Appendix
Table S1.
File Format: XLS
Title: Target region selection criteria.
Description: The 20 target regions were chosen based on previous GWAS, pathway analysis,
selection signatures and variance in local genomic estimated breeding value (GEBV)*. (Bold
values are within the top 5% of values for the genome).
Footnote: ** Windows presented were the closest to the SNP identified from the original 800k analysis. The
position of each 250kb window was taken as its midpoint.
Table S2.
File Format: DOC
Title: Sample size for GWAS of 20 imputed regions in dairy cattle.
Description: Sample size information.
Table S3.
File Format: XLS
Title: Description of 20 imputed regions.
Description: The density of variants in each region is indicated by the average distance in
base pairs (bp).
Table S4.
File Format: DOC
Title: Traits significant for 20 target regions.
Description: X denotes the traits for which the closest gene to the most significant variant in
the target region contained one or more significant variant (P<10-8). The target trait is the
experimental trait for this study (most significant trait for the QTL in the original GWAS).
An X* represents a calving interval gene with SNP significant at P<10-5.
Table S5.
File Format: XLS
Title: Description of abbreviated genes.
Description: List of abbreviated genes used in this study including NCBI gene identifications
and descriptions.
Table S6.
File Format: XLS
Title: Statistical support for genes within defined confidence intervals for each target region.
Description: P-values were created from multibreed association analyses, DE was assessed
using a t-test comparing mammary gland to 15 other tissues (see methods) and the ratio of
significant variants within the gene is presented.