Alison Mary Caswell
CURRENT POSITION
Principal Lecturer, School of Health and Wellbeing,
Faculty of Health and Social Sciences
QUALIFICATIONS
2003
2002
1982
1977
Postgraduate Certificate in Higher Education.
Leeds Metropolitan University.
Fellow/Registered Practitioner, Higher Education Academy.
PhD. University of Sheffield, Department of Biochemistry.
BSc (Hons) Biochemistry 1st Class.
University of Newcastle-upon-Tyne.
APPOINTMENT HISTORY
1/07-8/12
9/02-12/06
2/94-8/02
12/88-1/94
1987-1988
1984-1987
1981-1984
Subject Group Head, Public Health Safety and Environment
Principal Lecturer, School of Health and Human Sciences
Senior Lecturer, School of Health and Human Sciences,
Faculty of Health, Leeds Metropolitan University.
Lecturer (fixed-term),
Department of Biochemistry and Molecular Biology,
University of Leeds.
Department of Human Metabolism and Clinical Biochemistry,
University of Sheffield Medical School.
Research Assistant, Project Grant from
Action Research for the Crippled Child.
Research Assistant, Project Grant from
The Arthritis and Rheumatism Council.
MRC Advanced Training Fellowship
UNIVERSITY/FACULTY RESPONSIBILITIES
2004200420062003-2004
2003-2004
2002-2003
1998-2006
1997-2007
1995-2006
Faculty Health and Safety Co-Ordinator
Member of University Health and Safety Committee
Chair, Faculty Health and Safety Advisory Group
Member of Faculty Academic Monitoring Sub-Committee
Member of Faculty Academic Quality & Standards Committee
Member of University Progress Files Working Group.
Member of Faculty Health and Safety Advisory Group.
Course Leader, BSc (Hons) Human Biology.
Level 1 Tutor, BSc (Hons) Human Biology.
OTHER APPOINTMENTS
10/04-9/08
9/01-08/04
1990-2006
External Examiner, University of Salford,
Faculty of Health Care and Social Work,
School of Community, Health Sciences and Social Care.
Teaching Fellowship, Leeds Metropolitan University.
Member of Editorial Advisory Panel, Biochemical Journal.
MAIN TEACHING AND CURRICULUM DEVELOPMENT ACTIVITIES
Current
BSc (Hons) Biomedical Sciences (All Routes): teaching to levels 5 and 6.
BSc (Hons) Human Nutrition, and BSc (Hons) Dietetics: teaching to level 5.
Supervision of final year projects – various courses.
Preparation and management of modules for the above courses.
Significant input into development of courses within Public Health Safety and
Environment Group/Team including BSc (Hons) Public Health – Environmental
Health/BSc (Hons) Environmental Health, and MSc Environmental Health.
Historical
Course Development Team Leader BSc (Hons) Osteopathy and BSc (Hons)
Public Health – Health Studies.
Preparation of Course Documents for BSc (Hons) Human Biology.
Development of teaching materials to foster skills and career development, and
production of materials to provide online support for biochemistry.
MEMBERSHIP OF EXTERNAL ORGANISATIONS
Biochemical Society.
PUBLICATIONS
Papers
17 research papers in peer-reviewed journals 1983-1990.
Caswell, A.M., Whyte, M.P. & Russell, R.G.G. (1991). Hypophosphatasia and the
extracellular metabolism of inorganic pyrophosphate: clinical and laboratory aspects.
C.R.C. Critical Reviews in Clinical Laboratory Science, 28, pp. 175-232. (Review)
Caswell, A.M., Leong, W.S. & Russell, R.G.G. (1991). Evidence for the presence of
P2-purinoceptors at the surface of human articular chondrocytes in monolayer
culture.
Biochimica et Biophysica Acta, 1074, pp. 151-158.
Macfarlane, J.D., Poorthuis, B.J.H.M., Mulivor, R.A. & Caswell, A.M. (1991) Raised
urinary excretion of inorganic pyrophosphate in asymptomatic members of a
hypophosphatasia kindred.
Clinica Chimica Acta, 202, pp. 141-148.
Caswell, A.M., Leong, W.S. & Russell, R.G.G. (1992).
Interleukinhuman articular chondrocytes to
extracellular ATP. Biochimica et Biophysica Acta, 1137, pp. 52-58.
Howell, S., Caswell, A.M., Kenny, A.J. & Turner, A.J. (1993). Membrane peptidases
on human osteoblast-like cells in culture: hydrolysis of calcitonin and hormonal
regulation of endopeptidase-24.11. Biochemical Journal, 290, pp. 159-164.
Leong, W.S., Russell, R.G.G. & Caswell, A.M. (1993). Induction of enhanced
responsiveness of human articular chondrocytes to extracellular ATP by tumour
necrosis factor- Clinical Science, 85, pp. 569-575.
Oyajobi, B.O., Caswell, A.M. & Russell, R.G.G. (1994) Transforming growth factorincreases ecto-nucleoside triphosphate pyrophosphatase activity of human bonederived cells. Journal of Bone and Mineral Research, 9, pp. 99-109.
Oyajobi, B.O., Russell, R.G.G. & Caswell, A.M. (1994). Modulation of ectonucleoside triphosphate (NTP) pyrophosphatase activity of human osteoblast-like
-dihydroxyvitamin D3,
24R,25-dihydroxyvitamin D3, parathyroid hormone and dexamethasone. Journal of
Bone and Mineral Research, 9, pp. 1259-1266.
Leong, W.S., Russell, R.G.G. & Caswell, A.M. (1994). Stimulation of cartilage
resorption by extracellular ATP acting at P2-purinoceptors. Biochimica et Biophysica
Acta, 1201, pp. 298-304.
Mohiti, J., Caswell, A.M. & Walker, J.H. (1995). Calcium-induced relocation of
annexins IV and V in the human osteosarcoma cell line
MG-63. Molecular Membrane Biology 12, pp. 321-329.
Mohiti, J., Caswell, A.M.. Walker, J.H. (1997). The nuclear location of annexin V in
the human osteosarcoma cell line MG-63 depends on serum factors and tyrosine
kinase signaling pathways. Experimental Cell Research, 234, pp. 98-104.
Brown, C.J., Caswell, A.M., Rahman, S., Russell, R.G.G., Buttle, D.J. (1998)
Proteoglycan breakdown from bovine nasal cartilage is increased and from articular
cartilage is decreased, by extracellular ATP. Biochimica et Biophysica Acta, 1362,
pp. 208-220.
Caswell, A.M., West, J. (2002). An investigation into the factors affecting patient
selection of chronic low back management methods, with particular reference to nonutilization of the complimentary therapies, in the United Kingdom. Journal of Back
and Musculoskeletal Rehabilitation, 16, pp. 121-133.
Selected Abstracts
Shafique, M., Caswell, A.M. (2000). Differential effects of P1- and P2-purinoceptor
activation on proliferation of human osteoblasts. In: Proceedings of the 18th
International Congress of Biochemistry and Molecular Biology, July, Birmingham.
Biochemical Society, London, p344 (Abstract).
Caswell, A. (2002) Development of presentations to facilitate visualisation of
biomolecules by students with limited background in chemistry. Comparative
Biochemistry and Physiology, 132A, p.S207.
Caswell, A. & Taylor, J. (2007) Incorporating an e-Portfolio System into the
Assessment of a Personal Development Planning Module – Implications for Delivery.
Proceedings of the Annual Solstice Conference, Edgehill University (Poster
Presentation).
RESEARCH
Purinergic responses in bone, and their role in bone disease.
Previously involved with supervision of one MPhil student, two PhD students and
one student completing a PhD by published work.