H.
TRANSGENIC/KNOCKOUT ANIMALS
1. Will your study involve transgenic or knockout animals?
Yes ☐
No ☐
If "NO", proceed to Section I
2. If “YES”, complete the following:
a.
Describe the phenotype
b.
Describe any pain or distress associated with the phenotype expressed and your proposed
procedure(s) to avoid or alleviate pain:
c.
Describe your monitoring schedule.
d.
Who will be responsible for monitoring the ☐ HCCM Staff
animals?
☐ Laboratory Personnel
e.
Define the duration of survival after expression of the phenotype:
f.
Describe the criteria you will use to determine pain and distress in the animals and your plan
for monitoring the animals:
g.
The construction of transgenic animals must be approved by the Committee on Microbiological Safety
(COMS) or Partners Healthcare Institutional Biosafety Committee (PIBC).
COMS or PIBC Registration #
Contact the Biosafety Officer at 617-432-4727 (HMS/HSPH) or 617-964-8550 (NRB/HIM) or 800-825-5343
(BWH) for appropriate registration.
h.
If receiving animals from an outside source, identify the origin of the animals, or their COMS/PIBC
Registration Number, if on another HMA protocol.
Origin:
COMS or PIBC#:
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