MICRO # 289
Pathogenesis of Infectious Diseases II
March 18 to May 17, 2013
Course Director: Dennis J. O’Callaghan, Ph.D.
Department of Microbiology and Immunology
Office: 2-203A
Ph. 5-5754
Email: docall@lsuhsc.edu
LECTURERS: All are faculty of the Department of Microbiology and Immunology
Dr. Michelle M. Arnold
Dr. Jason M. Bodily
Dr. James A. Cardelli
Dr. Lindsey M. Hutt-Fletcher
Dr. Jeremy P. Kamil
Dr. David J. McGee
Dr. Martin I. Muggeridge
Dr. Dennis J. O’Callaghan
Dr. Kenneth M. Peterson
Dr. Martin J. Sapp
Dr. Ikuo Tsunoda
Dr. Matthew D. Woolard
Dr. Andrew D. Yurochko
marnold@lsuhsc.edu
jbodil@lsuhsc.edu
jcarde@lsuhsc.edu
lhuttf@lsuhsc.edu
jkamil@lsuhsc.edu
dmcgee@lsuhsc.edu
mmugge@lsuhsc.edu
docall@lsuhsc.edu
kpeter@lsuhsc.edu
msapp1@lsuhsc.edu
itsuno@lsuhsc.edu
mwoola@lsuhsc.edu
ayuroc@lsuhsc.edu
LECTURES: Daily at 8:00 to 8:50 am, and 1:00 to 2:00 PM on Fridays: Room 2-201
EXAMINATIONS: Saturdays at 9:00 AM in a large lecture room 4-326
Each lecture = 10 points of 500
Exam #1
Lectures #1 to 12
Exam #2
Lectures 13 to 25
Exam #3
Lectures 26 to 38
Exam #4
Lectures 39 to 50
Saturday April 6
Saturday April 27
Saturday May 11
Saturday May 25
120 points
130 points
130 points
120 points
COURSE OBJECTIVES
1. To understand the general principles and steps in the pathogenesis of an infectious
disease and the epidemiological aspects that influence the disease.
2. To learn the seven key points of the major pathogens discussed in the course: key
properties, location in nature, means of transmission, nature of the disease, means
for a diagnosis, treatment(s) available, and means to control and prevent.
3. To understand the role of innate and acquired immune responses in the control and
outcome of infection and how the immune system may be part of the pathogenesis of
some infections.
4. To appreciate the molecular interactions between the pathogen and the host cell and
the strategies employed by major pathogens to mediate a variety of outcomes that
may include cytocidal effects, latency, persistent infection, or transformation.
MICRO #289: Pathogenesis of Infectious Diseases II
1. Mon
2. Tue
Mar 18
Mar 19
8AM
8 AM
3. Wed
4. Thur
5. Fri
6. Mon
7. Tue
8. Wed
9. Thu
X
10. Tue
11. Wed
12. Thu
13. Fri
14. Fri
15. Mon
16. Tue
17. Wed
18. Thu
19. Fri
20. Fri
21. Mon
22. Tue
23. Wed
24. Thu
25. Fri
26. Fri
27. Mon
28. Tue
29. Wed
30. Thu
31. Fri
32. Fri
33. Mon
34. Tue
35. Wed
36. Thu
37. Fri
38. Fri
39. Mon
40. Tue
41. Wed
42. Thu
43. Fri
Mar 20
Mar 21
Mar 22
Mar 25
Mar 26
Mar 27
Mar 28
8 AM
8 AM
8 AM
8 AM
8 AM
8 AM
8 AM
Apr 2
Apr 3
Apr 4
Apr 5
Apr 5
Apr 8
Apr 9
Apr 10
Apr 11
Apr 12
Apr 12
Apr 15
Apr 16
Apr 17
Apr 18
Apr 19
Apr 19
Apr 22
Apr 23
Apr 24
Apr 25
Apr 26
Apr 26
Apr 29
Apr 30
May 1
May 2
May 3
May 3
May 6
May 7
May 8
May 9
May 10
8 AM
8 AM
8 AM
8 AM
1 PM
8 AM
8 AM
8 AM
8 AM
8 AM
1 PM
8 AM
8 AM
8 AM
8 AM
8 AM
1 PM
8 AM
8 AM
8 AM
8 AM
8 AM
1 PM
8 AM
8 AM
8 AM
8 AM
8 AM
1 PM
8 AM
8 AM
8 AM
8 AM
8 AM
Principles of Pathogenesis
Epidemiological Aspects of Infectious
Diseases
Outcomes of Infection at Cell and Host Levels
Innate Immune Responses: 1
Innate Immune Responses: 2
Adaptive Immune Responses: 1
Adaptive Immune Responses: 2
Adherence: Pili/Fimbriae, Afimbrial Adhesins
Biofilms: Primary Literature
Friday March 29 and Monday April 1: No class
Toxins: ADP Ribosylating, proteases
Pathogenicity Islands: Primary Literature
Regulation of Virulence Factors
Messing with Phagocytic Cells
Messing with Phagocytic Cells
Immune Evasion by Bacteria
Bacterial Protein Secretion
Staphylococcus
Streptococcus
Enterics: E. coli, Vibrio
Enterics: Salmonella, Shigella
Neisseria,
Bordetella and Haemophilus
Helicobacter, Campylobacter
Pseudomonas, Legionella
Mycobacterium
Spirochetes
Zoonoses
Molecular Mechanisms of Viral Pathogenesis
Genetics and Determinants of Virus Virulence
Immune Evasion by Viruses: 1
Immune Evasion by Viruses: 2
Viral infections of the Respiratory Tract: 1
Viral infections of the Respiratory Tract: 2
Viral infections of the Gastrointestinal Tract: 1
Viral infections of the Gastrointestinal Tract: 2
Hemorrhagic Fevers
Viral infections of CNS: 1 Acute Infections
Viral infections of CNS: 2 Chronic Infections
Oncogenic Viral Diseases
Oncogenic Viral Diseases
Viral Genitourinary and Urinary Infections
Sexually Transmitted Infections
Congenital and Perinatal Viral Infections
Dr. O’Callaghan
Dr, O’Callaghan
Dr. O’Callaghan
Dr. Yurochko
Dr. Yurochko
Dr. Woolard
Dr. Woolard
Dr. McGee
Dr. McGee
Dr. Peterson
Dr. McGee
Dr. Peterson
Dr. Cardelli
Dr. Cardelli
Dr. Woolard
Dr. McGee
Dr. Peterson
Dr. McGee
Dr. Peterson
Dr. Peterson
Dr. McGee
Dr. McGee
Dr. McGee
Dr. Woolard
Dr. McGee
Dr. Peterson
Dr. Cardelli
Dr. Bodily
Dr. Bodily
Dr. Yurochko
Dr. Yurochko
Dr. Muggeridge
Dr. Muggeridge
Dr. Arnold
Dr. Arnold
Dr. Tsunoda
Dr. Tsunoda
Dr. Tsunoda
Dr. Sapp
Dr. Sapp
Dr. Kamil
Dr. Kamil
Dr. Sapp
44. Fri
45. Mon
46. Tue
47. Wed
48. Thu
49. Fri
50. Fri
May 10
May 13
May 14
May 15
May 16
May 17
May 17
1 PM
8 AM
8 AM
8 AM
8 AM
8 AM
1 PM
Viral Infections of the Cardiovascular System
Infections of the skin
AIDS and Immunosuppressive Infections: 1
AIDS and Immunosuppressive Infections: 2
Viral Hepatitis: 1
Viral Hepatitis: 2
Prions
FOUR EXAMS SATURDAYS in a large classroom
Each lecture = 10 points of 500
Exam #1
Lectures #1 to 12
Saturday April 6
Exam #2
Lectures 13 to 25
Saturday April 27
Exam #3
Lectures 26 to 38
Saturday May 11
Exam #4
Lectures 39 to 50
Saturday May 25
9:00 AM
120 points
130 points
130 points
120 points
Dr. Yurochko
Dr. Sapp
Dr. O’Callaghan
Dr. O’Callaghan
Dr. Hutt-Fletcher
Dr. Hutt-Fletcher
Dr. Muggeridge