List of Funded Projects SIRG Awards SFI Research Scientist Subhadip Bodhak Total Award Multifunctional Nanofibrous Patch for Intervertebral Disc Regeneration 518,923.00 Genome-scale analysis of mammalian cell factories: Parallel multi-omic characterisation of CHO cells to enhance biopharmaceutical production. 515,033.00 Colin Clarke NUI Galway National Institute for Bioprocessing Research & Training Annie Curtis Trinity College Dublin A New Dimension to the Immune Response: Biological Molecular Clocks Controlling Inflammation. 519,652.00 Norman Davey University College Dublin Decoding the regulatory landscape of the intrinsically disordered proteome. 463,797.00 Ruslan Dmitriev University College Cork Development of bionic sensor materials for metabolic imaging in regenerative medicine 516,756.00 Stephen Dooley University of Limerick Realistic Reaction Kinetics Models for the Production of Platform Chemicals and Designer Fuels from Biomass 518,367.00 Tobias Engel Royal College of Suregeons Novel treatments and diagnostics for epilepsy via the ATPgated P2X7 receptor Investigating the capacity for multipotent adult progenitor cells to prolong graft survival through modulation of homeostatic proliferation Karen English Radka Fahey NUI Maynooth National Institute for Bioprocessing Research & Training 519,890.00 456,996.00 Epigenetic regulation of glycosylation and the impact on chemo-resistance in cancer 519,235.00 513,642.00 Sebastian Gornik NUI Galway The epigenetic basis of stem cell maintenance and cellular differentiation in the cnidarian Hydractinia Patrick Hayden Dublin City University Confined Time-Resolved Vacuum Ultraviolet (VUV) Laser Induced Breakdown Spectroscopy for Pharmaceutical Applications 475,483.00 Alex von Kriegsheim University College Dublin Knocking the Wnt out of Colon Cancer: Role of prolyl/asparaginyl-hydroxylases in colon cancer initiation 519,592.00 Eva JimenezMateos Royal College of Suregeons microRNA in the pathogenesis and prognosis of neonatal brain injury 519,635.00 NUI Galway Leveraging the Evolutionary Epigenetic Landscape for Understanding Regulatory Mechanisms of Abiotic Stress Tolerance 519,957.00 Avelino Alvarez Ordonez Teagasc New weapons to fight old enemies – biocontrol of spoilage and pathogenic bacteria in the dairy industry with novel inhibitors of quorum sensing and biofilm formation 519,532.00 Frederick Sheedy Trinity College Dublin Targeting microRNA to drive a successful host response to Mycobacterium tuberculosis – engineering a better vaccine 519,598.00 Michael Scanlon University College Cork Designing Reactive Functionalised Soft Interfaces – Selfhealing soft materials for solar energy conversion, energy storage, and sustainable low cost hydrogen production 509,092.00 Margaretha van der Merwe Orla O'Sullivan Teagasc Investigating the impact of high intensity exercise and/or protein intake levels on gut microbial diversity. 520,000.00 Stefan Schulz Tyndall National Institute Shaping the electronic and optical properties of non- and semi-polar nitride-based semiconductor nanostructures 448,328.00 Roles of histone demethylase complexes in the control of fungal development and secondary metabolite production 597,630.00 An Analytical Platform for Early Stage Developability Assessment of Monoclonal Antibodies – How ‘Manufacturable’ is a mAb Candidate? 609,205.00 629,241.00 2013 CDA Approved Awards Ozgur Bayram Jonathan Bones NUI Maynooth National Institute for Bioprocessing Research & Training Annette Byrne Royal College of Suregeons ColoForetell: A Xenopatient Discovery Platform for the integrated Systems based Identification of Predictive Biomarkers for Targeted Therapies in Metastatic Colorectal Cancer Gianpiero Cavalleri Royal College of Suregeons Genetic biomarkers for epilepsy predisposition and treatment 624,038.00 Paula Colavita Trinity College Dublin Rational design of amorphous carbon materials for the control of interfacial charge transfer and catalytic properties 623,662.00 Peter Crowley NUI Galway Supramolecular Approaches to Protein Surface Recognition and Self Assembly 619,488.00 David Finlay Trinity College Dublin Investigating Natural Killer (NK) cell metabolism as a determinant of NK cell anti-tumour activity 647,465.00 Mark Flanagan University College Dublin Signal-Space Cooperative Relaying Techniques for Future Wireless Networks (CooperaNET) 580,174.00 Jamie Goggins NUI Galway Achieving nearly zero energy buildings - A life cycle assessment approach to retrofitting existing buildings (acronym: nZEB-RETROFIT) 631,932.00 Fatima Gunning Tyndall National Institute Software Defined Control of Superchannel Transponders for super-Tb/s Elastic Optical Networks 812,153.00 David Henry University College Cork Nonlinear wave-current interactions in the nearshore: addressing the role of vorticity and nonlinearity in the modelling of ocean energy 571,802.00 Sarah Hudson University of Limerick Bio-availing of Antimicrobial Resources 617,510.00 Patrick Kiely University of Limerick Targeting RACK1 as a dynamic cog downstream of growth factor and adhesion signalling. 636,313.00 Caitriona Lally Dublin City University Fundamental Insights into Load Induced Fibre Remodelling in Arterial Tissue; Applications in Vascular Tissue Engineering and Medical Device Development 615,559.00 Sergei Lebedev Dublin Institute of Advanced Studies Structure and seismicity of Ireland's crust 535,539.00 Rachel McDonnell Trinity College Dublin Game Face: Perceptually Optimised Real-Time Facial Animation 533,615.00 Aoife Morrin Dublin City University SSCIN – Sensing SubCutaneously INvitro - New paradigms to overcome invasive diagnostics 643,026.00 Ken Nally University College Cork Identification of the Molecular Pathways that Mediate Cytokine Induced Immunopathology of the Gut Epithelium 648,643.00 Thomas Naughton NUI Maynooth Three-dimensional microbiological imaging, automated analysis, and display using digital holography 611,421.00 Christophe Silien University of Limerick Nonlinear optical micro-spectroscopy for multiplex suspension immunoassay 576,618.00 Jiafu Wang Dublin City University Novel long-acting biotherapeutics targeted to sensory neurons and/or inflammatory cells for treating chronic neuropathic and inflammatory pain 557,321.00 Kaye Burgess Teagasc Examining the ecology of verocytotoxigenic E. coli (VTEC) and the impact of the native microbiome on VTEC persistence in the primary production chain 618,823.00 Brian Kelleher Dublin City University Microbial uptake of atmospheric carbon in soil: can it be managed to sequester carbon and sustain soil quality? 633,499.00 Steven Kerrigan Royal College of Surgeons Ireland Endothelial dysfunction in severe blood stream infection 593,138.00 Brian MacNamee Dublin Institute of Technology DeepNovelty: Using Deep Learning for Novelty Detection 494,942.00 Markus Rehm Royal College of Surgeons Ireland Improving melanoma treatment and prognosis by deciphering and exploiting an autophagy-dependent pathway towards apoptotic cell death 620,927.00 Sinead Waters Teagasc Development of DNA-based biomarkers for compensatory growth in beef cattle 643,462.00 Elena Blokhina University College Dublin Microscale Energy Harvesting Systems: Nonlinear Analysis and Design Techniques 513,307.00 Ruairí de Fréin Waterford Institute of Technology EOLAS ("Knowledge" in Irish): Efficient monitoring Of Large Scale datacenters 468,541.00 Nathan Jackson Tyndall National Institute Development of Aluminium Nitride based Piezoelectric Materials with enhanced properties for Bio-MEMS applications 512,267.00 Ian Jeffrey University College Cork Development of knowledge abse necessary for novel diagnostic and therapeutic pipeline for the early identification and treatment of rheumatoid arthritis 518,499.00 Stephen Madden Royal College of Suregeons The Molecular Characterisation of Ovarian Cancer 441,806.00 Yuansong Qiao Athlone Institute of Technolgy Application-aware Video Distribution using Software Defined Networking 479,691.00 Reserve List CDA Reserve List SIRG