Inga Čikotienė
Curriculum Vitae
Contact information:
Department of Organic Chemistry, Faculty of Chemistry, Naugarduko 24, LT-03225, Vilnius, Lithuania
phone +370 5 219 3195; +370 5 219 3187; fax. +370 5 233 0987
e-mail: inga.cikotiene@chf.vu.lt
Professional Experience:
2014 – present Vilnius University, Faculty of Chemistry, Department of Organic Chemistry, professor.
2009 – 2014 Vilnius University, Faculty of Chemistry, Department of Organic Chemistry, assoc. prof.
2008 – 2010 Institute of Biotechnology, senior researcher (part-time)
2006 – 2009 Vilnius University, Faculty of Chemistry, Department of Organic Chemistry, lecturer.
Education:
2007 – 2008 Postdoctoral studies, Institute of Biotechnology, Lithuania. Advisor: dr. D. Matulis.
2003 – 2006 Vilnius University, Faculty of Chemistry, Department of Organic Chemistry; Doctoral
Studies, PhD Thesis: “Investigation Of Intramolecular Oxidation-Reduction And Cyclization Reactions Of 4Substituted 5-Nitropyrimidines”. Advisor: dr. A. Brukštus.
2001 - 2003 Vilnius University, Faculty of Chemistry, Master of Science, “Magna Cum Laude“ diploma.
1997 – 2001 Vilnius University, Faculty of Chemistry, Bachelor of Science.
Research interests:
Development of new synthetic methods; Investigation of reactions mechanisms; Synthesis of heterocyclic
compounds; Medicinal chemistry.
Selected publications:
1. I. Karpavičienė, G. Valiulienė, V. Raškevičius, I. Lebedytė, A. Brukštus, V. Kairysc, R. Navakauskienė,
I. Čikotienė; Synthesis and Antiproliferative Activity of α-Branched α,β-Unsaturated Ketones in
Human Hematological and Solid Cancer Cell Lines, Eur. J. Med. Chem., 2015, 98, 30 – 48.
2. R. Bukšnaitienė, I. Čikotienė; Electrophile-Promoted Cyclization of Propargylic Amides, Synlett,
2015, 26, 479 - 483.
3. R. Bukšnaitienė, A. Urbanaitė, I. Čikotienė; Formation of Condensed 1H-Pyrrol-2-ylphosphonates
and 1,2-Dihydropyridin-2-ylphosphonates via the Kabachnik-Fields Reaction of Acetylenic
Aldehydes and Subsequent 5-Exo-dig or 6-Endo-dig Cyclizations, J. Org. Chem., 2014, 79, 6532 –
6553.
4. C. Trujillo, G. Sánchez-Sanz, I. Karpavičienė, U. Jahn, I. Čikotienė, L. Rulíšek; Divergent Pathways and
Competitive Mechanisms of Metathesis Reactions between 3-Arylprop-2-inyl esters and Aldehydes:
An Experimental and Theoretical Study, Chem. Eur. J., 2014, 20, (33), 10360 – 10370.
5. I. Čikotienė; Rearrangements of Propargylic Esters can be Induced by Some Electrophiles, Org. Lett.,
2014, 16, 2260 – 2263.
6. I. Karpaviciene, I. Cikotiene, J. M. Padron; Synthesis and antiproliferative activity of α-branched α,βunsaturated ketones, Eur. J. Med. Chem., 2013, 70, 568 – 578.
7. I. Cikotiene, M. Jonusis, V. Jakubkiene; The first example of the Fischer–Hepp type rearrangement
in pyrimidines, Beilstein J. Org. Chem., 2013, 9, 1819 - 1825.
8. I. Karpaviciene, I. Cikotiene; A Unique Cascade Reaction between 3-Arylprop-2-inylcarboxylates and
Benzaldehydes Leading to the Formation of Morita–Baylis–Hillman Adducts, Org. Lett., 2013, 15 (1),
224 - 227.
9. V. Jakubkiene, J. Zurba, I. Cikotiene; N-Nitroso Moiety Assisted Nucleophilic Aromatic Substitution
of 6-Chloropyrimidines: A Facile and Efficient Synthesis of 4,6- and 2,4-Pyrimidinediamines,
Synthesis, 2013, 45 (4), 448 - 451.
10. I. Cikotiene, R. Buksnaitiene; Study on the Reactions of Acetylenic Aldehydes with
Dimethylphosphite in Basic Media: Phosphonate - Phosphate Rearrangement versus 5-exo-dig
Cyclization Reactions, Adv. Synth. Catal., 2012, 354, 2719 – 2726.
11. S. Y. Sharp, S. M. Roe, E. Kazlauskas, I. Cikotiene, P. Workman, D. Matulis, C. Prodromou, CoCrystalization
and
In
Vitro
Biological
Characterization
of
5-Aryl-4-(5-Substituted-2-4-
Dihydroxyphenyl)-1,2,3-Thiadiazole Hsp90 Inhibitors, PlosOne, 2012, 7 (9), e44642.
12. I. Cikotiene, Intramolecular Iodine-mediated Oxygen Transfer from Nitrogroups to C≡C bonds, Eur.
J. Org. Chem., 2012, 2766 - 2773.
13. R. Buksnaitiene, I. Cikotiene, A Facile and Efficient Synthesis of 1-Trichloromethyl-1,2dihydrobenzo[b][1,6]naphthyridines via Three-component Reaction Between 2-Alkynylquinoline-3carbaldehydes, Primary Amines and Chloroform, Heterocycl. Commun., 2012, 18, 87 - 92.
14. V. Jakubkienė, I. Cikotiene, Effect of substituent structure on pyrimidine electrophilic substitution:
A Rebuttal, Tetrahedron, 2012, 68, 2294 - 2298.
15. I. Karpaviciene, R. Lapinskaite, A. Brukstus, I. Cikotiene, Reductive Ring Cleavage of Nonconjugated
Δ2-Isoxazolines to β-Hydroxy Ketones with Aluminum and Copper (II) Chloride, Synlett, 2012, 23,
381 - 384.
16. C. Ríos-Luci , R. Domínguez-Kelly, L. G. León, E. Díaz-Rodríguez, R. Freire, A. Pandiella, I. Cikotiene, J.
M. Padrón, A modular mechanistic approach to trim cellular targets in anticancer drug discovery,
Bioorg. Med. Chem. Lett, 2011, 21, 6641 – 6645.
17. R. Buksnaitiene, I. Cikotiene, Novel Synthetic Method of 2-(2-Oxoethyl)-1H-indole-3-carbaldehydes,
Synlett, 2011, 2529 - 2532.
18. I. Cikotiene, R. Buksnaitiene, R. Sazinas, Rapid Access to Benzo-annelated Heterocycles,
Naphthalenes and Polysubstituted Benzenes through a Novel Benzannulation Reaction,
Tetrahedron, 2011, 67, 706 – 717.
19. I. Cikotiene, R. Sazinas, R. Mazeikaite, L. Labanauskas, Unexpected Regioselectivity in
Cycloisomerization of 2-Alkynyl-3-nitrothiophenes, Synlett, 2010, 3027 - 3030. Highlighted by
Synfacts, 2011, 2, 140.
20. I. Cikotiene, E. Pudziuvelyte, A. Brukstus, Efficient One-Pot Synthesis of 6-Arylpyrrolo[3,2d]pyrimidines from 6-Arylethynyl-5-nitropyrimidines, Synlett, 2010, 1107 - 1109.
21. S. Rudys, C. Ríos-Luci, E. Pérez-Roth, I. Cikotiene, J. M. Padrón, Antiproliferative Activity of Novel
Benzo[b][1,6]naphthyridines in Human Solid Tumor Cell Lines, Bioorg. Med. Chem. Lett, 2010, 20,
1504 - 1506.
22. I. Cikotiene, R. Buksnaitiene, S. Rudys, M. Morkunas, D. Motiejaitis, Tandem reactions of 6phenylethynylpyrimidine-5-carbaldehydes with alcohols: regioselective synthesis of 5-alkoxy-(7Z)-7benzylidene-5,7-dihydrofuro[3,4-d]pyrimidines
and
5-alkoxy-7-phenyl-5H-pyrano[4,3-
d]pyrimidines, Tetrahedron, 2010, 66, 251 - 258.
23. E. Pudziuvelyte, C. Ríos-Luci, L. G. León, I. Cikotiene and J. M. Padrón, Synthesis and
Antiproliferative Activity of 2,4-Disubstituted 6-Aryl-7H-pyrrolo[3,2-d]pyrimidin-7-one 5-Oxides,
Bioorg. Med. Chem., 2009, 17, 4955 - 4960.
24. I. Cikotiene, V. Kairys, R. Buksnaitiene, M. Morkunas, S. Rudys, A. Brukstus, M. X. Fernandes, Study
on the cyclization of 6-arylethynylpyrimidine-5-carbaldehydes with tert-butylamine: microwave
versus thermal preparation of pyrido[4,3-d]pyrimidines, Tetrahedron, 2009, 65, 5752 - 5759.
25. I. Cikotiene, A novel and simple benzannulation reaction using the potassium salt of methyl
mercaptoacetate for the synthesis of 3-aryl-2-methoxycarbonylacridines, Tetrahedron Lett., 2009,
50, 2570 - 2572.
26. I. Cikotiene, E. Kazlauskas, J. Matuliene, V. Michailoviene, J. Torresan, J. Jachno, D. Matulis, 5-Aryl4-(5-substituted-2,4-dihydroxyphenyl)-1,2,3-thiadiazoles as inhibitors of Hsp90 chaperone, Bioorg.
Med. Chem. Lett, 2009, 19, 1089 – 1092.
27. I.
Cikotiene,
M.
Morkunas,
methoxycarbonylquinazolines
via
The
First
Unexpected
and
Efficient
Reaction
of
carbaldehydes and Methyl Mercaptoacetate, Synlett, 2009, 2, 284 - 286.
Synthesis
of
7-Aryl-6-
6-Arylethynylpyrimidine-5-
28. I. Cikotiene, M. Morkunas, S. Rudys, R. Buksnaitiene, A. Brukstus; An Efficient One-Pot Synthetic
Method
of
2,4-Disubstituted
7-Arylpyrido[4,3-d]pyrimidines
from
2,4-Disubstituted
6-
Arylethynylpyrimidine-5-carbaldehydes and tert-Butylamine, Synlett, 2008, 18, 2799 - 2802.
Highlighted by Synfacts, 2009, 1, 16.
29. I. Cikotiene, M. Morkunas, D. Motiejaitis, S. Rudys, A. Brukstus; The First Tandem Acetalization/5Exo-dig Cyclization of 6-Phenylethynylpyrimidine-5-carbaldehydes: Efficient Synthesis of 5-Alkoxy(7Z)-7-benzylidene-5,7-dihydrofuro[3,4-d]pyrimidines, Synlett, 2008, 11, 1693 - 1698.
Honors and awards:
2015 Thieme Chemistry Journals Award.
2014 - 2015 Young scientist scholarship from Lithuanian Academy of Science.
2014 Scientific award from Rector of Vilnius University.
2009 Scientific award from Rector of Vilnius University.
2004 Theodor von Grothus scholarship.
2003 Young scientist award from Lithuanian Research Council.
2003 Magna Cum Laude Diploma of Vilnius University.