Berlin Institute of Health (BIH) Twinning Research Grants Full Proposal Form Luisenstraße 56 10117 Berlin Germany www.bihealth.org Full Proposal Form for BIH Twinning Research Grants Berlin Institute of Health (BIH) Twinning Research Grants Full Proposal Form Opening Remark This template offers guidance in preparing the Full Proposal for a BIH Twinning Research Grant (TRG). Instructions for completing the form are printed in grey. Grey text in parentheses (e.g. <grey>) is to be replaced by the applicant. Only text printed in black needs to appear in the final version. Please submit the completed document as one PDF file (up to 16 MB) via the online application portal (https://application.mdc-berlin.de/) until August 04th 2014 at 3pm. To submit your Full Proposal, please follow these steps: Login to the application portal and select the “my applications” button in the left hand menu. A list of submitted applications will appear. Click the magnifying glass to the right of your TRG Pre-Proposal. In the overview of your TRG application, click the top-right tab named “Full Proposal”. To upload the PDF File of your Full Proposal, click the edit button (pencil icon in the top right corner) and select the file to be uploaded. After uploading is completed, click the “save” icon. To finalize your submission, click the submit button. BIH Twinning Research Grant: <Title> Funding Period: From <Date> to <Date> Duration of project (2 years with a possible extension for another year, earliest start is January 1, 2015): Total amount of funding requested for the two year funding period: <Sum> € Coordinators of the BIH Twinning Research Grant: Principal investigator <Title, first name, last name> Phone E-mail address Keywords: (1) Please provide 3 to 5 keywords to your project (2) (3) Affiliation Subproject <institute, research group> <index number> Part 1: Research Program PART 1: RESEARCH PROGRAM Please describe the scientific concept of the planned BIH Twinning Research Grant, including topic, goals and leading question(s). Please address the following points in your proposal: Overall objectives, highlighting how the application fits into the BIH’s strategic perspective and the general framework of translational systems medicine. The major research question(s) (e.g. medical problem or knowledge gap) that will be addressed during the funding period. Do you consider the project as exploratory? The foreseen benefits of this research project on a scientific, clinical and patient level. The long-term perspective of the research project. How the overall project will be divided into subprojects and how the subprojects will be interlinked. Expected synergistic effects within the consortium. How is the cooperation of the involved scientists supported and organized? Are early career scientists promoted? Brief overview on the preliminary work. A bibliography of all references cited at the end of the text and a separate list with a maximum of 5 of your own publications per principal investigator that directly relate to the project. <Text> (18,000 - 24,000 characters including spaces, excluding references) 3 Part 2: Timeline of the Project PART 2: TIMELINE OF THE PROJECT Please restrict this list to the chief milestones of the proposal and describe the major tasks required for their achievement. Please indicate how you plan to sequence these tasks to achieve the overall goal(s). Please be aware that the milestones will be used to monitor the progress of your project. Please also include milestones that are planned for 2017 if funding is extended. # Task Name Subproject Start End Description 4 Part 3: Funds Requested PART 3: FUNDS REQUESTED Funding of a subproject is administered through either Charité or MDC. Please use the corresponding templates below to provide information on the funds requested and to indicate which institution will be responsible for the administration of the subproject. Pease duplicate the tables below if your proposal comprises more than two subprojects. Please provide a realistic and scientifically well justified estimate of direct costs. A substantial budget increase in the Full Proposal compared to the Pre-Proposal will be viewed negatively. Please give all figures in Euro. For further information please refer to the FAQs section available at the TRG Call page of the BIH website (https://www.bihealth.org/en/bih-twinning-research-grants-en). 3.1 Overview by category and year Please calculate personnel costs using the personnel rates* given below and provide costs for 2017 if funding is extended. The number of personnel refers to full time equivalents. Please enter doctoral students as 1 FTE. Please note that the funding of major research equipment (>10,000 €) is not foreseen within the TRGs. Funding administered through Charité Coordinator: <name> 2015 Cost Category Personnel Personnel Personnel Personnel Personnel Details Postdoctoral researcher or comparable (E13-3 to E14-2) Physician scientist (Ä1-2 to Ä2-1) Doctoral researcher (65% E13-2 to E14-1) Other research assistant (employees with bachelor’s degree, E9 to E12) Non-academic staff member (E2-1 to E9-2) Salary p. a. # 2016 ∑ # 2017 ∑ # Total Sum ∑ ∑ 65849 76166 40530 56568 47204 Total Personnel Consumables Travel Costs Animal Costs** External Services IT Equipment Core Facilities*** Other <Description and justification of costs> <Description and justification of costs> < total cost from 3.2> <Description and justification of costs> <Description and justification of costs> <Description and justification of costs> <Description and justification of costs> <Description and justification of costs> Total Consumables and Other Costs Overall Total *, Personnel rates provided represent average values based on personnel rates from the “Tarifvertrag TV-Charité” estimated for 2015-2017 (incl. planned personnel rate increases) . #, Number of persons ∑, Sum **, Please calculate Animal Costs on the basis of fees that the animal facility will be charging you and provide detailed information in section 3.2. ***, For a list of Core Facilities available at the BIH and their coordinators please refer to the TRG Call page of the BIH website. 5 Part 3: Funds Requested Funding administered through MDC Coordinator: <name> 2015 Cost Category Personnel Personnel Personnel Personnel Personnel Details Postdoctoral researcher or comparable (E13-3 to E14-2) Physician scientist (Ä1-2 to Ä2-1) Doctoral researcher (65% E13-2 to E14-1) Other research assistant (employees with bachelor’s degree, E9 to E12) Non-academic staff member (E2-1 to E9-2) Salary p. a. # 2016 ∑ # 2017 ∑ # Total Sum ∑ ∑ 67930 42510 59602 49223 Total Personnel Consumables Travel Costs Animal Costs** External Services IT Equipment Core Facilities*** Other <Description and justification of costs> <Description and justification of costs> < total cost from 3.2> <Description and justification of costs> <Description and justification of costs> <Description and justification of costs> <Description and justification of costs> <Description and justification of costs> Total Consumables and Other Costs Overall Total *, Personnel rates provided represent average values based on personnel rates from the “Tarifvertrag TVöD (Bund/Ost)” estimated for 2015-2017 (incl. planned personnel rate increases) . #, Number of persons ∑, Sum **, Please calculate Animal Costs on the basis of fees that the animal facility will be charging you and provide detailed information in section 3.2. ***, For a list of Core Facilities available at the BIH and their coordinators please refer to the TRG Call page of the BIH website. 3.2 Husbandry of laboratory animals Please list the funds requested for husbandry of laboratory animals. Please note that additional demands on animal facilities that result from the Twinning Research Grant project need to be discussed with and approved by the persons responsible for husbandry of laboratory animals at Charité or MDC prior to submission of the application. Please duplicate the tables below if the proposal comprises more than two subprojects. 6 Part 3: Funds Requested Funding administered through Charité Coordinator: <name> Year Species Number weeks kept Housing costs per animal and week Purchasing costs per animal ∑ Housing costs per animal and week Purchasing costs per animal ∑ 2015 2016 Total Funding administered through MDC Coordinator: <name> Year Species Number weeks kept 2015 2016 Total 3.3 Demands on Core Facilities If the proposed project requires the use of core facilities, please contact the responsible core facility coordinators to ensure the feasibility of your project before submitting the application. For a list of core facilities available at the BIH please refer to the TRG Call page of the BIH website. If applicable, please indicate which BIH, Charité or MDC core facilities will be required for the proposed research and estimate the associated workload for the core facilities. Please indicate whether fees will be charged to you. Costs arising there should be included in the calculation and listed under “Core Facilities”. <Text> 3.4 Demands on IT resources Please describe the relevant requirements on IT and Bioinformatics for this project, incl. server capacity (virtual or physical; operating system; CPUs; RAM; disk space), HPC compute and mass storage capacities, central storage needs (initially; expected yearly increase; archive), software licenses, bioinformatics services. <Text> 7 Part 4: Annex PART 4: ANNEX 4.1 Conditions and Obligations Please note that it is your responsibility to submit a complete application and that a formally incorrect application may be excluded from the evaluation procedure. Therefore, in case you have any questions about the application, please contact the BIH head office. Please be sure to work out a clearly understandable proposal. The proposal should be self-explanatory and not require the reviewers to read the literature that is either quoted or enclosed. In submitting this proposal to the BIH, applicants confirm that there is no double funding for the costs requested. In the event of future double funding, the applicants will inform the BIH immediately. Furthermore, applicants agree to: Adhere to the rules of good scientific practice. Have adhered to the guidelines regarding publication lists and bibliographies. Inform the BIH immediately of any changes to the information provided in this proposal. Observe all relevant laws, regulations and guidelines that pertain to the project and in particular to attain all necessary approvals, certifications, etc., in a timely manner. Use the grant exclusively and in a targeted manner to realize the funded project. Have discussed feasibility of the project demands on IT with the responsible coordinators. Have discussed feasibility of the project demands on core facilities with the responsible coordinators. Have discussed additional demands on animal facilities with responsible persons at MDC or Charité. Please tick: [ ] We accept the foregoing conditions and obligations. [ ] We agree to: The MDC’s electronic processing and storage of data provided in conjunction with this proposal. This information may be passed to reviewers and the BIH bodies as part of the review and decision-making process. Having all address and communication data (e.g. telephone, fax, e-mail, internet website), as well as information on the content of this research project, if approved, published in BIH reports. We understand that the electronic publication of this information may be opposed by contacting the BIH. The BIH requires signatures from all applicants listed above certifying that they accept and will comply with the conditions and obligations as stated. Multiple applicants are asked to sign and submit this form jointly. Original handwritten signatures can be supplied subsequently to the submission of the application. Place, date <Signature > <Name>, (Coordinator) Place, date <Signature> <Name>, (Coordinator) 8 Part 4: Annex 4.2 Academic curriculum vitae of the applicants Please attach the academic curriculum vitae of all applicants including the following details (please copy this part from your Pre-Proposal, if no information has changed). Curriculum vitae Last name Last name at birth First name(s) Academic Degree/title Gender m[ ] f[ ] Year of birth Year of PhD Affiliation Work address Phone number Fax E-mail address Research experience Experience as a coordinator Education <Please list, in reverse chronological order, your research experience including type of position, duration, the research topic, the institute and supervisor (if applicable).> <For the coordinators please state the experience in coordinating research consortia.> <Please list, in reverse chronological order, your education including the university, major subject and degree obtained.> Present position <In case you are between jobs please specify your last position.> Research field <Please describe the on-going research in your laboratory (max. 1,800 characters including spaces).> Top five publications <Please highlight your name in bold.> Previous scientific achievements <Please state important grants, awards, honors, fellowships, and memberships in professional societies.> 9