Supporting Information for Review and Online Publication Only Table 1. Assessment of the quality of adverse events reporting in randomised controlled trials published in the periodontal literature from 2002 to 2003 Authors Al-Mubarak et al. 2002 Al-Otaibi et al. 2003 Arweiler et al. 2002 Azmak et al. 2002 Bauroth et al. 2003 Berlucchi et al. 2002 Braun et al. 2003 Brown et al. 2002 Bruhn et al. 2002 Camargo et al. 2002 Cetiner et al. 2003 Chen et al. 2002 Chen et al. 2003 Christgau et al. 2002 Clavero et al. 2003 Couri et al. 2002 Cury et al. 2003a Cury et al. 2003b Daneshmand et al. 2002 Del Pizzo et al. 2002 Dentino et al. 2002 Eberhard et al. 2002 Eren et al. 2002 Feres et al. 2002 Grisi et al. 2002 Gründemann et al. 2002 Gutierrez et al. 2003 Han et al. 2002 Henderson et al. 2002 Hoang et al. 2003 Hu et al. 2003 Jansson et al. 2003 Jentsch et al. 2003 Jin et al. 2003 Joly et al. 2002 Kerdvongbundit & Wikesjö 2003 Kim et al. 2002 Kim et al. 2003 Lekovic et al. 2003 Lins et al. 2003 Loos et al. 2002 Machtei et al. 2003 Maragos et al. 2002 McGuire & Nunn 2003 Mengel et al. 2003 Mesa et al. 2003 Rec 1 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA Y Y NA Y NA NA Y NA NA NA NA Y NA NA Y NA NA Rec 2 NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA N Y NA Y NA NA Y NA N NA NA Y NA NA N NA NA Rec 3 N N N N N N N N N N N N N N N N N N N Y N N Y N N Y N N Y N Y N N N N N Rec 4 N N Y N N N N N N N Y N N N N N N N N Y Y N N N N Y N N Y N Y N N Y N N Rec 5 N N N N N N N N N N N N N N N N N N N Y N N Y N N N N N N N N N N N N N Rec 6 N N N N N N N N Y N Y N N N N N Y Y N Y Y Y N N N Y N N N N Y Y N Y Y Y Rec 7 N N NA N N N N N N NA NA N NA N N N NA N N NA NA N N N N Y N N NA N Y N N NA NA N Rec 8 N N N N N N N N N Y NA N NA Y N N NA N N Y NA N N N N Y N N NA N Y N N NA NA N Rec 9 N N NA N N N N N N NA NA N NA N N N NA N N N NA N N N N Y N N NA N NA N N NA NA N Rec 10 N N N N N N N N Y Y N N N Y N N N N N Y Y N Y N N Y N N Y N Y N N Y N N Fundi ng I U I U U U U NI I I U U NI I I U NI NI U U I I I NI U U U U I U U NI U U NI U NA NA NA NA NA NA NA Y NA NA NA NA NA NA NA NA NA N NA NA N N N N N N N N N N N N N N N N N Y N N N N N N N N N Y N N Y N Y N Y N N N N N N N NA N Y N N Y N N N N NA N Y N N Y N N N N NA N N N N N N N N N N N N N N Y N N U I U U U U U I I U Minabe et al. 2002 Miyazaki et al. 2003 Nafar et al. 2003 Nogueira-Filho et al. 2002 Novak et al. 2002 Oringer et al. 2002 Palioto et al. 2003 Pannuti et al. 2003 Paolantonio et al. 2002 Paquette et al. 2002 Paquette et al. 2003 Petersilka et al. 2003a Petersilka et al. 2003b Pistorius et al. 2003 Polansky et al. 2003 Pruthi et al. 2002 Reddy et al. 2003 Rodrigues et al. 2003 Rooney et al. 2002 Rosenstein et al. 2003 Salvi et al. 2002 Sastravaha et al. 2003 Saxer et al. 2003 Scheyer et al. 2002 Schwarz et al. 2003a Schwarz et al. 2003b Schwarz et al. 2003c Sculean et al. 2002a Sculean et al. 2002b Sculean et al. 2003a Sculean et al. 2003b Sculean et al. 2003c Sharma et al. 2002 Sharma et al. 2003 Silvestri et al. 2003 Stavropoulos et al. 2003 Sugaya et al. 2002 Taiyeb-Ali et al. 2003 Tal et al. 2002 Tonetti et al. 2002 Tsubura & Ikeda 2003 van der Weijden et al. 2002a van der Weijden et al. 2002b VanDyke et al. 2002 Vardar et al. 2003 Velasquez-Plata et al. 2002 Wachtel et al. 2003 Walters et al. 2003 Wang et al. 2003 Windisch et al. 2002 Yates et al. 2002 Yates et al. 2003 Yilmaz et al. 2003 Zucchelli et al. 2003 NA NA NA NA NA NA NA NA NA Y NA NA NA NA NA NA NA NA N NA NA NA Y NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA Y NA NA NA NA NA NA NA NA N NA NA NA N NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA N N N N N N N N N N N Y N N N N N N Y Y N N N N N N N N N N N N N N N N N N N Y N N N N N N N N N Y N Y N Y Y N N N N N Y Y N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N Y N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N Y Y N N N N N N N Y N N N N N N N N Y N Y N N Y Y N N N N N N N N N Y Y N N N N N N NA N N N N N N Y N Y N N Y N N N N N NA N N N NA NA NA NA NA NA NA NA NA N NA N N NA N N N N N N NA N N N N N N N N Y N Y NA N N N N N NA N N N NA NA NA NA NA NA NA NA NA N NA Y N NA N N N N N N NA N N N N N N Y N Y N N NA N N N N N NA N N N NA NA NA NA NA NA NA NA NA N NA Y N NA N N N N N N N N N N N N N N N Y N Y Y N N N N N Y N N N N N Y N N Y N N N N N N N N N N N N N N U I U NI I I NI U NI I U U U U U U I NI NI I I NI I I U U U U U U U I U U U I U I I I U I N Y Y Y Y Y NA NA NA Y U NA NA NA Y NA NA NA NA NA NA NA NA NA NA Y NA NA NA NA NA NA NA Y N N Y N N N N N N N N N N Y N N N N N N N N N N N N N N N N N N N N Y Y Y N N N N Y Y N N NA N NA NA NA N NA N NA N N NA N NA NA NA N NA N NA N N NA N NA NA NA N NA N NA Y N N Y N N N N N Y N U U I U I NI U U U I U Rec: Recommendation Y: Yes N: No N/A: Not applicable NI: Non-industry funded trial I: Industry funded trial U: Unclear Table 2. Assessment of the quality of adverse events reporting in randomised controlled trials published in the periodontal literature from 2011 to 2012 Authors Abrahamsson et al. 2012 Aghazadeh et al. 2012 Aimetti et al. 2012 Alkan & Parlar 2011 Alves et al. 2012 Al-Zahrani & Austah 2011 Aparna et al. 2011 Arweiler et al. 2011 Aspriello et al. 2011a Aspriello et al. 2011b Ayub et al. 2012 Badran et al. 2012 Baghele & Pol 2012 Bashutski et al. 2011 Becerik et al. 2011 Besegmez et al. 2011 Bittencourt et al. 2012 Bizhang et al. 2011 Campus et al. 2011 Cappuyns et al. 2012 Cardaropoli et al. 2012 Chandra et al. 2012 Chapple et al. 2012 Charles et al. 2011 Charles et al. 2012 Chawla et al. 2011 Chen et al. 2012 Cho et al. 2011 Chongcharoen et al. 2012 Cordaro et al. 2012 Cortelli et al. 2012 Cortellini et al. 2011 Cortellini & Tonetti 2011 Crespi et al. 2011 de Lima Oliveira et al. 2012 De Nardo et al. 2012 Elkhouli et al. 2011 Eltas & Orbak 2012a Eltas & Orbak 2012b Engebretson & HeyHadavi 2011 Feng et al. 2011 Flemmig et al. 2012 Funosas et al. 2012 Gamal et al. 2011 García et al. 2011 Gerlach & Amini 2012 Gómez et al. 2011 Gonzales et al. 2011 Rec 1 NA NA NA NA NA NA NA NA NA NA NA N NA NA NA NA Y NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA Rec 2 NA NA NA NA NA NA NA NA NA NA NA Y NA NA NA NA Y NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA Rec 3 N N Y N N N N N N N N N N N N N Y N N N N N N N N N N N N N N Y Y N N Rec 4 N N Y N N N N Y N N N Y N N Y N Y N Y Y N Y N N N N N N N N Y Y Y N N Rec 5 N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N Rec 6 N Y Y Y N N N Y Y N Y N N N N N Y Y Y N Y N Y N N N N N N N N N Y N N Rec 7 Y N N NA NA N NA NA NA N Y NA N N Y N NA N NA N NA N N NA NA NA NA N N N Y N Y N N Rec 8 Y N N NA NA N NA NA NA N N NA N N N N NA N NA N NA N N NA NA NA NA N N N Y Y Y N N Rec 9 N N N NA NA NA NA NA NA NA N NA N N N N NA N NA N NA N N NA NA NA NA N N N Y N N N N Rec 10 Y N Y N N N N N N N N Y N N N N N N N N N N N N N Y N N N N N N Y N N Fundi ng NI I NI NI NI NI U I U NI I I U I I NI NI I U I I NI I U I I NI NI I U I NI NI U NI Y NA NA NA NA N NA NA NA NA N N N N Y Y N N N N N N N N N N Y Y Y Y Y NA N N Y Y NA N N NA Y NA N N NA Y Y N N Y U U NI U I NA Y NA NA NA NA NA NA NA Y NA NA NA NA NA NA Y Y N N N N N N Y Y N N Y N N N N Y N N N N N N N Y N N N N N N N Y N NA NA N N N Y Y N NA NA N N N Y Y N NA NA N N N Y Y N N Y Y N N I NI U NI I I I I Goodson et al. 2012 Goyal et al. 2012a Goyal et al. 2012b Grbic et al. 2011 Haas et al. 2012a Haas et al. 2012b He et al. 2012a He et al. 2012b Heller et al. 2011 Jankovic et al. 2012 Kamil et al. 2011 Kaner et al. 2011 Kaushick et al. 2011 Klukowska et al. 2012 Knöfler et al. 2011 Koromantzos et al. 2012 Kraivaphan et al. 2012 Krück et al. 2012 Lafzi et al. 2011 Lekovic et al. 2012 Li et al. 2011 Li et al. 2012 Lin et al. 2012 Llambés et al. 2012 López et al. 2012 Machtei et al. 2011 Mahajan et al. 2012 Makhlouf et al. 2012 Malali et al. 2012 Mankodi et al. 2011 Mazzocco et al. 2011 McGuire et al. 2011 Mendonça et al. 2012 Meyle et al. 2011 Miani et al. 2012 Moder et al. 2012 Moeintaghavi et al. 2012 Morelli et al. 2011 Moslemi et al. 2011 Nakajima et al. 2012 Nazareth & Cury 2011 Noro Filho et al. 2012 Oliveira et al. 2011 Olsson et al. 2012 Ozcelik et al. 2011 Ozdemir & Okte 2012 Ozturan et al. 2011 Payne et al. 2011 Pera et al. 2012 Pereira et al. 2011 Persson et al. 2011 Pini Prato et al. 2011 Pradeep & Kathariya 2011 Pradeep et al. 2012a Pradeep et al. 2012b Pradeep et al. 2012c NA NA NA NA NA NA NA Y NA Y NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA Y NA NA NA NA NA Y NA NA NA NA NA NA NA NA NA NA NA Y NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA N NA Y NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA Y NA NA NA NA NA Y NA NA NA NA NA NA NA NA NA NA NA Y NA NA NA NA NA NA NA NA NA NA NA NA N N N Y N N N N Y N N N N N N N N N N N N N N N N Y N N N N N Y N N N N N Y N N N N N Y Y N N N N N N N N N N N N Y Y Y N N N Y Y Y N N N Y N N N N N N N Y N N N Y N N N Y N Y Y N N N N Y N N N N N Y Y N N N N Y N N N N N Y N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N Y N N N Y Y N Y N N N N N N N N N Y Y Y Y N N N N N N Y Y N N N N N Y N N Y Y N N N N N Y NA NA Y N N NA NA Y Y N N NA NA N N NA NA NA NA NA NA N N N N NA N N NA NA NA N N N N N N N NA NA N N Y NA NA NA N NA Y NA NA N N N N N NA NA Y N N NA NA Y NA N N NA NA N N NA NA NA NA NA NA N N N Y NA N N NA NA NA N N N N N N N NA NA N N Y NA NA NA N NA N NA NA N N N N N NA NA Y N N NA NA Y NA N N NA NA N N NA NA NA NA NA NA N N N Y NA N N NA NA NA N N N N N N N NA NA N N Y NA NA NA N NA N NA NA N N N N N N N Y N N N N N Y N N N N N N N N N N N Y N N N N N N N N N N Y N N N N N N N N N N Y N N N N N Y Y N N N N N NI I I U NI NI I I NI U NI NI U I U NI U NI NI NI U I NI NI I I U U NI I U I NI I NI NI NI I NI I NI NI NI I NI U NI NI U NI I NI I I I I Pradeep et al. 2012d Putt et al. 2012 Qadri et al. 2011 Rasperini et al. 2011 Ratka-Krüger et al. 2012 Ribeiro et al. 2011a Ribeiro et al. 2011b Rioboo et al. 2012 Röllke et al. 2012 Saini et al. 2011 Sampaio et al. 2011 Samuels et al. 2012 Santos et al. 2012 Sekhar et al. 2011 Serafini et al. 2012 Sharma et al. 2012a Sharma et al. 2012b Sharma & Pradeep 2011a Sharma & Pradeep 2011b Sharma & Pradeep 2012a Sharma & Pradeep 2012b Signoretto 2011 Silva et al. 2011 Slawik et al. 2011 Slot et al. 2011 Sofrata et al. 2011 Soo et al. 2012 Stavropoulos et al. 2011 Sun et al. 2011 Tangade et al. 2012 Thorat et al. 2011 Tonetti et al. 2012 Trombelli et al. 2012 Varela et al. 2011 Verma et al. 2011 Waghmare et al. 2011 Wennström et al. 2011 Wohlfahrt et al. 2012 Yadav et al. 2011 Yilmaz et al. 2012a Yilmaz et al. 2012b Yuen et al. 2011 Rec: Recommendation Y: Yes N: No N/A: Not applicable NI: Non-industry funded trial I: Industry funded trial U: Unclear NA NA NA NA NA NA NA NA NA NA NA Y NA NA Y NA NA NA NA NA NA NA NA NA N NA Y NA NA NA NA Y NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA NA Y NA NA Y NA NA NA NA NA NA NA NA NA Y NA Y NA NA NA NA N NA NA NA NA NA NA NA NA NA NA N N N N N N N Y Y N Y Y N N Y N N N N N N N N N Y N N N N N N N N Y N N N N N N N N Y N N N N N N Y Y N Y Y N N Y Y N N N Y Y N N N Y N Y N N N N Y N Y N N Y N N N N N N N N N N N N N N N N N N N Y N N N N N N N N N Y N N N N N N N N N N N N N N N N N N N N N N N Y N N N Y Y Y N N N Y N N N N N Y Y N N Y N N N N N Y N N N Y N Y Y Y N N N N N N Y Y Y Y N Y N NA NA Y N NA NA NA NA NA N Y NA NA N NA N N N NA Y N Y N NA NA NA NA N NA N N N N N N NA N N N N Y Y NA NA Y N NA NA NA NA NA N Y NA NA N NA N N N NA Y N Y N NA NA NA Y N NA N Y N N N N NA N N N N Y Y NA NA Y N NA NA NA NA NA N Y NA NA N NA N N N NA Y N Y N NA NA NA NA N NA N Y N N N N N N Y N Y N Y N N Y N N N Y Y Y N N N N N Y N N N N N Y Y N N Y N N N N N U I U U I NI NI I I U NI I NI U I I I NI NI I I NI NI NI NI NI I I NI U NI I NI NI U NI I I U U U NI Included papers Abrahamsson, P., Walivaara, D. A., Isaksson, S. & Andersson, G. (2012) Periosteal expansion before local bone reconstruction using a new technique for measuring soft tissue profile stability: a clinical study. J Oral Maxillofac Surg 70, e521-530. Aghazadeh, A., Rutger Persson, G. & Renvert, S. (2012) A single-centre randomized controlled clinical trial on the adjunct treatment of intra-bony defects with autogenous bone or a xenograft: results after 12 months. J Clin Periodontol 39, 666-673. Aimetti, M., Romano, F., Guzzi, N. & Carnevale, G. (2012) Full-mouth disinfection and systemic antimicrobial therapy in generalized aggressive periodontitis: a randomized, placebo-controlled trial. J Clin Periodontol 39, 284-294. Al-Mubarak, S., Ciancio, S., Aljada, A., Mohanty, P., Ross, C. & Dandona, P. (2002) Comparative evaluation of adjunctive oral irrigation in diabetics. J Clin Periodontol 29, 295-300. Al-Otaibi, M., Al-Harthy, M., Soder, B., Gustafsson, A. & Angmar-Mansson, B. (2003) Comparative effect of chewing sticks and toothbrushing on plaque removal and gingival health. Oral Health Prev Dent 1, 301-307. Al-Zahrani, M. S. & Austah, O. N. (2011) Photodynamic therapy as an adjunctive to scaling and root planing in treatment of chronic periodontitis in smokers. Saudi Med J 32, 1183-1188. Alkan, E. A. & Parlar, A. (2011) EMD or subepithelial connective tissue graft for the treatment of single gingival recessions: a pilot study. Journal of Periodontal Research 46, 637-642. Alves, L. B., Costa, P. P., Scombatti de Souza, S. L., de Moraes Grisi, M. F., Palioto, D. B., Taba Jr, M. & Novaes Jr, A. B., Jr. (2012) Acellular dermal matrix graft with or without enamel matrix derivative for root coverage in smokers: a randomized clinical study. J Clin Periodontol 39, 393-399. Aparna, S., Setty, S. & Thakur, S. (2011) Oily calcium hydroxide suspension in the treatment of infrabony periodontal defects: a randomized controlled clinical trial. Quintessence Int 42, 835-842. Arweiler, N. B., Henning, G., Reich, E. & Netuschil, L. (2002) Effect of an amine-fluoridetriclosan mouthrinse on plaque regrowth and biofilm vitality. J Clin Periodontol 29, 358-363. Arweiler, N. B., Pergola, G., Kuenz, J., Hellwig, E., Sculean, A. & Auschill, T. M. (2011) Clinical and antibacterial effect of an anti-inflammatory toothpaste formulation with Scutellaria baicalensis extract on experimental gingivitis. Clin Oral Investig 15, 909913. Aspriello, S. D., Ferrante, L., Rubini, C. & Piemontese, M. (2011a) Comparative study of DFDBA in combination with enamel matrix derivative versus DFDBA alone for treatment of periodontal intrabony defects at 12 months post-surgery. Clin Oral Investig 15, 225-232. Aspriello, S. D., Zizzi, A., Spazzafumo, L., Rubini, C., Lorenzi, T., Marzioni, D., Bullon, P. & Piemontese, M. (2011b) Effects of enamel matrix derivative on vascular endothelial growth factor expression and microvessel density in gingival tissues of periodontal pocket: a comparative study. J Periodontol 82, 606-612. Ayub, L. G., Ramos, U. D., Reino, D. M., Grisi, M. F., Taba, M., Jr., Souza, S. L., Palioto, D. B. & Novaes, A. B., Jr. (2012) A Randomized comparative clinical study of two surgical procedures to improve root coverage with the acellular dermal matrix graft. J Clin Periodontol 39, 871-878. Azmak, N., Atilla, G., Luoto, H. & Sorsa, T. (2002) The effect of subgingival controlledrelease delivery of chlorhexidine chip on clinical parameters and matrix metalloproteinase-8 levels in gingival crevicular fluid. J Periodontol 73, 608-615. Badran, Z., Boutigny, H., Struillou, X., Weiss, P., Laboux, O. & Soueidan, A. (2012) Clinical outcomes after nonsurgical periodontal therapy with an Er:YAG laser device: a randomized controlled pilot study. Photomed Laser Surg 30, 347-353. Baghele, O. N. & Pol, D. G. (2012) An evaluation of the effectiveness and predictability of transpositional flap vs connective tissue graft for coverage of Miller's class-I and class-II facial marginal tissue recession lesions: a clinical study. Indian J Dent Res 23, 195-202. Basegmez, C., Berber, L. & Yalcin, F. (2011) Clinical and biochemical efficacy of minocycline in nonsurgical periodontal therapy: a randomized controlled pilot study. J Clin Pharmacol 51, 915-922. Bashutski, J. D., Eber, R. M., Kinney, J. S., Benavides, E., Maitra, S., Braun, T. M., Giannobile, W. V. & McCauley, L. K. (2011) The impact of vitamin D status on periodontal surgery outcomes. J Dent Res 90, 1007-1012. Bauroth, K., Charles, C. H., Mankodi, S. M., Simmons, K., Zhao, Q. & Kumar, L. D. (2003) The efficacy of an essential oil antiseptic mouthrinse vs. dental floss in controlling interproximal gingivitis: a comparative study. J Am Dent Assoc 134, 359-365. Becerik, S., Turkoglu, O., Emingil, G., Vural, C., Ozdemir, G. & Atilla, G. (2011) Antimicrobial effect of adjunctive use of chlorhexidine mouthrinse in untreated gingivitis: a randomized, placebo-controlled study. APMIS 119, 364-372. Berlucchi, I., Francetti, L., Del Fabbro, M., Testori, T. & Weinstein, R. L. (2002) Enamel matrix proteins (Emdogain) in combination with coronally advanced flap or subepithelial connective tissue graft in the treatment of shallow gingival recessions. Int J Periodontics Restorative Dent 22, 583-593. Bittencourt, S., Del Peloso Ribeiro, E., Sallum, E. A., Nociti, F. H., Jr. & Casati, M. Z. (2012) Surgical microscope may enhance root coverage with subepithelial connective tissue graft: a randomized-controlled clinical trial. J Periodontol 83, 721-730. Bizhang, M., Ellerbrock, B., Preza, D., Raab, W., Singh, P., Beikler, T., Henrich, B. & Zimmer, S. (2011) Detection of nine microorganisms from the initial carious root lesions using a TaqMan-based real-time PCR. Oral Dis 17, 642-652. Braun, A., Krause, F., Nolden, R. & Frentzen, M. (2003) Subjective intensity of pain during the treatment of periodontal lesions with the Vector-system. J Periodontal Res 38, 135-140. Brown, J. B., Rosenstein, D., Mullooly, J., O'Keeffe Rosetti, M., Robinson, S. & Chiodo, G. (2002) Impact of intensified dental care on outcomes in human immunodeficiency virus infection. AIDS Patient Care STDS 16, 479-486. Bruhn, G., Netuschil, L., Richter, S., Brecx, M. & Hoffmann, T. (2002) Effect of a toothpaste containing triclosan on dental plaque, gingivitis, and bleeding on probing--an investigation in periodontitis patients over 28 weeks. Clin Oral Investig 6, 124-127. Camargo, P. M., Wolinsky, L. E., Burgess, A. V., Wagner, W. R., Paluk, S. F. & Kenney, E. B. (2002) Bovine-derived bone protein extract in the treatment of mandibular Class II furcations. Compend Contin Educ Dent 23, 1023-1028, 1030, 1032 passim; quiz 1042. Campus, G., Cagetti, M. G., Cocco, F., Sale, S., Sacco, G., Strohmenger, L. & Lingstrom, P. (2011) Effect of a sugar-free chewing gum containing magnolia bark extract on different variables related to caries and gingivitis: a randomized controlled intervention trial. Caries Res 45, 393-399. Cappuyns, I., Cionca, N., Wick, P., Giannopoulou, C. & Mombelli, A. (2012) Treatment of residual pockets with photodynamic therapy, diode laser, or deep scaling. A randomized, split-mouth controlled clinical trial. Lasers Med Sci 27, 979-986. Cardaropoli, D., Tamagnone, L., Roffredo, A. & Gaveglio, L. (2012) Treatment of gingival recession defects using coronally advanced flap with a porcine collagen matrix compared to coronally advanced flap with connective tissue graft: a randomized controlled clinical trial. J Periodontol 83, 321-328. Cetiner, D., Parlar, A., Balos, K. & Alpar, R. (2003) Comparative clinical study of connective tissue graft and two types of bioabsorbable barriers in the treatment of localized gingival recessions. J Periodontol 74, 1196-1205. Chandra, R. V., Sandhya, Y. P., Nagarajan, S., Reddy, B. H., Naveen, A. & Murthy, K. R. (2012) Efficacy of lycopene as a locally delivered gel in the treatment of chronic periodontitis: smokers vs nonsmokers. Quintessence Int 43, 401-411. Chapple, I. L., Milward, M. R., Ling-Mountford, N., Weston, P., Carter, K., Askey, K., Dallal, G. E., De Spirt, S., Sies, H., Patel, D. & Matthews, J. B. (2012) Adjunctive daily supplementation with encapsulated fruit, vegetable and berry juice powder concentrates and clinical periodontal outcomes: a double-blind RCT. J Clin Periodontol 39, 62-72. Charles, C. A., Amini, P., Gallob, J., Shang, H., McGuire, J. A. & Costa, R. (2012) Antiplaque and antigingivitis efficacy of an alcohol-free essential-oil containing mouthrinse: a 2-week clinical trial. Am J Dent 25, 195-198. Charles, C. A., McGuire, J. A., Sharma, N. C. & Qaqish, J. (2011) Comparative efficacy of two daily use mouthrinses: randomized clinical trial using an experimental gingivitis model. Braz Oral Res 25, 338-344. Chawla, K., Lamba, A. K., Faraz, F. & Tandon, S. (2011) Evaluation of beta-tricalcium phosphate in human infrabony periodontal osseous defects: a clinical study. Quintessence Int 42, 291-300. Chen, L., Luo, G., Xuan, D., Wei, B., Liu, F., Li, J. & Zhang, J. (2012) Effects of non-surgical periodontal treatment on clinical response, serum inflammatory parameters, and metabolic control in patients with type 2 diabetes: a randomized study. J Periodontol 83, 435-443. Chen, T., Zhou, Y., Liu, J., Xu, B., Wu, Z. & Li, D. (2002) Biological effects of hyperbaric oxygen on human severe periodontitis. Undersea Hyperb Med 29, 159-166. Chen, T. L., Lin, S. L., Liu, G. Q., Liu, J. C., Song, P. Z., Xu, B., Zhang, X. H., Wang, G. & Chen, J. 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