First Name John Surname Atkins Research Body (UCC) Pavel Baranov (UCC) Werner Blau (TCD) John Boland (TCD) Dermot Brabazon (DCU) Thomas Brazil (UCD) Dermot Brougham (DCU) Jim Buckley (UL) Miguel Bustamante (UCD) Geraldine Butler (UCD) Martin Caffrey (TCD) Jens Carlsson (UCC) Gianpiero Cavalleri (RCSI) Research Title Using ribosome profiling to study translation initiation/elongation and facilitate optimization of protein synthesis Development of computational resources for the analysis of Genome Wide Information on Protein Synthesis (GWIPS). Systematic Bottom-Up Assembly of Nanocarbon Based Photonic Materials Atom Level Engineering of Material-on-Insulator Devices and Sensors Laser processing for fabrication of advanced liquid chromatographic systems Green Power Amplifier Technologies for Future Wideband Reconfigurable Wireless Communication Systems (GrePATech) Long-circulating Magnetic Nanoparticles for Biomedical Applications through Mimetic Surface Chemistry Establishing best practice in Software Architecture Consistency Processes Genesis and Development of Extreme Events in Fluids Post-genomic analysis of biofilm and virulence characteristics of the pathogenic yeast, Candida parapsilosis. Membrane Structural and Functional Biology. Tackling communicable and noncommunicable diseases at the membrane level. Taxonomy and connectivity of animal species at the Moytirra hydrothermal vent field: developing methods for assessing ecological impacts of mineral extraction in the deep-sea The identification and characterisation of genomic signatures of hypoxia induced Total Award* 381,032 1,616,824 597,214 2,481,498 814,992 984,565 199,000 276,377 285,211 1,362,601 2,478,511 194,498 381,150 natural selection David Chew (TCD) David Clarke (UCC) Paula Colavita (TCD) Stephen Connon (TCD) John Costello (DCU) Emma Creagh (TCD) Bernie Creaven (ITT) Kenneth Dawson (UCD) Eithne Dempsey (ITT) Kevin Devine (TCD) Gary Donohoe (TCD) Sean Doyle (NUIM) Ken Duffy (NUIM) Laurence Egan (NUIG) Rachel Evans (TCD) Stephen Fahy (TNI) Microanalysis of detrital apatite: a new provenance proxy in sedimentary systems Characterizaton of choA, a gene encoding a novel cholesteroldegrading activity in the human gut microbiome Understanding lipid/carbon interactions for the rational design of biomaterials Anhydrides as nucleophiles in new catalytic asymmetric processes: development, scope expansion and application in drug development Stagnation Layers in Laser Ablation Based Analytical Techniques Identification & Functional Characterisation of Novel Inflammatory Mediators. Novel Dual SOD/CAT mimics: New Therapeutic Strategy for Oxidative Stress Related Diseases? Biological Identity of Nanoparticles Dispersed in Biological Media Implementation of Gold Quantitation ImmunoElectrochemistry (AURO-QUANT) Cell wall metabolism in Gram positive bacteria: investigating its regulation and exploiting its therapeutic potential. Characterising the neural basis of social cognition deficits in schizophrenia using imaging genetics A Vaccination Strategy Against Aspergillus fumigatus Infection. Quantitative analysis of immune cell fate: stochastic competition and censorship Molecular Regulation of the Tumor Microenvironment in Colon Cancer Metastasis High-Efficiency Conjugated Polymer-Inorganic Hybrids as Luminescent Solar Concentrators for Photovoltaics Ultrafast energy dissipation in semimetals and semiconductors: 279,826 244,360 306,216 1,404,834 816,950 210,169 203,300 1,758,794 353,600 1,240,385 284,650 358,497 228,820 281,760 325,371 1,299,545 Mario Fares (TCD) David Finlay (TCD) Garry Fleming (TCD) Nial Friel (UCD) Michael Gilchrist (UCD) Martin Glavin (NUIG) David Gregg (TCD) Darren Griffith (RCSI) Yurii Anne Marie Gun'ko Healy (TCD) (TCD) Mary Frances Heaney (NUIM) Katherine Howell (UCD) Suzi Jarvis (UCD) Leigh Jones (NUIG) Alan Jones (DIAS) Simulation based on first-principles electronic structure theory Understanding the role of molecular chaperones in robustness and functional innovation Characterising the role of mammalian Target Of Rapamcyin Complex 1 (mTORC1)/Srebp1c signaling in directing the differentiation and function of T cell subsets. DENTAL glass-ionomer restoratives: Development of an Enhanced Novel Tailored Aesthetic Ligand based glass-ionomer restorative Advances for the probabilistic analysis of network data Characterising Mechanical Properties of Brain Tissue using Novel Micro Indentation Tests Breast Cancer detection and classification using Ultra Wideband Radar Tomography Data-centric ultra-low power embedded computing Novel Strategy for Overcoming Chemoresistance and Toxicity Associated with Platinum Anticancer Compounds Chiral inorganic nanomaterials Co-processing of active pharmaceutical ingredients with functional excipients to prevent unintentional generation of amorphous phase "Clickable"• Azobenzenes, New Molecular Glues for Generation of Photoresponsive Biomolecular Scaffolds capable of Answering Biological Questions Elucidating the the potential therapuetic role of Erythropoietin in the treatment of Emphysema Nanoscale aqueous-substrate interfaces The Strategic Construction of Magnetic Coolant Materials IRECCSEM: Evaluating Ireland's potential for onshore carbon sequestration and storage using 371,358 261,606 309,617 289,240 315,007 243,900 563,120 192,029 808,460 188,919 215,339 348,343 1,233,925 179,675 278,616 electromagnetics Daniel J Kelly (TCD) Amir Khan (TCD) Vojislav Krstic (TCD) Ed Lavelle (TCD) James Lunney (TCD) Fiona Lyng (DIT) Sheila McBreen (UCD) Rachel McDonnell (TCD) Patrick McGarry (NUIG) Gerard McGlacken (UCC) John McInerney (UCC) Paul McLoughlin (UCD) Rachel McLoughlin (TCD) Tara McMorrow (UCD) Grace Morgan (UCD) Derek Morris (TCD) A tissue engineered biological joint replacement prosthesis for the treatment of degenerative joint disease Molecular Aspects of Immune Evasion and Subversion of Membrane Trafficking by Pathogens Next-generation III-V Quasi-1D Nanowires for Advanced Future Information-Processing Circuitry Modulation of innate and adaptive immunity by particulate adjuvants for improved parenteral and mucosal vaccination Pulsed laser deposition of thin films at atmospheric pressure Identification of clinically important, high risk oral lesions using Raman spectroscopy Advances in gamma-ray Space Science using Silicon Photomultipliers Cartoon Motion: Stylised facial animation from motion capture Active changes in artery structure and contractility in response to stenting The Direct Arylation of Pyrones, Coumarins, Pyridones and Quinolones Pulsed semiconductor lasers for metrology and remote sensing: synchronisation and stabilisation dynamics The role of the bone morphogenetic antagonist gremlin in the pathogenesis of chronic hypoxic lung disease Understanding cellular immunity to Staphylococcus aureus is required for novel anti-S. aureus vaccine design Molecular mechanisms of cilia loss in mammalian epithelial cells Nano-Assembly of Functional Magnetic and Magneto-Optical Materials Gene discovery in schizophrenia 1,715,936 1,204,672 362,475 1,797,268 252,595 193,700 247,382 272,270 226,094 377,092 205,270 1,308,097 384,042 319,180 320,651 355,395 Paul Moynagh (NUIM) Paul Murphy (NUIG) Yvonne Nolan (UCC) Stephen O'Brien (UL) David O'Connell (UCD) Cliona O'Farrelly (TCD) Luke O'Neill (TCD) Mani Ramaswami (TCD) Fernando Rhen (UL) James Rice (UCD) Thomas Ritter (NUIG) James Rohan (TNI) Robert Ryan (UCC) using family-based sequencing methods Defining the roles and mechanisms of action of Pellino proteins in immunity and inflammatory diseases Glycoside & glycoconjugate synthesis through development and application of chelation induced anomerization The nuclear receptor TLX as a cell intrinsic regulator underlying inflammation and stress-induced changes in hippocampal neurogenesis: relevance to cognitive disorders Applied mathematical modelling applied to enterprise, science and technology (MACSI) Novel affinity matrices for purification of biotherapeutics Is Natural Resistance to Hepatitis C in an Irish Cohort Associated with JAK/STAT Resistance to HCV Targeting? Towards New Anti-Viral Strategies Novel regulators of the Nlrp3 inflammasome and IL-1beta: prospects for novel therpeutics and diagnostics for inflammatory diseases Translational control of neuronal mRNAs: its mechanisms, and roles in memory and neurodegeneration. Nanostructured alloy for highenergy-efficient fuel cells Patterned nanomaterial’s using ferroelectric lithography for enhanced optical imaging Novel therapeutic approaches to improve corneal allograft survival by cell and gene therapy and insights into the mechanism of action Nanomaterials design and fabrication for Energy Storage Elucidation of the regulatory role of bacterial cell-cell signalling in persistent infection of the cystic fibrosis lung by Burkholderia cenocepacia 2,042,513 1,009,646 1,082,494 2,759,414 262,288 1,742,265 2,385,259 1,430,253 174,880 241,175 1,303,013 241,926 282,352 Corrado Santocanale (NUIG) Igor Shvets (TCD) Johannes Klaas Dagmar Slingerland (NUIM) Stengel (NUIG) Nathan Stevenson (UCC) Kevin Sullivan (NUIG) Nicolas Touzet (ITS) Paul Townsend (TNI) Wenxin Wang (NUIG) Graeme Watson (TCD) Leonie Young (RCSI) Xinmin Zhan (NUIG) Cdc7 regulation of Claspin stability and its effect on cell cycle checkpoint function Science of p-type transparent conducting oxides: materials towards transparent electronics Topological Order and Fault Tolerant Quantum Computation Iodine in commercially valuable Irish seaweeds: variability, pathways, and implications for industrial applications Automated assessment of brain maturation in the preterm infant using EEG Structure and assembly of vertebrate kinetochore-associated chromatin Physiology and molecular biology of microalgae for the biorefining of valuable metabolites Next Generation Photonic Access and Data Communication Systems Development and Delivery of Nonviral S/MAR Minicircles for Long-term Type VII Collagen Gene expression for the Treatment of Recessive Dystrophic Epidermolysis Bullosa Understanding the role of interfaces in solid oxide fuel cell efficiency: Optimising materials through predictive computer simulation SRC-1 mediation of cancer cell reprogramming in endocrine resistant breast cancer Green Farm: Development of OnFarm Co-Digestion of the Organic Fraction of Municipal Solid Waste and Animal Manure for Bioenergy Production and Resource Recycling 292,484 1,924,402 719,693 244,782 145,697 387,900 379,845 2,570,493 267,291 905,910 681,543 361,010 *Subject to final agreement with Awardee/Research Body; inclusive of approx. 30% overhead payment to Research Body