25TH ANNUAL MEETING OF THE
DUTCH SOCIETY FOR
CALCIUM AND BONE METABOLISM
PROGRAM AND ABSTRACTS
Zeist, the Netherlands
November 18-19, 2015
SPONSORS
ALEXION PHARMA NETHERLANDS
AMGEN NEDERLAND
LILLY NEDERLAND
CURAPHAR HEALTHCARE
STRATEC/NOVOTEC GMBH
GREINER BIO-ONE BV
LONZA BENELUX
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25TH MEETING OF THE DUTCH SOCIETY FOR CALCIUM AND BONE METABOLISM
ZEIST, NOVEMBER 18-19, 2015
25TH ANNUAL MEETING OF THE DUTCH SOCIETY FOR
CALCIUM AND BONE METABOLISM
November 18-19, 2015
Woudschoten Conference Centre
Woudenbergseweg 54, Zeist
The Netherlands
 + 31 343 492492 - Fax +31 343 492444 – www.woudschoten.nl
Organisation
DUTCH SOCIETY FOR BONE AND CALCIUM METABOLISM
Carola Zillikens, President
Astrid Bakker, Secretary
Bram van der Eerden, Treasurer
Secretariat: Dept Oral Cell Biology
ACTA – VU University Amsterdam
Gustav Mahlerlaan 3004 – 1081 LA Amsterdam - The Netherlands
 +31 20 5980224 – www.nvcb.nl
e-mail: a.bakker@acta.nl
25TH MEETING OF THE DUTCH SOCIETY FOR CALCIUM AND BONE METABOLISM
ZEIST, NOVEMBER 18-19, 2015
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SPONSORS
The Dutch Society for Calcium and Bone Metabolism is grateful for the generous
support of the following companies:
CORPORATE SPONSORS
SILVER SPONSORS
4
25TH MEETING OF THE DUTCH SOCIETY FOR CALCIUM AND BONE METABOLISM
ZEIST, NOVEMBER 18-19, 2015
PROGRAM
25TH MEETING OF THE DUTCH SOCIETY FOR CALCIUM AND BONE METABOLISM
ZEIST, NOVEMBER 18-19, 2015
5
Wednesday, November 18, 2015
12.00-13.00
Registration + lunch
SESSION I
Chair: Beatriz Betti & Yixuan Cao
13.00-13.10
Response to treatment with bisphosphonates in
polyostotic fibrous dysplasia and McCune Albright
syndrome: A case series
Natasha Appelman-Dijkstra1, Bas Majoor2, Sander Dijkstra2,
Neveen A.T. Hamdy
Center for Bone Quality Leiden University Medical Center
1
Department of Medicine: Division of Endocrinology,
2
Department of Orthopaedic Surgery
13.10-13.20
Osteogenesis and Osteoclastogenesis by Periodontal
Ligament Fibroblasts From Patients with Fibrodysplasia
Ossificans Progressiva
Teun J. de Vries1, Ton Schoenmaker1, Dimitra Micha2, Coen
Netelenbos3, Gerard Pals2, E. Marelise W. Eekhoff3, Nathalie
Bravenboer3
1
Periodontology, ACTA, UvA and VU University, MOVE
Research Institute, 2Clinical genetics and 3Endocrinology,
VUmc, Amsterdam, The Netherlands.
13.20-13.30
In-Vitro Models of Devitalized Extracellular Matrix to
Modulate the Osteogenic Potential of Mesenchymal
Stromal Cells
Marta Baroncelli1, Rodrigo Alves1, Jeroen Demmers2, Jeroen
van de Peppel1, Hans van Leeuwen1
1
Erasmus MC, Internal Medicine, 2Erasmus MC, Proteomics
Center
13.30-13.40
Association between bone marrow adiposity and bone
turnover before and after raloxifene
Kerensa Beekman1, Martin den Heijer1, Mario Maas2, Peter
Bisschop3, Nathalie Bravenboer4
1
2
3
VUmc,
Endocrinology,
AMC,
Radiology,
AMC,
4
Endocrinology and Metabolism, VUmc, Clinical Chemistry.
13.40-13.50
A diverse stimulatory role of IL-1β on different murine
osteoclast precursor subsets: a time-lapse microscopy
study
Yixuan Cao1, Ineke Jansen2, Sara Sprangers1, Jan Stap3,
Vincent Everts1, Teun J. de Vries2
1
Department of Oral Cell Biology and 2Periodontology, ACTA,
UvA and VU University, Amsterdam, MOVE Research
Institute; 3Van Leeuwenhoek Center for Advanced
Microscopy, AMC, UvA, Amsterdam, The Netherlands
6
25TH MEETING OF THE DUTCH SOCIETY FOR CALCIUM AND BONE METABOLISM
ZEIST, NOVEMBER 18-19, 2015
13.50-14.00
Reproducibility of a semi-automatic algorithm to assess
bone attenuation and thoracic kyphosis on chest CT
scans of patients with chronic obstructive pulmonary
disease
Mayke van Dort1, Erica Rutten2, Bert van Rietbergen3,
Elisabeth Romme4, Frank Smeenk4, Piet Geusens1, Emiel
Wouters5, Joop van den Bergh1,6
1
Department of Internal Medicine, MUMC; 2Research and
Education, Centre of expertise for chronic organ failure;
3
Department of Medical Engineering, TU/e; 4Department of
Respiratory Medicine, Catharina Hospital; 5Department of
Respiratory Medicine, MUMC; 6Department of Internal
Medicine, VieCuri Medical Centre
14.00-14.10
Maternal TRPV6 is Crucial for Early Bone Development
Bram van der Eerden1, Petra Weissgerber2, Marijke
Schreuders-Koedam1, Cindy van der Leije1, Marc Freichel3,
Johannes van Leeuwen1, Veit Flockerzi2.
1
Department of Internal Medicine, Erasmus Medical Centre,
Rotterdam, The Netherlands
2
Institute for Pharmacology and Toxicology, University of
Saarland, Homburg, Germany
3
Pharmacological Institute, University of Heidelberg,
Heidelberg, Germany
14.10-14.20
Assessment of Bone Material Strength index by
Reference Point Indentation in patients with acromegaly
Frank Malgo1, Neveen A.T. Hamdy1, Alberto M. Pereira2,
Nienke R. Biermasz2, Natasha M. Appelman-Dijkstra1
1
Department of Internal Medicine: Section of Endocrinology
and Center for Bone Quality, 2Department of Internal
Medicine: Section of Endocrinology and Center for Endocrine
Tumours, Leiden University Medical Center, Leiden
14.20-14.30
The association between glucose metabolism status and
a history of falls or fractures – The Maastricht Study
Ellis de Waard1, Annemarie Koster2, Tom Melai3, Tineke van
Geel4, Ronald Henry1, Miranda Schram1, Pieter Dagnelie5,
Carla van der Kallen1, Simone Sep1, Coen Stehouwer1,
Nicolaas Schaper1, Hans Savelberg3, Piet Geusens1, Joop
van den Bergh1,6
1
MUMC+, Internal Medicine, 2UM, Social Medicine,
3
UM, Human Movement Science, 4UM, Family Medicine,
5
UM, Epidemiology, 6VieCuri, Internal Medicine, the
Netherlands.
14.30-15.00
Coffee/Tea break
25TH MEETING OF THE DUTCH SOCIETY FOR CALCIUM AND BONE METABOLISM
ZEIST, NOVEMBER 18-19, 2015
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SESSION II
Chair: Joost de Jong & Frans Heyer
15.00-15.50
Key-note lecture:
The bone-vascular axis, lessons from chronic kidney disease
Prof Dr P Evenpoel
Laboratory of Nephrology Department of Immunology and
Microbiology, UZ Leuven, Belgium
15.50-16.00
Osteoporosis and Fractures among Residents with
Dementia in Nursing Homes: Which Residents have the
Greatest Risk for Fractures?
Rutger L. van Bezooijen1,2, Victor G.M. Chel,1 Natasha M.
Appelman-Dijkstra,3 Neveen A.T. Hamdy,3 Wilco P.
Achterberg1
1
Public Health and Primary Care, LUMC, 2Florence Health
and Care, The Hague, 3Endocrinology, LUMC
16.00-16.10
Bone Substrate Dictates Early Commitment of Different
Human Osteoclast Precursors
Sara Sprangers1, Ton Schoenmaker1,2, Yixuan Cao1, Vincent
Everts1, Teun J. de Vries1,2
1
Oral Cell Biology and 2Periodontology, ACTA-UvA, VU,
Amsterdam, MOVE Research Institute
16.10-16.20
GWAS meta-analysis for total body BMD unveils 14 new
BMD loci and variants exerting age-specific effects
Carolina Medina-Gomez1,2,3 et al.
1
Internal Medicine, Erasmus MC University 2The Generation
R Study Group, Erasmus Medical Center, 3Department of
Epidemiology, Erasmus Medical Center
16.20-16.30
Evaluating Effect Causality of the Effect of Bone Mineral
Density, Body Mass Index, Type-2 Diabetes and Chronic
Heart Disease on Fracture Risk: a Mendelian
Randomisation Study
Katerina Trajanoska1,2,*, Cathy Elks5,*, Charles Laurin5,*, Jack
Bowden6,*, Lauren Mokry3,*, Omar Ahmad3,4,*, Stephanie
Ross3,*, Hou Feng Zheng7, Ling Oei1,2, Vince Forgetta4, Dave
Evans5,*, Brent Richards3,4,7,*, Fernando Rivadeneira1,2,*
1
EMC, Department of Internal Medicine, 2EMC Department of
Epidemiology, 3LDI, Centre for Clinical Epidemiology, 4MGU,
Department of Medicine, 5UOB, Integrated Epidemiology
Unite, School of Social and Community Medicine, 6CU, MRC
Biostatistics Unit, 7MGU, Department of Human Genetics,
*these authors contributed equally to this work
16.30-16.50
Coffee/tea break
8
25TH MEETING OF THE DUTCH SOCIETY FOR CALCIUM AND BONE METABOLISM
ZEIST, NOVEMBER 18-19, 2015
16.50-17.00
Mechanical loading decreases IL-1β-induced MMP-13
expression in the temporomandibular condyle
Hessam Tabeian1, Beatriz F. Betti1, Teun J. de Vries2, Frank
Lobbezoo3, Vincent Everts1, Astrid D. Bakker1.
1
Depts of
Oral Cell Biology, 2Periodontology, 3Oral
Kinesiology, ACTA-UvA&VU, MOVE Research Institute
17.00-17.10
IL-1 receptor antagonist knockout mice: A potential
model for juvenile idiopathic arthritis in the
temporomandibular joint
Anouk V. ter Linde1, Astrid D. Bakker1, Teun J. de Vries2,
Frank Lobbezoo3, Peter van der Kraan4, Vincent Everts1,
Hessam Tabeian1.
1
Depts of
Oral Cell Biology, 2Periodontology, 3Oral
Kinesiology,
Academisch Centrum Tandheelkunde
Amsterdam UvA&VU, MOVE Research Institute, Amsterdam.
Dept of 4Rheumatology, Radboud University Nijmegen
Medical Center
17.10-17.20
Fracture Repair in the Distal Radius in Post-Menopausal
Women: Follow-Up at Two Years Post-Fracture Using
HRpQCT
Joost de Jong1, Frans Heyer2, Jacobus Arts3, Martijn Poeze2,
Paul Willems3, Bert van Rietbergen4, Joop P.W. van den
Bergh1,5,6, Piet P. Geusens1,6
1
MUMC+ Rheumatology, 2MUMC+ General Surgery,
3
MUMC+ Orthopedic Surgery, 4TU/e Biomedical Engineering,
5
VieCuri Internal Medicine, 6UHasselt Medicine and Life
Sciences
17.20-17.30
The Association Between Diabetes, Trabecular Bone
Score, Bone Mineral Density and Vertebral Fractures:
The Rotterdam Study
Fjorda Koromani1,2, Taulant Muka2, Ling Oei1,2, Carola
Zillikens1, Albert Hofman2, Oscar Franco2, Andre G.
Uitterlinden, Edwin Oei3, Didier Hans4, Fernando
Rivadeneira1,2
1
Department of Internal Medicine, Erasmus MC, 2Department
of Epidemiology, Erasmus MC, 3Department of Radiology,
Erasmus MC, 4Department of Bone & Joint, Center of Bone
Diseases, Lausanne University Hospital, Lausanne,
Switzerland
17.30-17.40
Autoimmune disease in patients with adult-onset
sternocostoclavicular hyperostosis and first degree
relatives: A Netherlands survey
Pieter Valkema1, Clare Luymes1, Janneke Witteveen1, Saskia
le
Cessie2,3,
Natasha
Appelman-Dijkstra1,
Pancras
4
1
Hogendoorn , Neveen Hamdy
1
LUMC, Internal Medicine, Division Endocrinology & Centre
for Bone Quality, 2LUMC, Medical Stats & Bioinformatics,
3
LUMC, Clinical Epidemiology, 4LUMC, Pathology
18.15-20.00
Dinner
20.00-21.00
Business meeting
25TH MEETING OF THE DUTCH SOCIETY FOR CALCIUM AND BONE METABOLISM
ZEIST, NOVEMBER 18-19, 2015
9
Thursday, November 19, 2015
07.30-08.50
Breakfast
08.00-08.50
Registration
SESSION III
Chair: Marta Baroncelli
8:50-9.00
The fracture patient phenotype: bone and fall-related risk
factors in patients at the Fracture Liaison Service
Lisanne Vranken1,2, Caroline Wyers1,2, Robert van der Velde1,
Piet Geusens3,4, Heinrich Janzing5, Wim Morrenhof6, Marcel
Janssen7, Joop van den Bergh1,2,4
1
VieCuri, internal medicine, 2UM, internal medicine, 3MUMC,
rheumatology, 4Hasselt Univ, 5VieCuri, surgery, 6VieCuri,
orthopedics, 7VieCuri, clinical chemistry
09.00-09.10
Effect of postponing puberty and cross-sex hormone
therapy on bone turnover markers and BMAD in
transgender adolescents
Mariska Vlot1,2,3, Daniel Klink2,4, Martin den Heijer1,2, Marinus
Blankenstein3, Joost Rotteveel2,4, Annemieke Heijboer3
1
VUmc, Endocrinology, 2VUmc, Center of Expertise on
Gender Dysphoria, 3VUmc Clinical chemistry: Endocrine
laboratory,4VUmc, Paediatric Endocrinology
09.10-09.20
Dissection of human mesenchymal stem cell population
heterogeneity using single cell gene expression analysis
Jeroen van de Peppel, Hans van Leeuwen
Bone and Calcium research group, Internal Medicine,
Erasmus MC, Rotterdam
09.20-09.30
Effect of mechanical loading on the temporomandibular
joint: a systematic review
Beatriz F. Betti1,2 , Astrid Bakker2 , Vincent Everts2 , Hessam
Tabeian2 Frank Lobbezoo1
1
ACTA-VU, Oral Kinesiology, 2ACTA-VU, Oral Cell Biology
09.30-10.20
Key-note lecture:
The role of bone changes in the process of osteoarthritis
Prof Dr FPJG Lafeber
Department Rheumatology & Clin. Immunol. UMC Utrecht
10.20-10.50
Coffee/tea break
10
25TH MEETING OF THE DUTCH SOCIETY FOR CALCIUM AND BONE METABOLISM
ZEIST, NOVEMBER 18-19, 2015
SESSION IV
Chair: Kerensa Beekman
10.50-11.00
Predicting long-term functional outcome after stable
distal radius fractures: An HR-pQCT exploratory study
Frans Heyer1,2, Joost de Jong3, Paul Willems4, Jacobus Arts4,
Martijn Poeze1, Piet Geusens3,5, Bert van Rietbergen6, Joop
van den Bergh2,3,5
1
MUMC+, General Surgery, 2VieCuri MC, Internal Medicine,
3
MUMC+, Rheumatology, 4MUMC+, Orthopaedic Surgery,
5
UHasselt, Life Sciences, 6TU/e, Biomedical Engineering
11.00-11.10
Mechanisms Involved in Aseptic Prosthesis Loosening: a
Descriptive Systematic Review of In Vitro Studies
Angela Oostlander1, Monique Schoeman1, Jan Schoones2,
Rob Nelissen1, Edward Valstar1,3
1
LUMC, Orthopaedics; 2LUMC, Walaeus Library; 3TU Delft,
Biomedical Engineering
11.10-11.20
Extracellular matrix characterization of periprosthetic
tissue: large variation in collagen content and tissue
stiffness
Angela Oostlander1, Astrid Moerman2, Amir Zadpoor2,
Monique Schoeman1, Rob Nelissen1, Edward Valstar1,2
1
LUMC, Orthopaedics, 2TU Delft, Biomechanical Engineering
11.20-11.30
The
effect
of
periodontitis
treatment
on
osteoclastogenesis
Ton Schoenmaker1, Doran Sol1, Irene Di Ciegli2, Peter van
Lent2, Sergio Bizzarro1, Teun J. de Vries1
1
Department of Periodontology and Oral Cell Biology, ACTA,
UVA and VU Amsterdam, 2Department of Rheumatology,
Radboud UMC, Nijmegen
11.30-11.40
Hypothermia reduces VEGF-165 Gene Expression, but
does not affect Osteogenic Differentiation of Human
Adipose Mesenchymal Stem Cells under Hypoxia
Nick C. Leegwater1, Astrid D. Bakker2, Jolanda M.A.
Hogervorst2, Peter A. Nolte1, Jenneke Klein-Nulend2
1
Department of Orthopedics, Spaarne Gasthuis, Hoofddorp,
The Netherlands
2
Department of Oral Cell Biology, Academic Centre for
Dentistry Amsterdam (ACTA), University of Amsterdam and
VU University Amsterdam, MOVE Research Institute
Amsterdam, Amsterdam, The Netherlands
25TH MEETING OF THE DUTCH SOCIETY FOR CALCIUM AND BONE METABOLISM
ZEIST, NOVEMBER 18-19, 2015
11
11.40-11.50
Increased Fracture Risk and Risk of Osteoporosis in
Middle-aged Persons with Lower but Normal Range
Serum Sodium Concentration
Chantal M. Wiepjes1,2, Renée de Mutsert2, Anna W. de
Boer2,3, Natasha M.Appelman-Dijkstra4, Frits R. Rosendaal2,5,
Martin den Heijer1,2
1
VUmc, Endocrinology; 2LUMC, Clinical Epidemiology;
3
LUMC, Public Health and Primary Care; 4LUMC
Endocrinology; 5 LUMC, Thrombosis and Hemostasis
11.50-12.00
Periprosthetic tissue cells produce alkaline phosphatase
and mineralized matrix in response to osteogenic stimuli
Monique Schoeman1, Angela Oostlander1, Karien de Rooij1,
Rob Nelissen1, Edward Valstar1,2
1
LUMC, Orthopaedics, 2TU Delft, Biomechanical Eng.
12.00-13.00
Lunch
SESSION V
Chair: Nick Leegwater
13.00-13.10
The development of a tracer technique to measure 25Hydroxyvitamin D3 (25(OH)D3) half-life
Kerry S Jones1,2, Les J Bluck1, Shujing Ding1, Shima Assar1,
Ann Prentice1,2 and Inez Schoenmakers1
1
MRC Human Nutrition Research, Cambridge, UK, 2MRC
Keneba, MRC Unit, Banjul, The Gambia
13.10-13.20
25(OH)D3 Half-life is longer in older than younger adults
Inez Schoenmakers, Jennifer Bell, Shima Assar, Ann
Prentice, Kerry S. Jones
MRC Human Nutrition Research, Cambridge, UK
13.20-13.30
Effect of One Year Cross-sex Hormonal Treatment on
Bone Mineral Density of the Lumbar Spine in
Transgender Patients
Chantal M. Wiepjes1, Mariska C. Vlot1,2, Maartje Klaver1,
Renate T. de Jongh1, Paul Lips1, Annemieke C. Heijboer2,
Martin den Heijer1
1
VUmc, Internal Medicine and Center of Expertise on Gender
Dysphoria 2VUmc, Clinical Chemistry
13.30-13.40
Risk factors in allogenous cortical graft surgery in
fibrous dysplasia of the proximal femur
Bas Majoor1, Natasha Appelman-Dijkstra2, Neveen A.T.
Hamdy2, Michiel van de Sande1, Sander Dijkstra1
Centre for Bone Quality, Leiden University Medical Centre:
1
Department of Orthopaedic Surgery, 2Department of
Medicine: Division Endocrinology
12
25TH MEETING OF THE DUTCH SOCIETY FOR CALCIUM AND BONE METABOLISM
ZEIST, NOVEMBER 18-19, 2015
13.40-14.30
Key-note lecture:
The assessment of bone quality in healthy and diseased
human bone
Dr B Busse
Department of Osteology and Biomechanics (IOBM)
University Medical Centre Hamburg-Eppendorf, Germany
14:30-14:50
Coffee/tea break
14.50-15.00
Use of SSRIs and bone mineral density change: a
population-based longitudinal study in middle-aged and
elderly individuals
Annelies C. Ham1*, Nikkie Aarts1,2*, Raymond Noordam1,2,
Fernando Rivadeneira1, Gijsbertus Ziere1,2, M. Carola
Zillikens1, et al. *contributed equally
1
Department of Internal Medicine, Erasmus MC - University
Medical Center Rotterdam, Rotterdam, the Netherlands.
2
Department of Epidemiology, Erasmus MC - University
Medical Center Rotterdam, Rotterdam, the Netherlands.
15.00-15.10
Positive Effects of Vitamin D in Bone Metastases: Role
for Extracellular Vesicles?
Marjolein van Driel1, Resti Rudjito1, Iris Robbesom1, Hideki
Chiba2, Hans van Leeuwen1
1
Department of Internal medicine, Erasmus MC, Rotterdam
2
Department of Basic Pathology, Fukushima Medical
University, Fukushima, Japan
15.10-15.25
Awards
15.25-15.30
Adjournment
25TH MEETING OF THE DUTCH SOCIETY FOR CALCIUM AND BONE METABOLISM
ZEIST, NOVEMBER 18-19, 2015
13