Online Appendix for the following JACC article
TITLE: Effect of Serelaxin on Cardiac, Renal and Hepatic Biomarkers in the RELAXAHF Development Program: Correlation With Outcome
AUTHORS:
Marco Metra, M.D.
Gad Cotter, M.D.
Beth A. Davison, Ph.D.
G. Michael Felker, M.D., M.H.S.
Gerasimos Filippatos, M.D.
Barry H. Greenberg, M.D.
Piotr Ponikowski, M.D., Ph.D.
Elaine Unemori, Ph.D.
Adriaan A. Voors, M.D., Ph.D.
Kirkwood F. Adams, Jr., M.D.
Maria Dorobantu, M.D.
Liliana Grinfeld, M.D.
Guillaume Jondeau, M.D.
Alon Marmor, M.D.
Josep Masip, M.D.
Peter S. Pang, M.D.
Karl Werdan, M.D.
Margaret F. Prescott, Ph.D.
Christopher Edwards
Samuel L. Teichman, M.D.
Angelo Trapani, Ph.D.
Christopher A. Bush, Ph.D.
Rajnish Saini, M.D.
Christoph Schumacher, Ph.D.
Thomas Severin, M.D.
John R. Teerlink, M.D.
for the RELAXin in Acute Heart Failure (RELAX-AHF) Investigators
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Supplemental Material:
Study Personnel
Executive Committee: Marco Metra, M.D. (Co-Chairperson; University of Brescia, Brescia,
Italy); John R. Teerlink, M.D. (Co-Chairperson; University of California at San Francisco and
San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA);
Gad Cotter, M.D. (Momentum Research Inc., Durham, NC, USA); Beth A. Davison, Ph.D.
(Momentum Research Inc., Durham, NC, USA); G. Michael Felker, M.D., M.H.S. (Duke
University School of Medicine and Duke Heart Center, Durham, NC, USA); Gerasimos
Filippatos, M.D. (Athens University Hospital, Attikon, Athens, Greece); Barry H. Greenberg,
M.D. (University of California at San Diego, San Diego, CA, USA); Piotr Ponikowski, M.D.,
Ph.D. (Medical University, Clinical Military Hospital, Wroclaw, Poland); Thomas Severin, M.D.
(Novartis Pharma AG, Basel, Switzerland); Sam L. Teichman, M.D. (Corthera, Inc., San Carlos,
CA, USA); Elaine Unemori, Ph.D. (Corthera, Inc., San Carlos, CA, USA); Adriaan A. Voors,
M.D., Ph.D. (University of Groningen, Groningen, the Netherlands).
Steering Committee: Kirkwood F. Adams, Jr., M.D. (University of North Carolina, Chapel Hill,
NC, USA); Maria Dorobantu, M.D. ("Floreasca" Emergency Clinical Hospital, Bucharest,
Romania); Liliana Grinfeld, M.D. (Hospital Italiano, Buenos Aires, Argentina); Guillaume
Jondeau, M.D. (Hôpital Bichat, Paris, France); Alon Marmor, M.D. (Ziv Medical Center, Safed,
Israel); Josep Masip, M.D. (Consorci Sanitari Integral, University of Barcelona, Barcelona,
Spain); Peter S. Pang, M.D. (Northwestern University, Chicago, IL, USA); Karl Werdan, M.D.
(Martin-Luther-Universität Halle-Wittenberg, Halle, Germany).
Data and Safety Monitoring Board: Barry M. Massie (Chairperson; University of California at
San Francisco and San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA);
Michael Böhm, M.D. (Klinik fur Innere Medizin III Kardiologie, Hamburg, Germany); Sidney
Goldstein, M.D. (Henry Ford Hospital, Detroit, MI, USA); Gary Francis, M.D. (University of
Minnesota, Minneapolis, MN, USA).
Clinical Events Committee: G. Michael Felker, M.D., M.H.S. (Chairperson; Duke Clinical
Research Institute, Durham, NC, USA); Javed Butler, M.D. (Emory University Hospital Center
for Heart, Atlanta, GA, USA); Adrian F. Hernandez, M.D. (Duke Clinical Research Institute,
Durham, NC, USA); Alan B. Miller, M.D. (University of Florida Health Sciences Center,
Jacksonville, FL, USA).
Statistical analysis: Beth A. Davison, Ph.D. (Momentum Research Inc., Durham, NC, USA);
Christopher A. Bush, Ph.D. (Novartis Pharmaceuticals Corp., East Hanover, NJ, USA); Corinne
Miede (Accovion GmBH, Marburg, Germany); Christopher Edwards (Momentum Research Inc.,
Durham, NC, USA)
Data management: Leslie Quinn (Momentum Research Inc., Durham, NC, USA); Margaret
Prescott (Novartis Pharmaceuticals Corp., East Hanover, NJ, USA); Kim New (Pharm-Olam
International, Durham, NC, USA); Kristie Barnes (Pharm-Olam International, Durham, NC,
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USA); Jason Pottratz (Clinical Reference Laboratory Corp., Lenexa, KS, USA); Sandra Malynn,
Ph.D. (ICON Central Laboratories, Farmingdale, NY, USA)
Investigative sites by Country (alphabetical order): Investigators in descending order of
patients enrolled (affiliation, city):
Argentina (71): Gustavo Maria Ferrari, M.D. (Hospital Britanico de Buenos Aires, Buenos
Aires); Ariel Quiroga, M.D. (Hospital Español, Rosario); Alberto Fernandez, M.D. (Sanatorio
Modelo de Quilmes, Quilmes); Eduardo Perna, M.D. (Instituto de Cardiologia de Corrientes "J.
F. Cabral", Corrientes); María Silvina Ramos, M.D. (Clinica Constituyentes, Moron); Luis
Guzman, M.D. (Sanatorio Allende, Cordoba); Guillermo Cursack, M.D. (Instituto
Cardiovascular de Rosario, Rosario - Santa Fe); Oscar Allall, M.D. (Hospital Cordoba,
Cordoba); Marcelo Gustavo Masuelli, M.D. (Complejo Medico de la Policia Dederal Argentina
Churruca Visca, Buenos Aires); Carlos Rapallo, M.D. (Sanatorio Itoiz S.A., Avellaneda).
France (21): Alain Cohen-Solal, M.D., Ph.D. (Hopital Lariboisiere, Paris); Michel Galinier, M.D.
(CHU de Rangueil, Toulouse); Guillaume Jondeau, M.D., Ph.D. (Hôpital Bichat, Paris); Richard
Isnard, M.D., Ph.D. (Hopital Pitie-Salpêtrière, Paris).
Germany (78): Hans-Georg Olbrich, M.D. (Asklepios Klinik Langen, Langen); Veselin Mitrovic,
M.D. (Kerckhoff-Klinik GmbH, Bad Nauheim); Karl Werdan, M.D. (Martin-Luther-Universität
Halle-Wittenberg, Halle); Stephan Felix, M.D. (Universitätsklinikum der Ernst-Moritz-ArndtUniversität Greifswald, Greifswald); Thomas Heitzer, M.D. (Klinikum Dortmund); Gerhard
Cieslinski, M.D. (Krankenhaus Nordwest GmbH, Frankfurt am Main); Karl Stangl, M.D.
(Charité - Universitätsmedizin Berlin, Berlin).
Hungary (151): János Tomcsányi, M.D., Ph.D. (Budai Irgalmasrendi Korhaz, Budapest); Dezso
Apró, M.D. (Allami Szivkorhaz, Balatonfured); Kálmán Tóth, M.D., Ph.D., Sc.D., F.E.S.C.
(Pecsi Tudomanyegyetem Klinikai Kozpont, Pecs); András Vértes, M.D. (Egyesített Szent István
és Szent László Kórház-Rendelőintézet, Budapest); Géza Lupkovics, M.D., Ph.D. (Zala Megyei
Korhaz, Zalaegerszeg); Zoltán László, M.D., Ph.D. (Fővárosi Önkormányzat Szent János
Kórháza, Budapest); Attila Cziraki, M.D., Ph.D. (Pécsi Tudományegyetem, Szívgyógyászati
Klinika, Pécs).
Israel (210): Alon Marmor, M.D. (Ziv Medical Center, Safed); Sorel Goland, M.D. (Kaplan
Medical Center, Rehovot); Amos Katz, M.D. (Barzilai Medical Center, Ashkelon); Reuven
Zimlichman, M.D. (Wolfson Medical Center, Holon); Doron Aronson, M.D. (Rambam Health
Care Campus, Haifa); Adi Butnaru, M.D. (Shaare-Zedek Medical Center, Jerusalem); Muhamad
Omary, M.D. (Nazareth Hospital EMMS, Nazareth); Xavier Alejandro Piltz, M.D. (Bikur
Cholim Hospital, Jerusalem); Doron Zahger, M.D. (Soroka University Medical Center, BeerSheva).
Italy (77): Marco Metra, M.D. (Azienda Ospedaliera Spedali Civili di Brescia, Brescia); Andrea
Mortara, M.D. (Policlinico di Monza, Monza); Manrico Balbi, M.D. (Azienda Ospedaliera
Universitaria "San Martino", Genova); Franco Cosmi, M.D. (Ospedale Valdichiana Santa
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Margherita, Cortona); Salvatore DiSomma, M.D., (Azienda Ospedaliera S. Andrea, Roma);
Maria Cristiana Brunazzi, M.D. (Ospedale Civile “Destra Secchia”, Pieve di Coriano Mantova).
Netherlands (10): Adriaan A. Voors, M.D., Ph.D. (University Medical Center Groningen,
Groningen); Peter E.F. Bendermacher, M.D. (Elkerliek, Helmond); Gert-Jan Milhous, M.D.
(Beatrix Ziekenhuis, Banneweg); Paul L. van Haelst, M.D., Ph.D. (Antonius Ziekenhuis,
Hanzeplein); Peter Dunselman, M.D. (Amphia Ziekenhuis, Breda).
Poland (258): Piotr Ponikowski, M.D., Ph.D. (Osrodek Chrob Serca, 4 Wojskowy Szpital
Kliniczny, Wroclaw); Piotr Jankowski, M.D. (Sadmodzielny Publiczny Zaklad Opieki
Zdrowotnej Szpital Uniwersytecki w Krakowie, Krakow); Andrzej Wysokinski, M.D., Ph.D.
(Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie, Lublin); Miroslaw Dluzniewski,
M.D., Ph.D. (Wojewodzki Szpital Brodnowski, Warszawa); Janina Stepinska, M.D., Ph.D.
(Instytut Kardiologii im. Prymasa Tysiaclecia Stefana Kardynala Wyszynskiego, Warszawa);
Wieslawa Tracz, M.D., Ph.D. (Krakowski Szpital Specjalistyczny im. Jana Pawla II, Krakow);
Maria Krzeminska-Pakula, M.D., Ph.D. (Wojewodzki Specjalistyczny Szpital im. WI.
Bieganskiego, Lodz); Jacek Grzybowski, M.D., Ph.D. (Instytut Kardiologii im. Prymasa
Tysiaclecia Stefana Kardynala Wyszynskiego, Warszawa); Krystyna Loboz-Grudzien, M.D.,
Ph.D. (Dolnoslaski Szpital Specjalistyczny im. T. Marciniaka, Wroclaw).
Romania (153): Dan-Domenic Ionescu, M.D., Ph.D. (Craiova Cardiology Centre, Craiova);
Costel Sorin Stamate, M.D., Ph.D. ("Sf. Pantelimon" Emergency Clinical Hospital, Bucharest);
Maria Dorobantu, M.D., Ph.D. ("Floreasca" Emergency Clinical Hospital, Bucharest); Calin Pop,
M.D., Ph.D. ("Dr. Constantin Opris" Emergency Clinical County Hospital, Baia Mare); Adrian
Matei, M.D., Ph.D. (Cardiovascular Diseases and Transplant Institute, Targu Mures); Tiberiu
Nanea, M.D., Ph.D. (Caritas Clinical Hospital, Bucharest); Mariana Radoi, M.D., Ph.D. (Brasov
Emergency Clinical County Hospital, Brasov); Adriana Salajan, M.D., Ph.D. (Oradea
Emergency Clinical County Hospital, Oradea).
Spain (18): Josep Masip, M.D., Ph.D. (Hospital Sant Joan Despí Moises Broggi, Barcelona);
Domingo Pascual, M.D., Ph.D. (Hospital Universitario Virgen de la Arrixaca, El Palmar –
Murcia); Manuel Gomez Bueno, M.D., Ph.D. (H. Puerta de Hierrro de Majadahonda,
Majadahonda); Roberto Muñoz, M.D., Ph.D. (Hospital Infanta Leonor, Madrid).
United States of America (114): Sheba Meymandi, M.D. (Olive View-UCLA Medical Center,
Sylmar, CA); Philip Levy, M.D., M.P.H. (Wayne State University/ Detroit Receiving Hospital,
Detroit, MI); Peter Pang, M.D. (Northwestern University, Chicago, IL); Craig Clark, D.O. (Iowa
Health Cardiology, Des Moines, IA); Gregory Fermann, M.D. (University of Cincinnati
University Hospital, Cincinnati, OH); Kirkwood Adams, Jr., M.D. (University of North Carolina,
Chapel Hill, NC); Biykem Bozkurt, M.D., Ph.D. (Baylor College of Medicine/ Michael E
DeBakey VA Medical Center, Houston, TX); James Fulmer, M.D. (River City Clinical Research,
Jacksonville, FL); Donna Mancini, M.D. (New York Presbyterian Hospital - Columbia
University Medical Center, New York, NY); Timothy Vittorio, M.S., M.D. (Mount Sinai
Medical Center, New York, NY); Ronald Zolty, M.D., Ph.D. (Albert Einstein College of
Medicine, Bronx, NY); Barry Greenberg, M.D., (University of California San Diego Medical
Center, La Jolla, CA); Eugene Chung, M.D. (The Lindner Research Center, Cincinnati, OH);
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Viorel Florea, M.D., Ph.D., Sc.D. (Minneapolis VA Medical Center, Minneapolis, MN); John
Heilman, III, M.D. (Black Hills Cardiovascular Research, Rapid City, SD); Alan Storrow, M.D.
(Vanderbilt University Medical Center, Nashville, TN); Maria Rosa Costanzo, M.D. (Midwest
Heart Foundation, Oakbrook Terrace, IL); Gervasio Lamas, M.D. (Mount Sinai Medical Center,
Miami Beach, FL); Mitchell Greenspan, M.D. (Grand View - Lehigh Valley Health Services,
Sellersville, PA); Marc Klapholz, M.D. (University of Medicine and Dentistry of New Jersey,
New Jersey Medical School, Newark, NJ); Joaquin Martinez-Arraras, M.D. (Amarillo Heart
Clinical Research Institute Inc., Amarillo, TX); Wm. Frank Peacock, M.D. (The Cleveland
Clinic, Cleveland, OH); Nizar Saleh, M.D. (St. Mary's Duluth Clinic Health System, Duluth,
MN); Roy Small, M.D. (Lancaster Heart & Stroke Foundation, Lancaster, PA); John R. Teerlink,
M.D. (San Francisco Veterans Affairs Medical Center and University of California at San
Francisco, San Francisco, CA); Benjamin Trichon, M.D. (Asheville Cardiology Associates,
Asheville, NC); Detlef Wencker, M.D. (Hartford Hospital University of Connecticut, Hartford,
CT).
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