Annual Symposium Wednesday 20 May 2015, Royal College of Physicians, Edinburgh
Poster presentations
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Posters
A Novel Fibrinogen-Binding Mechanism for a Staphylococcal Cell Wall Associated Protein
Amy Richards (1), Brandon Garcia(2), Andrea Bordt (2), Ian Monk (3), Giampiero Pietrocola (4),
Pietro Speziale (4), Timothy J. Foster (5), Andreas Lengeling (1), Magnus Hook (2) and J. Ross
Fitzgerald (1)
(1) The Roslin Institute, Infection and Immunity, University of Edinburgh, UK; (2) Texas A&M
University Health Science Centre, Houston, Texas; (3) University of Melbourne, Department of
Microbiology and Immunology, Melbourne, Australia; (4) University of Pavia, Department of
Molecular Medicine, Pavia, Italy; (5) Trinity College Dublin, Department of Microbiology, Dublin,
Ireland
AMR - a modern reality
Judith Oguguo and Kim Picozzi
Division of Infection and Pathway Medicine, University of Edinburgh
Biophysical characterization and activities of lymphostatin: a multitalented inhibitor of
lymphocyte function from attaching & effacing Escherichia coli
Robin L Cassady-Cain (1), Elizabeth A. Blackburn (2), Andrew Bease (1), Bettina Boettcher (2),
Martin Wear (2), Jayne Hope (1) and Mark P. Stevens (1)
(1) The Roslin Institute, University of Edinburgh, Easter Bush and (2) The Centre for Translational
and Chemical Biology (CTCB), University of Edinburgh, Michael Swann Building, King's Buildings
Bovine natural killer (NK) cells recirculate in steady – state conditions and increase their
expression of CD25 and production of IFN-γ after co-culture with BCG infected dendritic cells
(DCs)
Carly Hamilton (1), Gary Entrican (1,2) and Jayne Hope (1)
(1) The Roslin Institute, The University of Edinburgh; (2) Moredun Research Institute, Pentlands
Science Park
Cellular RNA editing enzyme ADAR1 interacts with Influenza A virus proteins during infection
and enhances virus replication.
Nikki Smith (1), Artur A Arikainen (2), Tali Jowers Pechenick (1), Helen Wise (1), Julian Hiscox (3)
and Paul Digard (1)
(1) The Roslin Institute, The University of Edinburgh, (2) University of Cambridge, (3) Institute of
Infection and Global Health, University of Liverpool
Defensins in the gastrointestinal tract influence the microbiome
Fiona Semple, Tina baker, Heather MacPherson, Sheila Webb, Nita Salzman, and Julia Dorin
MRC Human Genetics Unit & MRC Centre for Inflammation Research, University of Edinburgh,
Disease, Diagnosis and Dirt
Sonia Rehman and Kim Picozzi
Division of Infection and Pathway Medicine, University of Edinburgh
Dysregulated functioning of marginal zone B cells in aged mice
Turner, V.M. and Mabbott, N
Neurobiology Division, The Roslin Institute and the R(D)SVS, University of Edinburgh
Establishment of an in vitro infection model for investigating the role of Staphylococcus aureus
virulence factors during co-infection with Influenza A virus
Annual Symposium Wednesday 20 May 2015, Royal College of Physicians, Edinburgh
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Mariya Goncheva, Bernadette Dutia, Paul Digard and J. Ross Fitzgerald
The Roslin institute, The University of Edinburgh
Functional diversity outweighs phenotypic plasticity of macrophages in a helminth-bacterial coinfection model in vivo
Dominik Rückerl (1), Stephen J Jenkins (2), Sheelagh Duncan (1), Tom A Barr (3), James P
Hewitson (4), Tara E Sutherland (1), Lucy H Jones (1), Sharon M Campbell (1), David Gray (1), Rick
M Maizels (1) and Judith E Allen (1)
(1) Centre for Immunity Infection and Evolution, School of Biological Sciences, University of
Edinburgh, Edinburgh, UK; (2) Queens Medical Research Institute, The University of Edinburgh,
Edinburgh, UK; (3) Institute of Infection, Immunity and Inflammation, University of Glasgow,
Glasgow, UK; (4) Centre for Immunology and Infection, The University of York, York, UK
Host targeted miRNA therapeutics for the treatment of respiratory viral infections
Jana McCaskill, Diwakar Santhakumar, Andreas Alber, Christopher Plinston, Jane Redford, Jürgen
Schwarze, Gerry McLachlan, Bernadette Dutia, and Amy H Buck
University of Edinburgh
Identification of tick borne pathogens in wildlife in the Serengeti National Park from tsetse
bloodmeals using reverse line blotting
Ruaridh MacKay (1), Harriet Auty (2), Vincenzo Lorusso (1, 3) and Ewan MacLeod (1)
(1) Division of Infection and Pathway Medicine, University of Edinburgh, (2) SRUC, Epidemiology
Research Unit, Stratherrick Road, Inverness; (3) Vetquinol Laboratories, 37 Rue de la Victorie,
75009, Paris, France
Increased expression of Akt1 in avian macrophages may play a role in the differential resistance
of chicken lines to Salmonella infection
Karavolos M. H. (1), Cassady-Cain R. L. (1), Chintoan-Utah C. (1), Fife M. (2), Kaiser P. 1, and
Stevens M. P. (1)
(1) The Roslin Institute, University of Edinburgh, Edinburgh, UK and (2) The Pirbright Institute,
Compton Laboratory, Berkshire, UK
Investigating Differential T-cell Polarization in the two pathological forms of sheep
Paratuberculosis
L. Nicol (1), C. Watkins (2), A. Gossner (1), R. Dalziel (1) and J. Hopkins (1)
(1) The Roslin Institute & R(D)SVS, University of Edinburgh; (2) Moredun Research Institute,
Pentlands Science Park, Bush Loan
Investigating the formation and maturation of M cells
Anuj Sehgal, David S. Donaldson, Neil A. Mabbott
Roslin Institute and R(D)SVS, University of Edinburgh
Investigating the Role of the Host Cell Protein IQGAP1 in Actin-Based Motility of Burkholderia
pseudomallei
Niramol Jitprasutwit and Jo M. Stevens
Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh
Is High Risk HPV related disease modulated by autophagic mechanisms?
Chara Charsou (1), Rui Chen (2), Daniel Soong (5), Juergen Haas (2), Alistair Williams (3), Kate
Cuschieri (4), Sarah Howie (1)
(1) University of Edinburgh, MRC Centre for Inflammation Research, Queen’s Medical Research
Institute; (2) University of Edinburgh, Division of Infection and Pathway Medicine, Medical
School; (3) University of Edinburgh, Royal Infirmary of Edinburgh; (4) Scottish HPV Reference
Annual Symposium Wednesday 20 May 2015, Royal College of Physicians, Edinburgh
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Laboratory, Royal Infirmary of Edinburgh (5) University of Edinburgh, MRC Centre for
Reproductive Health, Queen’s Medical Research Institute
Ischemic stroke induces a loss of innate-like marginal zone B cell functions and a susceptibility
to bacterial pneumonia via b-adrenergic receptor signalling
L. McCulloch (1), S. Hulme (3), P. Tyrrell (2,3) S. Hopkins (4) , C. J. Smith (2,3) and B. McColl (1)
(1) The Roslin Institute, University of Edinburgh, Scotland, (2) University of Manchester, U.K, (4)
Stroke services, Clinical Sciences Building, Hope Hospital, Eccles Old Road, Salford, M6 8HD, (4)
North Western Injury Research Collaboration (NWIRC) Clinical Sciences Building, Hope Hospital,
Eccles Old Road, Salford M6 8HD
Jmjd6 – A Major Player in Innate Immune Response in Macrophages?
Janice Kwok, Tali Pechenick-Jowers, Marie O’Shea, Clare Pridan1, Pip Beard, David Hume and
Andreas Lengeling
The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh,
Regulation-innovation interactions in the development of veterinary antimicrobial drugs
Ann Bruce (Senior Research Fellow) and Jack Scannell (Visiting Fellow)
Innogen Institute, Science, Technology & Innovation Studies, University of Edinburgh
Secreted exosomes from Heligmosomoides polygyrus modulate cellular responses of the
murine host
G Coakley, F Simbari, H McSorley, J McCaskill, M Lear, R Maizels and A Buck
Institute of Immunology and Infection Research, University of Edinburgh
Silent spread of classical swine fever in the UK: where and when to worry?
Thibaud Porphyre (1), Carla Correia-Gomes (2), Kokouvi Gamado (3), Ian Hutchinson (2), Harriet K.
Auty (2), Lisa A. Boden (4) , Aaron Reeves (2), George Gunn (2), Mark E. J. Woolhouse (1)
(1) Epidemiology Research Group, Centre for Immunity, Infection and Evolution, University of
Edinburgh; (2) Epidemiology Research Unit, Scotland’s Rural College, Inverness; (3)
Biomathematics & Statistics Scotland, Edinburgh; (4) School of Veterinary Medicine, Boyd Orr
Centre for Population and Ecosystem Health, University of Glasgow
Staphylococcal enterotoxin-like toxin X (SElX) binds to Neutrophils in a sialic-acid dependent
manner and inhibits neutrophil Function
Stephen W. Nutbeam-Tuffs (1), Jovanka Bestebroer (2), W. Ivan Morrison1, Jos A.Van Strijp (2),
David James (3), Victor J. Torres (3), J. Ross Fitzgerald (1)
(1) The Roslin Institute, University of Edinburgh, Easter Bush, Midlothian, UK, (2) Dept. Medical
Microbiology, UMC Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands, (3)
Department of Microbiology, New York University School of Medicine, New York, NY 10016
Stratification of human neonatal immune response to sepsis using genomic exptession profile
Olanrewaju Samuel Akomolafe
Division of Infection and Pathway Medicine, University of Edinburgh
Studies on the intracellular life of the melioidosis pathogen Burkholderia pseudomallei
Nurhamimah Zainal Abidin and Jo Stevens
The Roslin Institute, University of Edinburgh
T helper cell transcription factor polymorphisms in nematode-infected sheep
Hazel Wilkie (1), Anton Gossner (1), Stephen Bishop (2) and John Hopkins (1)
(1) Department of Infection and Immunity, (2) Department of Genetics and Genomics, The Roslin
Institute, University of Edinburgh.
The role of hypochlorous acid in chloride ion-induced inhibition of virus replication
Annual Symposium Wednesday 20 May 2015, Royal College of Physicians, Edinburgh
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Baiyi Cai, Sandeep Ramalingam, Samantha J. Griffiths, Junsheng Wong, Matthew Twomey, Rui
Chen and Juergen G. Haas
Division of Infection and Pathway Medicine, University of Edinburgh
The role of segment 3 in H9N2 influenza virus pathogenicity
Anabel Clements (1,2), Saira Hussain (1), Helen Wise (1), Holly Shelton (2), Munir Iqbal (2) and
Paul Digard (1)
(1) The Roslin Institute, University of Edinburgh; (2)The Pirbright Institute
The role of the avian allele of the influenza A virus NS segment in setting host range and
pathogenicity
Matthew Turnbull (1), Helen Wise (1), Marlynne Quigg-Nicol (1), Nikki Smith (1), Rebecca Dunfee
(2), Pip Beard (1), Brett Jagger (2,3), Yvonne Ligertwood (1), Gareth Hardisty (1), Jeffery
Taubenberger (2), Samantha Lycett (1), Michael Weekes (4), Bernadette Dutia (1) and Paul Digard
(1)
(1) Department of Infection and Immunity, The Roslin Institute, The University of Edinburgh,UK
(2) Division of Intramural Research, National Institute of Allergy and Infectious Diseases,
Bethesda, USA; (3) Division of Virology, Department of Pathology, University of Cambridge, UK;
(4) Cambridge Institute for Medical Research and Department of Medicine, University of
Cambridge, Addenbrooke’s Hospital, Cambridge, UK
Towards new drugs for trypanosomatid diseases based on specific high-affinity inhibitors for
Trypanosoma brucei kinetoplastid RNA editing ligase 1
Stephan Zimmermann (1), Victoria Feher (2), Jesper Sørensen (2), Chris Smith (3), Laurence Hall
(1), Sean Riley (4), Mike Greaney (3), Rommie E. Amaro (2) and Achim Schnaufer (1)
(1) Centre for Immunity, Infection & Evolution, and Institute of Immunology & Infection Research,
University of Edinburgh, UK; (2) Department of Chemistry and Biochemistry, University of
California San Diego, La Jolla, CA, USA; (3) School of Chemistry, University of Manchester, UK; (4)
The Scripps Research Institute, San Diego, USA
Unravelling Salmonella pathogenesis in cattle
Prerna Vohra, Christina Vrettou, Jayne Hope, John Hopkins and Mark Stevens
The Roslin Institute & Royal (Dick) School of Veterinary Studies
Use of intravenous antibiotics in hospital – evidence of changing practice?
Claire L. Mackintosh (1), Oliver Koch (1), Rebecca Sutherland (1), Dáire O’Shea (1), Alison
Cockburn (2), Carol Philip (2), Laura Shaw (2) and Eilidh Fletcher (2)
(1) Regional Infectious Disease Unit, Western General Hospital, Edinburgh EH4 2XU and
Department of Infection and Pathway Medicine, University of Edinburgh; (2) Antimicrobial
Management team, NHS Lothian
Waddlia chondrophila stimulates CXCL8 expression in epithelial cells via p38 and p42/44 MAPK
dependent pathways
Nick Wheelhouse (1,2), Skye Storrie (1), Francesco Vacca (1), Peter Barlow (2) & David
Longbottom (1)
(1) Moredun Research Institute, Pentlands Science Park, Bush Loan, Edinburgh, (2) School of Life,
Sport and Social Sciences, Edinburgh Napier University, Edinburgh
Why do kinetoplastids need a kinetoplast?
Caroline Dewar (1), Paula MacGregor (1), Aitor Casas (2), Nick Savill (1), Alvaro Acosta-Serrano (2),
Keith Matthews (1) and Achim Schnaufer (1)
(1) Centre for Immunity, Infection & Evolution, and Institute of Immunology & Infection Research,
University of Edinburgh; (2) Liverpool School Tropical Medicine, University of Liverpool
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Complexity and dynamics of kDNA
Sinclair Cooper, Nick Savill, Achim Schnaufer
Centre for Immunity, Infection & Evolution, and Institute of Immunology & Infection Research,
University of Edinburgh
Rapid proteasomal elimination of 3-hydroxy-3-methylglutaryl-CoA reductase by interferon-𝜸 in
primary macrophages requires endogenous 25-hydroxycholesterol synthesis
Hongjin Lu, Simon Talbot, Kevin A. Robertson, Steven Watterson, Thorsten Forster, Douglas Roy,
Peter Ghazal
Division of Infection and Pathway Medicine