Developmental Molecular Genetics – BIO 265
Tuesday and Thursdays – 10:05 to 11:20 am
August 31st to December 9th, 2015
Classroom: 107 Marsh Life Science
Book: No required text. However it is recommended that all students have a Cell
Biology, Molecular Biology or Developmental Biology textbook as a reference.
Dr. Amanda Yonan
amanda.yonan@uvm.edu
802-656-0454
102 Marsh Life Science
Office Hours:
Tuesday
11:30 to 2 pm
Wednesday 2 to 3 pm
Thursday
11:30 to 2 pm
Grades:
Exams (2)
Final Exam
Participation
Paper
200
100
100
50
450 Total
There will be two take home exams throughout the semester, worth 100 points
each. Exam One is due by the beginning of class on October13th, Exam Two is
due by the beginning of class on November 19th.
The final will be also be take home and will be worth 100 points. The final exam
is due on December 15th at 10:30 am.
100 points of your grade will be based on your participation in the in class
discussions of the research papers. All students are expected to be present,
have read and understood the day’s paper and to participate in our discussion in
a thoughtful manner. Students who complete all these requirements will receive 5
participation points for that day’s class.
Students will also be required to find a research paper covering developmental
genetics that we have not discussed in class and write a 3 page paper discussing
the research in detail. The details of this assignment will be given out in class.
The final papers are due November 10th, with drafts due at earlier dates.
Schedule (Subject to change):
Date
1-Sep
3-Sep
8-Sep
10-Sep
15-Sep
17-Sep
22-Sep
24-Sep
29-Sep
1-Oct
6-Oct
8-Oct
13-Oct
15-Oct
20-Oct
22-Oct
27-Oct
29-Oct
3-Nov
5-Nov
10-Nov
12-Nov
17-Nov
19-Nov
24-Nov
26-Nov
1-Dec
3-Dec
8-Dec
15-Dec
Day
T
Th
T
Th
T
Th
T
Th
T
Th
T
Th
T
Th
T
Th
T
Th
T
Th
T
Th
T
Th
T
Th
T
Th
T
T
Paper
Textbook
Textbook
Seifert et al
Gurdon et al
Gregor et al
Brent et al
Lee et al
Simeoni et al
Hernandez et al
Lu et al
Hu et al
Manjon et al
Weil et al
Rohatgi et al
Schambony et al
Takeuch et al
Andrey et al
Brandford et al
Puk et al
Pei et al
Meyer et al
Gammill et al
Wozniak et al
Sick et al
10:30
Grade of:
A+
> 99%
A
= 92 to 98.9%
A= 90 to 91.9%
B+
= 88 to 89.9%
B
= 80 to 87.9%
B= 78 to 79.9%
C+
= 76 to 77.9%
C
= 69 to 75.9%
C= 67 to 68.9%
D+
= 65 to 66.9%
D
= 57 to 64.9%
D= 55 to 56.9%
F will be anything less than 55%
Topic
Development Basics
Molecular Methods
Frizzled/PCP signalling (Review)
Single cells can sense their position
Stability and nuclear dynamics
Permissive..patterning…mRNA localization
Inhibition of FGF signaling converts dorsal…
Interpretation of BMP signalling
Cyp26…retinoic acid response
FGF13 regulates proliferation and differentia
Border formation at Bmp gradient
Sharp boundaries of Dpp signalling
Exam One Due
Changes in bicoid mRNA
Patched 1 regulates Hedgehog
Wnt-5A/Ror2 regulates expression of
Sequential Arrival...Sema3F by Olfactory
Switch Between … Underlies HoxD Genes
Regulation of gut and heart assymetry
small-eye allele in paired box gene 6 (Pax6)
Environmental and genetic modifiers
eliminates unfit cells from developing tissues
Neuropilin 2…neural crest migration
Exam Two Due
Thanksgiving Break
Thanksgiving Break
neurodegeneration induced by ethanol
Wnt and Dkk determine hair follicle spacing
Graduate Student Presentations
Final Exam Due
Exams/Paper
Paper Topic Due
Exam One Due
Draft of Paper Due
Paper Due
Exam Two Due
Final Exam Due
Paper Assignments (Subject to change):
Date
1-Sep
3-Sep
8-Sep
10-Sep
15-Sep
17-Sep
22-Sep
24-Sep
29-Sep
1-Oct
6-Oct
8-Oct
13-Oct
15-Oct
20-Oct
22-Oct
27-Oct
29-Oct
3-Nov
5-Nov
10-Nov
12-Nov
17-Nov
19-Nov
24-Nov
26-Nov
1-Dec
3-Dec
8-Dec
15-Dec
Day
T
Th
T
Th
T
Th
T
Th
T
Th
T
Th
T
Th
T
Th
T
Th
T
Th
T
Th
T
Th
T
Th
T
Th
T
T
Paper
Student to start paper
Textbook
Dr. Yonan
Textbook
Dr. Yonan
Seifert et al
Dr. Yonan
Gurdon et al
Todero, Jenna E.
Gregor et al
Waldron, Ashley L.
Brent et al
Emerson, Sarah E.
Lee et al
Viola, Toni E.
Simeoni et al
Seyller, Ellen W.
Hernandez et al
Reetz, Ben D.
Lu et al
Pomichter, Ben P.
Hu et al
O'Hayre, Shannon J.
Manjon et al
O'Hagan, Andrew
Exam One Due
Weil et al
O'Brien, Maddie E.
Rohatgi et al
Miller, Alexander T.
Schambony et al
Merrill, Austin C.
Takeuch et al
Lindsey, Devon E.
Andrey et al
Jennings, Matt I.
Brandford et al
Hurlburt, Vicky V.
Puk et al
Horvath, James
Pei et al
Grundy, Jaye L.
Meyer et al
Girome, Sarah
Gammill et al
Dansereau, Alexandra R.
Exam Two Due
Thanksgiving Break
Thanksgiving Break
Wozniak et al
Egan, Meghan C.
Sick et al
Bellfy, Lauren N.
Grad Student Present
Sarah and Ashley
Final Exam