Session 1 Mon 2nd Dec 9-9.15 Immunology/Inflammation Speaker Opening Remarks Prof C Blanco 9.15-.9.30 9.30-9.45 PRITI Group Role of Surface Proteins in Colonization by Staphylococcus aureus of the skin of Atopic Dermatitis Patients The atopic march: a translational approach PI/Group Prof Padraic Fallon Orla Fleury Dr Sean Saunders 9.45-10.00 Characterisation of the Skin Barrier Dr Maeve McAleer Prof Alan Irvine 10.00-10.15 The role of novel IL-1 family members in paediatric inflammatory bowel disease Rachel Horan Dr Patrick Walsh 10.15-10.30 Exploring the protective role of protein C glycoforms in paediatric sepsis Dr Emer Gleeson Dr Roger Preston 10.30-10.45 Developmental changes in Pattern Recognition Receptor activity as the innate immune system develops from birth through to adolescence Dr Sarah Doyle Dr Sarah Doyle 10.45-11.00 A Novel Role for Von Willebrand Factor in the pathogenesis of Childhood Cerebral malaria. Niamh O Regan Prof James O'Donnell Prof. Owen Smith 11.00-11.15 Coffee 11.15-11.30 11.30-11.45 11.45-12.00 12.00-12.15 Dr Fiona Ringholz Gerard Higgins Dr Paul Buchanan Dr Monika Hollenhorst Dr. Valérie Urbach Dr. Paul McNally Prof Brian Harvey 12.15-12.30 Spontaeous Pro-Resolution Mediators in Paediatric Cystic Fibrosis Lung Disease Physiological Impact of Lipoxin A4 on Cystic Fibrosis Bronchial Epithelium Defective ALX/FPR2 receptor recycling and signalling in cystic fibrosis epithelia Influence of the lipid mediator Lipoxin A4 on ion transport and cell migration of colonic epithelial cells A Prospective Study of the incidence of Anaphylaxis in Irish Children Ioana Maris 12.30-12.45 Early Nutrition and eczema in the first year Dr Sinead O’Donovan 12.45-1.00 Diagnostic and prognostic indicators in paediatric primary antibody deficiency Dr Tanya Coulter Prof Jonathan Hourihane Prof Ronan O‘Sullivan Dr Deirdre Murray, Dr Mairead Kiely, Prof Louise Kenny, Prof Alan Irvine, Prof J Hourihane Prof Con Feighery 1.00-2.00 Lunch Session 2 Mon pm Obesity/Diabetes 2.00-2.15 Teen Nutrition Study Aoibheann Mc Murrow Ruth Connaughton Prof Helen Roche (Dr Fiona Lithander ) 2.15-2.30 Chronic inflammation and innate immune system dysregulation in childhood and adolescents Dr Eirin Carolan Dr Andy Hogan Prof Donal O’Shea Dr Declan Cody 2.30-2.45 Is it acceptable to systematically check the weight of children attending for routine consultation in General Practice ? Dr Brendan O’ Shea Prof Thomas O‘Dowd 2.45-3.00 Adolescent support systems increasing self efficacy trial Vincent Mc Darby Dr Declan Cody 3.00-3.15 Nutrition and Growth at 2 years: data from the BASELINE study Carol Ni Chaoimh 3.15-3.30 Formula protein content and early growth Hazel A Smith 3.30-3.45 Childhood obesity in Ireland: recent trends and determinants at the individual and ecological level Dr Eimear Keane Dr Deirdre Murray, Dr Mairead Kiely, Prof Louise Kenny, Prof Alan Irvine, Prof J Hourihane Dr Deirdre Murray Prof Jonathan Hourihane Dr Patricia LeahyWarren Dr Janas Harrington Prof Ivan Perry 3.45-4.00 Coffee Session 3 Mon pm Paediatric Cancer 4.00-4.15 4.15-4.30 Unravelling the biology of YWHAE-FAM22 in clear cell sarcoma of kidney Understanding the role of MLL4 in human cancer Colin Kenny Naomi McDonagh Prof Maureen O’Sullivan Prof Maureen O’Sullivan 4.30-4.45 Snf5 in malignant rhabdoid tumour Chris Egan Dr Adrian Bracken 4.45-5.00 Investigation into the anti-cancer effects of novel pyrrolobenzoxazepines in neuroblastoma Dr Jenny Lennon 5.00-5.15 Optimizing Apoptosis for miRNA Mediated Therapeutics for Neuroblastoma Dr Olga Piskareva 5.15-5.30 Small non-coding RNAs (ncRNAs) in the pathogenesis of childhood Leukaemia and relapse disease Dr. Suzanne MillerDelaney Prof Ray Stallings Session 4: Tue 3rd Dec 9.00-9.15 Clinical Research Unit Development and Implementation of an Emergency Department Paediatric Procedural Sedation Programme Prevalence and Management of Pain in Children in Pre-hospital Care in Ireland Transcriptional Biosignatures in Undifferentiated Febrile Illness in Children Experimental Studies on Asthma Spacer Devices in the Emergency Department Setting Siobhan McCoy Prof Ronan O’Sullivan 10.00-10.15 To establish reference ranges for coagulation parameters and to characterize plasma thrombin generation in very preterm infants Elaine Neary 10.15-10.30 Arthropathy of Down Syndrome: Clinical Features and biomarkers of arthritis in children with Trisomy 21 Charlene Foley 10.30-10.45 Attachment and Social-Emotional Development of Preterm Infants Dr Aoife Twohig 10.45-11.00 Central Vascular Catheters in Newborn Infants Dr Emily Kieran 11.00-11.15 Coffee 11.15-11.30 Management of skin graft donor sites in children: a randomized controlled study of three wound care products Carol Hilliard 11.30-11.45 Endothelial dysfunction in boys whose fathers have had early cardiac events Alan Macken 11.45-12.00 The Impact of a Changed Approach to Analgesia and Sedation Management in the PICU Claire Magner Session 5: Tue pm 12.00-12.15 Gastroenterology 9.15-9.30 9.30-9.45 9.45-10.00 12.15-12.30 DNA topology plays a key role in influencing motility and flagella gene expression in Campylobacter jejuni NADPH oxidases in mucosal immunity and inflammation Dr Daniela Zisterer Prof Ray Stallings Prof Ray Stallings Dr Adrian Murphy Sinead O’ Donnell Prof Ronan O Sullivan Clare Shortt Dr Patti Hayes Prof Naomi McCallion Dr Fionnuala Ni Ainle Dr Melanie Cotter Dr Orla Killeen Prof Fiona McNicholas Prof Eleanor Molloy Dr Colm O’Donnell Dr Marie Brenner Carol Hilliard Glynis Peel Prof Clodagh O’Gorman Prof Colum Dunne Dr Dermot Doherty Prof Seamus Cowman Dr Tadgh O’Cronin Prof Billy Bourke Prof B Bourke Prof Ulla Knaus 12.30-12.45 Structural and Molecular basis of Persistent Bowel Symptoms after Pull-Through Operation for Hirschsprung’s Disease Dr David Coyle Prof Prem Puri Dr Anne Marie O‘Donnell 12.45-1.45 Lunch Session 6: Tue pm Congenital Malformations 1.45-2.00 The impact of identifying rare disease genes on patient health Dr Jillian Casey Dr Sally Ann Lynch Dr Amanda Mc Cann 2.00-2.15 Prenatal Retinoic Acid Increases Lipofibroblast Expression in Hypoplastic Rat Lungs with Experimentally Induced Diaphragmatic Hernia Dr Florian Friedmacher Prof Prem Puri 2.15-2.30 The effect of rock inhibitor (y-27632) on the post-gastrulation chick embryo- a possible mechanism for ventral body wall defect Pulmonary FGF-9 and FGF-18 gene expression are downregulated in Nitrofen-induced hypoplastic lungs PDGFR-α-positive cells: A New Cell Type in the Human Colon Dr Johannes Duess Dr Jenny Thompson Prof Prem Puri Prof Prem Puri 2.30-2.45 2.45-3.00 3.00-3.15 3.15-3.30 Upregulation of serotonin-receptor-2A and serotonin transporter expression in the pulmonary vasculature of experimental congenital diaphragmatic hernia Molecular signalling disturbances in the foregut of the Adriamycin Mouse Model of Oesophageal Atresia/Tracheo Oesophageal Fistula 3.30-3.45 Coffee 3.45-4.00 Structural and Molecular Basis of Peristalsis in the Human Pelviureteric Junction in Health and Disease Autologous , elastogenic tissue-engineered vascular conduits for repair of congenital heart defects 4.00-4.15 Dr Hiromizu Takahashi Dr Anne Marie O’Donnell Dr Alex Hoffmann Prof Prem Puri Prof Prem Puri Dr Danielle McLaughlin Prof Prem Puri Dr Paula Murphy Mr Alec Blaney Dr Manuela Hunziker Prof Prem Puri Ian Woods Dr Tom Flanagan Session 7: tue PM Autism 4.15-4.30 Attention orienting and set-switching in autism spectrum disorders-an fMRI perspective Jackie Fitzgerald Prof Louise Gallagher 4.30-4.45 CNV Analysis by array CGH in well defined Autism Spectrum Disorder Dr Regina Regan 4.45-5.00 The characterization of recessive mutations in homozygous haplotypes implicated in Autism Spectrum Disorders IDeAs: Improving Diagnosis of Anxiety in autism spectrum disorders Dr Tiago Magalhaes Dr Sean Ennis Prof Louise Gallagher Dr Sean Ennis Codruta Sudrijan Prof Louise Gallagher 5.00-5.15 5.15-5.30 Concluding Remarks and Prizes