Radiation Curriculum Table of Contents I. Overview A. What is Radiation? B. Types of Radiation C. Chart of Wavelength D. X-Rays vs. Gamma Rays E. Units of Measurement for Radiation F. Earth’s Orbit and its Effects on Exposure to Radiation G. Biological Effects of Radiation II. Sources of Exposure to Radiation A. Background/Naturally Occurring B. Medical Process C. Abnormal/Man Made D. Prevention III. Uses/Effects A. Beneficial Applications of Radiation (Health, Industry, Etc.) B. Hazards of Radiation Exposure IV. Model Systems for Studying the Effects of Radiation V. Statistics Related to Radiation’s Health Effects on Humans Grade Level: Middle School (6th-8th); High School (9th-12th) Georgia Standards: S6E2, S6E6, S7L2, S7L4, S8P4; SCSh9, SP4, SMI5, SEV4, SAP5, SC2, SC3, SAST1, SAST3 Science Earth Science Standard; Science Life Science Standard; Science Physics Standard; Science Characteristics of Science high School Standard; Science MIcrobiology Science Standard; Science EnVironmental Science Standard; Science Human Anatomy and Phsyiology Science Standard; Science Chemistry Science Standard; Science ASTronomy Science Standard Purpose of activity: Educate students about radiation exposure and links to cancer and provide them with the knowledge to make informed decisions that will reduce their risk of exposure. Goals/Objectives: I. understand how the Earth's tilt and orbit contribute to energy transfer understand how cell structure is degraded from abnormal and natural radiation exposure understand the patterns and characteristic of waves to their contribution toward energy addresses how various elements and energies affect our environment and health through different mechanisms which target key organic structures Overview A. What is Radiation? i. Radiation is the term for energy that travels through space, including air, water, the ground, and outer space. Radiation travels in a path that looks like a series of waves. Depending on the shape of the waves and the rate at which the waves are formed, radiation can have different properties. Examples of radiation include the light we use to see, heat from the sun and the signals created and received by cell phones. One way in which types of radiation differ is in their wavelength. One wavelength is defined as the distance between the peaks of two adjacent waves. The complete range of frequencies and energies that characterize different forms of radiation is called the electromagnetic spectrum. It is comprised of radio waves, microwaves, infrared light, visible light, ultraviolet light, x-rays, and gamma rays. The speed, frequency, and energy of each wave type are used to sort radiation into different categories. (1) B. Types of Radiation i. Radiation can be split into two categories, non-ionizing radiation and ionizing radiation. (2) 1. Non-ionizing radiation a. This type of radiation is common in everyday life and we are regularly exposed to it. Normal amounts of this type of radiation are experienced as lower frequency radiation such as radio waves, infrared, visible, and ultraviolet light. However, extreme amounts of these non-ionizing radiations can lead to damage in human tissue. i. Radio frequency (RF) – Longest wavelength; typically used for communication, radio or radar signals ii. Microwaves (MW) – Has a slightly shorter wavelength than radiofrequency; used for radar, radio transmission, and cooking iii. Infrared (IR) – Falls just between microwaves and visible light on the spectrum; used for heat detection or remote controlled objects. iv. Visible light – This is a small band of color that human eyes are able to see; this type of radiation is expressed to us as colors, red, orange, yellow, green, blue, and violet. v. Ultraviolet Radiation (UV) – This form of radiation comes from the sun as well as other stars, and ravels to earth though our ozone as high energy. This type of radiation helps to heat the earth. 2. Ionizing Radiation a. There are two types of radiation categorized as ionizing radiation. First, there are electromagnetic waves, these types of waves have high frequencies, with the ability to break chemical bonds in which energy is released, effectively removing electrons or destroying the nucleus of the atom. Of the spectrum X-rays and Gamma-rays are located in the high frequency range. Exposure to these types of radiation can lead to severe tissue damage. Secondly, there are particles which are comprised of protons, electrons, and neutrons. These types of ionizing particles are alpha and beta particles. (3) i. X-rays – These are high energy waves, which fall after UV light on the EM spectrum. These are used by doctors and scientist of observe internal structures of the human body, such as bones, as well as cosmic gases. ii. Gamma-rays – These waves have the highest energy in the EM spectrum. Radiation given off from an atom undergoing radioactive decay. Have a high penetrating power, which can pose external and internal health hazards, and require lead or steel to shield the source. iii. Alpha particles - These particles are identical to the nucleus of helium atoms (2 protons + 2 neutrons).This type of radiation has a very short range and can be shielded with a thin sheet of paper. They cannot penetrate the first outer layers of skin, posing no serious external radiation hazards, however, if inhaled or ingested they can give way to serious health risks. (4) iv. Beta particles - These particles are common products of the radioactive process of nuclear fission, they occur naturally in radioactive decay process, and are comprised mainly of electrons. Beta particles are less ionizing than alpha particles, but can travel further and penetrate skin or tissue. This type of radiation is still hazardous as it can cause damage to internal organs or living cells. (4) C. Chart of Wavelengths Radiation Type Extremely Low Frequency Very Low Frequency Radio Microwaves Infrared Visible Light Ultraviolet X-rays Gamma rays D. X-Rays vs. Gamma Rays Wavelength 100,000 km – 10,000 km 100 km – 10km 10km – 1dm 1dm – 1mm 1mm – .7µm 700nm – 400nm 400nm – 100nm 10 nm – 0.01nm 0.1nm – 0.001nm i. Both are classified as high ionizing radiation; however they differ in how each is produced. X-rays originate from the clashing of electrons onto a target, or the result of rearrangement. Gamma Rays form as a product of radioactive decay from nucleus of radionuclide. (4) E. Units of Measurement for Radiation i. There are many different techniques and methods used today for assessing radiation levels. Surveys and measurements from ground and air can be taken to find the amount of contamination within the soul and environment around us. Using radiochemical methods, samples from the ground (soil, vegetation, and crops) can be analyzed to determine the type and amount of radiation present. (5) ii. Units of Measurement (5) Type of What is it used Measurement for? Biological Risk Measuring the risk that someone can endure from radiation exposure Absorbed Dose Measured by the amount of energy deposited per weight of human tissue Emitted Measuring Radiation how much radiation comes from a radiation source International System (SI) Sievert (Sv) Conventional System (U.S.) Rem 100 rem = 1 Sv Gray (Gy) Rad 100 rad = 1 Gy Becquerel (Bq) Curie (Ci) 1 uCi = 37,000 Bq F. Earth’s Orbit and its Effects on Exposure to Radiation i. It takes about 24 hours for a complete rotation on its axis and bout 365 days for earth to complete a revolution. ii. Earth is closer to the sun in the summer of the southern hemisphere and winter of the northern hemisphere. During these periods of time, the Earth’s surface receives more solar energy. Countries of the middle latitudes are exposed to more solar energy in the summer due to the suns location of being nearly overhead which, in turn, contributes to the longer duration of the day. Summer, in these countries, has the longest duration of sun exposure. The worst times of day are between 10 a.m. and 4 p.m. G. Biological Effects of Radiation i. Ultraviolet Radiation 1. When UV light hits the skin, damage occurs at a molecular level. The DNA selections that have thymine nucleotides next to each other undergo a reaction (breaking and forming bonds). The two thymine pairs for a dimer (two molecules together) which in turn forms a kink in the DNA. This kink can disrupt the replication of new DNA or produce mutated DNA when copied. When new cells are made from the mutated copy of DNA, these new cells can be irregular; many of these together can produce harmful irregularities on the skin. (6) (7) ii. Ionizing Radiation 1. Ionizing radiation can break or form new chemical bonds, such as double stranded DNA breaks, during which free radicals (highly reactive molecules) can be formed. This is done through the loss of electrons from the molecule as it is “ionized.”(8) 2. Collision of ionizing radiation in cells produces hydroxyl radicals (8) 3. Stop cell reproduction, by inhibiting key cell structures (organelles such as mitochondria). (9) 4. Cell death can result from high or frequent exposure from ionizing radiation. If cell death is not a result of the mutation caused by radiation then new mutated cells can be produced uncontrollably when the cell undergoes mitosis. The results of this cell can be potentially cancerous. (9) II. Sources of Exposure to Radiation A. Background/Naturally Occurring i. Radon (10) 1. This is the largest source of natural radiation exposure to humans 2. Passes through air space through soil and rock 3. Pressure differences can move the gas indoors 4. 200 millirems (mrem) of radon exposure on average per American ii. Isotopes (11) 1. Potassium & carbon, the body cannot differentiate between radioactive & non-radioactive particles iii. Terrestrial radiation (11) 1. Accounts for 8% of radiation (27 mrem) Americans are exposed to, annually. 2. High-energy particles bombard Earth’s atmosphere as Earth travels through space. B. Medical Process (11) i. Diagnosis 1. Nuclear tracers (injected into the blood stream) 2. X-rays ii. Therapy and Treatments 1. Cobalt irradiation (a treatment for cancer) 2. Radiation Therapy iii. 15% of annual exposure (53 mrem) C. Abnormal/Man Made (11) i. ii. iii. iv. v. vi. vii. Nuclear Power Neon signs Smoke detectors Tanning beds Airport scanners Gas mantels Consumer products 1. Tobacco 2. Natural Gas 3. Phosphate fertilizers 4. Brick or stone 5. Ceramics D. Prevention i. There are three basic strategies to prevent and protect against unnecessary exposure to radiation: (12) 1. Reduce the time you are exposed to the radiation source; the dose amount is directly proportional to the amount of exposure time. 2. Increase the distance between yourself and the radiation source; exposure decreases rapidly as the distance between person and source increases. 3. Increase shielding between yourself and the radiation source; placing a heavy material between your person and source will reduce the amount of exposure. ii. Microwave Oven: 1. “Microwaves are reflected, transmitted, or absorbed by material in their path.” (13) 2. Microwave ovens are built to contain these waves within the device, and generally will not work if the latch isn’t closed. 3. To prevent unnecessary leaks, insure that the seals remain clean, there are not visible signs of damage to the outer shell, and that the manufactures recommendations are followed. iii. Ultraviolet Light: (14) 1. Limit midday sun exposure by short time in the sun 2. Find shade 3. Wear protective clothing, sunglasses, hats, and sunscreen 4. Avoid the use of tanning beds 5. Apply sunscreen frequently iv. III. X-rays: (12) 1. Never put any part of your body in the expected path of the main beam. 2. Avoid being around the X-ray source as much as possible 3. Keep the enclosure doors closed whenever possible 4. When getting medical X-rays protect the parts that aren’t under xray with a heavy material Uses/Effects A. Beneficial Applications of Radiation (Health, Industry, Etc.) i. Radio Waves 1. Data Transmission ii. Microwaves (13) 1. TV broadcasting 2. Radar – air & sea navigation 3. Telecommunications 4. Processing materials 5. Diathermy treatment 6. Cooking Food iii. Ultraviolet Radiation 1. Stimulated Vitamin D production, aids in bone growth with presence of calcium 2. Solar Energy 3. Treatment of Psoriasis iv. X-rays 1. Used in medical field to observe internal structures, such as bones 2. Used in surgeries for accurate positioning 3. Diagnostic tool (CT or CAT scans) 4. Viewing contents of bags in airports v. Gamma Radiation 1. Can be useful for sterilization of medical equipment as it can kill all microorganisms present 2. Gamma-rays are effectively used as tracers in research sciences 3. Can be used as gauges for density and thickness monitoring 4. Used in food preservation to extend self-life and pasteurization 5. Very portable and require only a small amount of radioactive material vi. Carbon Dating 1. Used for determination of ages of fossils and other objects, through analyzing radioactive decay vii. Radiotherapy (15) 1. Kills cancerous cells to cure cancer or alleviate symptoms 2. Designed to maximize the relief and effectiveness while minimizing side-effects. viii. Radioactive material (11) 1. Smoke Detectors used Americium-241 to detect smoke particles in the air. 2. Sterilize products (cosmetics and medical supplies) 3. Shrink-wrap packaging B. Hazards of Radiation Exposure i. Radioactive Iodine (16) 1. Iodine concentrates in the thyroid, body cannot tell difference between radioactive iodine and non-radioactive. 2. Radioactive iodine can induce mutations leading to thyroid cancer. ii. Radon (17) 1. Settles in low spaces, such as basements and passes through crevasse easily. 2. Concentrates in the lungs and induces mutations which can cause lung-cancer. iii. Other radioactive material such as strontium and radium can accumulate in the bone tissue, leading to cancer. (18) iv. Ionizing Radiation 1. Increased breast cancer risk has been seen in young women exposed to high cumulative doses of x-ray exposure (19) 2. Leukemia and lung cancer seem more likely than other types of cancer to be produced by radiation (20) 3. At a more molecular level, ionizing radiation can induce damage in DNA, gene expression, mobilization of repair proteins, activation of cytokines, and disrupt remodeling of cellular microenvironment. (21) v. Nuclear fallout from events such as the Chernobyl nuclear reactor meltdown (23) and the incidents that took place in Japan during WWII lead to environmental changes: 1. Soil contamination 2. Crop contamination 3. Water contamination vi. Radiation is also a known carcinogen that can cause teratogen mutations, these mutations are induced by agents that disrupt the development of embryos and fetuses and can result in birth defects. vii. Mild exposure of radiation and cause acute radiation sickness, effects and symptoms include: (18) 1. Blood chemistry changes 2. Nausea 3. Fatigue 4. Vomiting 5. Hair loss 6. Diarrhea 7. Hemorrhages 8. Internal Bleeding 9. Damage to the central nervous system 10. Loss of consciousness 11. Death IV. Model Systems for Studying the Effects of Radiation A. Model systems are great for studying effects of different types of processed. These systems mimic results that are similarly seen in human models. They are better for use than humans because these systems grow quickly, are kept easily, provide sufficient number of offspring and are relatively cheap to keep. (22) Some common model systems used are: i. Mice share 99% of genes that humans have. They are easily raised and can have their DNA altered to express genes have might pose problems in humans. They are easy to keep and have contributed to many developments in science. ii. Cell lines are a good way to preserve a set of cells. These cell lines are distinct cells grown in culture, normally from a donor. The cells can live for an extensive amount of time and typically are clones. Cell lines are great for studying different aspects of illness and disease and have been used for many years to help contribute to biological developments and applications. V. Statistics Related to Radiation’s Health Effects on Humans A. The average annual radiation dose that Americans receive is around 400 millirems (mrems). i. 50% of the population would die within 30 days of receiving a dose between 350,000 to 500,00 mrem. (24) ii. Exposure comes from a variety of sources: (11) 1. Radon – 200mrem (55%) 2. Inside Human Body – 40mrem (11%) 3. Rocks & Soil – 28mrem (8%) 4. Cosmic – 27mrem (8%) 5. Medical/Dental X-rays – 39mrem (11%) 6. Nuclear Medicine – 14mrem (4%) 7. Consumer Products – 10mrem (3%) 8. Other Sources (<1%) B. Radiation and cancer i. Illness 1. In a group of 10,000 who are exposed to 1 rem of ionizing radiation (in small doses over a lifetime) 5 or 6 more people to die of cancer than would otherwise. (18) 2. Of this group, 2,000 are expected die of cancer from all nonradiation causes. (18) 3. 50% and 90% of skin cancer are due to UV raduation. (14) 4. 18 million people worldwide are blind from cataracts, 5% may be due to UV radiation. (14) ii. Therapy Statistics: (25) 1. Patients of breast cancer, prostate cancer, and lung cancer account for more than half (56%) of all those receiving radiation therapy. 2. Radiation therapy will be used in almost 2/3 of all cancer patients treatments C. Historical Data i. 1986 – Chernobyl nuclear reactor incident: 134 people received radiation doses of 80,000-1,600,000 mrem and suffered from acute radiation sickness; of these 28 died within 3 months of the accident. (24) ii. 10 years before the Chernobyl incident: In Belarus 1,342 adults and 7 children were diagnosed with thyroid cancers. (23) iii. 9 years after the Chernobyl incident: In Belarus 4,006 adults and 508 children were diagnosed with thyroid cancers. (23) VI. Resources 1. Electromagnetic Radiation. The Encyclopedia of Earth. Accessed 6 June. 2011 [http://www.eoearth.org] 2. Safety and Health Topics: Radiation. Occupational Safety & Health Administration. Accessed 6-8 June. 2011 [http://www.osha.gov] 3. Ionizing Radiation. Argonne National Laboratory. 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Appleby, A. “What Are the Sources of Ionizing Radiation?” The State University of New Jersey: RUTGERS. (1996) 12. Research X-ray Safety Manual. University of South Florida. 2003. [PDF] 13. Electromagnetic fields & public health: Microwave ovens. World Health Organization. Accessed 22 June. 2011 [http://www.who.int] 14. Ultraviolet radiation and human health. World Health Organization. Accessed 21. June 2011. [http://www.who.int] 15. Medical Uses of Radiation. International Atomic Energy Agency. [PDF] 16. Samet, J.M. “Radiation and cancer risk: a continuing challenge for epidemiologists.” Environ Health 10 (2011): S4 [PUBMED] 17. Krewski, D. “Residential Radon and Risk of Lung Cancer: A Combined Analysis of 7 North American Case-Control Studies.” Epidemiology 16 (2005): 137-145 [JSTOR] 18. Health Effects | Radiation Protection. Environmental Protection Agency. Accessed 13-18 June. 2011 [http://www.epa.gov] 19. Little, M.P. “Risk Associated with Low Doses and Low Does Rates of Ionizing Radiation: Why Linearity May Be (Almost) the Best We Can Do.” Radiology (2009): 6-12 [PUBMED] 20. Goldman, M. “Ionizing Radiation and Its Risk.” West J Med. 6 (1982): 540-547 [PUBMED] 21. Nelson, G.A. “Fundamental Space Radiobiology.” Gravitational and Space Biology Bulletin 12 (2003): 29-36 [GSB] 22. Alberts, B. Essential Cell Biology. Garland Science, 2009 23. “Present and future environmental impact of the Chernobyl accident” International Atomic Energy Agency. August 2001 [PDF] 24. Fact Sheet on Biological Effects of Radiation. United States Nuclear Regulatory Commission. Accessed 27 June. 2011 [http://www.nrc.gov] 25. Statistics: About Radiation Therapy. RT Answers. Accessed 11 July. 2011 [http://www.rtanswers.org]