Buzz words and core concepts for review Pulmonary 5 gm deoxygenated Hgb to have central cyanosis – you cannot be both anemic and cyanotic; you can look fine with cyanosis if you are polycythemic carbon monoxide – co-oximetry, pulse ox normal bronchiolitis – RSV bad bronchiolitis – preemies, congenital lung/heart disease ribavarin – RSV with congenital heart/lung defects bad asthma – ER visit 1 mo, more than 2 inhalers, 1 ICU/intubation, 2 hospitalization in 12 mo, 3 ER visits in 12 mo Aa gradient (quick): 140-PCO2 –PO2 NL max Aa gradient – (10+age)/10 asthma deaths – inspissated secretions – mucus plugs RSI in asthma - ketamine intubated asthma – think barotraumas if worse; permissive hypercapnia nasal polyps, RAD, NSAID’s combo (also atopic dermatitis) methemoglobin – co-oximetry; sats are low but look fine - dapsone, pyridium, well water, nitrites/nitrates/ peds with GI ARDS – aka NCPE – NL PCWP (<18), PO2<60 mmHg with FiO2>50%, bilateral alveolar infiltrates, normal heart size ARDS TV 6 cc/kg (NL 10 cc/kg) PNA - strep pneumo – most common, rusty sputum, rigor Klebsiella – currant jelly sputum, ethanol Legionella – older people, AMS, elevated LFTs, hyponatremia, cooling towers, GI stuff, relative bradycardia Staph aureus – post influenza, cavitation, empyema Chlamydia – staccato cough, intracellular Mycoplasma – extrapulm (GBS, encephalitis, EM, agglutinins) PCP – HIV <200 CD4, butterfly pattern, low sats, elevated LDH o Pentamidine – hyponatremia, hypotension o Dapsone - methemoglobinemia Miliary TB – millet seed - TB – upper lobe Pscitacossis – birds Histoplasma – Mississipi River, Ohio river valley Coccidioidomycosis – SW area Blastomycosis – SE USA Q fever – sheep, cow, abbatoir worker Anthrax – G pos rods, mediastinal nodes Hantavirus – SW USA, rodents Amp and gent for < 1 month (no ceftriaxone for newborns!) Doxycycline works for all exotic/bioterror stuff TB drugs side effects INH – neuropathies Ethambutol –gout, red-green color blindness PPD 15 mm if no risk factors 10 mm if IVDA, recent immigrants from high-risk location 5 mm HIV FB aspiration – expiration X rays best, lat decubs also good L sided effusion – PNA, dissection, Boerhaave’s, pancreatitis Cavitation – Staph, TB, pseudomona, klebsiella, aspergillus Anterior mediastinal mass – T’s (thymoma, teratoma, thyroid, T cell lymphoma, terrible bronchogenic CA) Tension pneumo – hypotension, JVD, absent breath sounds (also tracheal deviation) Massive hemoptysis - >200 ml in 24 hrs Bad side down (if you can ID) Embolization is best tx Pneumomediastimun – Hamman’s crunch Pleural effusion Transudate (liquid)– CHF, renal failure (nephrotic), CLD Exudates (have stuff)– PNA, inflammatory, neoplastic Virchow’s triad – stasis, endothelial damage, hypercoagulable PE ECG – nonspecific STT changes, TWI ant-inf leads, RAD, new RBBB, pulmonary P, S1Q3T3 CXR – elevated hemidiaphragm, Hampton’s hump (pleural based wedge infarct), Westermark sign (oligemia in proximal vessel) D-dimer – must be ELISA, not latex agglutination Testing in PE CT angio in PE – very specific, good sensitivity VQ scan – very sensitive but not very specific Pulm angio – gold standard TPA in PE – in shock only (clinically, and probably on echo) RSI Preparation, preoxygenation, premedication, performance, post-procedure Angioedema – C1 esterase deficiency, ACEI Pediatrics Colic – crying 3 hrs/d, 3 d/wk, x 3 weeks Hypoglycemia, metabolic acidosis combo – inborn errors of metabolism Bilious vomiting – malrotation of gut HPS – first born males, olive mass, projectile vomiting, hypochloremic/hypokalemic metabolic alkalosis Bloody diarrhea and febrile seizure = shigella Intussusception – colicky pain, currant jelly stool. Most common pedi surgical emergency in <2 y/o, US (dx) or air contrast enema (dx and tx) Jaundice admission Based on time and amt ALTE – scares people, apnea, color change (cyanosis/pallor), (tone) limp, coughing/gagging SIDS most common cause of death from 1 mo to 1 yr Bronchiolitis – wheezing/tachypnea/dyspnea. RSV (50-70%) Nebulized epi Pertussis – paroxysmal cough, post-tussive emesis TDaP used now due to resurgence (added acellular pertussis to diphtheria and tetanus) Simple febrile sz – GTC, <10 min, short/no post-ictal, 6 mo-6 yrs, neuro intact before or after, First 24 hrs illness, runs in families, fever usually >102 Hydrocephalus – large head, large scalp veins, bulging fontanelle, decreased upward gaze, decreased mental status, vomiting, increased LE tone Most commonly involved CN eye deficit – 6th (lat rectus) – due to long tract Idiopathic intracranial HTN – (pseudotumor) – HA, white/overweight females, tunnel vision TOF: Cyanosis not relieved by oxygen, “tet spells”, blood flowing from R to L, squatting increases PVR and increases lung blood flow, boot shaped heart Other cyanosis: tricuspid atresia, truncus arteriosus, transposition, TAPVR Cystic fibrosis: most common genetic disorder in whites Sickle cell: most common genetic disorder in blacks HSP: rash(purpura), abd pain, arthritis. Intussusception, renal involvement (hematuria) HUS (think TTP in peds): micronagiopathic hemolytic anemia, uremia, thrombocytopenia, neuro stuff, GI stuff. E. coli assoc. No abx. Meningitis <2 months: think Listeria (ampicillin) 2 months: usual stuff – Strep, Neisseria, H flu steroids – H flu Most common cause of pedi hip pain – toxic synovitis SCFE- rapid growth ages, boys, overweight, often bilateral. Referred knee pain. Slipped snowcone AVN – think sickle cell NEC X ray – pneumatosis intestinalis ITP – most common platelet disorder of childhood Pedi dehydration Mild: 50 cc/kg down Moderate: 100 cc/kg down Severe: 150 cc/kg down Maintenance (per 24 hrs): 100cc/kg x first 10 kg 50 cc/kg for second 10 kg 20 cc/kg thereafter PALS pearls 2J/kg defib 0.5Jkg for sync CV ETT size (uncuffed): (age/4)+4, subtract 0.5 – 1 for cuffed Uncuffed tube until age 8 Asystole most common arrest rhythm; brady 2nd No cric until age 10 Bolus 20 cc/kg Epi 0.01 mg/kg Atropine 0.02 mg/kg (min 0.1mg) ENT Air conduction>bone conduction Pinna hematomas: cauliflower ear if not treated Perichondritis/chondritis – cover pseudomonas Otic barotraumas: pain, hemorrhage, decreased hearing Otitis externa – pseudomonas Malignant otitis externa – elderly, diabetics Otitis media – 1/3 viral; strep pneumo, H flu, M. catarrhalis Bullous Myringitis – used to be Mycoplasma, now S. pneumo Serous OM – sterile, decreased hearing (affects learning and speech) Cholesteatoma – squamous epithelium mass Onset Nystagmus Central vertigo Slower onset Horiz/vertical nystagmus Not fatigable Symptoms Not that severe Peripheral vertigo Rapid onset Torsional or horizontal nystagmus Fatigable with fixation Severe No N/V/diaphoresis Deficits Other CN deficits No hearing loss Worse with movement N/V, diaphoresis No other CN deficits Hearing loss BPPV – most common cause of peripheral vertigo, otoliths, Dix-Hallpike, worse with head movement Vestibular neuronitis: nystagmus, sudden onset, no hearing loss (different from labyrinthitis) Labyrinthitis – infection, decreased hearing, and tinnitus Meniere’s – vertigo, tinnitus and decreased hearing, can last week to years Sinusitis Complications of sinusitis – orbital cellulitis, brain abscess/meningitis, cavernous sinus thrombosis, skul osteo Pott’s puffy tumor – skull osteo Same bugs as OM – Strep pneumo, H flu, M. catarrhalis Orbital cellulitis – pain with eye movement Kiesselbach’s plexus –most common source of anterior nosebleed Posterior packing risk – hypoxemia, hypercarbia, coronary ischemia, bradycardia, sinusitis, OM Posterior epistaxis – 5%, atherosclerosis Septal hematoma – saddlenose deformity if not drained CSF leaks – ring sign, glucose >30 mg/dl LeFort 1 – maxilla 2 – maxilla and nose 3 – maxilla, nose, orbit, and zygoma (craniofacial dissociation) Cavernous sinus thrombosis – fever, toxic looking, proptosis, chemosis, CN deficits (3,4,6) Salivary glands – mumps (viral), Staph (bacterial) Luwig’s angina – bilateral cellulitis of submandibular space; brawny edema, mixed aerobes and anaerobes ANUG (trench mouth) – gum problems – swollen, red, tender, foul odor. Flagyl and PCN Gum hyperplasia – dilantin, leukemia PTA – most common deep ENT infection Retropharyngeal abscess – most common deep ENT infection in peds; duck like voice; won’t look up; duck-like voice Diphtheria – pseudomembrane, bull neck, systemic symptoms (neuro, liver, heart, kidney). Antitoxin Bacterial tracheitis – look sick, airway obstruction, stridor Epiglottitis – pain with movement of thyroid cartilage, thumb sign on X ray Croup – laryngotracheitis, barking seal cough, stipple sign, viral. Rx steroids and epi Madible fx – neck (1), angle (2), body(3) Herpangina (coxsackie) – sore throat, fever, HA. many vesicles that spare buccal mucosa/gingival/lips Pericoronitis – third molar Alveolar osteitis – dry socket; severe pain 2-5 days post-extraction Avulsed teeth – 1% survival per minute out Ellis classification I – enamel II – dentin III – pulp IV – alveolar bone Thyroglossal duct cyst – central Brachial duct cyst – lateral Central vs peripheral VII palsy – forehead does not work on peripheral lesions Ramsay-Hunt syndrome: herpes zoster oticus, worse prognosis than Bell’s Hutchinson sign – herpes zoster ophthalmicus. Nasociliary branch of trigeminal nerve Trigeminal neuralgia – electric shock facial pain. Rx tegretol Scarlet fever – strawberry tongue and sandpaper rash, skin lines Nasal FB – unilateral foul smelling discharge Esophageal FBs – coronal plane Neuropsych Nerve levels Reflexes: Biceps – C6 Triceps – C7 Sacral nerves –rectal tone Knee – L4 Ankle – S1 Sensory: C4- clavicle Hand – C6 1st finger (OK): C7 MF, C8 - last 2 fingers T4 – nipple line T10 – belly button L1 – inguinal ligament (IL) AMS – DON’T mnemonic – dextrose, oxygen, naloxone, thiamine Cold calorics “COWS” – cold opposite, warm same (for the nystagmus part, which is a cortical function). The tonic deviation is cold same, hot opposite, which is a brainstem function. Doll’s eyes – eyes should stay ML when moving head L and R. brainstem reflex 8th nerve lesions – CPA tumor. Hearing loss/tinnitus, dizzy, ataxia/cerebellar. INO – palsy of medial gaze on affected eye, the other one has nystagmus, dx = MS Corneal reflex – 5 sensation and 7 for blink Headaches Trigeminal neuralgia – shooting facial pain Migraine – with/without aura Preventive therapy: BB’s, TCAD’s Abortive therapy: ergot (alpha constrictors), triptans (also alpha), antiemetics, narcotics +/- Clusters – minutes, in groups, ocular findings, males. Rx 100% oxygen Tension HA – tight Toxic metabolic – fever, hypoxia, ethanol, CO Post-concussive – follows trauma, more in peds Post-LP HA – 2-3 days after LP, worse when sitting up. Correlates: size of needle, number of attempts. Tx: caffeine, hydration, analgesia, blood patch (definitive, diagnostic and therapeutic) SAH – sentinel HA, “worst HA of life”, sudden onset (thunderclap), LP with xanthochromia. LP better early, LP better later, CT > 90% sensitive if within 12 hours Pseudotumor cerebri – young females, overweight. Papilledema. Slit-like ventricles. High OP Hydrocephalus ex vacuo – from cerebral atrophy NPH – triad of ataxia, incontinence, dementia SDH – more common than EDH, bridging veins. Assoc with brain parenchymal injury (worse outcome), crescent shaped. Does not cross ML. EDH – lucid interval, arterial bleed (middle meningeal artery), lens shaped. Does not cross suture lines Mass – HA worse in am or valsalva Toxo – most common brain infection in AIDS Meningitis HA, fever, AMS, stiff neck Kids: irritability, poor feeding, bulging fontanelle Meningitis and rash – meningococcemia Ages: < 1 month – GB strep, E coli, Listeria (add ampicillin + gent/cefotaxime) 1 mo-3 yrs – adults plus H. flu >3 yrs– pneumococcus, neisseria meningitidis (3rd gen cephalosporin and vanc) add vancomycin for bacterial meningitis (resistant strep) steroids: needed for bacterial meningitides, esp pneumococcus (NNT 5 for morbidity of hearing loss) needs CP prior to LP: >age 60, immunocompromised, hx prior CNS dz, recent sz, abnormal neuro exam LGB (Guillain-Barre) – ascending arreflexic paralysis. MS: optic neuritis (aching visual loss, color or saturation loss). Young females. Pathognomonic: bilateral INO. Dx MRI. LP: oligoclonal bands (IgG) Periodic paralysis – post exercise, assoc with high or low K, thyroid, pure motor. MG - antibody against Ach receptor. Bulbar muscles first. Fatigue with use. Thymoma association. Tensilon test. Myasthenic crisis – MG poor control Cholinergic crisis – too much physo Lambert Eaton syndrome - antibodies against presynaptic Ach receptor. Think with distal weakness in cancer. Other pure motor paralysis: tick paralysis, botulism, Eaton Lambert Wernicke’s encephalopathy: AMS, ataxia, EOM palsy or nystagmus. B1 deficiency Korsakoff – add confabulation West Nile virus – birds. Can give pure motor problems. Seizures: Todd’s paralysis: focal weakness after sz Generalized – T/C or absence. Both hemispheres Partial: simple (preserved mentation) or complex (affects mentation or behavior) Seizure tx: BDZ, phenytoin, phenobarb sequence for most Status – more than 2 sz without return to normal in between Status: think INH (use B6 – pyridoxine 5 gm or gm/gm ingested) UMN: spasticity, NL muscle mass, increased DTR’s LMN: atrophy, fasciculations, no DTR’s ALS (Lou Gehrig’s) – both UMN and LMN signs, sensation intact Cauda equina: LMN. Weakness, incontinence, saddle anesthesia. Think HNP. Urinary retention most sensitive finding > 90% sensitivity Conus medullaris – same symptoms, but no recovery Epidural abscess: back pain, +/- fever, weakness/paralysis. anything that causes bacteremia. Get MRI. Neurosurgical emergency. Syringomyelia – collection of fluid in center of cord. IO weakness, decreased pain/temp to fingers. Position vibration (post horns are normal) Stroke Ischemic most common Cortex – contralateral weakness to face and body ACA – more leg than arm weakness MCA: more arm than leg, Broca’s aphasia with dominant hemisphere, homonymous hemianopsia, hemineglect with non-dominant PCA – homonymous hemianopsia, cortical blindness when bilateral Brainstem – ipsilateral face and contralateral body Pons – coma and pinpoint pupils but NL respiration Cerebellar – balance, N/V, nystagmus. Can herniated quick. Vertebrobasilar – coma, “locked in” (can blink and vertical gaze) Lacunes – small vessels. Small defects. Wallenberg syndrome – decreased P/T one side, ipsilateral horner, ipsilateral face and contralateral body TPA: ischemic, measurable neuro deficit, not rapidly improving, time from onset 3 hrs, no contraindications Uncal herniation – ipsilateral blown pupil, contralateral weakness Cushing reflex – HTN (response to maintaining CPP) and bradycardia (carotid body response to HTN) Gardner wells tongs – 5lbs per vertebral level Myopathy – more prox weakness Neuropathy – more distal weakness RSD – pain, skin changes. Sympathetic problems to extremity Psych Functional – gradual onset, younger, clear sensorium, oriented, visual hallucinations Organic – age extremes, acute onset, disoriented, abnormal vitals, auditory/tactile hallucinations. Transient global amnesia – no recent or immediate memory Personality disorder Antisocial personality – impulsive behavior, no remorse Borderline – emotional lability, difficulty with relationships Histrionic – attention seeking Narcissistic – center of attention Anxiety disorders: PTSD: stress after traumatic event Panic attack – impending doom OCD – repetitive ritualistic behaviors Mood disorders Bipolar – mood changes, flamboyant, pressured speech Eating disorders – anorexia and bulimia (purge) Catatonia – waxy flexibility Munchausen – fake illness/create illness. Want test/procedures/admission Malingering – fake illness, have secondary gain or external incentives NMS – lead pipe rigidity Serot syndrome – AMS, autonomic instability, motor irritability Dystonia – sustained contraction Akathisia – inner restlessness Parkinsonism – cogwheeling, shuffling gait, masked facies Suicide – recently widowed men at greatest risk. Men succeed more; females attempt more Tarasoff – duty to protect potential victims supersedes confidentiality duty. Tourette’s – vocal/motor tics Night terror – 15 mins, “awake”, incoherent, amnesia Environmental Drowning – suffocation from immersion Near drowning – recover Secondary drowning – dies of complications later Immersion syndrome – immediate death from cold Dry (85%) vs wet drowning Shock and drowning – think trauma (spinal cord) Drowning survival: duration of immersion (#1), age, water temp, water contamination, bystander CPR, assoc trauma, assoc dysbarism Diving Boyle’s law – the volume of the gas is inversely proportional to the pressure applied to it. Squeeze syndromes Henry’s law – the partial pressure of a gas in a liquid is proportional to the partial pressure of that gas in contact with the surface of the liquid. Decompression sickness. Champagne bottle example. Dalton’s law – total pressure of a mixture of gases is equal to the sum of the partial pressure of each gas in the mixture. Nitrogen narcosis. Middle ear barotraumas – ear squeeze. Blocked Eustachian tubes External ear barotraumas – cerumen plugs Inner ear barotraumas – vertigo and hearing loss Barosinusitis – from URI’s Face barotraumas – mask squeeze AGE: rapid ascent, immediate symptoms. AMS. Dive immediately Nitrogen narcosis – euphoria, confusion, disorientation. Occurs at depth Decompression sickness (“the bends”). Depend on length and depth of dive. Delayed presentation. Type 1 – Caisson’s disease. Musculoskeletal. Cutis marmorata – skin bends Type 2 – CNS and spinal cord. Inner ear (“The staggers”), pulmonary (“the chokes”) POPS – from ascent with mouth closed. PTX, pneumomediastinum. Blast 1. Pressure wave. Top 4 organs – ears, lungs, GI, CNS 2. Shrapnel 3. Flying human 4. Other stuff – toxic chemicals, etc high altitude hypoxemia leading to vasodilatation and vascular leakage factors_ rate of ascent, ultimate altitude, duration at altitude (esp sleeping at altitude) Even 1K descent is useful brain: acute mountain sickness - >8K feet. HA/nausea/fatigue/insomnia. Rx acetazolamide (not to sulfa allergics), descent/oxygen/steroids HACE – ataxia/confusion/sz/coma. Rx descent, steroids, mannitol, HBO Lung HAPE – 2nd day. Leading cause of high altitude deaths. Steroids, HBO, nifedipine, descent. Hypothermia Radiation – most of heat loss (head) Conduction – increased 30-50x when wet Evaporation – important in hot environments Convection – windchill Hunter’s response – Cold-induced vasodilatation Cold diuresis Paradoxical core afterdrop – when rewarming, periphery vasodilates, cold lactate rich blood returns to core, both central pH and temp drop. Frostbite is irreversible, frostnip is reversible Frostbite – refreezing is very bad. Leave blisters intact. Conservative surgical management ECG in hypothermia – slow afib and Osborn J waves. Myocardial irritability Heat related illness Minor (cramps, edema, syncope, prickly heat) – NL core temp Moderate: exhaustion (slight core temp elevation). Dehydrated but sweaty. Severe: heat stroke. No/little sweat. Core temp >41 Classic – epidemic, non-exertional. High death rate Exertional – isolated, more complication, less deaths Target organs – brain (AMS), liver, blood (DIC) Treatment: fans with mist (convection), immersion Demerol and thorazine, IV BDZ – stop shivering thermogenesis Burns 1st 2nd 3rd 4th – muscle, fascia 4 cc/kg x BSA of LR – ½ in first 8 hrs. UOP 1 cc/kg/hr burn admits – 2nd degree >15% adults and 12% peds, 3rd 2-5%; inhalational; hand/perineum/face/feet/joints; co-morbid disease escharotomy – arterial insufficiency with circumferential burns; inadequate ventilation in chest burns current more important than voltage; AC (hold) worse than DC (thrown) low voltage< 1000V oral commissure burn – delayed labial artery (day 5) lightning – massive DC shock. 30% mortality. Asystole 1st, ST, motor paralysis, then VF keraunoparalysis – transient spinal cord dysfunction Lichtenberg figure – fern like rash HF acid burns – throbbing pain out of proportion. Rx calcium Radiation Ionizing radiation Alpha – least penetration Beta – 8mm burns Gamma – deep penetration 2Gy – probable survival medial lethal dose 4.5Gy 8Gy – no survival Earlier/more severe symptoms – worse outcome ALC at 48 hrs most important >1200 – good <300 lethal Biological weapons Doxy covers all organisms here Anthrax – black eschar, mediastinitis. Rx cipro or doxy Plague – pneumonic and bubonic, sepsis Cholera – rice water stools Smallpox – all lesions in same phase Ricin – castor bean Botulism – bulbar findings Strychnine – seizures while awake Nerve agents G agents – cholinesterase inhibitors. SLUDGE. Rx atropine and pralidoxime VX – same, liquid CN,CS, capsicum – irritating Phosgene – delayed pulm edema, fresh mown hay Mustard gas/lewisite – blistering Mammalian bites All Rx Augmentin Dog bite – Pasteurella, not that bad Human bite – Eikenella corrodens, worst Cat bite – Pasteurella, very bad Rabies – negri bodies. Bats, raccoon, skunk, fox Active – 0,3,7,14,21 (HDCV) 20 IU/kg (50% at wound, HRIG) paralytic vs furious rabies snakes seasnakes – neurotoxic coral – neurotoxic, red on yellow crotalidae – hemotoxic>>neurotoxic Wyeth – 5-10 vials, anaphylaxis, serum sickness CroFAB 4-6 vials, may need repeat doses Spiders Black widow – red hourglass, mimics acute abdomen. Analgesia, BDZ. Has antivenom Brown recluse – dark violin top, necrotic lesion (delayed). Dapsone, HBO, surgery Scorpions Centuroides- fasciculation, salivation, delirium. Have antivenom Hymenoptera (bees, ants, wasps, hornets) Anaphylaxis >10 stings can have toxic systemic reaction (DIC, renal failure) Tickborne diseases: hyponatremia, fever, tick bite. Hand and feet soles Tick paralysis – camper Tularemia – rabbits Dengue – breakbone fever, retroorbital pain Lyme disease – Bell’s palsy, target lesions Vibrio vulnificus – seawater, 3rd gen ceph + doxy Vibrio cholera – rice water stool Marine envenomations Most are heat labile – immerse in hot water, vinegar Box jellyfish – most deadly. Has antivenom Nematocysts – will deploy and make things worse Fish: zebra, lion, scorpion, stone (admit this, has antivenom) Cone snail – paralysis Pufferfish (fugu)- paralysis Endocrine Epinephrine and glucagon are counter-regulatory hormones C peptide differentiates too much endogenous vs exogenous insulin Glucose D50W adults D25W kids D10W neonates Octreotide – antidote for sulfonylurea. Blocks insulin release from pancreas Diabetes agents Sulfonylureas - end in “ide”. Long half lives. Repiglanide Metformin – no hypoglycemia. Metabolic acidosis Alpha glucosidase inhibitors – block hydrolysis of carbohydrates Thiazolidenediones – “glitazones”; no hypoglycemia Glucagon will not help in those with low glycogen stores (kids, alcoholics, malnourished, etc DKA – dehydration, free ketoacids, glycosuria, total body K deficit TX: fluids, insulin, treat precipitant, K Bicarb may increase risk of cerebral edema in peds. Also hypokalemia, hypernatremia, paradoxical spinal acidosis, decreased O2 offload to tissues Na correction – decreased 1.6 for each 100 of glucose >100 Alcoholic ketoacidosis Too little insulin and too many counter-regulatory hormones Tx: D5W saline Non-ketotic Hyperosmolar state (HONK) Glucose very high, profound dehydration, AMS, scant/no ketones, slow onset Tx – fluids (slow), tx precipitant, +/- insulin Thyroid Thyroid problems are generally primary Hyperthyroidism Grave’s disease #1 – antibodies to thyroid gland Thyroid storm – neurologic dysfunction RX – supportive (ASA displaces thyroid hormone from thyroglobulin), steroids (decreased conversions T4 to T3); peripheral blockade (beta blockers); blockade of hormone synthesis (PTU, methimazole); blockade of thyroid hormone release (Iodine after PTU or methimazole); tx precipitating events Hypothyroidism Post-Grave’s #1 and Hashimoto’s #2 Symptoms – myxedema, slowed DTR’s, “myxedema madness” Myxedema coma – most severe form Rx - supportive, steroids, IV T4 (thyroxine). Adrenals Most problems are from the pituitary (secondary) and hypothalamus (tertiary – from exogenous steroids) Glucocorticoids (cortisol) and mineralocorticoids (aldosterone – retain Na and pee K) Waterhouse Friderichsen syndrome – B adrenal hemorrhage post meningococcemia or trauma Addison – primary adrenal insuficiency (hyperpigmentation from too much ACTH). Cosyntropin stimulation abnormal Hallmark – low Na (most common) and high K. Also fever and hypotension Tx: fluids, hydrocortisone Cushing’s syndrome – from too much steroid, pituitary adenoma Truncal obesity (moon facies, buffalo hump, purple striae), HTN, hirsutism, glycosuria SIADH ADH = vasopressin – posterior pituitary Too much ADH when I don’t need it – dilution of serum and concentrated urine To solve problem – brain, lung, drugs (chlorpropamide, etc) Diabetes insipidus (the opposite of ADH) Pee too much, dilute urine too much and serum too concentrated Central (CNS not making ADH), nephrogenic (kidney not responsive to ADH, lithium) Pheochromocytoma – too much epi release from adrenal medulla. P’s – pressure, pain, perspiration, palpitations, pallor, paroxysms DX ; 24 hr urine for VMA Carcinoid syndrome – tumor secretes serotonin (flushed, diarrhea, vasodilation, wheezing) Sodium Hyponatremia: Symptoms depend on level and how fast it got there Hypovolemic_ V/D, diuretics (lost both Na and water). Rx saline Euvolemic – SIADH, psychogenic polydypsia. Rx water restriction Hypervolemic - IV volume is low so more ADH (CHF, cirrhosis, nephritic). Na and water restriction, +/- diuretics Pseudohyponatremia – glucose, lipids, proteins Central pontine myelinolysis – confusion, locked in. Restrict correction to 0.5-1mEq/hr Hypernatremia Most commonly from free water loss (GI, renal, skin) or decreased intake (CVA, kids, elderly) Tx – restore IV volume; Correct slow (0.5mEq/hr) to prevent cerebral edema Total water deficit: TBW (70% weight) – 1(desired Na/actual Na) Potassium Major intracellular cation Hypokalemia = weakness. ECG U waves Oral replacement best; 10MEq/hr when using IV Need normal magnesium to replace Hyperkalemia = arrhythmias, weakness Remember – kidney failure, digoxin toxicity, hemolysis, succ, acidosis ECG progression– peaked Ts, decreased PR, flat Ps, wide QRS, sine wave Rx – calcium gluconate (fast but short lived), albuterol, insulin/glucose, bicarb, kayexalate, HD Calcium PTH – increases Ca and lowers Phosphorus via kidneys VitD – kidney plus sunlight. Increases intestinal absorption of calcium Hypercalcemia (PAM P SCHMIDT)– hyperpara, MM, Paget’s, Cancer, milk alkali, excess vitamin D, thiazides. Stones, bones, moans, and psychic undertones ECG – short QTc Tx: volume and then diuretics Hypocalcemia Causes – post – parathyroidectomy, kidney failure, pancreatitis Chvostek and Trousseau ECG – long QTc Tx – calcium Magnesium Hypermagnesemia – rare. Renal failure, iatrogenic. Tx with calcium. Hyporrelexia Hypomagnesemia – think in malnourished Phosphate High phosphate – low PTH, renal failure. Rx phosphate binding gel or HD Low phosphate – weakness. Rx with oral vs IV phosphate Anion gap HAG – MUDPILES. Na- (Cl + Bicarb) Low anion gap – decreased unmeasured anions (proteins) or increased unmeasured cations (lithium, high calcium, high magnesium). Bromide is measured as chloride Normal anion gap – HARDUP. Think renal (RTA) or GI Metabolic alkalosis – GI loss of acid or to much base intake Osmolarity Normal: 285-295, NL gap up to 10 (Na) + glucose /18 + BUN/2.8 + ethanol /4.6 Dermatology and ID Eczema (atopic dermatitis) – related to hay fever or asthma. AC/pop fossa; infants in face. Rx steroids Contact dermatitis – immediate or delayed (allergic) Exfoliative dermatitis (erythroderma)– red skin all over. Drugs or malignancy Psoriasis – thick white/silver scales. Nail pitting. Arthritis assoc. Seborrheic dermatitis – yellow waxy scales. Scalp and face. Seborrhea shampoo Pityriasis rosea – herald patch. Christmas tree distribution. Supportive Petechia (<3mm) and purpura (>3mm): nonpalpable (superficial – low platelets), palpable (deep, vasculitis) Urticaria – hives, wheals. Superficial epidermis. IgE Angioedema – deeper dermis. Bradykinin mediated. Erysipelas – cellulitis from Group B strep. Shiny red. Well demarcated border Erythema nodosum – vasculitis of fat. Painful red/viotel nodules. Pretibial region classic Drug eruptions – think in all acute symmetric rashes Erythema multiforme/Stevens Johnson (<10%)/TEN(>30%) – target lesions, Nikolsky, mucosal involvement. Rx like burns SSSS – Nikolsky positive, assoc with Staph. Exotoxin. Young kids Pemphigus vulgaris – flaccid bullae. Autoimmune. Worst one Bullous pemphigoid – tense/thick bullae. Autoimmune. Better of two Basal cell – most common cell malignancy. Pearly rolled borders. Slow growing Malignant melanoma – worst one. #1 skin cancer cell. Sun exposed areas. Irregular (shape, color) Squamous – 2nd most common skin malignancy. Indurated raised borders, central ulcer. Face/ear/tongue/hands Dermatophytes (tineas) Capitis, barbae, pedis, cruris Hair loss in areas with hair Kerion – inflammatory reaction Topical antifungals – may need oral in hair or nails Versicolor – malassezia furfur, like seborrhea. Shampoo Gonococcemia – fever and arthritis (large joints), tenosynovitis. Aspiration often negative, but blood cultures positive Spirochetes All Doxy susceptible Leptospirosis – Weil’s disease (worst: fever, DIC, hepatitis, nephritis) Lyme’s – Ioxdes tick, erythema chronicum migrans (stage 1), Bell’s or myo/pericarditis/heart block or meningitis (stage 2), arthritis (stage 3) Syphilis – painless chancre (1st stage), rash palms and soles, condyloma lata (2nd stage), neuro and CV (third stage). Jarisch Herxheimer rxn – due to abx treatment TORCHS infections – cause congenital transmission Toxo, rubella, CMV, herpes, syphilis Meningococcemia – fever, HA, rash Purpura fulminans – bad outcome Waterhouse Friderichsen syndrome - adrenal hemorrhages from this Necrotizing soft tissue infections Nec fasc – pain out of proportion. Fournier’s gangrene – scrotum or vulva. MRSA CA-MRSA: purulent skin and soft tissue infections. Rx doxy, bactrim or clinda; vanco or linezolid for serious Toxic shock syndrome – tampons. Staph exotoxin Ticks RMSF – SE USA, centripetal rash, palms and soles. Thrombocytopenia and hyponatremia. Tetracycline Ehrlichiosis – like RMSF with no rash and affects WBC’s Babesiosis – NE USA. like malaria, affects RBC’s. Milder than malaria. Herpes virus CMV – congenital very bad, also bad in AIDS. Rx gancyclovir or foscarnet. One of TORCHS Herpes 1 – oral; herpes 2 – genital. Grouped vesicles. Rx acyclovir Herpetic whitlow Tzank smear – multinucleated giant cells Herpes encephalitis – temporal lobe, blood in CSF Herpes zoster (varicella) – dermatomal distribution, very painful Hutchinson sign – eye involvement Ramsay Hunt – CN 7 involvement Disseminated zoster – admit AIDS PCP is most frequent opportunistic infection Crypto meningitis – most common CNS fungal infection Toxo – most common cause of encephalitis. Ring enhancing lesions Oral candida – most common GI infection Kaposi’s – purple painless plaques Molluscum – umbilicated papules Mononucleosis – EBV. LAD, exudative pharyngitis, atypical lymphocytes. Splenic rupture. Dx with Monospot. NO abx (rash), no sports Occupational Needlesticks: Hep B surface antigen- infectious. Surface antibody – immunized. E antigen – highly infectious. 2% risk infection with surface antigen and 25-30% with E antigen Antibody >10 probably good for life. Can rx with immuneglobulin +/- vaccine. Hep C – 2% risk for exposures. No tx available HIV risk from needlestick 0.3%. increased risk – visible blood contamination; deep injury, hollow needle, source with heavy viral load. Rx – start 1-2 hrs; multi-drug regimens (2-3 meds) x4 weeks. Malaria – most important travel-related illness. Falciparum – most severe disease, lots of resistance. Tx = quinidine + doxy in chloroquine resistant areas (i.e. Africa) Black water fever – severe hemolysis Thick and thin smears Pedi rashes – Erythema infectiosum (5th disease)– Parvo B19, slapped cheeks, lacy rash. Keep away from SCD and pregnant patients (aplastic crisis with parvo, hydrops in pregnancy) Hand foot mouth – Coxsackie. Painful oral lesions to anterior mouth; fever; gray vesicles to palms and soles. Supportive Herpangina – oral ulcers on back of OP. HSP – vasculitis. Abd pain (GIB, intussusception), renal (hematuria), joints, and the vasculitic rash (buttocks and legs) Kawasaki – MCLNS. Vasculitis. Coronary artery aneurysms. Criteria – 5 days of fever and 4 of these – conjunctivitis, oral changes, extremity changes, rash, adenopathy. Tx ASA, IV IG Impetigo – honey colored crusts. Bullous impetigo – staph Rubella (German Measles) – 3day measles. adenopathy (posterior), rash goes head down. TORCHS Rubeola (measles) – bad one – 3C’s – cough, coryza and conjunctivitis, Koplik’s spots. Roseola (exanthema subitum)– herpes. Fever/febrile sz. Fever stops and the rash Scarlet fever – strawberry tongue, exudative pharyngitis, sandpaper rash. While lines in skin folds. Desquamation. ASO titer. Tx PCN Varicella (chicken pox) – different stages (dew drop on a rose petal). Complications – PNA, encephalitis. Can rx acyclovir. Vaccine (live) Salycilate – Reye’s syndrome Lice – Scabies (burrows; thin skin areas), crabs, etc. rx Kwell, Nix, RID, Elimite, etc Norwegian scabies – high mite burden Heme onc Central cyanosis – 5 gm deoxygenated Hgb. Look in tongue metHgb – 1.5 grams deoxygenated hgb. Fe+3. Local anesthetics, nitrates, aniline dyes. O2 sat 85% regardless on O2 administration. Rx methylene blue COhgb – “chery red”, but more like don’t turn blue Sulfhgb – 0.5 grams for cyanosis. Irreversible. 95% oxygen carried in Hgb, not dissolved cyanosis unresponsive to O2 – abnormal Hgb or R to L shunt coombs positive – antibodies to RBC’s G6PD – most common enzyme deficiency PRBC – each until increases Hgb 1 grams Citrate – chelates Ca – hypocalcemia HyperK, worse with older blood Infuse with NSS (LR has calcium) Blood content – 70 cc/kg or 5L in man Massive transfusion – early transfusion of other products – platelets and FFP Transfusion rxns Acute hemolytic transfusion rxn - Wrong blood type. Fever, back pain, SOB. Stop, hydrate, send blood to lab – free Hgb, haptoglobin, Coombs. Febrile non-hemolytic – rxn to protein antigens. like the hemolytic one. Labs above are negative. Allergic transfusion rxns – Not dose related. hives, wheezing, can be anaphylactic. Can continue depending on severity Infections – HIV 1:2million, Hep C 3:10K Other – vol overload, hypothermia, hyperK, hypoCa Type O - universal donor. Rh negative for women of child bearing age. Type AB – universal recipient Platelets – 5 day storage. Donated by apheresis. 1 unit of platelet raises by 10K (50-60 K if apheresis unit) spont bleeding with platelets <10K; 50K for procedures/trauma dysfunctional platelets – ASA (irreversible inhibition), kidney failure low platelets – ethanol, aplastic marrow, large spleen ITP – immune rxn to platelets. low platelets. Stop immune system first and then give platelets if bleeding. Tx = steroids splenectomy TTP – systemic endothelial damage, release of vWF, platelet aggregation, microangipathic hemolytic anemia HUS – like TTP but kids and more kidney involvement FFP - what remains after RBC and platelets removed – give 1 per each 5U PRBC’s Cryo – subproduct of FFP. Pooled (more risk of infection) Hemostasis test Bleeding time now done by platelet function test Von Willebrand factor – released from vessels, tells platelets to aggregate if not in vessel lumen. It also carries factor 8 Protime - measures extrinsic system and common pathway (5, 7, 9). Warfarin PTT – measures intrinsic and common. Heparin DIC – can either cause ischemia (consumption coagulopathy) or bleeding. Low platelets, low fibrinogen, increased FSP, high dimmer, fragmented RBC’s. Prolonged PT!! Rx – give FFP if bleeding, consider heparin if thrombosis Heparin – does not cross placenta. HIT complication, antidote: protamine LMWH - smaller molecule, no monitoring. Less freq dosing. Warfarin – inhibits 2,7,9,10, C, S (Vit K dependent). Rx with vit K and PCC (FFP if no PCC) Contraindications to thrombolysis – BP >185/100, active bleeding or recent <14d bleeding, recent spine or brain surgery (2 weeks), brain tumor or malformations, recent CVA (2-6 mo) or hemorrhagic CVA, bleeding diathesis, on anticoagulants, pregnancy, suspected aortic dissection or pericarditis. Sickle cell anemia – anemia, high retic count, pain, functional asplenia Pain crisis – from cell sludging Chest syndrome – leading cause of death in sicklers. Pulm infarction. Tx = abx, exchange transfusion Splenic sequestration – kids with shock. 2nd most common cause of death Aplastic crisis CNS crisis – strokes Hand foot syndrome – kids with swollen hands and feet. Priapism Salmonella – it thrives on iron rich tissues Hemophilia – blood bad to cartilage A – 85% of cases. factor 8 def. Give DDAVP and then factor 8 concentrate (FFP if not available). Treat before studies. B – factor 9 def Von Willebrand disease – Most common inherited coagulation disorder. “guides” platelets and carries factor 8. Rx same as hemophilia HIV related emergencies Lactic acidosis – mitochondrial damage. Medication reaction Immune reconstitution syndrome – when HAART reactivates immune system, exaggerated immune response Kidney stones – indinavir. Radiolucent Hypoglycemia – pentamidine metHgb - dapsone CMV and varicella – eye complications PCP – single cell fungus. CD4<200. Disproportionate dyspnea and hypoxemia. Steroids before abx if hypoxic (PaO2<70 or A-a gradient >35, Bactrim 1st line, atovaquone or pentamidine 2nd line Toxo (ring enhancing lesion) and criptococcus (most common systemic fungus, India ink)– CD4<50. Thrush Oncology Cord compression –lung, breast, prostate. Thoracic back pain Airway obstruction – voice changes, stridor Pericardial effusions – lung and breast, melanoma. Beck’s triad – JVD, hypotension, muffled heart sounds. ECG – low voltages, electrical alternans SVC syndrome – Lung cancer. egress of blood from head is obstructed. Neck veins, plethora, face swelling, HA Hypercalcemia – PTH hormone-like substance secretion. Also from mets. Lung, renal, MM, breast. ECG short QTc. Stones, bones, moans, and psychic undertones. Rx fluids and diuretics. Biphosphonates etc later. Calcium x phosphorus product =40 Hyperventilation causes functional hypocalcemia (twitchy etc) SIADH – tumor secrete ADH. Hyponatremia and concentrated urine. Hyperviscosity syndrome – proteins (MM) or WBCs (leukemia). Roulleaux formation Adrenal insufficiency – consider with fever, dehydration, resistant shock. Hyponatremia/hyperkalemia/eosinophilia/hypoglycemia Tumor lysis – post chemo. hyperK, hyperphos, low calcium. High uric acid. Rx fluids, lower phosphorus, alkalinize urine, lower uric acid (allopurinol – inhibits xanthine oxidase; or rasburicase – recombinant urate oxidase) Neutropenic fever – 50% have occult infection Rheumatology Joint fluids Septic arthritis –low glucose, WBC >75K, low viscosity, very turbid. Staph (most common overall), salmonella in SCD Gonococcal – rash (necrotic pustules), girls, menses Inflammatory - <50K WBC’s, NL glucose, can have crystals Gout – needle like. Negative birefringence. Podagra – big toe (75%). Rx NSAIDs and colchicine Pseudogout – calcium pyrophosphate, rhomboid. Positive birefringence. Rx as gout. Lyme – rash (ECM, central clearing), neuro (CN 7th), heart (arrhythmias, heart block) SLE Antiphospholipid syndrome – excessive clotting. recurrent fetal loss Butterfly rash (malar), or discoid lesions (scars) Renal – nephritic, nephritic cerebritis Rx steroids Seronegative spondyloarthropathies (rheumatoid factor negative) – symmetric, sacral involvement of joints and tendon/ligament insertions Ankylosing spondylitis – bamboo spine, uveitis (most common extra articular finding) Reiter’s – arthritis, urethritis, conjunctivitis. Heel preference (“lover’s heel”) Psoriatic arthritis IBD arthritis – both UC and Crohn’s Rheumatic fever – Jones criteria (CASES); GABHS infection 2 major, or 1 major and 2 minor OB/Gyn STD’s Ulcerative lesions increase risk for HIV Non-ulcerative lesions have discharge Chlamydia - #1 STD. related to PID. Can be asymptomatic. Nuclear amplification test. Rx doxy PID – cause of infertility and ectopics. Fever, discharge, CMT, abd pain, and adnexal tenderness – treat empirically TOA – Admit. Fitz-Hugh-Curtis – perihepatitis from PID. Admit LGV – C. trachomatis also. Buboes (groove sign) with no genital lesion. Rx doxy x 3 weeks GC – #2 STD. related to PID. gram neg diplococci. Copious purulent discharge. Rx cephalosporin. Gonococcemia (dermatitis arthritis syndrome). Eye emergency (melts cornea) Syphilis – painless chancre. Rash, condyloma latum (2ry); CNS – psychosis/neuropathies/tabes dorsalis – no propioception, and heartaortitis (3ry). Rx PCN LA 2.4 million units Chancroid – painful ulcer and bubo at same time. Herpes – type 2. Painful vesicles in crops. Recurrent Trichomonas - strawberry cervix. Grey yellow malodorous frothy discharge. pH>4.5. rx flagyl Genital warts – HPV, assoc with cervical CA. BV – Polymicrobial. copious vaginal discharge, fishy odor. Clue cells. pH>4.5. rx flagyl Candida – white cottage cheese, KOH with hyphae. Rx fluconazole Bartholin gland abscess – lower aspect of introitus at 5 and 7 o’clock. Drain and insert Word catheter x weeks Mittleschmerz – ovulation 14 days before menstrual cycle. Pain with ovulation Ovarian cyst – usually in luteal phase. Ruptured look like ectopic. Can torse if bigger (>4 cms) (like torsed testicle, dx with US). Ovarian masses – can also torse, esp dermoids. Ovarian CA – 2nd most common gyn malignancy. Meig’s syndrome (ascites and pleural effusion) Endometriosis – chocolate cysts. Can be anywhere. Catamenial PTX. Assoc with infertility. Uterine fibroids – excessive bleeding Uterine CA – consider in AUB in perimenopausal women; painless uterine enlargement. Cervical CA – HPV assoc. is an AIDS defining illness AUB: irregular excessive bleeding Do pregnancy test DUB – anovulatory bleeding. No luteal phase OB stuff Fundus at umbilicus at 20 wks HCG doubles every 2-3 days for 1st 7-8 weeks Positive within days of ovulation, stays positive x 2-3 weeks Miscarriage Threatened – bleeding, closed os Inevitable – open os, bleeding Incomplete – bleeding pain, products at os Complete – bleeding decreased, sono negative (empty uterus) Missed – retained products Septic abortion – infection, rare Ectopic pregnancy – positive preg test, abd pain, bleeding. Discriminatory zone: 2K for transvag and 65K for transabdominal Beware of heterotopic in assisted reproduction patients. RhoGam: passive immunization to all Rh negative moms. 50 mcg if <12 weeks and 300 mcg after that Molar pregnancy – very high HCG’s, snowstorm appearance on US; passing “grape like stuff” Abruptio placentae – risks – cocaine/trauma. Uterine tetany, fetal distress. Painful 3rd trimester with dark blood Placenta previa – reliably seen in US, bright red painless bleeding. NO pelvic exam! Pregnancy-induced HTN – unknown cause >20 weeks, >140/90 pre-eclampsia – HTN, edema, proteinuria HELLP – Hemolytic anemia, elevated LFTs, low platelets, NL clotting Eclampsia – pre-eclampsia plus seizures. RX magnesium and hydralazine/labetalol Hypermagnesemia – rx calcium Appendicitis – most common surgical emergency in females. Do same w/up. Same risk as non-pregnant, but more dx delays and more complications Drugs to avoid in pregnancy – Coumadin, tetracycline, quinolones, live vaccines, erythromycin estolate, sulfa (3rd trim), ASA (3rd trim), flagyl (1st trimester) Trauma Maternal stabilization is 1st Displace uterus in hypotension third trimester KB test for fetomaternal hemorrhage APGAR – appearance, pulse, appearance, grimace, respiration PROM – ferning test, nitrazine paper – high pH. Sterile exam. Umbilical cord prolapse – knee chest position, arrest delivery, emergent C-section Amniotic fluid embolism – CV collapse soon after delivery. Supportive. 50-80% mortality Fetal distress – late decelerations, also marked tachycardia and bradycardia Monitor after 26 weeks after trauma Post partum hemorrhage - #1 cause is uterine atony Perimortem C section – within 5 minutes of CPR Endometritis – foul smelling lochia Mastitis – staph, analgesia, warm compress, abx (dicloxacillin) Renal/urology Nephrotic syndrome – protein in urine; hypercoagulable (urinates antithrombin 3), high lipids (lose lipid transporting proteins) Nephritic syndrome (active sediment – casts, red cells); HTN, volume up Test taking strategies Note key word and red flags Eliminate obviously wrong answers OK to guess Do questions! Avoid controversial answers, stay with gold standard Pictorial – read the question and try to answer before you see the picture Don’t get stuck on calculations – waste of time and increases frustration B most common correct answer; D after that – for numerical questions. Written choices are randomized by first letter of answer, and most verbs start with vowels, which tends to randomize most to ABC Stem – question part Foil –wrong answer 4 types of questions Fact questions often have a destabilizer – a rarely know fact. Often not the answer. Can be a “red herring” if in the stem – nothing do to with the case. 2 part question – present a disease and then ask about management or complications. Look at the answers then go back and make the dx long question with lots of info (camouflage)– look at the answers first and then read the statement again research questions – similar questions throughout the exam. They are looking at correlation with scores (“test questions”)