Ahrens, Werner, Lassmann_Invited Review /Supplementary Table S1 prepared for
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Supplementary Table S1: Overview of published studies addressing miRNA’s in
serum of patients with esophageal cancers. NE= normal epithelium; ESCC=esophageal
squamous cell carcinoma; BAC= Barrett’s adenocarcinoma and precursor lesions of
BE=Barrett’s Epithelium; IEN= Intraepithelial Neoplasia.
miRNA
let-7c
miR-10a
miR-10b*
Tumor
Sample
exosomes
from serum
ESCC
serum
ESCC
salivary
ESCC
serum
ESCC
serum
ESCC
serum
ESCC
salivary
ESCC
serum
higher levels compared to healthy samples
ESCC
exosomes
from serum
exosomal miR-21 were significantly higher in
ESCC patients and correlated with tumor
progression and aggressiveness
ESCC
serum
upregulated in ESCC patients. Suggested as
biomarker by parallel profiling of 7 miRNAs.
ESCC
serum
higher serum levels in ESCC patients
ESCC
serum
miR-21
miR-25
miR-100
miR-127ESCC
3p
miR-133
ESCC
miR-144
miR-145
miR148b
miR200c
miR-223
Reference
(Tanaka,
higher levels compared to healthy samples
Kamohara et al.
2013)
upregulated in ESCC patients. Suggested as (Zhang, Wang et
biomarker by parallel profiling of 7 miRNAs.
al. 2010)
were significantly upregulated in salivary
(Xie, Chen et al.
samples of ESCC patients
2013)
may useful biomarker for cancer detection
(Hirajima,
and monitoring of tumor dynamics in patients Komatsu et al.
with ESCC.
2013)
(Komatsu,
significantly higher in ESCC patients and
Ichikawa et al.
correlation with recurrence and invasion
2011)
higher levels in ESCC patients and associated (Cai, Gao et al.
with metastasis
2012)
were significantly upregulated in salivary
(Xie, Chen et al.
samples of ESCC patients
2013)
ESCC
miR-18a
miR-22
Findings
serum
serum
ESCC
salivary
ESCC
serum
ESCC
serum
ESCC
serum
ESCC
serum
ESCC
serum
ESCC
serum
upregulated in ESCC patients. Suggested as
biomarker by parallel profiling of 7 miRNAs.
upregulated in ESCC patients. Suggested as
biomarker by parallel profiling of 7 miRNAs.
upregulated in ESCC patients. Suggested as
biomarker by parallel profiling of 7 miRNAs.
were significantly upregulated in salivary
samples of ESCC patients
higher levels compared to healthy samples
upregulated in ESCC patients. Suggested as
biomarker by parallel profiling of 7 miRNAs.
higher levels compared to healthy samples,
correlated with poor response to
chemotherapy
and shortened progression-free survival
upregulated in ESCC patients. Suggested as
biomarker by parallel profiling of 7 miRNAs.
significantly higher in ESCC patients and
association with poorer survival
miR-375
significantly lower in ESCC patients
(Tanaka, Miyata
et al. 2013)
(Tanaka,
Kamohara et al.
2013)
(Zhang, Wang et
al. 2010)
(Wu, Li et al.
2014)
(Zhang, Wang et
al. 2010)
(Zhang, Wang et
al. 2010)
(Zhang, Wang et
al. 2010)
(Xie, Chen et al.
2013)
(Tanaka, Miyata
et al. 2013)
(Zhang, Wang et
al. 2010)
(Tanaka, Miyata
et al. 2013)
(Zhang, Wang et
al. 2010)
(Wu, Li et al.
2014)
(Komatsu,
Ichikawa et al.
2011)
Ahrens, Werner, Lassmann_Invited Review /Supplementary Table S1 prepared for
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miR-451
miR1246
ESCC
serum
ESCC
salivary
ESCC
serum
lower serum levels in ESCC patients were
associated with poorer survival
were significantly upregulated in salivary
samples of ESCC patients
correlated with TNM stage/strongest
independent risk factor for poor survival/
potential diagnostic and prognostic biomarker
(Wu, Li et al.
2014)
(Xie, Chen et al.
2013)
(Takeshita,
Hoshino et al.
2013)
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