Name:
Zhao-Yi (Charlie) Wang
Address:
16611 Spring Circle, Omaha, NE 68130.
Telephone:
Fax:
E.Mail:
402-280-3542
402-280-3543
zywang@creighton.edu
Education:
1982
1987
1994
B.S. Hangzhou University, P.R.China. (Biology)
M.S. Shanghai Inst. of Cell Biology, Academia Sinica. (Cell
Ph.D. Washington University at St. Louis. (Molecular Genetics)
Biology)
Postdoctoral Training:
Research Fellowships:
4/1994-12/1994
Research Fellow. The Jewish Hospital of
St. Louis.Division of Hematology and Oncology.
1/1995-1/1996
Research Fellow, Princeton University,
Department of Molecular Biology.
Academic Appointments:
7/1982-9/1983
1/1996-4/2003
5/2003-3/2009
10/2006-now
4/2009-now
Instructor of Biology, Hangzhou Normal School.
Assistant Professor of Medicine, Harvard Medical School.
Associate Professor, Departments of Surgery, Pathology, and
Medical Microbiology and Immunology, Creighton University
Medical School.
Prevedel Professorship of Cancer Research, Department of
Medical Microbiology and Immunology, Creighton University
Medical School.
Professor, Department of Medical Microbiology and Immunology,
Creighton University Medical School.
Hospital Appointments:
1
1987-1990
Research Assistant in Medicine, The Jewish Hospital of
St. Louis.
1990-1995
Research Associate in Medicine, The Jewish Hospital of
St. Louis.
1996- 2003 Assistant Professor of Medicine, Beth Israel Deaconess Medical Center.
Harvard Medical School.
2003-2009
Associate Professor, Departments of Surgery and Pathology, Creighton
University Medical Center.
2009-now
Professor, Department of Pathology, Creighton University Medical Center.
Memberships, Offices and Committee Assignments in Professional Societies:
1984-1987
1984-1987
19981997-2003
2000-2007
2004-
Member, The Chinese Biochemistry Society.
Member, The Chinese Cell Biology Society.
Active member, American Association for Cancer Research.
Member, American Society of Hematology
Member, American Society of Cell Biology
Member, American Society of Endocrinology
Funding:
RO1 (DK070016)
PI
4/1/2006-3/30/2012 (no cost
extension)
NIH/NIDDK,
$205,000 (direct cost)/year
Estrogen signaling in normal and transformed cell growth.
LB 595,
Cancer Biology Component 1,
State of Nebraska
Estrogen receptor variant ER-46 in Breast Cancer.
DOD (BC101532).
PI
Department of Defense
Breast cancer stem cells in antiestrogen resistance.
7/1/2009-6/30/2014
$100,000 (direct cost)/year
6/1/2011-5/30/2013
$187,500 (direct cost/year).
Nebraska Department of Health and Human Services, PI,
7/1/2011-6/30/2013
$150,000 direct cost/year
ER-36: Roles in breast cancer stem cells.
Patents:
1. UBIQUITIN CONJUGATING ENZYMES HAVING TRANSCRIPTIONAL
REPRESSOR ACTIVITY.
US patent number: 5,770,720.
2. ESTROGEN RECEPTORS AND METHODS FOR THEIR USE.
2
US patent number: 7,745,230; PCT/US2005/007857
3. ANTIBODY THAT BINDS TO ER-36.
US patent number: 8,013,127.
3
Bibliography
Original Reports:
1.
Takimoto,Y., Wang, Z-Y., Kobler,K. and Deuel,T.F. "Promoter Region of the Human
Platelet-derived Growth Factor A-chain Gene." Proc. Natl. Acad. Sci. USA. 1991;
88:1686-1690.
2.
Wang, Z-Y.,Lin,X-H. andDeuel,T.F. " Analysis of the Promoter Region of the Human
Platelet-derived Growth Factor A-chain Gene." The Transaction of the Association of
American Physicians.CIV, 1991; 10: 1-10.
3.
Wang, Z-Y.,Lin,X-H., Nobyuoshi, M., Qiu,Q-Q. and Deuel T.F. "Binding of Singlestranded Oligonucleotides to a Non-B-form DNA Structure Results in Loss of Promoter
Activity of the Platelet- derived Growth Factor A-chain Gene." J. Biol. Chem. 1992; 267:
13669-13674.
4.
Wang, Z-Y.,Lin,X-H., Qiu,Q-Q. andDeuel,T.F. "Modulation of Transcription of the
Platelet-derived Growth Factor A-chain gene by a Promoter Region Sensitive to S1
Nuclease." J. Biol. Chem. 1992; 267: 17022-17031.
5.
Wang, Z-Y.,Madden,S.L., Deuel,T.F. and Rauscher,F.J. III. " The Wilms' Tumor Gene
Product, WT1, Represses Transcription of the PDGF A-chain Gene". J. Biol. Chem.
1992; 267: 21999-22002.
6.
Wang, Z-Y. and Deuel, T. F. "An S1Nuclease Sensitive Homopurine/ Homopyrimidine
Domain in the PDGF A-chain Promoter Contains a Novel Binding site for the Growth
Factor-inducible Protein EGR-1".Biochem. Biophy. Res. Commun. 1992; 188: 433-439.
7.
Lin, X-H.,Wang, Z-Y., Gu,L-J. andDeuel,T.F. "Functional Analysis of the Human
Platelet-derived Growth Factor A-chain Promoter Region" J. Biol. Chem. 1992; 267:
25614-25619.
8.
Wang, Z-Y.,Lin,X-H. Nobuyoshi,M. and Deuel,T.F. " Identification of a Single-stranded
DNA-Binding Protein That Interacts with An S1 Nuclease-sensitive Region in the
Platelet-derived Growth Factor A-chain Gene Promoter" J. Biol. Chem. 1993; 268:1068110685.
9.
Wang, Z-Y.,Qiu,Q-Q. andDeuel,T.F. " The Wilms' Tumor Gene Product WT1 Activates
or Suppresses Transcription through Separate Functional Domains" J. Biol. Chem. 1993;
268:9172-9175.
4
10.
Wang, Z-Y.,Qiu,Q-Q. andDeuel,T.F. " A Second Transcriptionally Active DNA-Binding
Site for the Wilms' Tumor Gene Product, WT1" Proc. Natl. Acad. Sci. U.S.A. 1993; 90:
8896-8900.
11.
Takimoto,Y., Li, W.Y., Wang, Z-Y., Tong, B.D. and Deuel,T.F. "Nucleotide Sequence of
the 5’ Region of the Human Platelet-derived Growth Factor A-chain Gene." Hiroshima J.
Med. Sci. 1993; 42: 47-52.
12.
Wang, Z-Y.,Qiu, Q-Q, and Deuel, T.F. " An S1 Nuclease Sensitive Region in the PDGF
A-Chain Gene Promoter Contains a Positive Transcriptional Regulatory Element"
Biochem. Biophy. Res. Comm. 1994; 98: 103-110.
13.
Wang, Z-Y.,Nobuyoshi,M., Takimoto,Y. and Deuel,T.F. "An S1 Nuclease-sensitive
Domain in the First Intron of Human PDGF A-chain Gene Contains a Negatively Acting
Cell Type-specific Regulatory Element." Nucleic Acid Res. 1994; 3: 457-464.
14.
Wang, Z-Y.,Qiu,Q-Q. andDeuel,T.F. "Alternatively Spliced Products of the Wilms'
Tumor Suppressor Gene, wt1, have Altered DNA Binding Specificity and Regulated
Transcription in Different Ways". Oncogene 1995; 10: 415-422.
15.
Wang, Z-Y.,Qiu, Q-Q., Gurrieri, M., Huang, J. and Deuel, T.F. " WT1, the Wilms' Tumor
Gene Product, Represses Transcription Through a Cellular Protein". Oncogene 1995;
10:1243-1247.
16.
Wang, Z-Y.,Qiu, Q-Q., Seufert, W., Taguchi, T., Testa, J.P., Whitmore, S.A., Callen, D.,
Shenk, T and Deuel, T.F “ Molecular Cloning and Chromosome Localization of Ubiquitin
Conjugating Enzyme 9.” J. Biol. Chem. 1996; 271: 24811-24816.
17.
Nobyuoshi, M., Lin, X-H.,Takimoto, Y., Deuel T.F. and Wang, Z-Y "Transcription
Regulation of the PDGF A-chain Gene by First Intron Elements." Biochem. Biophy. Res.
Commun. 1997; 230: 569-572.
18.
Zhang, N., Zhong, R., Wang Z-Y, and Deuel, T.F. “Human breast cancer growth inhibited
in vivo by a dominant negative pleiotrophin mutant” J. Biol. Chem. 1997, 272: 1673316736.
19.
Guan, L-S. andWang, Z-Y “ A Point Mutation Within Exon 5 of WT1 Gene Associated
with Sporadic Unilateral Wilms’ Tumor Alters Gene Function.” Cancer Research.1998;
58: 4180-4184.
5
20.
Guan, L-S., Michael Rauchman and Wang, Z-Y. “ Induction of Rb associated protein
(RbAp46) by Wilms’ tumor suppressor WT1 mediates growth inhibition.” J. Biol. Chem.
1998; 273: 27047-27050.
21.
Liu, J-J.,Wang, Z-Y, Deuel, T.F. and Xu, Y-H. “ Imbalance of WT1 Isoforms may
contribute to Sporadic Unilateral Wilms’ Tumor.”Biochem. Biophy. Res. Commun. 1999; 8:
197-199.
22.
Deuel, T. F., Guan, L-S. andWang, Z-Y. “Wilms’ Tumor Gene Product WT1 Arrests
Macrophage Differentiation of HL-60 Cells Through Its Zinc-Finger Domain”.Biochem.
Biophy. Res. Commun1999; 8:192-196.
23.
Liu, X.W. Gong, L. J., Guo, L. Y., Katagiri, Y., Jiang, H., Wang, Z. Y., Johnson, A.C. and
Guroff, G. “The Wilms' tumor gene product WT1 mediates the down-regulation of the rat
epidermal growth factor receptor by nerve growth factor in PC12 cells”. J. Biol. Chem.
1998; 273: 27047-27050
24.
Guan, L-S.Li, G.C. Chen, G.C. Liu, L.Q. and Wang, Z-Y. “ Rb associated protein
(RbAp46) suppresses the transformed phenotypes of HEK 293 cells.” Intl. J. Cancer. 2001;
93: 333-338.
25.
Chen, G-C., Guan, L-S., Yu, J-H., Li, G-C., Kim, H-R. andWang, Z-Y. “Rb Associated
Protein 46 (RbAp46) Inhibits Transcriptional Transactivation Mediated by BRCA1.”
Biochem. Biophys. Res. Commun. 2001; 284: 507-514.
26.
Chen, G-C, Guan, L-S., Hu, W-L. and Wang, Z-Y. “Functional Repression of Estrogen
Receptor  by Arsenic Trioxide in Human Breast Cancer Cells.” Anticancer Research
2002; 20: 633-638.
27.
Li, G-C., Guan, L-S. andWang, Z-Y. “Overexpression of RbAp46 Facilitates StressInduced Apoptosis and Suppresses Tumorigenicity of Neoplastigenic Breast epithelial
cells.” International J. Cancer. 2003; 105: 762-768.
28.
Zhang, T.F., Yu, S-Q., Guan, L-S. andWang, Z-Y. “Inhibition of Breast Cancer Cell
Growth by the Wilms’ Tumor Suppressor WT1 is Associated with a Destabilization of Catenin.” Anticancer Research. 2003; 3: 35785-35874.
6
29.
Zhang, T.F., Yu, S-Q., Guan, L-S. andWang, Z-Y. “Constitutive Expression of Rb
Associated Protein 46 (RbAp46) Reverts Transformed Phenotypes of Breast Cancer Cells.”
Anticancer Research. 2003; 23: 3735-3740.
30.
Zhang, T.F., Yu, S-Q., Guan, L-S. andWang, Z-Y. “Inducible Expression of RbAp46
Activates c-Jun NH2-terminal Kinase Dependent Apoptosis and Suppresses Progressive
Growth of Tumor Xenografts in Nude Mice.” Anticancer Research. 2003; 23: 4621-4628.
31.
Zhang, X.T., Shen, P., Coleman, M,,Zou, W., Loggie, B. W., Smith L.M. and Wang, Z-Y.
“Caveolin-1 Downregulation Activates Estrogen Receptor Alpha Expression and Leads to
17-estradiol-Stimulated Mammary Tumorigenesis.” Anticancer Research. 2005; 25: 369376.
32.
Wang , Z-Y., Zhang, X.T., Shen, P., Loggie, B.W., Chang, Y.C. and Deuel, T. F.
“Identification, Cloning and Expression of Human Estrogen Receptor-36, a Novel Variant
of Human Estrogen Receptor-.” Biochem. Biophy. Res. Commun2005; 336: 1023-1027.
33.
Zhang, N., Zhong, R., Wang, Z. Y., Deuel, T.F. “Identification of the Pleiotrophin
Angiogenesis Signaling Domain Defines a Mechanism of an Angiogenic Switch.”
Biochem. Biophys. Res. Commun.2006; 343: 653-658.
34.
Wang , Z-Y., Zhang, X.T., Shen, P., Loggie, B.W., Chang, Y.C. and Deuel, T. F. “A
Variant of Estrogen Receptor-, hER-36: Transduction of Estrogen and Anti-Estrogen
Dependent Membrane-Initiated Mitogenic Signaling.” Proc. Natl. Acad. Sci. U.S.A. 2006;
103: 9063-9068.
35.
Li, G-C. andWang, Z-Y. “Constitutive Expression of RbAp46 Induces EpithelialMesenchymal Transition in Mammary Epithelial Cells.” Anticancer Research.2006;
26:3555-3560.
36.
Li, G-C. andWang, Z-Y. “Rb Associated Protein 46 (RbAp46) Attenuates -catenin/TCF
Signaling through up-regulation of GSK-3 expression.” Anticancer Research. 2006; 26:
4511-4518.
37.
Zhang, T.F., Yu, S-Q. andWang, Z-Y. “RbAp46 Inhibits Estrogen-stimulated Progression
of Neoplastigenic Breast Epithelial Cells.” Anticancer Research. 2007. 27: 3205-3209.
38.
Lee, L, M-J.,Cao,J., Chen,P.,Gatalica Z. and Wang, Z-Y. “ER-α36, a Novel Variant of
ER-, is Expressed in ER-α Positive and Negative Human Breast Carcinomas”. Anticancer
Research. 2008. 28: 479-484.
7
39.
Wang, L. and Wang, Z-Y. “The Wilms’ Tumor Suppressor WT1 Inhibits Malignant
Progression of Neoplastigenic Mammary Epithelial Cells”.Anticancer Research 2008.28:
2153-2158.
40.
Kang, L.G., Ding, L. and Wang, Z-Y.“Dietary IsothiocyanatesRepress Estrogen Receptor α
Expression in ER-positive Breast Cancer Cells”.Oncology Reporters 2009, 21: 185-192.
41.
Jiang, H.P., Teng, R.Y,, Wang, Q., Zhang, X., Wang, H.H., Wang, Z-Y., Cao, Jand Teng,
L.S. “Transcriptional analysis of estrogen receptor alpha variant mRNAs in colorectal
cancers and their matched normal colorectal tissues”. The Journal of Steroid Biochemistry
and Molecular Biology2008 11: 20-24.
42.
Zou, Y. Ding, L., Coleman M. and Wang,Z-Y.“Estrogen Receptor-alpha (ER-) Suppresses
Expression of its Variant ER-36”.FESEB Letters2009, 583: 1368–1374.
43.
Shi, L., Dong, B., Li, Z.W., Lu, Y.W., Ouyang, T., Li, J. F., Wang, T. F., Fan,Z. Q.,Fan, T.,
Lin, B.Y., Wang, Z. Y. and Xie,Y. T. “Expression of ER-36, a Novel Variant of Estrogen
Receptor-, and Resistance to Tamoxifen Treatment in Breast Cancer”. J. Clinical Oncology
2009, 27: 3423-3429.
44.
Lin, S.L., Yan, L.Y., Liang, X.W., Zhen-Bo Wang, Z.B., Wang, Z.Y., Qiao, J., Schatten, H.
and Sun, Q. Y.“A novel variant of ER-alpha, ER-alpha36 mediates testosterone-stimulated
ERK and Akt activation in endometrial cancer Hec1A cells” Reproductive Biology and
Endocrinology 2009, 7:102-106.
45.
Wang, L. and Wang, Z-Y. “The Wilms’ Tumor Suppressor WT1 Induces Estrogen
Independent Growth and Antiestrogen Resistance in ER-positive Breast Cancer MCF7
Cells”.Oncology Reports. 2010, 23: 1109-1117.
46.
Kang, L.G., and Wang, Z-Y. “Growth Inhibition of ER-positive Breast Cancer Cells by
Phenethyl Isothiocyanate is Associated With Downregulation of ER-36, a Variant of
Estrogen Receptor-alpha”.J. Cellular and Molecular Medicine. 2010, 14: 1485-1493.
47.
Kang, L.G., Zhang, X.T. Xie, Y., Tu Y.P., Wang, D., LiuZ.M. and Wang, Z-Y. “The
Involvement of Estrogen Receptor Variant ER-6, not GPR30, in Non-Genomic Estrogen
Signaling”. Molecular Endocrinology. 2010, 24: 709-721.
48.
Lin, S.L., Yan, L.Y., Zhang, X.T., Yuan, J., Li, M., Qiao, J., Wang, Z-Y. and Sun, Q-Y.
"ER-36, a Variant of ER-, Promotes Tamoxifen Agonist Action in Endometrial Cancer
Cells via the MAPK/ERK and PI3K/Akt Pathways". pLosONE, 2010, 5(2): e9013.
8
49.
Shi, Y.N.E. Chen, Y.D. Dackour, R., Potters, L., Wang, S., Ding, Q., Wang, Z-Y.and Liu, Y.
L. “Synuclein Stimulates Membrane Initiated Estrogen Signaling by Chaperoning Estrogen
Receptor (ER)-36, a Variant of ER-AmericanJ Pathology, 2010, 177: 964-973.
50.
Wang, L., Zhang, X.T. and Wang Z.Y. “The Wilms’ Tumor Suppressor WT1 Regulates
Expression of Members of the Epidermal Growth Factor Receptor (EGFR) and Estrogen
Receptor in Acquired Tamoxifen Resistance”. AntiCancer Research. 2010, 30: 3637-3642.
51.
Vranic, S, Gatalica, Z., Deng, H., Frkovic-Grazio, S., Lee, LMJ., Olga Gurjeva, O. and
Wang, Z-Y. “ER-α36, a Novel Isoform of ER-α66, is Commonly Over-expressed in
Apocrine and Adenoid Cystic Carcinomas of the Breast”. J.of Clinical
Pathology. 2011, 64: 54-57.
52.
Kang, L, G., Wang, L. and Wang Z.Y. “Opposite Regulation of ER- and its Variant ER36 by the Wilms’ Tumor Suppressor WT1”. Oncology Letters. 2011, 2: 337-341.
53.
Xie, H., Sun,M., Liao,X, B., Yuan, L.Q., Sheng, Z.F., Meng,J.-C., Wang,D.,Yu,Z.Y.,
Zhang,L. Y. Zhou, H. D., Luo,X. H., Li,H., Wu,X. P. Wei , Q. Y. Tang, S. Y. 5, Wang, ZY.and Liao, E. Y. “Estrogen receptor-alpha36 Mediates a Bone-sparing Effect of 17betaestrodiol in Postmenopausal Women”. J. Bone and Mineral Res.2011, 26: 156-168.
54.
Zhang, X.T., Kang, L.G. Ding, L., Vranic, S., Gatalic, Z. andWang , Z-Y. “A Positive
Feedback Loop of ER-36/EGFR Promotes Malignant Growth of ER-negative Breast Cancer
Cells”. Oncogene 2011, 30: 770-780.
55.
Guo, Y. M, Zhang, X. T., Meng, J. and Wang, Z. Y. “An Anticancer Agent Icaritin induces
Sustained Activation of the Extracellular Signal Regulated Kinase (ERK) Pathway and
Inhibits Growth of Breast Cancer Cells”.European Journal of Pharmacology, 2011, 658:
114-122.
56.
Kang, L.G., Guo, Y. M, Zhang, X. T., Meng, J. and Wang, Z. Y. “A Positive CrossRegulation of HER2 and ER-α36 Controls ALDH1 Positive Breast Cancer Cells”. The
Journal of Steroid Bochemistry and Molecular Biology, 2011, 127: 262-268.
57.
Zhao Y.C., Deng, C.S., Lu, W.D. Xiao, J., Ma, D. J., Guo, M.X., Recker, R. R., Catalica, Z.,
Wang Z-Y. and Xiao G. S. “Let-7 MicroRNAs Induce Tamoxifen Sensitivity by
Downregulation of Estrogen Receptor a Signaling in Breast Cancer” Mol. Med. 2011, 17:
1233-1241.
58.
Vranic S., Gatalica, Z.and Wang, Z.Y. “Update on the molecular profile of the MDA-MB453 cell line as a model for apocrine breast carcinoma studies”. Oncology Letters. 2011, 2:
1131-1137.
9
59.
Zhang, X.T., Ding, L., Kang, L.G., and Wang , Z-Y. “Estrogen Receptor alpha 36 Mediates
Mitogenic Antiestrogen Signaling in ER-negative Breast Cancer Cells”. PLos ONE. 2012,
7(1): e30174.
60.
Zhang, X.T., Ding, L., Kang, L.G.,and Wang , Z-Y.“Involvement of ER-36, Src, EGFR and
STAT5 in the Biphasic Estrogen Signaling”.Oncology Reports, 2012 27:2057-2065.
61.
Zhang, X.T., Meng J. and Wang , Z-Y. “A Switch Role of Src in the Biphasic EGF
Signaling of ER-negative Breast Cancer Cells ”.PLos ONE. 2012, 7(8): e41613.
62.
Zhang, X.T. and Wang, Z-Y. “Estrogen Receptor- Variant, ER-36, is Involved in
Tamoxifen Resistance and Estrogen Hypersensitivity”. Endocrinology. 2013, 154: 19901998
63.
Guo, M. X., Wang, M. L.,Zhang, X. T., Deng H.and Wang, Z. Y. “Broussoflavonol B
Restricts Growth of ER-negative Breast Cancer Stem-like Cells”.AntiCancer Research.
2013, 1873-1880.
64.
Guo, F. J., Feng, Li., Huang, C., Ding, H.X., Zhang, X.T., Wang, Z.Y. and Li, Y.M.
“Prenylflavone Derivatives from Broussonetiapapyrifera inhibit the growth of breast
cancer cells in vitro and in vivo.” Phytochemistry Letters. 2013, 6: 331-336.
65.
Guo, M. X., Wang, M. L.,Zhang, X. T., Deng H.and Wang, Z. Y. “A Novel Anticancer
Agent Broussoflavonol B Downregulates ER-36 Expression and Inhibits Growth of ERnegative Breast Cancer MDA-MB-231 Cells”. European Journal of Pharmacology, 2013,
714: 56-64.
66.
Deng, H., Zhang, X.T., Wang, M. L., Zheng, H. Y.,Liu, L. J., Wang, Z. Y.“ER-36mediated Rapid Estrogen Signaling Positively Regulates ER-positive Breast Cancer
Stem/Progenitor Cells.”PLos ONE. 2014, e88034.
67.
Zhang, X. T., Deng H.,Wang Z. Y. “Estrogen Activation of the Mitogen-Activated Protein
Kinase is Mediated by ER-36 in ER-positive Breast Cancer Cells”. Journal of Steroid
Bochemistry and Molecular Biology, 2014, 143: 434-443.
68.
Yin,L., Zhang, X. T., Bian X. W.,Guo Y. M., Wang, Z. Y. “Disruption of the ER-36EGFR/HER2 Positive Regulatory Loops Restores Tamoxifen Sensitivity in Tamoxifen
Resistance Breast Cancer Cells”.PLos ONE. In Press.
69.
Deng,H., Yin, L., Zhang,X.T., Li-Jiang Liu2, Mo-Lin Wang3, Zhao-Yi Wang1ER-
Variant ER-36 Mediates Antiestrogen Resistance in ER-positive Breast Cancer
Stem/Progenitor Cells
10
Book Chapters and Reviews:
1.
Deuel, T.F., Wang, Z-Y. and Kawahara, R.S. “Would healing and angiogenesis. In
Hemostasis and Thromobosis”. In: Colman RW, Hirsh J, Marder VJ, and E,W, Salzman
EW, eds. Basic Principles and Clinical Practice. Philadelphia: J.B. Lippencott Co. 1994:
797-804.
2.
Lin, X-H.,Wang, Z-Y., Kim, H.R., and Deuel, T.F. “Mechanisms of Potentiation of PDGF
in Atherosclerosis” In: Gallo LL edsCardiovascular Disease 2 New York Plenum Press.
129-132.
3.
Wang, Z-Y. andDeuel, T.F." S1 Nuclease Sensitive Sites and Transcription Regulation of
the Human PDGF A-chain Gene" Progress in Nucleic Acid Research and Molecular
Biology (eds., W.E. Cohn and K. Moldave), Academic Press, Inc., San Diego, CA. 1996. 55:
227-244.
4.
Deuel, T.F., Zhang, N., Yeh, H-J., Silos-Santiago, I. and Wang, Z.-Y. “ Pleiotrophin: A
Cytokine with Diverse Functions and a Novel Signaling Pathway” Archives of Biochemistry
and Biophysics. 2002, 397: 162-171.
5.
Wang, Z.-Y. Zhang, XT., Kang, LK.“ER-Alpha36 Mediates Non-Genomic Estrogen and
Anti-Estrogen signaling in Breast Cancer Cells” Breast Cancer-Carcinogenesis, Cell
Growth and Signaling Pathways.InTech. Inc. Rijeka, Croatia. 2011:
Abstracts and Meeting Presentations:
A1.
Wang, Z-Y.,Takimoto, Y., and Deuel, T.F. "SP1 binding site is sensitive to S1 nuclease
in the PDGF A-chain promoter." [Abstract] J. Cell. Biol. 1989; 7:91a.
A2.
Wang, Z-Y., Lin, X-H., and Deuel, T.F. "Analysis of the promoter region of the human
PDGF A-chain gene." [Oral Presentation] Clin. Res. 1991; 39:190a.
A3.
Wang, Z-Y., Lin, X-H., and Deuel, T.F. "Modulation of human platelet-derived growth
factor (PDGF) A-chain gene transcription by promoter sites sensitive to S1
nuclease."[Abstract] FASEB J. 1991; 5:818a.
A4.
Wang, Z-Y., and Deuel, T.F. "The Wilms' tumor gene product, WT1 both negatively and
positively regulates PDGF gene expression." [Oral Presentation] Blood
1992;
80(Suppl.1):357a.
11
A5.
Wang, Z-Y.,Qiu, Q-Q., and Deuel, T.F. "Transcriptional regulation of the PDGF A-chain
gene by the alternatively spliced Wilms' tumor gene product WT1." [Abstract] Blood
1993; 82(Suppl.1):121a.
A6.
Wang, Z-Y., Deuel, T.F. and Shenk,T. " TRAF functions as an auxiliary factor to mediate
the transcriptional repression of the Wilms' tumor suppressor gene product" [Oral
Presentation] Cold Spring Harbor Meeting on Cancer Cells ,1995.
A7.
Wang, Z-Y.,Qiu,Q-Q., Sefert,W., Deuel, T.F. and Shenk, T. "Human ubiquitin
conjugating enzyme 9 functions as a co-factor in the repression of transcription by the
Wilm’s tumor repressor gene product." [Abstract] Blood. 1995; 86(Suppl.1): 654a.
A8.
Guan, L-S., and Wang, Z-Y. “Induction of RbAp46 by Wilms’ Tumor suppressor, WT1”
[Abstract] Blood 1997; 90 (Suppl): 489a.
A9.
Wang, Z-Y., Liu, J-J., Xu, Y-H. and Deuel, T.F. “Imbalance of WT1 isoforms in sporadic
unilateral Wilms’ tumor” [Abstract] Blood 1997; 90 (Suppl): 489a.
A10.
Guan, L-S., and Wang, Z-Y. “Induction of RbAp46 by Wilms’ tumor suppressor, WT1
mediates growth Inhibition and tumor suppression” [Oral Presentation] Proceedings of the
American Association for Cancer Research 1999; 40: 726.
A11.
Chen, G-C., Guan L-S., Li, G-C. andWang, Z-Y. "RB-associated protein (RbAp46): a
Novel Tumor Suppressor." [Oral Presentation] Cold Spring Harbor Meeting on Cancer
Genetics & Tumor Suppressor Genes, 2000.
A12.
Li, G-C., Guan, L-S., Chen G-C. and Wang, Z-Y. “Constitutive expression of RbAp46 in
TG3B epithelial cells induces epithelial-mesenchymal transition” [Late-Breaking Abstract]
Proceedings Supplement of the American Association for Cancer Research. 2001; 75:
726.
Li, G-C., Guan, L-S., Chen G-C. andWang, Z-Y.“Rb-Associated Protein 46 (RbAp46)
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