11-12 ******* 2014

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Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences

BIOCHIP-IMB LLC

International Conference "Molecular mechanisms of growth and progression of malignant neoplasms", dedicated to the 55th anniversary of the Engelhardt Institute of Molecular Biology of the

Russian Academy of Sciences and the 120th anniversary of

W.A. Engelhardt

Program

Moscow, Russia

December 11-12, 2014

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Organized by

Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences

BIOCHIP-IMB LLC

Sponsored by

Federal Agency Research Organizations

Russian Foundation for Basic Research

Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences

“Molekulyarnaya Biologiya” Journal

BIOCHIP-IMB LLC

Ltd "BioVitrum"

Dia-M

Company Algimed LTD

ORGANIZING COMMITTEE

Vadim L. Karpov

Peter M. Chumakov

Irina O. Ermolinskaya

Yurii P. Lysov

Marianna V. Moldaver

Vladimir S. Prassolov

Vladimir N. Pustobayev

Eugenia V. Stepanova

Irina I. Tomina

Alexander S. Zasedatelev

Nailya F. Zotova

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PROGRAM

December, 11, Thursday

10-00 – 10-10

Opening Ceremony

Zasedatelev A.S. (Engelhardt Institute of Molecular Biology, RAS, Moscow, Russia)

Chairperson: Boris Fehse (University Medical Center Hamburg-Eppendorf, Hamburg, Germany)

10-10 – 10-30

Carol Stocking (Heinrich Pette Institute, Leibniz Institute of Experimental Virology, Hamburg

Germany). «RUNX1: setting the stage for leukemic transformation».

10-30 – 10-50

Thomas Speiseder (Heinrich Pette Institute, Leibniz Institute of Experimental Virology, Hamburg

Germany).

«Adenovirus mediated transformation of primary human cells: A model system to study virus induced cell transformation».

10-50 – 11-10

Olga A. Dontsova (Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical

Biology, Lomonosov Moscow State University, Moscow, Russia).

«Unusual features of telomerase and novel telomerase inhibitors».

11-10 – 11-30

Boris Fehse (University Medical Center Hamburg-Eppendorf, Hamburg, Germany). « Genetic barcoding to assess clonality of malignant diseases».

Coffee Break

11-30 – 11-50

Chairperson: Zasedatelev A.S. (Engelhardt Institute of Molecular Biology, RAS, Moscow, Russia)

11-50 – 12-10

Fiodor L. Kisseljov (Institute of Carcinogenesis N. N. Blokhin Cancer Research Center, Moscow,

Russia).

«From viruses towards target therapy of tumours».

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12-10 – 12-30

Evgeny N. Imyanitov (N.N. Petrov Institute of Oncology, St.-Petersburg, Russia).

«Molecular diagnostics in clinical oncology» .

12-30 – 12-50

Marina S. Drutskaya (Engelhardt Institute of Molecular Biology, RAS, Moscow, Russia). « The role of cytokines in chemically-induced skin cancer, as studied in mice

».

12-50 – 13-10

Natalia L. Lazarevich (Institute of Carcinogenesis N.N.Blokhin Cancer Research Center, Moscow,

Russia). «Integrative analysis of molecular aberrations associated with pathogenesis of hepatocellular carcinoma using exome and transcriptome sequencing methods».

Lunch

13-10 – 14-40

Chairperson: Evgeny N. Imyanitov (N.N. Petrov Institute of Oncology, St.-Petersburg, Russia)

14-40 – 15-00

Kristoffer Riecken (University Medical Center Hamburg-Eppendorf, Hamburg Germany).

«RGB-

Marking for clonal tracking of cancer cells in vitro and in vivo» .

15-00 – 15-20

Peter M. Chumakov (Engelhardt Institute of Molecular Biology, RAS, Moscow, Russia). «Trends in Oncolytic Biotherapy».

15-20 – 15-40

Natalia N. Mazurenko (Institute of Carcinogenesis N.N. Blokhin Cancer Research Center, Moscow,

Russia).

«Spectrum of driver mutations in melanoma subtypes».

15-40 – 16-00

Marina A. Zenkova (Institute of Chemical Biology and Fundamental Medicine, SD RAS,

Novosibirsk, Russia).

«Mechanism of antitumor activity of natural ribonucleases: whole transcriptome analyses and genome-wide profiles of miRNAs of LLC-bearing after treatment with RNase A».

16-00 – 16-20

Sergey M. Deev (Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS, Moscow,

Russia).

«Multifunctional agents for cancer bioimaging and therapy

».

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16-20 – 16-40

Elena L. Chernolovskaya (Institute of Chemical Biology and Fundamental Medicine, SD RAS,

Novosibirsk, Russia).

«Small Interfering RNAs: delivery, structure, activity».

Coffee Break

16-40 – 17-00

Chairperson: Sergei A. Nedospasov (Engelhardt Institute of Molecular Biology, RAS, Moscow,

Russia)

17-00 – 17-20

Alexander G. Gabibov (Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS, Moscow,

Russia). « Modern pharmacology: magic bullet & combinatorial approaches».

17-20 – 17-40

Dmitry V. Kuprash (Engelhardt Institute of Molecular Biology RAS, Moscow, Russia). « p53dependent expression of CXCR5 chemokine receptor in MCF-7 breast cancer cells».

17-40 – 18-00

Ella Kim (University Mainz, Department of Neurosurgery Johannes Gutenberg University Medical

Center Mainz, Germany).

«The role of stem-like glioma cells in GBM progression and posttreatment recurrence».

18-00 – 18-20

Anton Buzdin (Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS, Moscow, Russia).

«

OncoFinder, a new bioinformatic tool for the analysis of complex intracellular signaling and metabolic networks and its application to molecular biology, drug discovery and anticancer therapy».

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December, 12, Friday

Chairperson: Dmitry V. Kuprash (Engelhardt Institute of Molecular Biology RAS, Moscow, Russia)

10-00 – 10-20

Georgii P. Georgiev (Institute of Gene Biology, RAS, Moscow, Russia).

«Protective proteins against cancer».

10-20 – 10-40

Eugene D. Sverdlov (Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, RAS, Moscow,

Russia).

«Prospects for non-viral cancer gene therapy».

10-40 – 11-00

Sergey V. Netesov (Novosibirsk State University, Novosibirsk, Russia). «The expression of apoptin gene by recombinant vaccinia virus vector and oncolytic properties of this recombinant vaccinia strain».

11-00 – 11-20

Ioanna Trivai (Department of Stem Cell Transplantation, University Medical Center Hamburg-

Eppendorf Hamburg, Germany).

«Delineating neoplastic stem cell heterogeneity in primary myelofibrosis».

Coffee Break

11-20 – 11-40

Chairperson: Peter M. Chumakov (Engelhardt Institute of Molecular Biology, RAS, Moscow,

Russia)

11-40 – 12-00

Nina I. Drize (Hematological Research Center, Ministry of Health of the Russian Federation,

Moscow, Russia). « Malignant cells of patients with acute leukemia damage the bone marrow mesenchymal stromal precursor cells».

12-00 – 12-20

Vladimir A. Richter (Institute of Chemical Biology and Fundamental Medicine, SD RAS,

Novosibirsk, Russia). « Proapoptotic agent Lactaptin – prospects and problems of antitumor therapy».

12-20 – 12-40

Valentin V. Vlassov (Institute of Chemical Biology and Fundamental Medicine, SD RAS,

Novosibirsk, Russia).

«Therapeutic nucleic acids: prospects and challenges».

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12-40 – 13-00

Raisa I. Yakubovskaya (P.A. Hertzen Moscow Institute of Oncology, Moscow, Russia).

«The development of gene therapy products for cancer treatment».

13-00 – 13-20

Vladimir A. Mitkevich (Engelhardt Institute of Molecular Biology, RAS, Moscow, Russia).

«Molecular basis of the ribonuclease binase antitumor activity».

13-20 – 13-40

Sergey Tolmachev (Ltd "BioVitrum", Moscow, Russia).

«Enabling Translational Medicine by

Multiplex Digital Quantification of Various Biomarkers

».

13-40 -14-00

Denis Dmitrienko (Dia-M, Moscow, Russia). «Cell Signal Transduction Molecules and

Regulatory Pathways Visualization Using Luminescence: Abcam Antibodies for Western

Blotting, Cell Sorting and Immunocytochemistry; Vilber Lourmat Documentation Systems with UV/VIS/IR/NIR Fluorescence and Chemiluminescence Detection Capabilities; Olympus

Confocal Microscopy».

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