GENETICS 2 June Plenary presentations: 9.30-11.00 Co-Chairmen: S.G. Inge-Vechtomov, M. Lynch S.G. Inge-Vechtomov (St. Petersburg St. Un.; St. Petersburg Branch of Vavilov Inst. of General Genetics, RAS, St. Petersburg, Russia) (30 min) Template principle in biology M. Lynch (Dept. of Biology, Indiana Un. Bloomington, Indiana USA) (30 min) Evolution of the mutation rate A.A. Rubel et al. (St. Petersburg St. Un., St. Petersburg, Russia; Georgia Inst. Tech., Atlanta, Georgia, USA) (30 min) Protein assembly disorders and protein-based inheritance 11.20-13.00 Co-Chairmen: I.A. Tikhonovich, M.S. Gelfand I. Kulakovsky (Engelhardt Institute of Molecular Biology; Vavilov Institute of General Genetics, Moscow, Russia) (30 min) Is there a nucleotide-level genetic code for gene expression control? Yu. Pavlov (Eppley Inst. for Research in Cancer, Un. of Nebraska Med. Center, USA) (30 min) Mechanisms of global and region-specific control of mutagenesis N.A. Kolchanov (Institute of Cytology and Genetics SB RAS, Novosibirk, Russia) (30 min) Evolution of regulatory genetics systems 2 JUNE Oral presentations: Mechanisms of genetic processes 15.00-17.00 Co-Chairmen: Yu. Pavlov, I. Kulakovsky N.A. Koltovaya (Joint Inst. for Nuclear Research, Dubna, Russia) (20 min) Genome stability: genetic and epigenetic factors Lada A.G. et al. (St. Petersburg State Un., St. Petersburg, Russia; Eppley Inst. for Research in Cancer and Allied Diseases, Un. of Nebraska Medical Center, Omaha, Nebraska, USA) (20 min) Transcription determines the landscape and clustering of mutations induced in diploid yeast by aid/apobec deaminases Nizhnikov A. A., Antonets K.S. (St. Petersburg St. Un.; St. Petersburg Branch of Vavilov Inst. of General Genetics, RAS. St. Petersburg, Russia) (20 min) Screenings for novel amyloid-forming proteins in bacteria Escherichia coli Aksenova A.Y. et al. (Department of Biology, Tufts Un., Medford, MA, USA; St. Petersburg St. Un., St. Petersburg, Russia) (20 min) Instability of interstitial telomeric sequences 17.20 -18.00 N. Koltovaya, A.A. Nizhnikov Khlestkina E.K. Shoeva O. (Inst. of Cytology and Genetics SB RAS, Novosibirsk, Russia) (20 min) Organization and evolution of the duplicated flavonoid biosynthesis genes in triticeae Proshkina E.N. et al. (Inst. of Biology of Komi Science Center of Ural Branch of RAS; Syktyvkar St. Un., Syktyvkar; Moscow Inst. of Physics and Technology, Dolgoprudny; Engelhardt Inst. of Molecular Biology, RAS, Moscow, Russia) (20 min) The influence of the activity of DNA damage recognition and repair genes on the lifespan of Drosophila melanogaster 4 JUNE Oral presentations: Cancer genetics & Cancer therapy 15.00-17.00 Co-Chairmen: M. Rosemann, L. Bullinger Rosemann M. (Helmholtz Center Munich, German Research Center for Environmental Health Inst. of Radiat. Biol., Munich, Germany) (30 min) Stem cells and radiation effects Sander S., van Chu T., Rajewsky K. (Immune Regulation and Cancer, Max-DelbrückCenter for Molecular Medicine in the Helmholtz Association, Berlin, Germany) (30 min) From cancer genetics to targeted therapies - modeling human lymphoma pathogenesis in mice Bullinger L. (Department of Internal Medicine III, University of Ulm, Germany) (30 min) Acute myeloid leukemia leads the way in molecular cancer genetics: precision medicine at reach? Ayinde F., Zyuzikov N. (University of the West Indies, St Augustine, Trinidad and Tobago) Tumour treating fields - new type of cancer therapy (30 min) 17.20-18.00 Co-Chairmen: N.A. Zyuzikov, Sander S. Evstratova E.S., et al. (A. Tsyb Scientific Research Centre of Radiology of the Hertsen Federal Medical Research Centre of the Ministry of Health of the RF, Obninsk, Russia) (20 min) Radiobiological basis of densely ionizing radiation application in nuclear medicine 2 JUNE Poster session: Mechanisms of genetic processes 13.00-14.00 Akbarova G. (Khazar University, Baku, Azerbaijan) The correction of the UV-induced mutagenesis by extract from kiwi fruit Aliev K., Partoev K., Naimov A.(Inst. of Botany, Plant Physiology and Genetic of Academy Science of the Republic of Tajikistan) Combining of recombination methods with biotechnology in potato breeding in Tajikistan Andreychuk Y.V. et al (St.Petersburg St. Un.; St.Petersburg Branch of Vavilov Institute of General Genetics, RAS, St. Petersburg, Russia) Prion [PSI+] has an impact in the control of genome stability in yeast Saccharomyces cerevisiae Antonets K.S., Drozdova P.B., Nizhnikov A.A. (St.Petersburg St. Un.; St.Petersburg Branch of Vavilov Institute of General Genetics, RAS, St. Petersburg, Russia) Amyloidogenic properties of archeal proteins depend on environmental conditions Antosyuk O.N., Marvin N.A., Shihova S.V. (Ural Federal Un. named after the first President of Russia B.N. Yeltsin, Yekaterinburg, Russia) The influence of the long direct selection on a mutagenesis of hetezygotes vg+vg. Dobrovolskaya E., et al. (Inst. of Biology of Komi Science Center of Ural Branch of RAS, Syktyvkar; Syktyvkar St. Un., Syktyvkar; Moscow Inst. of Physics and Technology, Russia) Caloric restriction influences lifespan of Drosophila melanogaster individuals whose genes controlling circadian rhythms are overexpressed in peripheral tissues Golyasnaya N.V, Tsvetkova N.A (Inst. of Ecology and Genetics of Microorganisms, Ural Branch of RAS, Perm, Russia) Nucleotide sequence context and mutability of Escherichia coli genes Kliver S., Lada A., Pavlov Y. (St. Petersburg St. Un., Russia; Eppley Inst. for Research in Cancer and Allied Diseases, Un. of Nebraska Medical Center, Omaha, Nebraska, USA) Genome-wide identification of mutation clustering using a new hierarchical method Partoev K., et al (Inst. of Botany, Plant Physiology and Genetics of the Academy of Sciences of the Republic of Tajikistan; Centre of Innovative Development of Sciences and New Technologies of the Academy Science of the Republic of Tajikistan) Crossing and grafting of American artichoke (Helianthus tuberosus l.) with sunflower (Helianthus annuus l.) in the conditions of Tajikistan Proshkina E.N. et al. (Inst. of Biology of Komi Science Center of Ural Branch of RAS; Syktyvkar St. Un., Syktyvkar; Moscow Inst. of Physics and Technology, Dolgoprudny; Engelhardt Inst. of Molecular Biology, RAS, Moscow, Russia) (20 min) The influence of the activity of DNA damage recognition and repair genes on the lifespan of Drosophila melanogaster Shiriaeva A.A., et al (St.Petersburg St. Un.; St.Petersburg Branch of Vavilov Institute of General Genetics, RAS, St. Petersburg, Russia) The origin of sterile cytoductants obtained in the alpha-test Stepchenkova E.I., Tarakhovskaya E.R., Pavlov Y.I. (St. Petersburg St. Un.,; St. Petersburg Branch of Vavilov Institute of General Genetics, RAS, St. Petersburg, Russia; Un. of Nebraska Medical Center, USA) Fe-S clusters associated with the C-terminus of the DNA polymerase delta are essential for DNA polymerases switch and in this way control spontaneous and induced mutagenesis Tsvetkova N.A., Golyasnaya N.V. (Institute of Ecology and Genetics of Microorganisms, Ural Branch of RAS, Perm, Russia) Antibiotic resistance of strains Pseudomonas aeruginosa ATCC 27853 and small-colony variants Yakovlev A, et al (Russian Inst. of Genetics and Breeding FANO, St-Petersburg, Russia) The use of DNA technology to monitor genetic heterogeneity in broiler lines Zhuk A.,et al (St.Petersburg St. Un.; St.Petersburg Branch of Vavilov Institute of General Genetics, RAS, St. Petersburg, Russia) Molecular nature of primary DNA lesions detected in the alpha-test 2 JUNE Poster session: Cancer genetics & Cancer therapy 13.00-14.00 Ameliyanovich M. D.( Inst. of Genetics and Cytology NAS Belarus, Minsk, Belarus) Association between metabolic syndrome and gene polymorphism in Belarusian population Djansugurova L., et al (Inst. of General Genetics and Cytology, SC MES RK, Almaty, Kazakhstan) Analysis of critical regions of candidate genes for familial and sporadic colorectal cancer cases Makarenko S.A., Zamulaeva I.A (A. Tsyb Scientific Research Centre of Radiology of the Hertsen Federal Medical Research Centre of the Ministry of Health of the RF, Obninsk, Russia) Realization cytogenetic damage in irradiated human cells for additional action of comutagen Effects of photodynamic therapy on cancer stem cells (CSCs) in vitro Pylypchuk E.P, Domina E.A (R.E. Kavetsky Experimental Pathology, Oncology and Radiobiology Inst., NAS of Ukraine, Kiev, Ukraine) Realization of cytogenetic damage in irradiated human cells for additional action of comutagen Pronyushkina K.A., et al (A.Tsyb Medical Radiological Research Center, P. Hertsen Federal Medical Research Center Branch, Ministry of Health of the RF, Obninsk; Inst. of Carcinogenesis, Blokhin Cancer Research Center, RAMS, Moscow; Engelhardt Inst. of Molecular Biology, RAS, Moscow, Russia) Radiomodifying effect of dimeric bisbenzimidazoles on cancer stem cells (CSCs) of breast adenicarcinoma line MCF-7 Vorobtzova I., Semenov A., et al. (Federal State Institution Russian Research Center for Radiology and Surgical Technologies, St. Petersburg, Russia) Fish analysis of exfoliated urine cells for detection of bladder cancer Vyazovskaya N.S., Rusinova G.G., Azizova T.V. (Southern Urals Biophysics Institute Ozyorsk, Russia) Role of CYP1A1 polymorphism of cytochrome P450 family genes in susceptibility to lung cancer in Mayak PA workers Zimatkina T.I., Goncov A.I. (Grodno State Medical University, Grodno, Belarus) Ecologo-hygienic approaches to restriction of the medical irradiation for prevention of the development of the malignant tumors 4 JUNE Discussion: Variability laws 17.20- 17.40