Tayler Vence Bio 1010 11/27/13 De-extinction Many species of animals have become extinct over the course of the Earth’s history, but what if they could be resurrected? With recent advances in genetics, it may be more of a reality than a fantasy. There are three main methods of de-extinction that have been proposed, the first (and also most popular) of these methods, is cloning. Cloning would be possible through the reconstruction of extinct species’ genomes; however, it would only work for recently extinct species, as older species’ DNA is extremely hard to find, or non-existent altogether. For cloning to work scientists will have to gather DNA samples from these extinct species and then attempt to reconstruct the genome of the extinct animal. Following the reconstruction of the species’ genome, scientists could attempt to resurrect this once extinct species in one of two ways. The first way would be to combine the nucleus of a lab-created cell of the extinct animal with an egg of a genetically similar animal that has had its nucleus removed. The second approach would be to progressively splice the extinct species’ genetic sequences to replace corresponding genetic sequences of a genetically similar non-extinct species’ genome. After much repetition such a method could eventually revive the once extinct species. Another method of de-extinction that may be feasible is a matter of “reverse engineering” an extinct species. If the relative of an extinct species is still alive, it is believed that researches could manipulate the genome to reverse-engineer the extinct species. Researchers are currently trying to resurrect the passenger pigeon that went extinct in 1914 by altering the DNA of its closest relative, the band-tailed pigeon. Scientists at Harvard are sequencing the genomes of both birds and analyzing the genetic variations to figure out how they could tweak the genome of the band-tailed pigeon to bring about traits that were present in the once living passenger pigeon. However, the biggest challenge in itself is going to be combining all the desired traits, both behavioral and physical, to bring this once extinct species back to life. The third and final de-extinction method is breeding backwards. It is proposed that backwards breeding may be even simpler than the first two de-extinction methods, but how is it possible? The process would use strategic mating to hopefully restore the genome and also the anatomy of a once extinct animal. Currently scientists are trying to revive the auroch, the ancestor of domestic cattle. This process would be very advantageous, as it would utilize cattle from the current ecological setting rather than attempting to revive an animal from a different time and climate. This approach would require a scientifically guided mating program, and possibly some human assistance; for example artificial insemination. After some testing, trial and error, and perseverance the de-extinction process may well be a very viable reality. However, many seem to wonder whether or not we should actually be bringing once dead species back to life. On one hand, we could bring back species that were killed off because of humankind (right our wrongs, so to speak), preserve biodiversity, gain useful science through the study of the once extinct species’ genomes, and reintroduce these extinct species into proper habitats that are suffering ecologically. However, on the other hand focusing too heavily on these species could distract from preserving species that are endangered, it could upset the natural ecological balance, and the extinct species may not be able to thrive due to the very different climate the Earth has today. Personally I believe bringing back an extinct species would be very beneficial. Although I don’t believe it should just be any species. The species selected should have a relatively high need for resurrection, meaning it would be important to the ecosystem. On top of that the chosen species would also need to be able to survive given today’s current climate. Through the revival of extinct species we could help dying ecosystems, and learn a lot about why the species went extinct in the first place, possibly being able to prevent future extinction of certain endangered animals in addition to learning about genetic variation of many types of animals.