Running Head: Colorectal Cancer Delays Supplementary Table 1. List of ICD-9 codes indicating comorbid conditions of the gastrointestinal tract that were excluded from study sample. Diagnosis/Symptom ICD-9 code Crohn's Disease Regional enteritis small intestines 555.0 Regional enteritis large intestines 555.1 Regional enteritis small intestines with large intestines 555.2 Regional enteritis unspecified site 555.9 Colitis of unspecified etiology, Inflammatory Bowel Disease Ulcerative (Chronic) entero-colitis 556.0 Ulcerative (Chronic) ileocolitis 556.1 Ulcerative (Chronic) proctitis 556.2 Ulcerative (Chronic) proctosigmoiditis 556.3 Pseudopolyposis of colon 556.4 Left sided ulcerative (chronic) colitis 556.5 Universal ulcerative (chronic) colitis pancolitis 556.6 Other ulcerative colitis 556.8 Ulcerative colitis unspecified 556.9 Other and unspecified non-infectious gastroenteritis and colitis 558.9 Irritable bowel syndrome/diarrhea Irritable bowel syndrome 564.1 Colitis mucous* 564.1, 564.9 Spastic colon 564.1 Functional diarrhea 564.5 Diarrhea not otherwise specified 787.91 Incontinence of feces 787.6 Diverticulitis Colon- Diverticulitis (without mention of hemorrhage) 562.11 Colon- Diverticulitis (with hemorrhage) 562.13 Diverticulitis of small intestine without hemorrhage 562.01 Diverticulitis of small intestine with hemorrhage 562.03 High risk diseases and condition with symptoms similar to CRC Benign neoplasm of other parts of digestive system- duodenum, jejunum, and ileum 211.2 Benign neoplasm of other parts of the digestive system- colon 211.3 Benign neoplasm of other parts of the digestive system- Rectum and Anal Canal 211.4 Neoplasm of uncertain behavior of stomach intestines and rectum 235.2 Personal history of malignant neoplasm, gastrointestinal tract unspecified V10.00 Personal history of malignant neoplasm, large intestine V10.05 Personal history of malignant neoplasm, rectum rectosigmoid juntion and anus V10.06 Colonic polyps V12.72 Anal and rectal polyps 569.0 Colorectal Cancer Delays Family history of malignant neoplasm of gastrointestinal tract V16.0 Abcess of intestine (rationale: could be symptom of Crohns, diverticulitis, colitis, etc.) 569.5 *Code changed between 1998-2005. 2 Colorectal Cancer Delays Supplementary Table 2. List of ICD-9 codes indicating clinical manifestations, symptoms, and diagnoses suggestive of colorectal cancer in the year prior to CRC diagnosis. Diagnosis/Symptom type ICD-9 code Abdominal pain Abdominal pain unspecified site 789.00 Abdominal pain right upper quadrant 789.01 Abdominal pain left upper quadrant 789.02 Abdominal pain right lower quadrant 789.03 Abdominal pain left lower quadrant 789.04 Abdominal pain periumbilic 789.05 Abdominal pain epigastric 789.06 Abdominal pain generalized 789.07 Abdominal pain other specified site 789.09 Abdominal pain, swelling, or mass Abdominal pain, swelling or mass, unspecified site 789.30 Abdominal pain, swelling or mass, right upper quadrant 789.31 Abdominal pain, swelling or mass, left upper quadrant 789.32 Abdominal pain, swelling or mass, right lower quadrant 789.33 Abdominal pain, swelling or mass, left lower quadrant 789.34 Abdominal pain, swelling or mass, periumbilic 789.35 Abdominal pain, swelling or mass, epigastric 789.36 Abdominal pain, swelling or mass, generalized 789.37 Abdominal pain, swelling or mass, other specified site 789.39 Abnormal Stool Nonspecific abnormal finding in other body substances; stool contents 792.1 Anal/rectal pain, anal spasm Anal or rectal pain 569.42 Anal spasm 564.6 Anemia Iron deficiency anemias secondary to blood loss (chronic) 280.0 Iron deficiency anemia unspecified 280.9 Acute posthemorragic anemia 285.1 Anemia unspecified 285.9 Anorexia or unexplained weight loss Abnormal loss of weight* 783.2, 783.21 Anorexia 783.0 Constipation Constipation* 564.0, 564.01 Slow transit constipation 564.01 Outlet dysfunction constipation 564.02 3 Colorectal Cancer Delays Other constipation 564.09 Fatigue Other malaise and fatigue* 780.7, 780.79 Flatulence, eructation and gas pain Flatulence, eructation and gas pain 787.3 Observation for suspected neoplasm Observation for suspected malignant neoplasm V71.1 Other GI symptoms, other bowel changes Other symptoms involving digestive system, other change in bowel habits 787.99 Rectal bleeding or rectal/GI tract hemorrhage Hemorrhage of rectum and anus 569.3 Hemorrhage of gastrointestinal tract unspecified 578.9 Blood in Stool 578.1 Vomiting or nausea Nausea with vomiting 787.01 Nausea alone 787.02 Vomiting alone 787.03 *Code changed between 1998-2005. 4