Supporting Information for Review and Online Publication Only
Table 1. Assessment of the quality of adverse events reporting in randomised controlled trials
published in the periodontal literature from 2002 to 2003
Authors
Al-Mubarak et al. 2002
Al-Otaibi et al. 2003
Arweiler et al. 2002
Azmak et al. 2002
Bauroth et al. 2003
Berlucchi et al. 2002
Braun et al. 2003
Brown et al. 2002
Bruhn et al. 2002
Camargo et al. 2002
Cetiner et al. 2003
Chen et al. 2002
Chen et al. 2003
Christgau et al. 2002
Clavero et al. 2003
Couri et al. 2002
Cury et al. 2003a
Cury et al. 2003b
Daneshmand et al. 2002
Del Pizzo et al. 2002
Dentino et al. 2002
Eberhard et al. 2002
Eren et al. 2002
Feres et al. 2002
Grisi et al. 2002
Gründemann et al. 2002
Gutierrez et al. 2003
Han et al. 2002
Henderson et al. 2002
Hoang et al. 2003
Hu et al. 2003
Jansson et al. 2003
Jentsch et al. 2003
Jin et al. 2003
Joly et al. 2002
Kerdvongbundit &
Wikesjö 2003
Kim et al. 2002
Kim et al. 2003
Lekovic et al. 2003
Lins et al. 2003
Loos et al. 2002
Machtei et al. 2003
Maragos et al. 2002
McGuire & Nunn 2003
Mengel et al. 2003
Mesa et al. 2003
Rec
1
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
Y
Y
NA
Y
NA
NA
Y
NA
NA
NA
NA
Y
NA
NA
Y
NA
NA
Rec
2
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
N
Y
NA
Y
NA
NA
Y
NA
N
NA
NA
Y
NA
NA
N
NA
NA
Rec
3
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
Y
N
N
Y
N
N
Y
N
N
Y
N
Y
N
N
N
N
N
Rec
4
N
N
Y
N
N
N
N
N
N
N
Y
N
N
N
N
N
N
N
N
Y
Y
N
N
N
N
Y
N
N
Y
N
Y
N
N
Y
N
N
Rec
5
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
Y
N
N
Y
N
N
N
N
N
N
N
N
N
N
N
N
N
Rec
6
N
N
N
N
N
N
N
N
Y
N
Y
N
N
N
N
N
Y
Y
N
Y
Y
Y
N
N
N
Y
N
N
N
N
Y
Y
N
Y
Y
Y
Rec
7
N
N
NA
N
N
N
N
N
N
NA
NA
N
NA
N
N
N
NA
N
N
NA
NA
N
N
N
N
Y
N
N
NA
N
Y
N
N
NA
NA
N
Rec
8
N
N
N
N
N
N
N
N
N
Y
NA
N
NA
Y
N
N
NA
N
N
Y
NA
N
N
N
N
Y
N
N
NA
N
Y
N
N
NA
NA
N
Rec
9
N
N
NA
N
N
N
N
N
N
NA
NA
N
NA
N
N
N
NA
N
N
N
NA
N
N
N
N
Y
N
N
NA
N
NA
N
N
NA
NA
N
Rec
10
N
N
N
N
N
N
N
N
Y
Y
N
N
N
Y
N
N
N
N
N
Y
Y
N
Y
N
N
Y
N
N
Y
N
Y
N
N
Y
N
N
Fundi
ng
I
U
I
U
U
U
U
NI
I
I
U
U
NI
I
I
U
NI
NI
U
U
I
I
I
NI
U
U
U
U
I
U
U
NI
U
U
NI
U
NA
NA
NA
NA
NA
NA
NA
Y
NA
NA
NA
NA
NA
NA
NA
NA
NA
N
NA
NA
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
Y
N
N
N
N
N
N
N
N
N
Y
N
N
Y
N
Y
N
Y
N
N
N
N
N
N
N
NA
N
Y
N
N
Y
N
N
N
N
NA
N
Y
N
N
Y
N
N
N
N
NA
N
N
N
N
N
N
N
N
N
N
N
N
N
N
Y
N
N
U
I
U
U
U
U
U
I
I
U
Minabe et al. 2002
Miyazaki et al. 2003
Nafar et al. 2003
Nogueira-Filho et al. 2002
Novak et al. 2002
Oringer et al. 2002
Palioto et al. 2003
Pannuti et al. 2003
Paolantonio et al. 2002
Paquette et al. 2002
Paquette et al. 2003
Petersilka et al. 2003a
Petersilka et al. 2003b
Pistorius et al. 2003
Polansky et al. 2003
Pruthi et al. 2002
Reddy et al. 2003
Rodrigues et al. 2003
Rooney et al. 2002
Rosenstein et al. 2003
Salvi et al. 2002
Sastravaha et al. 2003
Saxer et al. 2003
Scheyer et al. 2002
Schwarz et al. 2003a
Schwarz et al. 2003b
Schwarz et al. 2003c
Sculean et al. 2002a
Sculean et al. 2002b
Sculean et al. 2003a
Sculean et al. 2003b
Sculean et al. 2003c
Sharma et al. 2002
Sharma et al. 2003
Silvestri et al. 2003
Stavropoulos et al. 2003
Sugaya et al. 2002
Taiyeb-Ali et al. 2003
Tal et al. 2002
Tonetti et al. 2002
Tsubura & Ikeda 2003
van der Weijden et al.
2002a
van der Weijden et al.
2002b
VanDyke et al. 2002
Vardar et al. 2003
Velasquez-Plata et al. 2002
Wachtel et al. 2003
Walters et al. 2003
Wang et al. 2003
Windisch et al. 2002
Yates et al. 2002
Yates et al. 2003
Yilmaz et al. 2003
Zucchelli et al. 2003
NA
NA
NA
NA
NA
NA
NA
NA
NA
Y
NA
NA
NA
NA
NA
NA
NA
NA
N
NA
NA
NA
Y
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
Y
NA
NA
NA
NA
NA
NA
NA
NA
N
NA
NA
NA
N
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
N
N
N
N
N
N
N
N
N
N
N
Y
N
N
N
N
N
N
Y
Y
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
Y
N
N
N
N
N
N
N
N
N
Y
N
Y
N
Y
Y
N
N
N
N
N
Y
Y
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
Y
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
Y
Y
N
N
N
N
N
N
N
Y
N
N
N
N
N
N
N
N
Y
N
Y
N
N
Y
Y
N
N
N
N
N
N
N
N
N
Y
Y
N
N
N
N
N
N
NA
N
N
N
N
N
N
Y
N
Y
N
N
Y
N
N
N
N
N
NA
N
N
N
NA
NA
NA
NA
NA
NA
NA
NA
NA
N
NA
N
N
NA
N
N
N
N
N
N
NA
N
N
N
N
N
N
N
N
Y
N
Y
NA
N
N
N
N
N
NA
N
N
N
NA
NA
NA
NA
NA
NA
NA
NA
NA
N
NA
Y
N
NA
N
N
N
N
N
N
NA
N
N
N
N
N
N
Y
N
Y
N
N
NA
N
N
N
N
N
NA
N
N
N
NA
NA
NA
NA
NA
NA
NA
NA
NA
N
NA
Y
N
NA
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
Y
N
Y
Y
N
N
N
N
N
Y
N
N
N
N
N
Y
N
N
Y
N
N
N
N
N
N
N
N
N
N
N
N
N
N
U
I
U
NI
I
I
NI
U
NI
I
U
U
U
U
U
U
I
NI
NI
I
I
NI
I
I
U
U
U
U
U
U
U
I
U
U
U
I
U
I
I
I
U
I
N
Y
Y
Y
Y
Y
NA
NA
NA
Y
U
NA
NA
NA
Y
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
Y
NA
NA
NA
NA
NA
NA
NA
Y
N
N
Y
N
N
N
N
N
N
N
N
N
N
Y
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
Y
Y
Y
N
N
N
N
Y
Y
N
N
NA
N
NA
NA
NA
N
NA
N
NA
N
N
NA
N
NA
NA
NA
N
NA
N
NA
N
N
NA
N
NA
NA
NA
N
NA
N
NA
Y
N
N
Y
N
N
N
N
N
Y
N
U
U
I
U
I
NI
U
U
U
I
U
Rec: Recommendation
Y: Yes
N: No
N/A: Not applicable
NI: Non-industry funded trial
I: Industry funded trial
U: Unclear
Table 2. Assessment of the quality of adverse events reporting in randomised controlled trials
published in the periodontal literature from 2011 to 2012
Authors
Abrahamsson et al. 2012
Aghazadeh et al. 2012
Aimetti et al. 2012
Alkan & Parlar 2011
Alves et al. 2012
Al-Zahrani & Austah 2011
Aparna et al. 2011
Arweiler et al. 2011
Aspriello et al. 2011a
Aspriello et al. 2011b
Ayub et al. 2012
Badran et al. 2012
Baghele & Pol 2012
Bashutski et al. 2011
Becerik et al. 2011
Besegmez et al. 2011
Bittencourt et al. 2012
Bizhang et al. 2011
Campus et al. 2011
Cappuyns et al. 2012
Cardaropoli et al. 2012
Chandra et al. 2012
Chapple et al. 2012
Charles et al. 2011
Charles et al. 2012
Chawla et al. 2011
Chen et al. 2012
Cho et al. 2011
Chongcharoen et al. 2012
Cordaro et al. 2012
Cortelli et al. 2012
Cortellini et al. 2011
Cortellini & Tonetti 2011
Crespi et al. 2011
de Lima Oliveira et al.
2012
De Nardo et al. 2012
Elkhouli et al. 2011
Eltas & Orbak 2012a
Eltas & Orbak 2012b
Engebretson & HeyHadavi 2011
Feng et al. 2011
Flemmig et al. 2012
Funosas et al. 2012
Gamal et al. 2011
García et al. 2011
Gerlach & Amini 2012
Gómez et al. 2011
Gonzales et al. 2011
Rec
1
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
N
NA
NA
NA
NA
Y
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
Rec
2
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
Y
NA
NA
NA
NA
Y
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
Rec
3
N
N
Y
N
N
N
N
N
N
N
N
N
N
N
N
N
Y
N
N
N
N
N
N
N
N
N
N
N
N
N
N
Y
Y
N
N
Rec
4
N
N
Y
N
N
N
N
Y
N
N
N
Y
N
N
Y
N
Y
N
Y
Y
N
Y
N
N
N
N
N
N
N
N
Y
Y
Y
N
N
Rec
5
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
Rec
6
N
Y
Y
Y
N
N
N
Y
Y
N
Y
N
N
N
N
N
Y
Y
Y
N
Y
N
Y
N
N
N
N
N
N
N
N
N
Y
N
N
Rec
7
Y
N
N
NA
NA
N
NA
NA
NA
N
Y
NA
N
N
Y
N
NA
N
NA
N
NA
N
N
NA
NA
NA
NA
N
N
N
Y
N
Y
N
N
Rec
8
Y
N
N
NA
NA
N
NA
NA
NA
N
N
NA
N
N
N
N
NA
N
NA
N
NA
N
N
NA
NA
NA
NA
N
N
N
Y
Y
Y
N
N
Rec
9
N
N
N
NA
NA
NA
NA
NA
NA
NA
N
NA
N
N
N
N
NA
N
NA
N
NA
N
N
NA
NA
NA
NA
N
N
N
Y
N
N
N
N
Rec
10
Y
N
Y
N
N
N
N
N
N
N
N
Y
N
N
N
N
N
N
N
N
N
N
N
N
N
Y
N
N
N
N
N
N
Y
N
N
Fundi
ng
NI
I
NI
NI
NI
NI
U
I
U
NI
I
I
U
I
I
NI
NI
I
U
I
I
NI
I
U
I
I
NI
NI
I
U
I
NI
NI
U
NI
Y
NA
NA
NA
NA
N
NA
NA
NA
NA
N
N
N
N
Y
Y
N
N
N
N
N
N
N
N
N
N
Y
Y
Y
Y
Y
NA
N
N
Y
Y
NA
N
N
NA
Y
NA
N
N
NA
Y
Y
N
N
Y
U
U
NI
U
I
NA
Y
NA
NA
NA
NA
NA
NA
NA
Y
NA
NA
NA
NA
NA
NA
Y
Y
N
N
N
N
N
N
Y
Y
N
N
Y
N
N
N
N
Y
N
N
N
N
N
N
N
Y
N
N
N
N
N
N
N
Y
N
NA
NA
N
N
N
Y
Y
N
NA
NA
N
N
N
Y
Y
N
NA
NA
N
N
N
Y
Y
N
N
Y
Y
N
N
I
NI
U
NI
I
I
I
I
Goodson et al. 2012
Goyal et al. 2012a
Goyal et al. 2012b
Grbic et al. 2011
Haas et al. 2012a
Haas et al. 2012b
He et al. 2012a
He et al. 2012b
Heller et al. 2011
Jankovic et al. 2012
Kamil et al. 2011
Kaner et al. 2011
Kaushick et al. 2011
Klukowska et al. 2012
Knöfler et al. 2011
Koromantzos et al. 2012
Kraivaphan et al. 2012
Krück et al. 2012
Lafzi et al. 2011
Lekovic et al. 2012
Li et al. 2011
Li et al. 2012
Lin et al. 2012
Llambés et al. 2012
López et al. 2012
Machtei et al. 2011
Mahajan et al. 2012
Makhlouf et al. 2012
Malali et al. 2012
Mankodi et al. 2011
Mazzocco et al. 2011
McGuire et al. 2011
Mendonça et al. 2012
Meyle et al. 2011
Miani et al. 2012
Moder et al. 2012
Moeintaghavi et al. 2012
Morelli et al. 2011
Moslemi et al. 2011
Nakajima et al. 2012
Nazareth & Cury 2011
Noro Filho et al. 2012
Oliveira et al. 2011
Olsson et al. 2012
Ozcelik et al. 2011
Ozdemir & Okte 2012
Ozturan et al. 2011
Payne et al. 2011
Pera et al. 2012
Pereira et al. 2011
Persson et al. 2011
Pini Prato et al. 2011
Pradeep & Kathariya 2011
Pradeep et al. 2012a
Pradeep et al. 2012b
Pradeep et al. 2012c
NA
NA
NA
NA
NA
NA
NA
Y
NA
Y
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
Y
NA
NA
NA
NA
NA
Y
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
Y
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
N
NA
Y
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
Y
NA
NA
NA
NA
NA
Y
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
Y
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
N
N
N
Y
N
N
N
N
Y
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
Y
N
N
N
N
N
Y
N
N
N
N
N
Y
N
N
N
N
N
Y
Y
N
N
N
N
N
N
N
N
N
N
N
N
Y
Y
Y
N
N
N
Y
Y
Y
N
N
N
Y
N
N
N
N
N
N
N
Y
N
N
N
Y
N
N
N
Y
N
Y
Y
N
N
N
N
Y
N
N
N
N
N
Y
Y
N
N
N
N
Y
N
N
N
N
N
Y
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
Y
N
N
N
Y
Y
N
Y
N
N
N
N
N
N
N
N
N
Y
Y
Y
Y
N
N
N
N
N
N
Y
Y
N
N
N
N
N
Y
N
N
Y
Y
N
N
N
N
N
Y
NA
NA
Y
N
N
NA
NA
Y
Y
N
N
NA
NA
N
N
NA
NA
NA
NA
NA
NA
N
N
N
N
NA
N
N
NA
NA
NA
N
N
N
N
N
N
N
NA
NA
N
N
Y
NA
NA
NA
N
NA
Y
NA
NA
N
N
N
N
N
NA
NA
Y
N
N
NA
NA
Y
NA
N
N
NA
NA
N
N
NA
NA
NA
NA
NA
NA
N
N
N
Y
NA
N
N
NA
NA
NA
N
N
N
N
N
N
N
NA
NA
N
N
Y
NA
NA
NA
N
NA
N
NA
NA
N
N
N
N
N
NA
NA
Y
N
N
NA
NA
Y
NA
N
N
NA
NA
N
N
NA
NA
NA
NA
NA
NA
N
N
N
Y
NA
N
N
NA
NA
NA
N
N
N
N
N
N
N
NA
NA
N
N
Y
NA
NA
NA
N
NA
N
NA
NA
N
N
N
N
N
N
N
Y
N
N
N
N
N
Y
N
N
N
N
N
N
N
N
N
N
N
Y
N
N
N
N
N
N
N
N
N
N
Y
N
N
N
N
N
N
N
N
N
N
Y
N
N
N
N
N
Y
Y
N
N
N
N
N
NI
I
I
U
NI
NI
I
I
NI
U
NI
NI
U
I
U
NI
U
NI
NI
NI
U
I
NI
NI
I
I
U
U
NI
I
U
I
NI
I
NI
NI
NI
I
NI
I
NI
NI
NI
I
NI
U
NI
NI
U
NI
I
NI
I
I
I
I
Pradeep et al. 2012d
Putt et al. 2012
Qadri et al. 2011
Rasperini et al. 2011
Ratka-Krüger et al. 2012
Ribeiro et al. 2011a
Ribeiro et al. 2011b
Rioboo et al. 2012
Röllke et al. 2012
Saini et al. 2011
Sampaio et al. 2011
Samuels et al. 2012
Santos et al. 2012
Sekhar et al. 2011
Serafini et al. 2012
Sharma et al. 2012a
Sharma et al. 2012b
Sharma & Pradeep 2011a
Sharma & Pradeep 2011b
Sharma & Pradeep 2012a
Sharma & Pradeep 2012b
Signoretto 2011
Silva et al. 2011
Slawik et al. 2011
Slot et al. 2011
Sofrata et al. 2011
Soo et al. 2012
Stavropoulos et al. 2011
Sun et al. 2011
Tangade et al. 2012
Thorat et al. 2011
Tonetti et al. 2012
Trombelli et al. 2012
Varela et al. 2011
Verma et al. 2011
Waghmare et al. 2011
Wennström et al. 2011
Wohlfahrt et al. 2012
Yadav et al. 2011
Yilmaz et al. 2012a
Yilmaz et al. 2012b
Yuen et al. 2011
Rec: Recommendation
Y: Yes
N: No
N/A: Not applicable
NI: Non-industry funded trial
I: Industry funded trial
U: Unclear
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
NA
Y
NA
NA
Y
NA
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NA
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NA
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NA
N
NA
Y
NA
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NA
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NA
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NA
NA
NA
NA
NA
NA
NA
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NA
NA
NA
NA
NA
NA
NA
NA
NA
Y
NA
NA
Y
NA
NA
NA
NA
NA
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NA
NA
NA
Y
NA
Y
NA
NA
NA
NA
N
NA
NA
NA
NA
NA
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NA
NA
NA
NA
N
N
N
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N
Y
Y
N
Y
Y
N
N
Y
N
N
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N
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N
Y
N
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N
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N
Y
N
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Y
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Y
Y
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Y
Y
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Y
Y
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Y
Y
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Y
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Y
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Y
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Y
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Y
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Y
Y
Y
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Y
Y
Y
Y
N
Y
N
NA
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Y
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Y
NA
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Y
N
Y
N
NA
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Y
Y
NA
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Y
N
NA
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Y
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Y
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Y
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Y
N
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Y
N
N
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Y
Y
NA
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Y
N
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Y
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Y
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Y
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Y
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Y
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Y
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Y
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Y
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U
I
U
U
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NI
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U
NI
I
NI
U
I
I
I
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NI
Included papers
Abrahamsson, P., Walivaara, D. A., Isaksson, S. & Andersson, G. (2012) Periosteal expansion
before local bone reconstruction using a new technique for measuring soft tissue
profile stability: a clinical study. J Oral Maxillofac Surg 70, e521-530.
Aghazadeh, A., Rutger Persson, G. & Renvert, S. (2012) A single-centre randomized
controlled clinical trial on the adjunct treatment of intra-bony defects with autogenous
bone or a xenograft: results after 12 months. J Clin Periodontol 39, 666-673.
Aimetti, M., Romano, F., Guzzi, N. & Carnevale, G. (2012) Full-mouth disinfection and
systemic antimicrobial therapy in generalized aggressive periodontitis: a randomized,
placebo-controlled trial. J Clin Periodontol 39, 284-294.
Al-Mubarak, S., Ciancio, S., Aljada, A., Mohanty, P., Ross, C. & Dandona, P. (2002)
Comparative evaluation of adjunctive oral irrigation in diabetics. J Clin Periodontol
29, 295-300.
Al-Otaibi, M., Al-Harthy, M., Soder, B., Gustafsson, A. & Angmar-Mansson, B. (2003)
Comparative effect of chewing sticks and toothbrushing on plaque removal and
gingival health. Oral Health Prev Dent 1, 301-307.
Al-Zahrani, M. S. & Austah, O. N. (2011) Photodynamic therapy as an adjunctive to scaling
and root planing in treatment of chronic periodontitis in smokers. Saudi Med J 32,
1183-1188.
Alkan, E. A. & Parlar, A. (2011) EMD or subepithelial connective tissue graft for the
treatment of single gingival recessions: a pilot study. Journal of Periodontal Research
46, 637-642.
Alves, L. B., Costa, P. P., Scombatti de Souza, S. L., de Moraes Grisi, M. F., Palioto, D. B.,
Taba Jr, M. & Novaes Jr, A. B., Jr. (2012) Acellular dermal matrix graft with or
without enamel matrix derivative for root coverage in smokers: a randomized clinical
study. J Clin Periodontol 39, 393-399.
Aparna, S., Setty, S. & Thakur, S. (2011) Oily calcium hydroxide suspension in the treatment
of infrabony periodontal defects: a randomized controlled clinical trial. Quintessence
Int 42, 835-842.
Arweiler, N. B., Henning, G., Reich, E. & Netuschil, L. (2002) Effect of an amine-fluoridetriclosan mouthrinse on plaque regrowth and biofilm vitality. J Clin Periodontol 29,
358-363.
Arweiler, N. B., Pergola, G., Kuenz, J., Hellwig, E., Sculean, A. & Auschill, T. M. (2011)
Clinical and antibacterial effect of an anti-inflammatory toothpaste formulation with
Scutellaria baicalensis extract on experimental gingivitis. Clin Oral Investig 15, 909913.
Aspriello, S. D., Ferrante, L., Rubini, C. & Piemontese, M. (2011a) Comparative study of
DFDBA in combination with enamel matrix derivative versus DFDBA alone for
treatment of periodontal intrabony defects at 12 months post-surgery. Clin Oral
Investig 15, 225-232.
Aspriello, S. D., Zizzi, A., Spazzafumo, L., Rubini, C., Lorenzi, T., Marzioni, D., Bullon, P.
& Piemontese, M. (2011b) Effects of enamel matrix derivative on vascular endothelial
growth factor expression and microvessel density in gingival tissues of periodontal
pocket: a comparative study. J Periodontol 82, 606-612.
Ayub, L. G., Ramos, U. D., Reino, D. M., Grisi, M. F., Taba, M., Jr., Souza, S. L., Palioto, D.
B. & Novaes, A. B., Jr. (2012) A Randomized comparative clinical study of two
surgical procedures to improve root coverage with the acellular dermal matrix graft. J
Clin Periodontol 39, 871-878.
Azmak, N., Atilla, G., Luoto, H. & Sorsa, T. (2002) The effect of subgingival controlledrelease delivery of chlorhexidine chip on clinical parameters and matrix
metalloproteinase-8 levels in gingival crevicular fluid. J Periodontol 73, 608-615.
Badran, Z., Boutigny, H., Struillou, X., Weiss, P., Laboux, O. & Soueidan, A. (2012) Clinical
outcomes after nonsurgical periodontal therapy with an Er:YAG laser device: a
randomized controlled pilot study. Photomed Laser Surg 30, 347-353.
Baghele, O. N. & Pol, D. G. (2012) An evaluation of the effectiveness and predictability of
transpositional flap vs connective tissue graft for coverage of Miller's class-I and
class-II facial marginal tissue recession lesions: a clinical study. Indian J Dent Res 23,
195-202.
Basegmez, C., Berber, L. & Yalcin, F. (2011) Clinical and biochemical efficacy of
minocycline in nonsurgical periodontal therapy: a randomized controlled pilot study. J
Clin Pharmacol 51, 915-922.
Bashutski, J. D., Eber, R. M., Kinney, J. S., Benavides, E., Maitra, S., Braun, T. M.,
Giannobile, W. V. & McCauley, L. K. (2011) The impact of vitamin D status on
periodontal surgery outcomes. J Dent Res 90, 1007-1012.
Bauroth, K., Charles, C. H., Mankodi, S. M., Simmons, K., Zhao, Q. & Kumar, L. D. (2003)
The efficacy of an essential oil antiseptic mouthrinse vs. dental floss in controlling
interproximal gingivitis: a comparative study. J Am Dent Assoc 134, 359-365.
Becerik, S., Turkoglu, O., Emingil, G., Vural, C., Ozdemir, G. & Atilla, G. (2011)
Antimicrobial effect of adjunctive use of chlorhexidine mouthrinse in untreated
gingivitis: a randomized, placebo-controlled study. APMIS 119, 364-372.
Berlucchi, I., Francetti, L., Del Fabbro, M., Testori, T. & Weinstein, R. L. (2002) Enamel
matrix proteins (Emdogain) in combination with coronally advanced flap or
subepithelial connective tissue graft in the treatment of shallow gingival recessions.
Int J Periodontics Restorative Dent 22, 583-593.
Bittencourt, S., Del Peloso Ribeiro, E., Sallum, E. A., Nociti, F. H., Jr. & Casati, M. Z. (2012)
Surgical microscope may enhance root coverage with subepithelial connective tissue
graft: a randomized-controlled clinical trial. J Periodontol 83, 721-730.
Bizhang, M., Ellerbrock, B., Preza, D., Raab, W., Singh, P., Beikler, T., Henrich, B. &
Zimmer, S. (2011) Detection of nine microorganisms from the initial carious root
lesions using a TaqMan-based real-time PCR. Oral Dis 17, 642-652.
Braun, A., Krause, F., Nolden, R. & Frentzen, M. (2003) Subjective intensity of pain during
the treatment of periodontal lesions with the Vector-system. J Periodontal Res 38,
135-140.
Brown, J. B., Rosenstein, D., Mullooly, J., O'Keeffe Rosetti, M., Robinson, S. & Chiodo, G.
(2002) Impact of intensified dental care on outcomes in human immunodeficiency
virus infection. AIDS Patient Care STDS 16, 479-486.
Bruhn, G., Netuschil, L., Richter, S., Brecx, M. & Hoffmann, T. (2002) Effect of a toothpaste
containing triclosan on dental plaque, gingivitis, and bleeding on probing--an
investigation in periodontitis patients over 28 weeks. Clin Oral Investig 6, 124-127.
Camargo, P. M., Wolinsky, L. E., Burgess, A. V., Wagner, W. R., Paluk, S. F. & Kenney, E.
B. (2002) Bovine-derived bone protein extract in the treatment of mandibular Class II
furcations. Compend Contin Educ Dent 23, 1023-1028, 1030, 1032 passim; quiz 1042.
Campus, G., Cagetti, M. G., Cocco, F., Sale, S., Sacco, G., Strohmenger, L. & Lingstrom, P.
(2011) Effect of a sugar-free chewing gum containing magnolia bark extract on
different variables related to caries and gingivitis: a randomized controlled
intervention trial. Caries Res 45, 393-399.
Cappuyns, I., Cionca, N., Wick, P., Giannopoulou, C. & Mombelli, A. (2012) Treatment of
residual pockets with photodynamic therapy, diode laser, or deep scaling. A
randomized, split-mouth controlled clinical trial. Lasers Med Sci 27, 979-986.
Cardaropoli, D., Tamagnone, L., Roffredo, A. & Gaveglio, L. (2012) Treatment of gingival
recession defects using coronally advanced flap with a porcine collagen matrix
compared to coronally advanced flap with connective tissue graft: a randomized
controlled clinical trial. J Periodontol 83, 321-328.
Cetiner, D., Parlar, A., Balos, K. & Alpar, R. (2003) Comparative clinical study of connective
tissue graft and two types of bioabsorbable barriers in the treatment of localized
gingival recessions. J Periodontol 74, 1196-1205.
Chandra, R. V., Sandhya, Y. P., Nagarajan, S., Reddy, B. H., Naveen, A. & Murthy, K. R.
(2012) Efficacy of lycopene as a locally delivered gel in the treatment of chronic
periodontitis: smokers vs nonsmokers. Quintessence Int 43, 401-411.
Chapple, I. L., Milward, M. R., Ling-Mountford, N., Weston, P., Carter, K., Askey, K.,
Dallal, G. E., De Spirt, S., Sies, H., Patel, D. & Matthews, J. B. (2012) Adjunctive
daily supplementation with encapsulated fruit, vegetable and berry juice powder
concentrates and clinical periodontal outcomes: a double-blind RCT. J Clin
Periodontol 39, 62-72.
Charles, C. A., Amini, P., Gallob, J., Shang, H., McGuire, J. A. & Costa, R. (2012)
Antiplaque and antigingivitis efficacy of an alcohol-free essential-oil containing
mouthrinse: a 2-week clinical trial. Am J Dent 25, 195-198.
Charles, C. A., McGuire, J. A., Sharma, N. C. & Qaqish, J. (2011) Comparative efficacy of
two daily use mouthrinses: randomized clinical trial using an experimental gingivitis
model. Braz Oral Res 25, 338-344.
Chawla, K., Lamba, A. K., Faraz, F. & Tandon, S. (2011) Evaluation of beta-tricalcium
phosphate in human infrabony periodontal osseous defects: a clinical study.
Quintessence Int 42, 291-300.
Chen, L., Luo, G., Xuan, D., Wei, B., Liu, F., Li, J. & Zhang, J. (2012) Effects of non-surgical
periodontal treatment on clinical response, serum inflammatory parameters, and
metabolic control in patients with type 2 diabetes: a randomized study. J Periodontol
83, 435-443.
Chen, T., Zhou, Y., Liu, J., Xu, B., Wu, Z. & Li, D. (2002) Biological effects of hyperbaric
oxygen on human severe periodontitis. Undersea Hyperb Med 29, 159-166.
Chen, T. L., Lin, S. L., Liu, G. Q., Liu, J. C., Song, P. Z., Xu, B., Zhang, X. H., Wang, G. &
Chen, J. (2003) [Effects and holding time of hyperbaric oxygen on human severe
periodontitis]. Shanghai Kou Qiang Yi Xue 12, 403-405.
Cho, H. B., Lee, H. H., Lee, O. H., Choi, H. S., Choi, J. S. & Lee, B. Y. (2011) Clinical and
microbial evaluation of the effects on gingivitis of a mouth rinse containing an
Enteromorpha linza extract. J Med Food 14, 1670-1676.
Chongcharoen, N., Lulic, M. & Lang, N. P. (2012) Effectiveness of different interdental
brushes on cleaning the interproximal surfaces of teeth and implants: a randomized
controlled, double-blind cross-over study. Clin Oral Implants Res 23, 635-640.
Christgau, M., Bader, N., Felden, A., Gradl, J., Wenzel, A. & Schmalz, G. (2002) Guided
tissue regeneration in intrabony defects using an experimental bioresorbable
polydioxanon (PDS) membrane. A 24-month split-mouth study. J Clin Periodontol
29, 710-723.
Clavero, J., Baca, P., Junco, P. & Gonzalez, M. P. (2003) Effects of 0.2% chlorhexidine spray
applied once or twice daily on plaque accumulation and gingival inflammation in a
geriatric population. J Clin Periodontol 30, 773-777.
Cordaro, L., di Torresanto, V. M. & Torsello, F. (2012) Split-mouth comparison of a
coronally advanced flap with or without enamel matrix derivative for coverage of
multiple gingival recession defects: 6- and 24-month follow-up. Int J Periodontics
Restorative Dent 32, e10-20.
Cortelli, S. C., Cortelli, J. R., Wu, M. M., Simmons, K. & Charles, C. A. (2012) Comparative
antiplaque and antigingivitis efficacy of a multipurpose essential oil-containing
mouthrinse and a cetylpyridinium chloride-containing mouthrinse: A 6-month
randomized clinical trial. Quintessence Int 43, e82-94.
Cortellini, P., Stalpers, G., Mollo, A. & Tonetti, M. S. (2011) Periodontal regeneration versus
extraction and prosthetic replacement of teeth severely compromised by attachment
loss to the apex: 5-year results of an ongoing randomized clinical trial. J Clin
Periodontol 38, 915-924.
Cortellini, P. & Tonetti, M. S. (2011) Clinical and radiographic outcomes of the modified
minimally invasive surgical technique with and without regenerative materials: a
randomized-controlled trial in intra-bony defects. J Clin Periodontol 38, 365-373.
Couri, C. J., Maze, G. I., Hinkson, D. W., Collins, B. H., 3rd & Dawson, D. V. (2002)
Medical grade calcium sulfate hemihydrate versus expanded polytetrafluoroethylene
in the treatment of mandibular class II furcations. J Periodontol 73, 1352-1359.
Crespi, R., Cappare, P., Gherlone, E. & Romanos, G. E. (2011) Comparison of modified
widman and coronally advanced flap surgery combined with Co2 laser root irradiation
in periodontal therapy: a 15-year follow-up. Int J Periodontics Restorative Dent 31,
641-651.
Cury, P. R., Jeffcoat, M. K., Sallum, A. W., Cafesse, R., Nociti Junior, F. H. & Sallum, E. A.
(2003a) Clinical and radiographic evaluation of guided tissue regeneration in the
treatment of class II furcation defects. A randomized clinical trial. Am J Dent 16 Spec
No, 13A-16A.
Cury, P. R., Sallum, E. A., Nociti, F. H., Jr., Sallum, A. W. & Jeffcoatt, M. K. (2003b) Longterm results of guided tissue regeneration therapy in the treatment of class II furcation
defects: a randomized clinical trial. J Periodontol 74, 3-9.
Daneshmand, N., Jorgensen, M. G., Nowzari, H., Morrison, J. L. & Slots, J. (2002) Initial
effect of controlled release chlorhexidine on subgingival microorganisms. J
Periodontal Res 37, 375-379.
de Lima Oliveira, A. P., de Faveri, M., Gursky, L. C., Mestnik, M. J., Feres, M., Haffajee, A.
D., Socransky, S. S. & Teles, R. P. (2012) Effects of periodontal therapy on GCF
cytokines in generalized aggressive periodontitis subjects. J Clin Periodontol 39, 295302.
De Nardo, R., Chiappe, V., Gomez, M., Romanelli, H. & Slots, J. (2012) Effects of 0.05%
sodium hypochlorite oral rinse on supragingival biofilm and gingival inflammation.
Int Dent J 62, 208-212.
Del Pizzo, M., Modica, F., Bethaz, N., Priotto, P. & Romagnoli, R. (2002) The connective
tissue graft: a comparative clinical evaluation of wound healing at the palatal donor
site. A preliminary study. J Clin Periodontol 29, 848-854.
Dentino, A. R., Derderian, G., Wolf, M., Cugini, M., Johnson, R., Van Swol, R. L., King, D.,
Marks, P. & Warren, P. (2002) Six-month comparison of powered versus manual
toothbrushing for safety and efficacy in the absence of professional instruction in
mechanical plaque control. J Periodontol 73, 770-778.
Eberhard, J., Heilmann, F., Acil, Y., Albers, H. K. & Jepsen, S. (2002) Local application of n3 or n-6 polyunsaturated fatty acids in the treatment of human experimental gingivitis.
J Clin Periodontol 29, 364-369.
Elkhouli, A. M. (2011) The efficacy of host response modulation therapy (omega-3 plus lowdose aspirin) as an adjunctive treatment of chronic periodontitis (clinical and
biochemical study). J Periodontal Res 46, 261-268.
Eltas, A. & Orbak, R. (2012a) Clinical effects of Nd:YAG laser applications during
nonsurgical periodontal treatment in smoking and nonsmoking patients with chronic
periodontitis. Photomed Laser Surg 30, 360-366.
Eltas, A. & Orbak, R. (2012b) Effect of 1,064-nm Nd:YAG laser therapy on GCF IL-1beta
and MMP-8 levels in patients with chronic periodontitis. Lasers Med Sci 27, 543-550.
Engebretson, S. P. & Hey-Hadavi, J. (2011) Sub-antimicrobial doxycycline for periodontitis
reduces hemoglobin A1c in subjects with type 2 diabetes: a pilot study. Pharmacol
Res 64, 624-629.
Eren, K. S., Gurgan, C. A. & Bostanci, H. S. (2002) Evaluation of non-surgical periodontal
treatment using 2 time intervals. J Periodontol 73, 1015-1019.
Feng, H. S., Bernardo, C. C., Sonoda, L. L., Hayashi, F., Romito, G. A., De Lima, L. A.,
Lotufo, R. F. & Pannuti, C. M. (2011) Subgingival ultrasonic instrumentation of
residual pockets irrigated with essential oils: a randomized controlled trial. J Clin
Periodontol 38, 637-643.
Feres, M., Haffajee, A. D., Allard, K., Som, S., Goodson, J. M. & Socransky, S. S. (2002)
Antibiotic resistance of subgingival species during and after antibiotic therapy. J Clin
Periodontol 29, 724-735.
Flemmig, T. F., Arushanov, D., Daubert, D., Rothen, M., Mueller, G. & Leroux, B. G. (2012)
Randomized controlled trial assessing efficacy and safety of glycine powder air
polishing in moderate-to-deep periodontal pockets. J Periodontol 83, 444-452.
Funosas, E., Feser, G., Escovich, L. & Maestri, L. (2012) Alteration of hemostasis in patients
treated with subgingival NSAIDs during periodontal therapy. Acta Odontol Latinoam
25, 103-108.
Gamal, A. Y., Kumper, R. M., Sadek, H. S. & El Destawy, M. T. (2011) Chlorhexidine
controlled-release profile after EDTA root surface etching: an in vivo study. J
Periodontol 82, 751-757.
Garcia, V., Rioboo, M., Serrano, J., O'Connor, A., Herrera, D. & Sanz, M. (2011) Plaque
inhibitory effect of a 0.05% cetyl-pyridinium chloride mouth-rinse in a 4-day nonbrushing model. Int J Dent Hyg 9, 266-273.
Gerlach, R. W. & Amini, P. (2012) Randomized controlled trial of 0.454% stannous fluoride
dentifrice to treat gingival bleeding. Compend Contin Educ Dent 33, 134-136, 138.
Gomez, C., Dominguez, A., Garcia-Kass, A. I. & Garcia-Nunez, J. A. (2011) Adjunctive
Nd:YAG laser application in chronic periodontitis: clinical, immunological, and
microbiological aspects. Lasers Med Sci 26, 453-463.
Gonzales, J. R., Harnack, L., Schmitt-Corsitto, G., Boedeker, R. H., Chakraborty, T.,
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