Budny 10:00 T/Th, Group R13 NANOTECHNOLOGY: THE ETHICS OF ROBOTIC MEDICINE Trevor Leong (trl27@pitt.edu) without you ever knowing you were sick” [3]. These nanobots would do so by monitoring the body for irregular conditions. All medical conditions carry a “biochemical signature” [3]. These machines would respond to the signature by releasing a corresponding medicine. This is potentially life changing; imagine a world without worries like cancer or even the common cold, all these problems eliminated by the constant monitoring of nanobots. The benefits of a technology like this are that the body can be constantly monitored, and diseases and other maladies may be treated almost instantaneously, leading to reduced fatality rates. Of course, there’s nothing to stop the machines from malfunctioning once inserted into the body, but I believe that these problems can be minimized the same way that we have minimized them with pacemakers and the like. The small size of the machines renders their malfunction mostly harmless. Another use for these nanobots in the same vein is one that utilizes already familiar technology to deal with cancer. A “nanoparticle” (read, nanobot) developed in the University of North Carolina’s labs shows “potential for a more effective delivery of chemotherapy” [4]. This nanobot shows increased capacity for drugs and improved leakage control, building on the achievements of the previous nanobots from the IEEE article. This is a significant development in the year that has transpired since the IEEE article. It ensures that the nanobots require less maintenance, last longer, and thus decrease health risk if they malfunction. This only increases the feasibility of using nanobots to further medical research and treatment. However, these qualities can still be improved. This is an engineer’s job, to make and improve technologies that provide innovative and efficient solutions to existing and future problems. ACTING ETHICALLY IN ENGINEERING The National Society of Professional Engineers (NSPE) provides a “code of ethics” for all who are seeking to become or have already become engineers. Engineers are bound morally to uphold this code of ethics. [1] Therefore, as a prospective engineer, it is my own moral duty to determine whether or not my own ambitions fall inside the bounds of the code. Should an engineer fail to comply with one or more of the ethical guidelines, the consequences could be disastrous. The over-arching message of code of ethics is that engineers are supposed to hold the interests of the public first, and also to reinforce a positive reputation for all engineers [1]. If engineers instead act in their own self-interests instead of working to preserve the public’s rights and desires, an engineer could potentially usurp and warp science in such a way that they benefit from the downfall of others. This could be like a mechanical engineer using shoddy equipment to construct parts that end up endangering and even killing human lives. Alternately, an engineer that destroys the reputation of all engineers will cause mistrust and eventual destruction of the engineering profession by discouraging future students from ever pursuing engineering degrees. It is therefore imperative that engineers comply with the code of ethics. In the previous paper, I discussed the “Grand Challenge” of “Engineering Better Medicine” [2]. I stated that I found this particular challenge alluring because I wanted to use my engineering degree to expand upon and improve current medicinal means. I believe this challenge is important because it seeks to expand the ability of modern medicine to save more human lives and allow improved quality of life. Many research groups currently attempt to field new technologies in medicine, but I find the nanotechnology ventures the most fascinating; they deal with the human body on a level that is microscopic, which is as close to the source of all medical problems as possible. I believe that once we can cut off problems at the source, medicine becomes much more efficient. This, of course, prompts the question of how ethical this specific type of medicine would be. IMPROVING HEALTHCARE WITH ROBOTS The “nanobots”, as they are currently designed, would be injected into the human body to perform a specific task, such as performing scans and ensuring that the body is operating within normal parameters, or administering a pre-specified dose of medicine periodically to a particular problem spot (via self-contained vials) [3]. Due to the “biochemical signature” given off by different medical conditions, nanobots would be able to report anomalies and potential threats to the body to a doctor or other monitoring specialist. The main question is, does this type of medicine violate the code of ethics for both engineers in general, and bioengineers? Upon examining both codes myself, I can say that I believe this type of medicine is well within the boundaries of the codes of ethics. Biomedical engineers are called upon to “consider the larger consequences of their work in regard to cost, availability, and delivery of health NANOMEDICINE AND THE FUTURE OF HEALING It would first be instructive to detail what exactly nanotechnology is. One of the most recently toted uses for nanotechnology is one that I believe will demonstrate the capacity this technology has for bettering mankind. This is a new technology recently developed involving little robots called “nanobots”. An article in IEEE Spectrum states that the “biomolecular machines might someday make you well University of Pittsburgh Swanson School of Engineering 1 Submitted: November 1, 2011 Trevor Leong care” [6]. With regards to the nanobots, I think that they would greatly increase both availability and delivery of health care, while decreasing overall costs. Additionally, this type of medicine does not attempt to “deceive the public”, but instead strives to “serve the public interest” [1]. pressing issue in today’s society. These technologies do not just provide some benefit to a specific group of people, such as that of access to clean water, but to all people in general; every person will benefit from improved medicine. That’s why it is important to focus on this particular “Grand Challenge” [2]. I believe that the best way to fulfill this challenge is through the research of nanotechnology, but there are many other equally valid ways to further medicine. However, I think that the future of medicine rests primarily in nanomedicine; eventually, all medicine will rely on the robots smaller than we can see. WHY ETHICAL STUDIES MATTER Ethical dilemmas are no new problem for science. Every scientific controversy from stem cell research to testing new products on animals falls under ethical scrutiny. Questions arise on how to act humanely, how to ensure the protection of basic human rights, and how to protect the average person from being an unwilling tool of science. It is important for the potential engineer to study these cases and examine for himself or herself whether or not their engineering ambitions protect these things. This would allow the engineer to develop a moral guide on their actions in the engineering field, and also to have a position on certain ethical dilemmas which is grounded in a common ethical viewpoint. Personally, many of my ethical beliefs are justified due to my religious views; it is possible that studying engineering ethics would aid someone in understanding the importance of ethics just as much as my religion does. Engineers that act and think ethically will more easily follow the code of ethics, and also will think of the common good before their own. CHALLENGES AND ETHICS: THE FRESHMAN RESEARCH Researching the challenge of engineering better medicine and the ethical ramifications of this engineering have led me to believe that ethical constraints are better in the long run for prospective engineers to study. The Grand Challenges offer a great opportunity to see what the pressing issues of our generation are, but there is a flip-side to this coin. I have found that although my personal ambition to engineer better medicine does not conflict with any ethical standpoint, there are some challenges that do, such as nuclear technology/weaponry and the like. I believe other students would benefit from studying the code of ethics and determining for themselves based on the guidelines what is truly ethical. This will strengthen the moral character of other engineers to come, and hopefully halt any moral depravity that has come to light in recent years in terms of scientific advancement. WHY WE SHOULD CONTINUE RESEARCHING NANOMEDICINE The problem with the current system of medicine is that most of is it purely reactive. We identify problems when patients come in with symptoms, and we prescribe cures or treatments. The body also generally does not react well to medical procedures; the procedures “do not work in harmony with our natural systems” [5]. I believe that if we improve this nanomedicine, then the future of medicine will be much more proactive. With the ability to detect and eliminate threats before they become serious, these nanobots could very well become a standard in medicine. I think that they would eliminate the need for constant injections, such as those that patients with diabetes receive. This technology could also be used to repair physical damage, such as one might receive from trauma, and thus eliminate many of the problems that hemophiliacs face. [5] Nanobots are not limited to metal parts either. Researchers have recently found a way to create a functioning, programmable machine out of DNA. [2] With this organic type of medicine, nanomedicine will be much easier for the body to cope with and use; patients won’t suffer as much from the body’s immune system reacting as the nanobots administer medicine. As far as engineering goes, nanomedicine is a wonderful application of modern-day engineering to a very ETHICAL SCIENCE Science has always been key in advancing the state of human technology and culture, whether or not it is ethically sound. Had we not perfected weaponry, perhaps our society would be far more peaceful, but that is a question that cannot be answered by science. Truly, science is a tool, to be used for good or for evil. The result is up to the user, and that is why I believe ethics in engineering is so important; I believe that if we have a strong ethical standpoint, we can use science to do amazing things for mankind. All we need are the guidelines. REFERENCES [1] (2011). “NSPE Code of Ethics for Engineers.” National Society of Professional Engineers. [Online: Website]. Available: http://www.nspe.org/Ethics/CodeofEthics/index.html [2] (2011). “Introduction to the Grand Challenges for Engineering.” National Academy of Engineering Grand Challenges for Engineering. [Online: Website]. Available: http://www.engineeringchallenges.org/cms/8996/9221.aspx [3] W.D. Jones. (2010, December). “DNA Robot Could Deliver Cancer Drugs.” IEEE Spectrum. [Online: Website]. Available: http://spectrum.ieee.org/robotics/medical-robots/dna-robot-could-deliver- 2 Trevor Leong cancer-drugs [4] (2011, September). “Potential of new nanoparticle design for cancer therapy demonstrated.” Science Daily. [Online: Website]. Available: http://www.sciencedaily.com/releases/2011/09/110920103825.htm [5] (2009, July). “How Nanobots Can Repair Damaged Tissue.” Introduction to Nanotechnology. [Online: Website] Available: http://nanogloss.com/nanobots/how-nanobots-can-repair-damagedtissue/#axzz1Zltb8NxZ [6] (2004, February). “Biomedical Engineering Society Code of Ethics.” ADDITIONAL SOURCES H. Fountain. (2009, November). “Sending Drugs to Specific Spots in a Tiny Cage.” The New York Times. [Online: Website] Available: http://www.nytimes.com/2009/11/03/science/03obcage.html?ref=nanotechn ology R. A. Freitas Jr. (2005). “Current State of Nanomedicine and Medical Nanorobotics.” Journal of Computational and Theoretical Nanoscience. [Online: Website] Available: http://www.nanomedicine.com/Papers/NMRevMar05.pdf (2008, February). “How Many Grand Challenges Are Really Policy Challenges?” The New York Times. [Online: Website] Available: http://dotearth.blogs.nytimes.com/2008/02/20/how-many-grandengineering-challenges-are-really-policy-challenges/ (2011, January). “Nanotech medicine to rebuild damaged parts of the human body.” Science Daily. [Online: Website] Available: http://www.sciencedaily.com/releases/2011/01/110118092140.htm J. Newman. (2011, March). “The Human Heart Could Power Gadgets of the Future.” Time Magazine. [Online: Website] Available: http://techland.time.com/2011/03/30/human-heart-could-power-gadgets-ofthe-future/ S. Unger. (2010). “Responsibility in Engineering: Victor Paschkis vs. Werner von Braun.” IT Professional. [Online article]. 12 (3), pp. 6-7. Available: DOI 10.1109/MITP.2010.94 D. Halber. (2011). “Minuscule Medical Monitors.” Massachusetts Institute of Technology. [Online article] Available: http://spectrum.mit.edu/wpcontent/images/2011-fall/spectrum-2011-fall-web.pdf Z.G. Wang, J. Elbaz, F. Remacle, R.D. Levine, and I Willner. (2010, October). “All-DNA Finite-State Automata With Finite Memory.” National Academy of Sciences of the United States of America. [Online: Website] Available: http://www.pnas.org/content/107/51/21996.abstract?sid=fb0e84d1-2eac4a42-9cd3-a5f441e8448f Acknowledgments I would like to acknowledge Professor Dan Budny for being my teacher in Engineering Analysis and providing ideas for engineering topics. I would also like to thank Jack Pidgeon for providing support throughout the writing of this paper. 3