Application form
Commissioned Research
Support for Vaccine Development
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In most cases, initial discussions will need to occur with service provider to estimate
budget request
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Please be aware that all research support offered here must be applied for specifically
as needed in the context of vaccine development. For specific questions regarding the
individual services, please contact the providers directly
Adjuvants
Evaluation of potency of new exploratory adjuvants bench-marked against the established adjuvants
systemically and/or mucosally as pertain to immune-profiling and functionality of the immune
response in mice. University of Gothenburg, A. Harandi (ali.harandi@microbio.gu.se)
21,500€/adjuvant/1 full experiment with control and bench-mark arms. Click here for more
information.
Pre-clinical QS-21 is available for use in their early vaccine formulations and GMP quality QS-21 for
human clinical trials. Desert King International (ADITEC affiliated partner), D. Hiley
(dfhiley@desertking.com).
Three independent adjuvants: sodium arsenite, gramacidine and dithiocarbonate and high
throughput template to analyse sequentially molecular interactions between any other adjuvant and
dendritic T and B cells with particular reference to the inflammasome and homeostatic pathways
leading to immunological memory. King’s College of London, T. Lehner (thomas.lehner@kcl.ac.uk).
Animal models
Mouse Model: University of Siena, D Medaglini (Medaglini@unisi.it)
Perform pre-clinical studies in the mouse model to assess the immunogenicity of vaccine
formulations and prime-boost strategies. Click here for more information.
Chlamydia Challenge Mouse Model: Statens Serum Institut, Frank Follmann (FRF@ssi.dk)
Perform immunogenicity analysis and challenge experiment in the Chlamydia mouse model.
Immunogenicity + Challenge of a group of 12 mice. The prize includes control groups (negative /
positive). 12.000€ / vaccine group (of 10 mice) up to 4 groups. Click here for more information.
TB Challenge Mouse Model: Statens Serum Institut, Else Marie Agger (EAG@ssi.dk)
Perform immunogenicity analysis and challenge experiment in the TB mouse model.
Immunogenicity + Challenge of a group of 10 mice. The prize includes control groups (negative /
positive). 10.000€ / vaccine group (of 10 mice) up to 4 goups. Click here for more information.
Influenza Challenge Mouse Model: Imperial College London, J Tregoning
(john.tregoning@imperial.ac.uk)
Perform influenza challenge models following immunisation. Immunisation can be by various
routes, both mucosal and systemic. Infection can be with H1N1, H3N2 or B strains, enabling
homologous or heterologous infection and protection assessed by disease and viral load
measurements. Assess immunogenicity in the same animals – both antibody and cellular. N=5
mice per group, max 6 groups per study. Click here for more information.
Non-Human Primate Model: CEA, Immuno-Virology & IDMIT infrastructure, R.LeGrand
(roger.le-grand@cea.fr)
NHP models for HIV, Flu, Chicungunya virus, Dengue, Chlamydia,
Immuno-monitoring core : Flow Cytometry, Mass Cytometry (CyTof)
In vivo imaging. Click here for more information.
Human Trials
Human Challenge Models for Typhoid and parathyphoid vaccination/infection University of Oxford,
A. Pollard (andrew.pollard@paediatrics.ox.ac.uk). Click here for more information.
Human Trials (including infants) for systems immunology to study transcriptome, B/T cell
immunology University of Oxford, A. Pollard (andrew.pollard@paediatrics.ox.ac.uk). Click here for
more information.
Clinical trial support from concept through to completion. Services can include: protocol design and
review, regulatory submissions and approvals, sponsorship of clinical trials, project management of
trial, pharmacovigilance and monitoring support, clinical trial delivery ,laboratory processing of
samples, data management, statistical analysis and clinical study reporting. Surrey Clinical
Research Centre, D. Lewis (D.J.Lewis@surrey.ac.uk). Click here for more information.
MLPA Assay Reverse Transcription Multiplex Ligation-dependent Probe Amplification is high
throughput assay, which can rapidly profile mRNA expression of host. Leiden University Medical
Center, T.Ottenhoff (T.H.M.Ottenhoff@lumc.nl). Click here for more information.
Multiplex detection of cytokine and chemokine biomarkers: evaluate the production of
cell signaling proteins, such as cytokines, chemokines, and inflammatory biomarkers in multiple
samples, using the Bio-Plex suspension array system University of Siena, A Ciabattini
(annalisa.ciabattini@unisi.it). Click here for more information.
Formulation of vaccine antigens onto biodegradable particles: Formulate sub-unit or
vaccine components onto biodegradable particles, containing or not in their core, different immunemodulators, such as TLR or Nod ligands, by using passive adsorption process onto Poly Lactic Acid
(PLA) particles of 150<x<200nm size. CNRS, B Verrier. (bernard.verrier@ibcp.fr). Click here for more
information.
Systems biology analysis and mathematical modeling: Construction, simulation and
identification of stochastic and deterministic dynamical mathematical models of adaptive immune
response in animal models. Statistical analysis of experimental data (probability distribution function
estimation, classification, etc.). Interference of gene regulation networks. Università di Siena –
Dipartimento di Ingegneria dell’Informazione e Scienze Matematiche, A Vicino (vicino@ing.unisi.it).
Click here for more information.
Serological Assays for Vaccine Evaluation: Evaluation and validation of serological assays
specifically designed for vaccines immunogenicity assessment, with particular regards for influenza
seasonal and pandemic formulations. Services are focused on the assessment of antibody response
by means of serological assays required for Influenza vaccines licensing (Haemagglutination
Inhibition, Single Radial Haemolysis, MicroNeutralization etc.) with the possibility of setting-up
alternative platforms ss Pseudo-particles-based Neutralization and Neuraminidase assay. On
request, evaluation of cell mediated immune response can be performed using ELISPOT and FACS.
VisMederi SRL, Emanuele Montomoli (montomoli@vismederi.com)
Reagent Set and Standards Production for Viral Diagnostic: Provide validated reagents
collections for production and validation of diagnostic kits designed to identify viral diseases with
particular focus for influenza A and B. VisMederi, Simona Piccirella picirella@vismederi.com
Description of laboratory Please describe your laboratory and its associated facilities in relation to this
request
Relevant Publications Please list here your publications (with d.o.i) relevant to your application maximum 5 –
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ADITEC Project: Sclavo Vaccines Association Siena Italy Email
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