Press Release: 27 July 2014 Bionorica Executive Board awards EUR 1 million for new approaches in herbal medicines Mallorca, Spain/Neumarkt i.d.OPf.: “I am extremely pleased about this honor because the prize is exactly what I need to further research at scientific institutions in these current times of reduced government support and tight budgets,” says Dr. Birgit Kraus from the Department of Pharmaceutical Biology at the University of Regensburg. Kraus is one of 20 winners at the Global Research Initiative (GRI), which was honored by the Executive Board of German herbal medicines specialist Bionorica at the end of 2013. “I am pleased that so many innovative and promising entries were submitted. Such a large and high-quality response to the first-time call for submissions proves that herbal medicine is gaining further relevance among the scientific community as well,” says Dr. Michael Popp, CEO and owner of the internationally successful manufacturer of scientifically researched herbal medicines, German-based Bionorica SE. Dr. Popp will pay out a total of one million euros for the unique herbal medicine research campaign. He is expecting that the 20 prizes of EUR 50,000 each for research will result in new stimulus for the field of herbal medicine to be able to offer patients an even greater variety of products. “In addition to new analysis processes, the focus is also the search for innovative approaches to new development of herbal medicines,” says pharmacist Dr. Popp. Dr. Andreas Körberle, Institute of Pharmacy, University of Jena The jury reviewed some 129 submissions from various treatment fields, including respiratory diseases, osteoporosis, gynecological diseases, bladder cancer and Alzheimer’s disease, among others. Seven of the prize winners were from Germany. Dr. Johanna Brandner from Hamburg, for example, deals in medicinal herbs from traditional Chinese medicine and their applications in wound healing. “I appreciate Bionorica’s support for my efforts in deciphering molecular mechanisms of phytomedicine. This is a field of research which, despite its essential importance for using the full power of nature for human health was neglected for a long time,“ says prize winner Dr. Andreas Köberle from University of Jena, stressing the importance of the prize for his research on a new pharmacological strategy for inflammation-inhibiting medications. Dr. Johanna M. Brandner, Hamburg-Eppendorf University Medical Center Prize winner Dr. Birgit Kraus, Institute of Pharmacy, University of Regensburg Seven x EUR 50,000 for German junior researchers – 20 international prize winners The 20 prize winners from 13 nations received their awards on Sunday, 27 July 2014, within the scope of the international symposium “Inflammations – Challenges and Opportunities” at the Bionorica Herbal Medicines Competence Center Sa Canova in Sa Pobla, Mallorca. “Creating a connection between nature’s healing powers and state-of-the-art methods in science and technology is something that drives and fascinates me,” says Popp. As a researching pharmaceutical company, Bionorica’s main interest is to continuously further decipher the effectiveness of medicinal plants. “We want to combine the best that nature offers us with the best that humans can achieve. To do this one must understand the medicinal plant world, and that is a never-ending process.” Dr. Popp encouraged this year’s prize winners of the Global Research Initiative to continue venturing into the unknown and going down innovative paths. Bionorica is a manufacturer of herbal medicines and is active in some 50 countries. With its unique quality concept and its focus on consistent standardization of cultivation and production, Bionorica has been able to grow into a worldwide leading company in the promising sector of herbal medicines in the past 15 years. Below is a list of the seven prizes that were awarded to scientists in Germany: Dr. Johanna M. Brandner, Center for Internal Medicine, Clinic for Dermatology and Venerology, University Hospital Hamburg-Eppendorf, Hamburg. Dr. Temuujin Dansranjavin, Andrological Urological Research Laboratory, Clinic and Polyclinic for Urology, University of Gießen Dr. Andreas Köberle, Department of Pharmaceutical/Medical Chemistry, Institute for Pharmacy, University of Jena Dr. Birgit Kraus, Department of Pharmaceutical Biology, Institute for Pharmacy, University of Regensburg Dr. Markus Krohn, Neurodegeneration Research Lab (NRL) / Department of Neurology, University Hospital of Magdeburg Dr. Jens Wild, Institute for Microbiology and Hygiene, University of Regensburg Dr. Oliver Zierau and Annekathrin Keiler, Professorship for Molecular Cell Physiology and Endocrinology, Technical University Dresden Press kit and additional images available upon request. Media contact: Thomas Eibenberger Senior Referent Corporate Communications Tel.: +49 9181 231-450 thomas.eibenberger@bionorica.de -2- Global Research Award 2013/14 All 20 prize winners according to category Group 1: Respiratory System Rebecca Clarke, Queens University Belfast, Ireland, for a novel human in-vitro model to study modulatory properties of plant-based medicines. Dr. Claudina Perez Novo, University Hospital Ghent, Belgium, for analysis of the molecular mechanisms involved in the anti-inflammatory action of an herbal preparation on chronic rhinosinusitis. Dr. Laura Sadofsky, University of Hull, England, for researching the effect of the natural agonists and antagonists of the airway irritant receptors in vitro. Prof. Adil Katarbayev, Kazakh State Medical University in Almaty, Kazakhstan, for Preclinical studies of an herbal preparation in acute intestinal infection. Dr. Diana Zabolotnaya, National Academy of Medical Sciences, Kiev, Ukraine, for a study of an adjuvant effect of phyto products on antibody formation against influenza virus antigens in experimental animals. Group 2: Gynaecology / Osteoporosis Dr. Annekathrin Keiler and Dr. Oliver Zierau, Technical University Dresden, Germany, for researching the effects of a hops extract on osteoporosis in a rat model. Dr. Anastasia Savilova, Moscow State University, Russia, for an investigation the mechanism of action of an herbal preparation on endometrial mesenchymal stromal cells. Dr. Petra Stute, Inselspital Bern, Switzerland, for researching the impact of black cohosh on hippocampal and hypothalamic gene expression profiles in ovariectomized rats. Group 3: Other Indications Dr. Johanna Brandner, University Hospital Hamburg-Eppendorf, Germany, for a study on the Effects of Arnebia euchroma extracts on different stages of wound healing. Dr. Temuujin Dansranjavin, University of Giessen, Germany, for the Characterization of the epigenetic regulation in prostatitis and prostate cancer by an herbal preparation. Dr. Svetlana Kalinina, Perm State Pharmaceutical Academy, Russia, for researching Verbascum nigrum extract as a new complex phytotherapeutic agent. Dr. Markus Krohn, University of Magdeburg, Germany, for Defining specific extracts from St. John’s Wort for the treatment of Alzheimer’s disease. Dr. Cassandra Leah Quave, Emory University Atlanta, USA, for a study on Botanical natural product inhibitors of acne biofilms. -3- Dr. Miroslaw Szczepanski, Medical University of Warsaw, Poland, for Researching anticancer effect of an herbal preparation in head and neck squamous cell carcinoma. Group 4: Optimisation, New Technologies and Targets Dr. Camilla Bergonzi, University of Florence, Italy, for Innovative formulations to enhance oral bioavailability of herbal extracts. Dr. Andreas Köberle, University of Jena, Germany, for Targeting of bioactive lipid networks: a novel pharmacological strategy for anti-inflammatory phytomedicine. Dr. Birgit Kraus, University of Regensburg, Germany, for Correlating the structure of differently substituted chalcones with transcriptome data and bioactivity in liver cells. Dr. Denisa Margina, University of medicine and pharmacy Bucharest, Rumania, for Studies on certain biological effects of encapsulated vegetal extracts with known cardiovascular positive outcome. Dr. Stefan Schwaiger, University of Innsbruck, Austria, for researching Natural products with effects on the NPS/NPSR system. Dr. Jens Wild, University of Regensburg, Germany, for researching Bactericidal/ permeability-increasing protein as potential new target for antimicrobial and immunomodulatory activities. Service: You can find images of the prize winners, brief CVs, abstracts of the selected projects and photos of the awards ceremony at: www.bionorica.de/research.initiative2013 Media contact: Thomas Eibenberger Senior Referent Corporate Communications Tel.: +49 9181 231-450 thomas.eibenberger@bionorica.de -4-