, member 2B
1.560
-1.874
-2.359
3.103
-1.655
-2.487
2.399
-1.714
1.791
2.511
2.380
Summary of significant DE genes their respective fold change expressed in affected
birds in found within the “Axonal Guidance Signaling” canonical pathway. This table is a
product of Ingenuity Pathway Analysis (IPA®).