Yiy Chen - What is Biostatistics?

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Yiyi Chen
Assistant Professor
PERSONAL DATA
Oregon Clinical and Translational Research Institute
OHSU Knight Cancer Institute
Dept. of Public Health & Preventive Medicine
Division of Biostatistics
Oregon Health & Science University
E-mail: chenyiy@ohsu.edu
Phone: 503-3460790
EDUCATION:
July 2008
PhD, Dept. of Biostatistics, University of Iowa
 Dissertation Title: Optimal Adaptive Group Sequential Design for Phase II Clinical Trials:
A Bayesian Decision Theoretic Approach.
Dissertation Advisor: Dr. Brian J Smith
2005
MS, Dept. of Biostatistics, University of Iowa
2004
MA, Dept. of Economics, University of Iowa
2001
MA, Research Institute of World Economy, Fudan University
1998
BA, Dept. of Economics, Zhejiang University
CURRENT INTERESTS:
Bayesian Statistics, Clinical Trials, Adaptive Design, Decision Theory, Computational Statistics, Categorical Data
Analysis, Survival Analysis, Longitudinal Data Analysis.
EXPERIENCE:
2008-current
Assistant Professor, Oregon Health and Science University (OHSU) joint appointment of Dept. of
Public Health and Preventive Medicine (PHPM), Knight Cancer Institute and Oregon Clinical and
Translational Research Institute (OCTRI).
 Collaborate actively and closely with clinical investigators, especially those from Knight
Cancer institute and OCTRI.
o Grant application
o Data analysis
o Manuscript preparation
o General Consult
 Teach Biostatistics courses for the department of PHPM.
o PHPM 524: Introduction to Biostatistics
o Design and Analysis of Clinical Trials. (under development)
 Serve on review board of OHSU Clinical Research Review Committee (CRRC).
2004- 2007
Research Assistantship, UIHC Dept. of Internal Medicine
 Independently in charge of statistical consulting and analysis for multiple biomedical studies.
 Conduct collaborative research with clinical investigators and epidemiologists, and write
statistical analysis sections for peer reviewed journals.
 Assist in preparing grant applications and writing statistical components.
2004- 2005
Research Assistantship, University of Iowa College of Dentistry
 Conduct Meta analysis, regression, sample size computation, and correlated data analysis
under the supervision of a senior faculty.
 Data management.
2001- 2003
Teaching Assistantship, University of Iowa Dept of Economics
 Instruct class discussion sections on Business Statistics and Macroeconomics.
PUBLICATIONS:
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Chen Y, Chen Z, Motomi M (2010). The use of testing confidence value for the transitional decisions of
single-arm phase II oncology trials.Submitted.
Tanyi JA, Chen Y, Kato CM, Chen Z, Fuss M(2009). Image-guidance in Linac-based framesless intracranial
stereotactic radiosurgery: 2D stereoscopic imaging vs. 3D volumetric imaging. Submitted.
Tanyi JA, Kato C, Chen Y, Chen Z, and Fuss M (2009). Impact of the high-definition multileaf collimator (HD-MLC)
on linear-accelerator-based intracranial stereotactic radiosurgery (SRS), Journal of Neurosurgery, (in press).
Chen Y and Smith BJ (2009). Adaptive Group Sequential Design for Phase II Clinical Trials: A Bayesian Decision
Theoretic Approach. Statistics in Medicine , 28: 3347-3362.
Tanyi JA, Summers PA, McCracken CL, Chen Y, Ku L-C and Fuss M (2009). Implications of a High-Definition
Multi Leaf Collimator (HD-MLC) on Treatment Planning Techniques for Stereotactic Body Radiation Therapy
(SBRT): a Planning Study. Radiation Oncology, 10;4:22.
Polgreen PM, Chen Y, Beekmann S, Srinivasan A, Neill MA, Gay T and Cavanaugh JE (2008). Elements of
Influenza Vaccination Programs that Predict Higher Vaccination Rates: Results of an Emerging Infections Network
Survey. Clinical Infectious Diseases, 46(1), 14-19.
Kurago ZB, Lam-ubol A, Stetsenko A, Mater CDL, Chen Y, Dawson DV(2008). Lipopolysaccharide-Squamous Cell
Carcinoma-Monocyte Interactions Induce cancer-Supporting Factors Leading to Rapid STAT3 Activation. Head and
Neck Pathology, 2(1): 1-12.
Herwaldt LA, Appelgate D, Kuntz J, Chen Y and Pottinger J (2007). Infection Control Resources in Iowa. American
Journal of Infection Control, 35(10), 662-665.
Quinn LK, Chen Y, and Herwaldt LA (2007). Survey of Long-Term Care Facilities in Iowa for Policies and Practices
Regarding Residents with Clostridium Difficile Infection. Infection Control and Hospital Epidemiology, 28(11),
1228-1232.
Polgreen P, Chen Y, Cavanaugh J, Ward M, Coffman S, Hornick D, Diekema DJ, Herwaldt LA(2007). An Outbreak
of Severe Clostridium Difficile-Associated Disease Possibly Related to Inappropriate Antimicrobial Therapy for
Community-Acquired Pneumonia. Infection Control and Hospital Epidemiology, 28(2), 212-214.
Polgreen P, Beekmann SE, Chen Y, Doern GV, Pfaller MA, Brueggemann AB, Herwaldt LA, Diekema DJ (2006).
Epidemiology of Methicillin-Resistant Staphylococcus Aureus and Vancomycin-Resistant Enterococcus in a Rural
State. Infection Control and Hospital Epidemiology, 27(3), 252-256.
Polgreen P, Diekema DJ, VandeBerg J, Wiblin RT, Chen Y, David S, Rasmus D, Gerdts N, Ross A, Katz L, Herwaldt
LA (2006). Risk Factors for Groin Wound Infection Following Femoral Artery Catheterization: A Case Control
Study. Infection Control and Hospital Epidemiology, 27(1), 34-37.
Chen Y (2000). On Industry Policy to Solve Current Problem of Surplus Economy. World Economy Outlook, 6, 32-36.
Chen Y (1999). Japanese Economy Depression: Main Causes and Countermeasures. World Economy Outlook, 20, 1217.
MANUCRIPT IN PREPARATION:
PRESENTATIONS:
Chen Y, Chen Z and Motomi M (2009). The Use of Testing Confidence Value for Transitional Decisions for Singlearm Phase II Oncology Trials. 2009 ICSA Applied Statistics Symposium, San Francisco CA.
Chen Y, Chen Z and Motomi M (2009).The Use of Testing Confidence Value for “Go / No Go” Decisions for Phase
II Oncology Trials. 2009 WNAR-IMS Meeting, Portland OR.
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Huang W, Li X, Tudorica LA, Morris EA, Chen Y, Tagge I, Thakur S, Korenblit M, Wang Y, Zhang Z, Koutcher JA,
Springer CS (2009). ROI Biomarkers for Breast Cancer Diagnosis: Shutter-Speed DCE-MRI Experience with Seventy
Seven Suspicious Lesions. 2009 ISMRM 17th Scientific meeting & Exhibition, Honolulu HI. Electronic Multimedia
Posters.
Tagge I, Chen Y, Li X, Morris E, Tudorica A, Springer C, Huang W (2009) Parametric Mapping and Histogram
Analysis of Pixel Pharmacokinetic Parameters for Discrimination of Benign and Malignant Breast Lesions: A
Preliminary Shutter-Speed DCE-MRI Study. 2009 ISMRM 17th Scientific meeting & Exhibition, Honolulu HI.
Electronic Multimedia Posters.
Chen Y and Smith BJ (2008). Optimal Adaptive Group Sequential Design for Phase II Clinical Trials: A Bayesian
Decision Theoretic Approach. 2008 Society for Clinical Trials, St. Louis MO.
Chen Y and Smith BJ (2008). Optimal Adaptive Group Sequential Design for Phase II Clinical Trials: A Bayesian
Decision Theoretic Approach. 2008 ENAR Meeting, Washington D.C., Poster Presentation.
Chen Y and Smith BJ (2008). Optimal Adaptive Group Sequential Design for Phase II Clinical Trials: A Bayesian
Decision Theoretic Approach. 2008 Bayesian Biostatistics Conference, Houston TX, Poster Presentation.
Chen Y and Smith BJ (2007). Optimal Adaptive Group Sequential Design for Phase II Clinical Trials: A Bayesian
Decision Theoretic Approach. 30th Annual Midwest Biopharmaceutical Statistics Workshop, Muncie IN, Poster
Presentation.
Polgreen PM, Chen Y, Ward M, Coffman S, Diekema DJ, Hornick D, Herwaldt LA(2005). An Outbreak of C.
difficile-associated Diarrhea among Elderly Patients in a Small Rural Hospital. Society for Healthcare Epidemiology
of America Meeting, San Diego CA, Poster Presentation.
Gehl A, Chen Y, Dawson D, Mcdaniel A, Southard T, Southard K(2005). The Association between Profile Aesthetic
Scores and Cephalometric Variables. 52nd Annual Meeting of the Iowa Section of the American Association for Dental
Research (AADR), Iowa City IA, Poster Presentation.
HONORS
2008
2007-2008
2008
2007
2007
1998-2000
1998
1994-1997
Student Scholarship for excellent research from Society for Clinical Trials, St. Louis, MO
Amgen Pre-Doctoral Fellowship
Travel Grant of 2008 Bayesian Biostatistics Conference, Houston TX
Charles B. Sampson Student Poster Award 1st Place, 30th Annual Midwest Biopharmaceutical
Statistics Workshop, Muncie, IN
University of Iowa Graduate Summer Fellowship
Yitouhiroharu Graduate Student Fellowship
The Most Outstanding College Graduate of Hangzhou City
Zhejiang University Outstanding Student Scholarship
MEMBERSHIPS:
Institute of Mathematical Statistics
International Society of Bayesian Analysis
American Statistical Association
International Chinese Statistical Association
Society for Clinical Trials
Delta Omega Public Health Honor Society
RESEARCH SUPPORT (ONGOING):
1 UL1 RR024140-01 (Orwoll, Eric) 09/30/2006 - 06/30/2011
NIH/NCRR “Oregon Clinical and Translational Science Institute”
The OCTSI will fundamentally change biomedical research to create a vibrant academic home for
clinical/translational research. At the heart of the OCTSI is a robust partnership between OHSU and
Kaiser Permanente's Center for Health Research that brings together a strong biomedical research
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university and an innovative practice-based research center associated with a large patient population.
The collaboration provides unique opportunities for expansion across the spectrum of human
investigation, and sets the stage for major advances in human health.
Role: Biostatistician
1 R01 CA120861-01A2 Huang (PI) 9/17/2007 -7/31/2010
NCI/NIH
Shutter-Speed DCE-MRI Discrimination of Benign and Malignant Breast Disease.
Major goal: To use a new pharmacokinetic model, shutter-speed model, for quantitative analysis of
breast DCE-MRI data for the purpose of improving breast cancer diagnostic specificity and reducing
unnecessary biopsy procedures.
Role: Co-Investigator
OCTRI/Knight Cancer Institute pilot project funding 12/1/2009 – 11/30/2010
The Use of Testing confidence Value for Transitional Decisions of Single-Arm Phase II Oncology
Trials.
Role: PI
GRANTS PENDING:
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