INNATE IMMUNITY
Microbiology 204 Tony DeFranco
September 30, 2015
Required Reading: Discussion paper: 63; Review: 17 (or another review of your choice); additional original article: 35
Reviews:
General:
1. Janeway, CA, Jr (1992). The immune system evolved to discriminate infectious nonself from noninfectious self. Immunol. Today 13:
11-16.
2.
Janeway CA Jr, and Medzhitov R. (2002). Innate immune recognition. Ann. Rev. Immunol. 20: 197-216.
3.
Jin, MS and Lee JO. (2008). Structures of the Toll-like receptor family and its ligand complexes. Immunity 29: 182-191.
4.
Barton, G.M. and Kagan, J.C. (2009). A cell biological view of Toll-like receptor function: regulation through compartmentalization.
Nat. Rev. Immunol. 9: 535-542.
5.
Moresco, E.M.Y., LaVine, D., Beutler, B. (2011). Toll-like receptors. Current Biol. 21: R488-93.
6.
Casanova JL, Abel L, Quintana-Murci L. (2011). Human TLRs and IL-1Rs in host defense: natural insights from evolutionary, epidemiological, and clinical genetics. Annu Rev Immunol. 29: 447-491.
7.
Medzhitov R. (2008). Origin and physiological roles of inflammation. Nature 454:428-35.
8.
Elliott, M.R., Ravichandran, K.S. (2010). Clearance of apoptotic cells: implications in health and disease. J. Cell Biol. 189: 1058-1070.
9.
Dinarello, C.A. (2010) Anti-inflammatory agents: present and future. Cell 140: 935-950.
10.
Vance, R.E., Isberg, R.R., Portnoy, D.A. (2009). Patterns of pathogenesis: discrimination of pathogenic and nonpathogenic microbes by the innate immune system. Cell Host Microbe 23: 10-21,
11.
Baltimore, D. (2011). NF B is 25. Nature Immunol. 12: 683-685 (and adjacent review articles).
12.
Malynn, B., Ma, A. (2010). Ubiquitin makes its mark on immune regulation. Immunity: 33: 843-852.
13.
Nish, S., Medzhitov, R. (2011). Host defense pathways: role of redundancy and compensation in infectious disease phenotypes.
Immunity 34: 629-636.
14.
Deretic,V., Saitoh, T. and Akira, S. (2013). Autophagy in infection, inflammation, and immunity. Nat. Rev. Immunol. 13: 722-37.
15.
Moore, K.J., Sheedy, F.J., and Fisher, E.A. (2013). Macrophages in atherosclerosis: a dynamic balance. Nat. Rev. Immunol. 13: 709-21.
16.
Gay, N.J., Symmons, M.F., Gangloff, M. & Bryant, C.E. (2014). Assembly and localization of Toll-like receptor signalling complexes.
Nat. Rev. Immunol. 14: 546-558.
17.
Lamkanfi, M. and Dixit, V.M. (2014). Mechanisms and functions of inflammasomes. Cell 157: 1013-22
18.
Blander, J.M. (2014). A long awaited merger of pathways mediating host defense and programmed cell death. Nat. Rev. Immunol. 14:
601-18.
19.
Smale, S.T., Tarakhovsky, A., Natoli, G. (2014). Chromatin contributions to the regulation of innate immunity. Ann. Rev. Immunol. 32:
489-511.
20.
Carpenter, S., Ricci, E.P., Mercier, B.C., Moore, M.J. and Fitzgerald, K.A. (2014). Post-transcriptional regulation of gene expression in innate immunity. Nat. Rev. Immunol. 14: 361-372.
Anti-bacterial and anti-fungal defense
21.
Bogdan, C, Rollinghoff, M, and Diefenbach, A (2000). Reactive oxygen and reactive nitrogen intermediates in innate and specific immunity. Curr. Opin. Immunol. 12: 64-76.
22.
Lekstrom-Himes JA, and Gallin JI (2000). Immunodeficiency diseases caused by defects in phagocytes. New Engl. J. Med. 343: 1703-
1714.
23.
Ernst JD. (2000) Bacterial inhibition of phagocytosis. Cell Microbiol. 2:379-86.
24.
Walport, M.J. (2001). Complement. N. Eng. J. Med. 344: 1058-1066 and 1140-1144.
25.
Fujita, T. et al. (2004). The lectin-complement pathway—it’s role in innate immunity and evolution. Immuno. Rev. 198: 185-202.
26.
Papayannopoulos V, Zychlinsky A. (2009). NETs: a new strategy for using old weapons. Trends Immunol. 2009 30: 513-521.
27.
Serruto, D., Rappuoli, R. , Scarselli, M., Gros, P., van Strijp, J.A.G. (2010). Molecular mechanisms of complement evasion: learning from staphylococci and meningococci. Nature Rev. Microbiol. 8: 393-399.
28.
Brodsky, I.E., Medzhitov, R. (2011). Pyroptosis: macrophage suicide exposes hidden invaders. Curr. Biol. 21: R72-75.
29.
Bevins, C.L., Salzman, N.H. (2011). Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis. Nature Rev.
Microbiol. 9: 356-368.
30.
Osorio, F., Reis e Sousa, C. (2011). Myeloid C-type lectin receptors in pathogen recognition and host defense. Immunity 34: 651-664.
31.
Netea MG, Wijmenga C, O'Neill LA. (2012). Genetic variation in Toll-like receptors and disease susceptibility. Nat Immunol. 13:535-
42.
32.
Brown GD, Netea MG. (2012). Exciting developments in the immunology of fungal infections.Cell Host Microbe. 11:422-4.
33.
Philpott, D.J., Sorbara, M.T., Robertson, S.J., Croitoru, K. and Girardin, S.E. (2014). NOD proteins: regulators of inflammation in health and disease. Nat. Rev. Immunol. 14: 19-23.
34.
Von Moltke, J., Ayres, J.S., Kofoed, E.M, Chavarria-Smith, J. and Vance, R.E. (2013). Recognition of bacteria by inflammasomes.
Ann. Rev. Immunol. 31: 73-106.
35.
Broz, P., and Monack, D.M. (2013). Newly described pattern recognition receptors team up against intracellular pathogens. Nat. Rev.
Immunol. 13: 551-565.
Anti-viral defense
36.
Roulston, A. et al. (1999). Viruses and apoptosis. Ann. Rev. Microbiol. 53: 577-628.
37.
Tortorella, D., Gewurz, B.E., Furman, M.H., Schust, D.J., and Ploegh, H.L. (2000). Viral subversion of the immune system. Ann. Rev.
Immunol. 18: 861-926.
38.
Taniguchi, T., et al. (2001). IRF family of transcription factors as regulators of host defense. Ann. Rev. Immunol. 19: 623-655.
1

39.
Plasterk, RHA (2002). RNA silencing: The genome’s immune system. Science 296: 1263-65 (and accompanying articles).
40.
Liu, Y.-J. (2005). IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Ann. Rev. Immunol.
23: 275-306.
41.
Plantanias, L.C. (2005). Mechanisms of type I- and type II-interferon-mediated signaling. Nat. Rev. Immunol. 5: 375-386.
42.
Yoneyama M and Fujita T. (2008). Structural mechanism of RNA recognition by the RIG-I-like receptors. Immunity 29: 176-180.
43.
Ranjan P, Bowzard JB, Schwerzmann JW, Jeisy-Scott V, Fujita T, Sambhara S. (2009). Cytoplasmic nucleic acid sensors in antiviral immunity. Trends Mol Med. 15:359-68.
44.
Evans DT, Serra-Moreno R, Singh RK, Guatelli JC. (2010) BST-2/tetherin: a new component of the innate immune response to enveloped viruses. Trends Microbiol. 18:388-96.
45.
Yan, N., and Chen, Z.J. (2012). Intrinsic anti-viral immunity. Nat Immunol. 13: 214-22.
46.
Emerman, M. and Malik HS. (2010). Paleovirology—modern consequences of ancient viruses. PLoS Biology 8: e1000301.
47.
Loo, Y.-M., Gale, M. (2011). Immune signaling by RIG-I-like receptors. Immunity 34: 680-692.
48.
Hatziloannou, T. and Bieniasz, PD (2011). Anti-retroviral restriction factors. Curr. Opin. Virol. 1: 519-525.
49.
Moresco EMY and Beutler, B (2011). Resisting viral infection: the gene by gene approach. Curr. Opin. Virol. 1: 513-8.
50.
Iwasaki, A., and Pillai, P.S. (2014). Innate immunity to influenza virus infection. Nat. Rev. Immunol. 14: 315-328.
51.
Schneider, W.M., Chevillotte, M.D., and Rice, C.M. (2014). Interferon-stimulated genes: a complex web of host defenses. Ann. Rev.
Immuno. 32: 513-545.
52.
Hornung, V., Hartmann, R., Ablasser, A., and Hopfner, K.-P. (2014) OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids. Nat. Rev. Immunol. 14: 521-528
Original articles:
Toll-like receptors
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2.
Medzhitov R, Preston-Hurlburt, P, and Janeway, CA, Jr. (1997). A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388: 394-397.
3.
Poltorak, A, He, X, Smirnova, I, Liu, M-Y, Van Huffel, C, Du, X, Birdwell, D, Alejos, E, Silva, M, Galanos, C, Freudenberg, M,
Ricciardi-Castagnoli, P, Layton, B, and Beutler, B (1998). Defective LPS signaling in C3H/Hej and C57BL/10ScCr mice: mutations in
Tlr4 gene. Science 282: 2085-2088.
4.
Takeuchi, O, Hoshino, K, Kawai, T, Sanjo, H, Takada,o H, Ogawa, T, Takeda, K, and Akira, S. (1999). Differential roles of TLR2 and
TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11: 443-451.
5.
Kawai, T, Adachi, O, Ogawa, T, Takeda, K, and Akira, S. (1999). Unresponsiveness of MyD88-deficient mice to endotoxin.
Immunity 11:115-122.
6.
Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, Matsumoto M, Hoshino K, Wagner H, Takeda K, and Akira S (2000). A
Toll-like receptor recognizes bacterial DNA. Nature 408: 740-745.
7.
Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. (2001). Recognition of double-stranded RNA and activation of NF-

B by Toll-like receptor 3. Nature 413:732-738.
8.
Latz E, Schoenemeyer A, Visintin A, Fitzgerald KA, Monks BG, Knetter CF, Lien E, Nilsen NJ, Espevik T, Golenbock DT, (2004).
TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nat Immunol. 5:190-8.
9.
Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, Akira S, Lipford G, Wagner H, Bauer S. (2004). Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science. 303:1526-9.
10.
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11.
Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H, Takeuchi O, Sugiyama M, Okabe M, Takeda K, Akira S. (2003). Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science 301: 640-3.
12.
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(2003). Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 424:743-8. (“Lps2” = TRIF)
13.
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14.
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17.
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18.
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19.
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2

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4