Yiyi Chen Assistant Professor PERSONAL DATA Oregon Clinical and Translational Research Institute OHSU Knight Cancer Institute Dept. of Public Health & Preventive Medicine Division of Biostatistics Oregon Health & Science University E-mail: chenyiy@ohsu.edu Phone: 503-3460790 EDUCATION: July 2008 PhD, Dept. of Biostatistics, University of Iowa Dissertation Title: Optimal Adaptive Group Sequential Design for Phase II Clinical Trials: A Bayesian Decision Theoretic Approach. Dissertation Advisor: Dr. Brian J Smith 2005 MS, Dept. of Biostatistics, University of Iowa 2004 MA, Dept. of Economics, University of Iowa 2001 MA, Research Institute of World Economy, Fudan University 1998 BA, Dept. of Economics, Zhejiang University CURRENT INTERESTS: Bayesian Statistics, Clinical Trials, Adaptive Design, Decision Theory, Computational Statistics, Categorical Data Analysis, Survival Analysis, Longitudinal Data Analysis. EXPERIENCE: 2008-current Assistant Professor, Oregon Health and Science University (OHSU) joint appointment of Dept. of Public Health and Preventive Medicine (PHPM), Knight Cancer Institute and Oregon Clinical and Translational Research Institute (OCTRI). Collaborate actively and closely with clinical investigators, especially those from Knight Cancer institute and OCTRI. o Grant application o Data analysis o Manuscript preparation o General Consult Teach Biostatistics courses for the department of PHPM. o PHPM 524: Introduction to Biostatistics o Design and Analysis of Clinical Trials. (under development) Serve on review board of OHSU Clinical Research Review Committee (CRRC). 2004- 2007 Research Assistantship, UIHC Dept. of Internal Medicine Independently in charge of statistical consulting and analysis for multiple biomedical studies. Conduct collaborative research with clinical investigators and epidemiologists, and write statistical analysis sections for peer reviewed journals. Assist in preparing grant applications and writing statistical components. 2004- 2005 Research Assistantship, University of Iowa College of Dentistry Conduct Meta analysis, regression, sample size computation, and correlated data analysis under the supervision of a senior faculty. Data management. 2001- 2003 Teaching Assistantship, University of Iowa Dept of Economics Instruct class discussion sections on Business Statistics and Macroeconomics. PUBLICATIONS: 1 Chen Y, Chen Z, Motomi M (2010). The use of testing confidence value for the transitional decisions of single-arm phase II oncology trials.Submitted. Tanyi JA, Chen Y, Kato CM, Chen Z, Fuss M(2009). Image-guidance in Linac-based framesless intracranial stereotactic radiosurgery: 2D stereoscopic imaging vs. 3D volumetric imaging. Submitted. Tanyi JA, Kato C, Chen Y, Chen Z, and Fuss M (2009). Impact of the high-definition multileaf collimator (HD-MLC) on linear-accelerator-based intracranial stereotactic radiosurgery (SRS), Journal of Neurosurgery, (in press). Chen Y and Smith BJ (2009). Adaptive Group Sequential Design for Phase II Clinical Trials: A Bayesian Decision Theoretic Approach. Statistics in Medicine , 28: 3347-3362. Tanyi JA, Summers PA, McCracken CL, Chen Y, Ku L-C and Fuss M (2009). Implications of a High-Definition Multi Leaf Collimator (HD-MLC) on Treatment Planning Techniques for Stereotactic Body Radiation Therapy (SBRT): a Planning Study. Radiation Oncology, 10;4:22. Polgreen PM, Chen Y, Beekmann S, Srinivasan A, Neill MA, Gay T and Cavanaugh JE (2008). Elements of Influenza Vaccination Programs that Predict Higher Vaccination Rates: Results of an Emerging Infections Network Survey. Clinical Infectious Diseases, 46(1), 14-19. Kurago ZB, Lam-ubol A, Stetsenko A, Mater CDL, Chen Y, Dawson DV(2008). Lipopolysaccharide-Squamous Cell Carcinoma-Monocyte Interactions Induce cancer-Supporting Factors Leading to Rapid STAT3 Activation. Head and Neck Pathology, 2(1): 1-12. Herwaldt LA, Appelgate D, Kuntz J, Chen Y and Pottinger J (2007). Infection Control Resources in Iowa. American Journal of Infection Control, 35(10), 662-665. Quinn LK, Chen Y, and Herwaldt LA (2007). Survey of Long-Term Care Facilities in Iowa for Policies and Practices Regarding Residents with Clostridium Difficile Infection. Infection Control and Hospital Epidemiology, 28(11), 1228-1232. Polgreen P, Chen Y, Cavanaugh J, Ward M, Coffman S, Hornick D, Diekema DJ, Herwaldt LA(2007). An Outbreak of Severe Clostridium Difficile-Associated Disease Possibly Related to Inappropriate Antimicrobial Therapy for Community-Acquired Pneumonia. Infection Control and Hospital Epidemiology, 28(2), 212-214. Polgreen P, Beekmann SE, Chen Y, Doern GV, Pfaller MA, Brueggemann AB, Herwaldt LA, Diekema DJ (2006). Epidemiology of Methicillin-Resistant Staphylococcus Aureus and Vancomycin-Resistant Enterococcus in a Rural State. Infection Control and Hospital Epidemiology, 27(3), 252-256. Polgreen P, Diekema DJ, VandeBerg J, Wiblin RT, Chen Y, David S, Rasmus D, Gerdts N, Ross A, Katz L, Herwaldt LA (2006). Risk Factors for Groin Wound Infection Following Femoral Artery Catheterization: A Case Control Study. Infection Control and Hospital Epidemiology, 27(1), 34-37. Chen Y (2000). On Industry Policy to Solve Current Problem of Surplus Economy. World Economy Outlook, 6, 32-36. Chen Y (1999). Japanese Economy Depression: Main Causes and Countermeasures. World Economy Outlook, 20, 1217. MANUCRIPT IN PREPARATION: PRESENTATIONS: Chen Y, Chen Z and Motomi M (2009). The Use of Testing Confidence Value for Transitional Decisions for Singlearm Phase II Oncology Trials. 2009 ICSA Applied Statistics Symposium, San Francisco CA. Chen Y, Chen Z and Motomi M (2009).The Use of Testing Confidence Value for “Go / No Go” Decisions for Phase II Oncology Trials. 2009 WNAR-IMS Meeting, Portland OR. 2 Huang W, Li X, Tudorica LA, Morris EA, Chen Y, Tagge I, Thakur S, Korenblit M, Wang Y, Zhang Z, Koutcher JA, Springer CS (2009). ROI Biomarkers for Breast Cancer Diagnosis: Shutter-Speed DCE-MRI Experience with Seventy Seven Suspicious Lesions. 2009 ISMRM 17th Scientific meeting & Exhibition, Honolulu HI. Electronic Multimedia Posters. Tagge I, Chen Y, Li X, Morris E, Tudorica A, Springer C, Huang W (2009) Parametric Mapping and Histogram Analysis of Pixel Pharmacokinetic Parameters for Discrimination of Benign and Malignant Breast Lesions: A Preliminary Shutter-Speed DCE-MRI Study. 2009 ISMRM 17th Scientific meeting & Exhibition, Honolulu HI. Electronic Multimedia Posters. Chen Y and Smith BJ (2008). Optimal Adaptive Group Sequential Design for Phase II Clinical Trials: A Bayesian Decision Theoretic Approach. 2008 Society for Clinical Trials, St. Louis MO. Chen Y and Smith BJ (2008). Optimal Adaptive Group Sequential Design for Phase II Clinical Trials: A Bayesian Decision Theoretic Approach. 2008 ENAR Meeting, Washington D.C., Poster Presentation. Chen Y and Smith BJ (2008). Optimal Adaptive Group Sequential Design for Phase II Clinical Trials: A Bayesian Decision Theoretic Approach. 2008 Bayesian Biostatistics Conference, Houston TX, Poster Presentation. Chen Y and Smith BJ (2007). Optimal Adaptive Group Sequential Design for Phase II Clinical Trials: A Bayesian Decision Theoretic Approach. 30th Annual Midwest Biopharmaceutical Statistics Workshop, Muncie IN, Poster Presentation. Polgreen PM, Chen Y, Ward M, Coffman S, Diekema DJ, Hornick D, Herwaldt LA(2005). An Outbreak of C. difficile-associated Diarrhea among Elderly Patients in a Small Rural Hospital. Society for Healthcare Epidemiology of America Meeting, San Diego CA, Poster Presentation. Gehl A, Chen Y, Dawson D, Mcdaniel A, Southard T, Southard K(2005). The Association between Profile Aesthetic Scores and Cephalometric Variables. 52nd Annual Meeting of the Iowa Section of the American Association for Dental Research (AADR), Iowa City IA, Poster Presentation. HONORS 2008 2007-2008 2008 2007 2007 1998-2000 1998 1994-1997 Student Scholarship for excellent research from Society for Clinical Trials, St. Louis, MO Amgen Pre-Doctoral Fellowship Travel Grant of 2008 Bayesian Biostatistics Conference, Houston TX Charles B. Sampson Student Poster Award 1st Place, 30th Annual Midwest Biopharmaceutical Statistics Workshop, Muncie, IN University of Iowa Graduate Summer Fellowship Yitouhiroharu Graduate Student Fellowship The Most Outstanding College Graduate of Hangzhou City Zhejiang University Outstanding Student Scholarship MEMBERSHIPS: Institute of Mathematical Statistics International Society of Bayesian Analysis American Statistical Association International Chinese Statistical Association Society for Clinical Trials Delta Omega Public Health Honor Society RESEARCH SUPPORT (ONGOING): 1 UL1 RR024140-01 (Orwoll, Eric) 09/30/2006 - 06/30/2011 NIH/NCRR “Oregon Clinical and Translational Science Institute” The OCTSI will fundamentally change biomedical research to create a vibrant academic home for clinical/translational research. At the heart of the OCTSI is a robust partnership between OHSU and Kaiser Permanente's Center for Health Research that brings together a strong biomedical research 3 university and an innovative practice-based research center associated with a large patient population. The collaboration provides unique opportunities for expansion across the spectrum of human investigation, and sets the stage for major advances in human health. Role: Biostatistician 1 R01 CA120861-01A2 Huang (PI) 9/17/2007 -7/31/2010 NCI/NIH Shutter-Speed DCE-MRI Discrimination of Benign and Malignant Breast Disease. Major goal: To use a new pharmacokinetic model, shutter-speed model, for quantitative analysis of breast DCE-MRI data for the purpose of improving breast cancer diagnostic specificity and reducing unnecessary biopsy procedures. Role: Co-Investigator OCTRI/Knight Cancer Institute pilot project funding 12/1/2009 – 11/30/2010 The Use of Testing confidence Value for Transitional Decisions of Single-Arm Phase II Oncology Trials. Role: PI GRANTS PENDING: 4