NCMM Molecular Medicine Research Course
Course no.:
MF9120BTS - Molecular Medicine (national PhD-level course)
Time:
November 19-30, 2012
Place:
Oslo Research Park, Level 2, Lecture room 10 / B / 205 (see daily plan)
Organized by: Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo
and Oslo University Hospital
Topics and Programme
1. Disease mechanisms and development (11h)
a. Disease mechanisms in cancer
- Molecular pathogenesis of cancer (1h, Lars Akslen)
- Tumor angiogenesis (1h, Lars Akslen)
- Cancer genomics: from risk loci to gene networks and cancer phenotypes (1h, Toni
Hurtado)
- Cancer metabolism and possibilities for targeting (1h, Ian Mills)
- Tumor immune evasion mechanisms (1h, Kjetil Taskén)
- Cancer vaccine strategies (1h, Bjarne Bogen)
b. Patophysiology of excitatory diseases in the brain (Vidar Gundersen) (2h)
c. Disease mechanisms in cardiovascular diseases (2h, Geir Christensen)
d. Epigenetics, genetic imprinting and disease (1h, Philippe Collas)
2. Animal models of disease (6h)
a. Introduction to use of animal disease models (1h, Judith Staerk)
b. Autoimmune diseases and animal models (2h, Ole Petter Rekvig)
c. DNA repair mechanisms, neurodegeneration and aging (1h, Arne Klungland)
d. Animal models in cancer (2h, Martin Jechlinger, EMBL Monterotundo)
3. Biobanks, health registries and biomarker discovery (8h)
a. Use of population biobanks to understand human disease (2h, Kristian Hveem)
b. Predictive medicine: Use of health registries and epidemiology (2h, Steinar Tretli)
c. Cancer biomarkers (2h, Ragnhild Lothe)
d. Biomarkers for early diagnosis and management of heart diseases (2h, Torbjørn
Omland)
4. Imaging disease (6h)
a. Imaging cardiovascular diseases in animal models and patients (2h, Ivar Sjaastad)
b. Brain MR imaging in schizophrenia and bipolar disorder – the linking between risk
genes and behavioral phenotypes? (2h, Ole Andreassen)
c. Multiphoton imaging of brain diseases (2h, Erlend Nagelhus)
5. Drug targeting and pharmacology (8h)
a. Introduction to pharmacology and G-protein-coupled receptors as drug targets (2h,
Finn Olav Levy)
b. Medicinal Chemistry and Drug Development (2h, Jo Klaveness)
c. Basics of Chemical Biology and High throughput screening (2h, Arnaud David)
d. Drug development in colorectal cancer (2h, Stefan Krauss)
6. Structure-based understanding of disease and drug targeting (6 h)
a. Introduction to structural biology (2h, Preben Morth)
b. Demonstration, viewing macromolecular structures (4h)
7. Tailored and personalized medicine (4 h)
a. Introduction to Personalized Medicine (1h, Kjetil Tasken)
b. Sequence-based tumor diagnostics as a means to select alternative, pathway-based
therapies for cancer patients (1h, Ola Myklebost)
c. Tailored breast cancer therapies (2h, Per-Eystein Lønning)
8. Advanced cell-based therapies (6 h)
a. Stem cells and inducible pluripotent cells as basis for future therapies (1h, Judith
Staerk)
b. Cell based therapies in medicine – Laboratory work flow and clinical practice in
cancer treatment (2h, Gunnar Kvalheim)
c. T cell receptor engineering and T cell therapies in cancer (1h, Johanna Olweus)
d. Regenerative Medicine: Organ and cell transplantation, Tissue Engineering (2h, Aksel
Foss, Einar Martin Aandahl, Hanne Scholz)
9. Organizational
a. Introduction and organization (1h, Kjetil Tasken)
b. Student seminars (4h or more, see separate list)
Total 60 hours
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Week 1 Schedule; NCMM Molecular Medicine Research Course
Date
19.11.2012
Day/Room
Mon
Room 10
Time
09.00 – 10.45
19.11.2012
Mon
Room 10
11.00 – 12.45
19.11.2012
Mon
Room 10
Tue
Room 10
14.00 – 15.45
20.11.2012
09.00 – 10.45
20.11.2012
Tue
Room 10
11.00 – 12.45
20.11.2012
Tue
Room 10
14.00 – 15.45
21.11.2012
Wed
Room 10
09.00 – 10.45
Topic
Organizational
Animal disease
models
Drug targeting &
pharmacology
Drug targeting &
pharmacology
Disease
mechanisms
Animal disease
models
Disease
mechanisms
Disease
mechanisms
Tailored and
personalized
medicine
21.11.2012
Wed
Room 10
11.00 – 12.45
21.11.2012
Wed
Room 10
14.00 – 15.45
22.11.2012
Thu
Room 10
09.00 – 10.45
Imaging disease
22.11.2012
Thu
Room 10
Thu
Room 10
Fri
11.00 – 12.45
Animal disease
models
Animal disease
models
Drug targeting &
pharmacology
22.11.2012
23.11.2012
14.00 – 15.45
09.00 – 10.45
Room 205
23.11.2012
Fri
11.00 – 12.45
Room 205
23.11.2012
Fri
14.00 – 15.45
Biobanks, health
registries and
biomarker
discovery
Disease
mechanisms
Drug targeting &
pharmacology
Organizational
Title
Information and
organization
Introduction to use of
animal models
- Introduction to
pharmacology
- G-protein-coupled
receptors as drug targets
Medicinal chemistry and
drug development
-Epigenetics, genetic
imprinting and disease
- Reversible modifications
on RNA; role in disease
- Molecular pathogenesis
of cancer
- Tumor angiogenesis
- Cancer genomics: from
risk loci to gene networks
and cancer phenotypes
- Cancer metabolism and
possibilities for targeting
- Introduction to
Personalized Medicine
-Sequence-based tumor
diagnostics as a means to
select alternative,
pathway-based therapies
for cancer patients
Biomarkers for early
diagnosis and
management of heart
diseases
Disease mechanisms in
cardiovascular diseases
Imaging cardiovascular
diseases in animal models
and patients
Animal models in cancer
Autoimmune diseases and
animal models
Basics of chemical biology
and high-throughput
screening
Drug development in
colorectal cancer
Student seminars
Lecturer
Kjetil Taskén
Judith Staerk
Finn Olav Levy
Jo Klaveness
Philippe Collas
Arne Klungland
Lars Akslen
Lars Akslen
Toni Hurtado
Ian Mills
Kjetil Tasken
Ola Myklebost
Torbjørn
Omland
Geir
Christensen &
Ida G. Lunde
Ivar Sjaastad
Martin
Jechlinger
Ole Petter
Rekvik
Arnaud David
Stefan Krauss
All students
Room 205
Page 3 of 5
Week 2 Schedule; NCMM Molecular Medicine Research Course
Date
26.11.2012
Day/Room
Mon
Room B
Time
09.00 – 10.45
26.11.2012
Mon
Room B
11.00 – 12.45
26.11.2012
Mon
Room B
Tue
Room B
14.00 – 15.45
27.11.2012
Tue
Room B
11.00 – 12.45
27.11.2012
Tue
Room B
14.00 – 15.45
28.11.2012
Wed
Room 10
09.00 – 10.45
28.11.2012
Wed
Room B
11.00 – 12.45
28.11.2012
Wed
Room B
14.00 – 15.45
29.11.2012
Thu
Room B
09.00 – 10.45
27.11.2012
09.00 – 10.45
Topic
Biobanks, health
registries and
biomarker
discovery
Biobanks, health
registries and
biomarker
discovery
Imaging disease
Biobanks, health
registries and
biomarker
discovery
Tailored and
personalized
medicine
Imaging disease
Structure-based
understanding of
disease
Structure-based
understanding of
disease
Structure-based
understanding of
disease
Advanced cellbased therapies
29.11.2012
Thu
Room B
11.00 – 12.45
Advanced cellbased therapies
29.11.2012
Thu
Room B
14.00 – 15.45
Disease
mechanisms
30.11.2012
Fri
09.00 – 10.45
Room 205
30.11.2012
Fri
11.00 – 12.45
Disease
mechanisms
14.00 – 15.45
Organizational
Room 205
30.11.2012
Fri
Advanced cellbased therapies
Title
Predictive medicine: Use
of health registries and
epidemiology
Lecturer
Steinar Tretli
Use of population
biobanks to understand
human disease
Kristian Hveem
Multiphoton imaging of
brain diseases
Cancer biomarker
discovery - with focus on
colorectal cancer
Erlend A.
Nagelhus
Ragnhild Lothe
Tailored breast cancer
therapies
Per Eystein
Lønning
Brain MR imaging in
schizophrenia and bipolar
disorder – the linking
between risk genes and
behavioral phenotypes?
Introduction to structural
biology
Ole A.
Andreassen
Demonstration: Viewing
structures of
macromolecules
Demonstration: Viewing
structures of
macromolecules
- Stem cells and inducible
pluripotent cells as basis
for future therapies
- T cell-based
immunotherapy in cancer
Cell based therapies –
Laboratory work flow and
clinical practice
- Tumor immune evasion
mechanisms
- Cancer vaccine strategies
Regenerative medicine:
- Kidney and liver
transplantation;
- Langerhans islet cell
transplantation
- Tissue Engineering
Patophysiology of
excitatory diseases in the
brain
Student seminars
J. Preben Morth
and others
J. Preben Morth
J. Preben Morth
and others
Judith Staerk
Johanna
Olweus
Gunnar
Kvalheim
Kjetil Taskén
Bjarne Bogen
Einar Martin
Aandahl
Hanne Scholz
Aksel Foss
Vidar
Gundersen
All students
Room 205
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Contacts:
Course responsible: Kjetil Taskén and NCMM Group Leaders
Kjetil Tasken, mobile: 90860759, email: kjetil.tasken@ncmm.uio.no
Erlend Nagelhus, mobile: 91736316, email: e.a.nagelhus@ncmm.uio.no
Ian Mills, mobile: 91865854, email: i.g.mills@ncmm.uio.no
J. Preben Morth, mobile: 41295885,email: j.p-morth@ncmm.uio.no
Toni Hurtado, mobile: 97613994, email: a.h.rodriguez@ncmm.uio.no
Judith Staerk, mobile: 94235011, email: judith.staerk@ncmm.uio.no
Admin: Berit Barkley, tel 22 84 05 49, mobile: 99 35 56 41, email: berit.barkley@biotek.uio.no
IT: Cheng Gang, mob 46262945; Melaku Tadesse: mob 91773924; Jean Lorentzen: mob 95722238
Contact for Programme and Student Seminars: see distribution on days below
Week 1
19.11.2012: Judith Staerk
20.11.2012: Toni Hurtado
21.11.2012: J. Preben Morth
22.11.2012: Ian Mills
23.11.2012: Toni Hurtado
Week 2
26.11.2012: Erlend Nagelhus
27.11.2012: Ian Mills
28.11.2012: J. Preben Morth
29.11.2012: Judith Staerk
30.11.2012: Erlend Nagelhus
Page 5 of 5