Name ____________________________________________________________ Date ___________________
DNA: PROTEIN SYNTHESIS AND MUTATIONS
Use the DNA sequences below, to translate the codons into amino acids. Use the
codon decoder to help you build the polypeptides.
1. Original DNA Sequence:
T A C A C C T T G G C G A C G A C T
mRNA Sequence:
__________ __________ __________ __________ __________ __________
Amino Acid Sequence:
__________ __________ __________ __________ __________ __________
2. Original DNA Sequence:
T A C G C C T A C G C G A G G A T C
mRNA Sequence:
__________ __________ __________ __________ __________ __________
Amino Acid Sequence:
__________ __________ __________ __________ __________ __________
3. Based on the activity ‘Mutation Telephone’, describe the term mutation.
_________________________________________________________________________________________________
_________________________________________________________________________________________________
_________________________________________________________________________________________________
Complete
Student
Demonstation
for
Concept
Development
4. Do you think that mutations could be helpful? Explain. Give an example of a
mutation you feel might be helpful.
_________________________________________________________________________________________________
_________________________________________________________________________________________________
_________________________________________________________________________________________________
Example:______________________________________________________________________________________
_________________________________________________________________________________________________
4. Being that mutations are copying errors, (mistakes), you should realize that many
are harmful. Explain why mutations often present complications to an organism.
Give an example of a harmful mutation.
_________________________________________________________________________________________________
_________________________________________________________________________________________________
_________________________________________________________________________________________________
Example:______________________________________________________________________________________
_________________________________________________________________________________________________
4. When do you think mutations occur? __________________________________________________
_________________________________________________________________________________________________
5. How do you think mutations occur? ____________________________________________________
_________________________________________________________________________________________________
6. Predict the effect frameshift mutations have on the translation of amino acids.
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_________________________________________________________________________________________________
_________________________________________________________________________________________________
7. Look at the DNA sequence from #1 again:
Original DNA Sequence:
T A C A C C T T G G C G A C G A C T
Suppose there was a copying error and the sequence was changed to:
T A C A C C T T C G C G A C G A C T
a. Circle or highlight where the mutation occurred.
b. Create a mRNA strand that would carry this new code and translate this code into
amino acids.
‘New’ mRNA Sequence:
__________ __________ __________ __________ __________ __________
‘New’ Amino Acid Sequence:
__________ __________ __________ __________ __________ __________
c. Would there be any effect due to this mutation? (Refer back to #1) ____________ Explain:
_________________________________________________________________________________________________
_________________________________________________________________________________________________
What kind of mutation is this? ______________________________________________________________
8. Going back to the original DNA sequence in #1, (T A C A C C T T G G C G A C G A C T),
Suppose there was a copying error and the sequence was changed to:
T A C A C C T T G G C G C G A C T
a. Circle or highlight where the mutation occurred.
b. Create a mRNA strand that would carry this new code and translate this code into
amino acids.
‘New’ mRNA Sequence:
__________ __________ __________ __________ __________ __________
‘New’ Amino Acid Sequence:
__________ __________ __________ __________ __________ __________
c. Would there be any effect due to this mutation? (Refer back to #1) ____________ Explain:
_________________________________________________________________________________________________
_________________________________________________________________________________________________
What kind of mutation is this? ______________________________________________________________
9. Going back to the original DNA sequence in #1, (T A C A C C T T G G C G A C G A C T),
Suppose there was a copying error and the sequence was changed to:
T A C A C C T T G C C G A C G A C
T
a. Circle or highlight where the mutation occurred.
b. Create a mRNA strand that would carry this new code and translate this code into
amino acids.
‘New’ mRNA Sequence:
__________ __________ __________ __________ __________ __________
‘New’ Amino Acid Sequence:
__________ __________ __________ __________ __________ __________
c. Would there be any effect due to this mutation? (Refer back to #1) ____________ Explain:
_________________________________________________________________________________________________
_________________________________________________________________________________________________
What kind of mutation is this? ______________________________________________________________
Name ____________________________________________________________ Date ___________________
DNA: PROTEIN SYNTHESIS AND MUTATIONS
TICKET OUT
Read the following questions and answer them in full sentences.
1. What are the two types of mutations? Explain how they differ.
_________________________________________________________________________________________________
_________________________________________________________________________________________________
_________________________________________________________________________________________________
2. Which type of mutation is more harmful, a point mutation or a frameshift
mutation? Explain.
_________________________________________________________________________________________________
_________________________________________________________________________________________________
_________________________________________________________________________________________________
3. What type of mutation causes sickle cell anemia? How do you know?
_________________________________________________________________________________________________
_________________________________________________________________________________________________
_________________________________________________________________________________________________
Name ____________________________________________________________ Date ___________________
DNA: PROTEIN SYNTHESIS AND MUTATIONS
TICKET OUT
Read the following questions and answer them in full sentences.
1. What are the two types of mutations? Explain how they differ.
_________________________________________________________________________________________________
_________________________________________________________________________________________________
_________________________________________________________________________________________________
2. Which type of mutation is more harmful, a point mutation or a frameshift
mutation? Explain.
_________________________________________________________________________________________________
_________________________________________________________________________________________________
_________________________________________________________________________________________________
3. What type of mutation causes sickle cell anemia? How do you know?
_________________________________________________________________________________________________
_________________________________________________________________________________________________
_________________________________________________________________________________________________
A
A
A
A
A
A
A
U
U
U
U
U
U
U
G
G
G
G
G
G
G
C
C
C
C
C
C
C
A
A
A
A
A
A
A
T
T
T
T
T
T
T
G
G
G
G
G
G
G
C
C
C
C
C
C
C
T
F
W
C
A
T
H
H
A
E
A
T
H
A
E
T
T
T
E
E
T