COOPERATIVE AGREEMENT By and Between the ________________________ And the UNIVERSITY OF FLORIDA This Cooperative Agreement (the “Agreement”) is made and entered into as of ________________ (the “Effective Date”) by and between The University of Florida Board of Trustees, a public body corporate and university of the State of Florida, located in Gainesville, Florida, United States of America for the benefit of One Health Center of Excellence for Research and Training, hereinafter referred to as "Florida," and , a _____________________________ located in ______________________ , hereafter referred to as “ _____________ ." Florida and __________ shall collectively be referred to herein as the “parties.” The parties hereto agree as follows: I. Philosophical Intent a. Florida and The primary objective of this Agreement is the development of cooperative efforts between , which will enhance the academic and research interchange between the two institutions. Recognizing the importance of mutual collaboration and the contributions to society made by institutions of higher education, the parties desire to promote exchange between the faculty and students of the two institutions as well as the exchange of academic and research information. b. Specific projects in an area of educational or research interest will be selected as a result of coordination by Florida and at the appropriate administrative level in each institution. As these projects are developed, each will require a specific written agreement made in advance, setting forth the terms and conditions thereof and executed by authorized representatives of both parties. The President, Dean of the International Center, or the Senior Vice President for Academic Affairs and Provost are authorized signatories for Florida. ________________ is the authorized signatory for ________________. II. General Provisions a. All collaborative activities conducted pursuant to this Agreement shall be conducted in Page 1 of 10 Cooperative Agreement accordance with the laws and regulations that apply where the activities take place and each of the parties shall also comply with the laws, regulations and policies applicable to it. In the case of Florida, these include the laws of the United States of America and of the State of Florida, and the rules, regulations and policies of Florida and the Florida Board of Governors. In the case of include the laws of b. and the rules, regulations and policies of the , these . The “term” of this Agreement begins on the Effective Date and continues for a period of five (5) years thereafter. The term may thereafter be extended in a written extension signed by authorized representatives of both parties. Notwithstanding the foregoing, either party may terminate this Agreement early by giving at least 60 days' advance written termination notice to the other party, specifying the end date (or a shorter notice period if earlier termination is required to comply with applicable laws). c. Notices with respect to this Agreement shall be provided to the parties as indicated on Attachment A hereto, entitled “Administration of Program and Contact Information,” which is incorporated by reference herein. d. The English language version of this Agreement shall govern in the event of a conflict or ambiguity with any translation in another language, and resolution of disputes shall be conducted in English. Termination of the Agreement shall be the only remedy for breach of this Agreement, except respecting a breach of clause “e” below. This Agreement is the only agreement of the parties concerning the subject matter covered and supersedes and voids any previous or contemporaneous negotiations, drafts, and other communications. Captions are for convenience and have no legal effect. Waivers of any provisions contained herein are only effective if made in writing by the authorized signatory of the waiving party and cover only the particular provision waived on the particular occasion. e. This Agreement does not confer any rights in or to use trademarks, logos or names, except to factually state that this Agreement between the parties is or was in effect during the term and that University of Florida and _________________________________ are or were collaborating on the possible development of projects of mutual interest in health education or research or in a dispute, any media statements concerning this Agreement or the parties’ activities under it must be agreed upon in advance by the parties through their news offices. f. The relationship of the parties under this Agreement is that of independent contractors (not legal partners) and no party has the authority to bind the other party in contract or to incur any debts or obligations on behalf of the other party. g. Under this Agreement, there are no payments owed or earned by either party to the Page 2 of 10 Cooperative Agreement other, there is no physical presence, residence or bank account established by either party in the other party’s country, there is no intellectual property to be developed, and, with the exception of brief visits, the activities of each party will be largely undertaken in its home country. It is not expected that any tax or excise will be owed or filings will be required by either party or their employees to or in the other party’s country as a consequence of entering into this Agreement. If intellectual property will be developed for a project, the terms set forth in Attachment B attached hereto shall apply and be incorporated as part of this Agreement. If funding is being pursued for a project, the parties will enter into a separate written agreement to set forth the conditions and agreements between the parties related to such funding. IN WITNESS WHEREOF the parties hereto have executed two original counterparts of this instrument, each of which, when all counterparts are delivered, shall be considered an original, in the presence of a witness whose signature also appears below. UNIVERSITY OF FLORIDA BOARD OF TRUSTEES [NAME OF COOPERATING INSTITUTION] By:________________________________________________ Prof. Leonardo A. Villalón By:____________________________________________ XXX (Name) Dean, UF International Center XXX (Title) Date:_____________________________________________ Date:_________________________________________ WITNESSED WITNESSED __________________________________________________ _______________________________________________ Date:_____________________________________________ Date:__________________________________________ Form pre-approved as of May 2012 by Office of the Vice President and General Counsel at University of Florida; any changes to the form must be approved by the Vice President and Office of General Counsel. Page 3 of 10 Cooperative Agreement ATTACHMENT A ADMINISTRATION OF PROGRAM AND CONTACT INFORMATION Florida -- Administration of this Agreement for Florida is housed in the International Center at the University of Florida. Such functions are under the direct responsibility of the Executive Director, International Center; provided that the authorized signatories to contract for Florida are the Dean of the International Center or the Senior Vice President for Academic Affairs and Provost. Academic responsibilities are housed in College of Public Health & Health Professions. Correspondence regarding this Agreement and activities under it shall be directed to: UF Administrative/Fiscal Management Dr. Susanne Hill Executive Director International Center P.O. Box 113225 170 HUB University of Florida Gainesville, Florida, 32611-3225 Phone: 352-273-1500 Fax: 352-392-5575 E-mail: shill@ufic.ufl.edu http://www.ufic.ufl.edu UF Academic Management Dr. Gregory Gray Center Director and Professor Environmental and Global Health Department, College of Public Health & Health Professions P.O. Box 100188 101 S. Newell Dr, Suite 2150A University of Florida Gainesville, Florida 32610 Phone: 352-273-9449/9418 Fax: 352-273-6070 E-mail: gcgray@phhp.ufl.edu <<Name of Foreign Institution>>: Administration of this Agreement for ______ is by ________, provided that the authorized signatory to contract for _________ is __________. Academic responsibilities are housed in __________. Correspondence regarding this Agreement and activities under it shall be directed to : (SECTION TO BE COMPLETED BY COOPERATING INSTITUTION) Partner Institutional Contact Name Title College Department Office Address City, State, Postal Code Country Phone: Fax: E-mail: Website: Page 4 of 10 Cooperative Agreement ATTACHMENT B INTELLECTUAL PROPERTY AND FUNDING TERMS Ownership of any inventions, improvements, or discoveries, patentable or unpatentable, which are conceived or made solely by one or more persons who are employed solely by the University of Florida, shall be determined in accordance with the policies of the University of Florida. Ownership of any inventions, improvements, or discoveries, patentable or unpatentable, which are conceived or made solely by one or more persons who are employed solely by the ___________, shall be determined in accordance with the policies of ____________. Ownership of any inventions, improvements, or discoveries, patentable or unpatentable, which are conceived or made by one or more persons, all of whom are simultaneously employed or appointed by the University of Florida and ____________, shall be determined in accordance with the University of Florida Intellectual Property Policy and any applicable provisions of the conflict of interest exemption monitoring plan. Ownership of any inventions, improvements, or discoveries, patentable or unpatentable, which are conceived or made by more than one person, where at least one such person is employed solely by __________ and at least one such person is simultaneously employed or appointed by the University of Florida and by _________, shall be jointly owned by the University of Florida and __________ (with respect to University of Florida, in accordance with its Intellectual Property Policy and any applicable provision of the conflict of interest exemption monitoring plan), subject to any other applicable agreements. Page 5 of 10 Cooperative Agreement ADDENDUM to the COOPERATIVE AGREEMENT by and between the ___________________________________ and the UNIVERSITY OF FLORIDA One Health Center of Excellence for Research and Training Based at the University of Florida’s Emerging Pathogens Institute As a specific project under our cooperative agreement we agree to collaborate in the One Health Center for Research and Training that is home-based at the University of Florida. The information regarding this center is appended to this document as “One Health Center of Excellence for Research and Training”, dated November 20th, 2013. IN WITNESS WHEREOF the parties hereto have executed two original counterparts of this addendum, each of which, when all counterparts are delivered, shall be considered an original, in the presence of a witness whose signature also appears below. UNIVERSITY OF FLORIDA OTHER INSTITUTION’S NAME HERE By:________________________________________________ Gregory C. Gray, MD, MPH Center Director and Professor Environmental and Global Health Department, College of Public Health & Health Professions By:________________________________________________ [Official Institutional representative] Date: _____________________________________________ Date: _________________________________________ By:________________________________________________ J. Glenn Morris, MD, MPH&TM Director, Emerging Pathogens Institute By:________________________________________________ [Official Institutional representative] Date: _____________________________________________ Date: _________________________________________ By:________________________________________________ Prof. Leonardo A. Villalón Dean, UF International Center By:________________________________________________ [Official Institutional representative with final signature authority] Date: _____________________________________________ Date: _________________________________________ Page 6 of 10 Cooperative Agreement February 8, 2016 One Health Center of Excellence for Research and Training Based at the University of Florida Summary: With rapid transportation of people, animals, and food, now the norm in many world economies, we are facing new complex zoonotic diseases and food safety problems on a scale never seen before. To respond to and control these problems, we will need new approaches. One Health, a new interdisciplinary approach, has been embraced as a way forward by many groups of professional experts (Table 1). In this proposal we outline a strategy to create an international network of institutions that embrace the One Health approach and agree to collaborate in research and education. Table 1. Organizations that have endorsed the One Health Initiative as of January 2013 American Academy of Pediatrics American Association of Public Health Physicians (AAPHP) American Association of Veterinary Laboratory Diagnosticians American Association of Wildlife Veterinarians American College of Veterinary Microbiologists American College of Veterinary Pathologists American College of Veterinary Preventive Medicine American Medical Association American Nurses Association American Physiological Society American Phytopathological Society American Society for Microbiology American Society of Tropical Medicine and Hygiene American Veterinary Medical Association Association of Academic Health Centers Association of American Medical Colleges Association of American Veterinary Medical Colleges Association of Schools of Public Health Auburn University’s College of Veterinary Medicine, Auburn, Alabama (USA) Bella Moss Foundation, United Kingdom Biomedical Technology, Epidemiology and Food Safety Global Network: Brno, Czech Republic CAB International (CABI) http://www.cabi.org College of Veterinary Medicine and Biomedical Sciences, Texas A&M University (USA) Conservation through Public Health (CTPH) http://www.ctph.org/index.php Corporation Red SPVet, Bogota-Columbia Council for Agricultural Science and Technology (CAST) Council of State and Territorial Epidemiologists Croatian Society for Infectious Diseases Delta Society Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine Exuberant Animal Federation of Veterinarians of Europe (FVE) Global Alliance for Rabies Control Immune Macro Biotic Technology (IMBT), UK Immuno Valley Consortium in The Netherlands Indian Veterinary Public Health Association Institute of Tropical Medicine, Department of Animal Health, Antwerp, Belgium Italian Society of Preventive Medicine National Association of State Public Health Veterinarians National Environmental Health Association (NEHA) National Park Service (USA) New Zealand Centre for Conservation Medicine (NZCCM) - Auckland Nigerian Biomedical and Life Scientists Nigerian Veterinary Medical Association One Health in Epidemiology, Massey University, New Zealand Praecipio International SAPUVET III Project Silent Heroes Foundation Society for Tropical Veterinary Medicine SpayFIRST, Inc. State Environmental Health Directors United States Animal Health Association (USAHA) Veterinarians without Borders/ Vétérinaires sans Frontières - Canada Veterinarni Medicina, the international journal for biomedical and veterinary sciences http://vetmed.vri.cz/ Volunteers for Intercultural and Definitive Adventures (VIDA) www.vidavolunteertravel.org WiLDCOAST/COSTASALVAjE http://www.wildcoast.net/ World Association of Veterinary Laboratory Diagnosticians Zoonotic and Emerging Diseases, Edinburgh, UK from http://www.onehealthinitiative.com/supporters.php Need: In 2001, Taylor et al. published a report documenting that 868 (61%) of the 1415 organisms known to be pathogenic to humans are zoonotic, with 99 (75%) of 132 emerging human pathogens considered zoonotic.1 They further demonstrated that zoonotic pathogens are twice as likely to be associated with emerging human diseases than non-zoonotic pathogens.1 Examples of emerging zoonotic diseases include many that have captured international attention and have been associated with animal workers: Ebola virus, SARS virus, avian and swine influenza viruses, Hendra virus, hepatitis E virus, Nipah virus, human immunodeficiency viruses, and monkey pox virus. Zoonotic pathogens have been associated with countless large food-borne disease outbreaks. Control of these zoonotic infections are difficult because they often originate in rural agricultural settings and human health professionals are often not trained to recognize, report or mitigate these hazards. The success of public health practitioners in recognizing and preventing zoonotic illnesses is inhibited by lack of training. In addition, there are significant gaps in data such that they cannot make informed decisions Page 7 of 10 Cooperative Agreement regarding health and safety policy. These gaps are often due to under-reporting of occupational infections.2 Controlling zoonotic infections is further complicated by the complex ecological nature of these pathogens. For example, a government investigation of a deadly Q Fever outbreak in farm animals and farm workers in the Netherlands showed that response to the outbreak was slow, uncoordinated, and delayed by poor communication and collaboration between public health, medical and veterinary communities.3 Similarly, our understanding of how to reduce the threat of emergent pathogens in food, such as methicillin-resistant Staphylococcus aureus (MRSA) and pathogenic E. coli, are tremendously lacking. Former US Surgeon General Susan Blumenthal recently summarized the zoonotic pathogen and food safety problem well: Over the past five years, from the E. coli scare found in California spinach to the recent outbreak of salmonella in ground turkey, serious and sometimes fatal illnesses resulting from contaminated food have occurred more frequently than expected. Since 2006, the U.S. Centers for Disease Control and Prevention (CDC) has issued 39 warnings of multi-state foodborne illness occurrences….It is estimated that 48 million people are infected by foodborne diseases in the United States each year, resulting in $152 billion in medical costs annually. And these outbreaks show no sign of abating; the incidence of salmonella infections alone has increased 20 percent since 1997. With 170 countries exporting food to the U.S., and more than 70,000 food safety violations on food that is imported into America reported from 1998 to 2004 alone, the E. coli outbreak in Germany -- with additional cases reported in France and the U.S. -- shines a spotlight on why the issue of food safety is an international concern.4 Many emerging zoonotic diseases are associated with animals and farming. Health professionals who tackle these problems need to have an understanding of zoonotic disease risk factors that in the past have been stove piped into separate training programs for premarket and post-market food safety, human public health, veterinary health, and environmental health. As the ecology of zoonotic infections is often very complex, preventing zoonotic infections often requires multidisciplined partnerships. Researchers need special crossdisciplinary training to develop practical interventions for reducing such zoonotic infections. Such interventions may include educational programs for workers, increasing the availability of personal protective gear, developing engineering controls, developing rapid and simple-to-use clinic-based-diagnostics, employing vaccines against the zoonotic agents, and improving food storage systems. The One Health approach Cross-disciplinary international collaborations are required in tackling difficult global health problems. This is particularly true with respect to zoonotic diseases and food safety where the concept of working across disciplines has been termed the One Health approach (Fig. 1). One Health thinking seeks to include human, animal and environmental experts in problem solving. Internationally applauded, the One Health approach is strongly endorsed by human medicine, public health, veterinary medicine, the CDC, and various other national and international institutions and organizations. Perhaps it is best summarized by this quote from the American Veterinary Medical Association: Fig. 1. Complex zoonotic disease problems often cannot be solved without the partnership of professionals from a number of disciplines to identify the often inter-related human, animal, and environmental risk factors Although new opportunities have emerged to promote health in the rapidly changing human, animal, and environment domains, our ability to protect, improve, and advance health cannot be based on strategies and mindsets in the past. Rather, we need to adopt an integrated, holistic approach that reflects both our profound interdependence and the realization that we are part of a larger ecological system—exquisitely and elaborately connected.5 Page 8 of 10 Cooperative Agreement It is clear to the numerous international, national, and professional organizations that have embraced the cross-disciplinary One Health approach, that zoonotic infections are so complex that they cannot otherwise be well-controlled through standard single discipline approaches. Through interdisciplinary training of professionals, environments will become safer as hazards will be identified faster, controlled more efficiently, and prevented through effective education. Purpose: In this proposal we agree to link up our institutions in a network of One Health research and training collaboration. We propose the University of Florida as the core of this collaborative Center, as the University of Florida is already very well-positioned to organize this international research and education network. This is due in part because our campus, unlike most other US campuses, has 16 health science and land-grant colleges that provide the unique multi-disciplinary research and training engagement (public health, agricultural health, environmental engineering, and veterinary health) that such a collaborating Center requires. Regarding research, the University of Florida’s Emerging Pathogens Institute, established in 2010 is an interdisciplinary institution that is already home for numerous international scholars working on zoonotic disease and food safety threats. In fact, approximately 200 investigators are now associated with the institute collaborating with international investigators from more than 50 countries. We will build upon these already well-established collaborations. In addition, we are already engaged in international One Health research efforts. A good example is the NIH/NIEHS/FIC-sponsored One Health GEOHUB we are building in Eastern Europe and Central Asia. As guided by the University of Florida, this research Hub is designed to guide environmental and occupational research in Romania, Albania, Moldova, Georgia, Armenia, and Kazakhstan. We have also recently won a NIH-funded 5-yr grant to employ One Health, international and interdisciplinary approaches to tackle Mongolia’s difficult zoonotic problems. As another example, we are drafting a proposal for developing an international research network to study emerging adenovirus threats (killer cold virus) and have easily found willing collaborators who agree to share respiratory specimens (Fig. 2). Fig 2. International network of collaborating laboratories for adenovirus surveillance Regarding education, the University of Florida is again an internationally recognized leader in interdisciplinary training. Already, through the University of Florida’s College of Public Health and Health Professions, The Department of Environmental and Global Health, we have three levels of formal One Health graduate education which are the first in the United States: Page 9 of 10 Cooperative Agreement Certificate in One Health – The primary purpose if this nine-credit hour certificate is to provide One Health-specific training to public health, veterinary health, and environmental health professionals and students who wish to follow such careers. Training includes lectures, tutorials, field experiences, laboratory exercises, public health demonstrations, and written exams. This is the first such One Health certificate in the United States. Master’s of Health Science, One Health Concentration - The 40-credit hour MHS program is designed to provide students with advanced analytical skills for applied research careers and a solid knowledge base of public health and theory. This degree includes advanced research and technical skills needed to address emerging and global environmental health threats. The MHS curriculum addresses a diverse range of health issues, but has a strong focus upon infectious diseases. Courses are carefully structured to enable students to develop competence in very specific health skills. This is the first such One Health Master’s degree program in the United States. PhD in Public Health, One Health Concentration – This 90-credit hour PhD program is a researchoriented health degree that emphasizes working across public health, veterinary health, and environmental health disciplines to tackle difficult health problems. The PhD program focuses on global health and infectious diseases, while emphasizing research and elements of grant writing and funding. This is the first known One Health PhD degree program in the world. Strategy: The Center will be directed by Professor Gregory C. Gray, MD, MPH of the University of Florida. Center activities will be promoted through a dedicated web site, email messages to various professional distribution groups, and success in winning research grants and producing research projects. Benefits to center institutions: There are likely many benefits to collaborating institutions under this Center. Some are now recognized and others will be recognized later. Recognized benefits include: Access to rich and diverse opportunities to collaborate in research with University of Florida faculty, laboratories, and institutions. Special reduced graduate tuition rates as currently approved for the Certificate and MHS One Health programs. See http://egh.phhp.ufl.edu/academic-programs/ Leadership in organizing an International Symposium on One Health Research to be held every 2 to 3 years. Increased probability to win research funding via the collaborative network. Access to the Center’s technical scientific editing service for manuscript and scientific report generation. Details to be described at a later date Exchange of faculty for engaging graduate students. Exchange of laboratory and modeling professionals for research training. Exchange of graduate students for enhanced learning opportunities. References: 1. Taylor LH, Latham SM, Woolhouse ME. Risk factors for human disease emergence. Philos Trans R Soc Lond B Biol Sci. Jul 29 2001;356(1411):983-989. 2. Organization IL. Report VI: Safety and Health in Agriculture. . Geneva: International Labor Conference;2000. 3. Khan L. Lessons from the Netherlands. Bulletin of Atomic Scientists 2011; http://www.thebulletin.org/webedition/columnists/laura-h-khan/lessons-the-netherlands. Accessed January 10, 2011, 2011. 4. Blumenthal S. Food Safety In The 21st Century. Huffington Post. 2011. http://www.huffingtonpost.com/susan-blumenthal/food-safety_b_918282.html. Accessed August 8, 2011. 5. Association AVM. One Health : A New Professional Imperative: AVMA; July 15, 2008 2008. Page 10 of 10 Cooperative Agreement